Breaking News
May 3, 2019 - Vaping and Smoking May Signal Greater Motivation to Quit
May 3, 2019 - Dementia looks different in brains of Hispanics
May 3, 2019 - Short-Staffed Nursing Homes See Drop In Medicare Ratings
May 3, 2019 - Study of teens with eating disorders explores how substance users differ from non-substance users
May 3, 2019 - Scientists develop new video game that may help in the study of Alzheimer’s
May 3, 2019 - Arc Bio introduces Galileo Pathogen Solution product line at ASM Clinical Virology Symposium
May 3, 2019 - Cornell University study uncovers relationship between starch digestion gene and gut bacteria
May 3, 2019 - How to Safely Use Glucose Meters and Test Strips for Diabetes
May 3, 2019 - Anti-inflammatory drugs ineffective for prevention of Alzheimer’s disease
May 3, 2019 - Study tracks Pennsylvania’s oil and gas waste-disposal practices
May 3, 2019 - Creating a better radiation diagnostic test for astronauts
May 3, 2019 - Vegans are often deficient in these four nutrients
May 3, 2019 - PPDC announces seed grants to develop medical devices for children
May 3, 2019 - Study maps out the frequency and impact of water polo head injuries
May 3, 2019 - Research on Reddit identifies risks associated with unproven treatments for opioid addiction
May 3, 2019 - Good smells may help ease tobacco cravings
May 3, 2019 - Medical financial hardship found to be very common among people in the United States
May 3, 2019 - Researchers develop multimodal system for personalized post-stroke rehabilitation
May 3, 2019 - Study shows significant mortality benefit with CABG over percutaneous coronary intervention
May 3, 2019 - Will gene-editing of human embryos ever be justifiable?
May 3, 2019 - FDA Approves Dengvaxia (dengue vaccine) for the Prevention of Dengue Disease in Endemic Regions
May 3, 2019 - Why Tonsillitis Keeps Coming Back
May 3, 2019 - Fighting the opioid epidemic with data
May 3, 2019 - Maggot sausages may soon be a reality
May 3, 2019 - Deletion of ATDC gene prevents development of pancreatic cancer in mice
May 2, 2019 - Targeted Therapy Promising for Rare Hematologic Cancer
May 2, 2019 - Alzheimer’s disease is a ‘double-prion disorder,’ study shows
May 2, 2019 - Reservoir bugs: How one bacterial menace makes its home in the human stomach
May 2, 2019 - Clinical, Admin Staff From Cardiology Get Sneak Peek at Epic
May 2, 2019 - Depression increases hospital use and mortality in children
May 2, 2019 - Vicon and NOC support CURE International to create first gait lab in Ethiopia
May 2, 2019 - Researchers use 3D printer to make paper organs
May 2, 2019 - Viral infection in utero associated with behavioral abnormalities in offspring
May 2, 2019 - U.S. Teen Opioid Deaths Soaring
May 2, 2019 - Opioid distribution data should be public
May 2, 2019 - In the Spotlight: “I’m learning every single day”
May 2, 2019 - 2019 Schaefer Scholars Announced
May 2, 2019 - Podcast: KHN’s ‘What The Health?’ Bye-Bye, ACA, And Hello ‘Medicare-For-All’?
May 2, 2019 - Study describes new viral molecular evasion mechanism used by cytomegalovirus
May 2, 2019 - SLU study suggests a more equitable way for Medicare reimbursement
May 2, 2019 - Scientists discover first gene involved in lower urinary tract obstruction
May 2, 2019 - Researchers identify 34 genes associated with increased risk of ovarian cancer
May 2, 2019 - Many low-income infants receive formula in the first few days of life, finds study
May 2, 2019 - Global study finds high success rate for hip and knee replacements
May 2, 2019 - Taking depression seriously: What is it?
May 2, 2019 - With Head Injuries Mounting, Will Cities Put Their Feet Down On E-Scooters?
May 2, 2019 - Scientists develop small fluorophores for tracking metabolites in living cells
May 2, 2019 - Study casts new light into how mothers’ and babies’ genes influence birth weight
May 2, 2019 - Researchers uncover new brain mechanisms regulating body weight
May 2, 2019 - Organ-on-chip systems offered to Asia-Pacific regions by Sydney’s AXT
May 2, 2019 - Adoption of new rules drops readmission penalties against safety net hospitals
May 2, 2019 - Kids and teens who consume zero-calorie sweetened beverages do not save calories
May 2, 2019 - Improved procedure for cancer-related erectile dysfunction
May 2, 2019 - Hormone may improve social behavior in autism
May 2, 2019 - Alzheimer’s disease may be caused by infectious proteins called prions
May 2, 2019 - Even Doctors Can’t Navigate Our ‘Broken Health Care System’
May 2, 2019 - Study looks at the impact on criminal persistence of head injuries
May 2, 2019 - Honey ‘as high in sugars as table sugar’
May 2, 2019 - Innovations to U.S. food system could help consumers in choosing healthy foods
May 2, 2019 - FDA Approves Mavyret (glecaprevir and pibrentasvir) as First Treatment for All Genotypes of Hepatitis C in Pediatric Patients
May 2, 2019 - Women underreport prevalence and intensity of their own snoring
May 2, 2019 - Concussion summit focuses on science behind brain injury
May 2, 2019 - Booker’s Argument For Environmental Justice Stays Within The Lines
May 2, 2019 - Cornell research explains increased metastatic cancer risk in diabetics
May 2, 2019 - Mount Sinai study provides fresh insights into cellular pathways that cause cancer
May 2, 2019 - Researchers to study link between prenatal pesticide exposures and childhood ADHD
May 2, 2019 - CoGEN Congress 2019: Speakers’ overviews
May 2, 2019 - A new strategy for managing diabetic macular edema in people with good vision
May 2, 2019 - Sagent Pharmaceuticals Issues Voluntary Nationwide Recall of Ketorolac Tromethamine Injection, USP, 60mg/2mL (30mg per mL) Due to Lack of Sterility Assurance
May 2, 2019 - Screen time associated with behavioral problems in preschoolers
May 2, 2019 - Hormone reduces social impairment in kids with autism | News Center
May 2, 2019 - Researchers synthesize peroxidase-mimicking nanozyme with low cost and superior catalytic activity
May 2, 2019 - Study results of a potential drug to treat Type 2 diabetes in children announced
May 2, 2019 - Multigene test helps doctors to make effective treatment decisions for breast cancer patients
May 2, 2019 - UNC School of Medicine initiative providing unique care to dementia patients
May 2, 2019 - Nestlé Health Science and VHP join forces to launch innovative COPES program for cancer patients
May 2, 2019 - Study examines how our brain generates consciousness and loses it during anesthesia
May 2, 2019 - Transition Support Program May Aid Young Adults With Type 1 Diabetes
May 2, 2019 - Study shows how neutrophils exacerbate atherosclerosis by inducing smooth muscle-cell death
May 2, 2019 - Research reveals complexity of how we make decisions
Blood test predicts silent heart disease risk

Blood test predicts silent heart disease risk

[ad_1]

Study shows that blood troponin levels can predict risk of heart attack and death, and response to statins.

A high-sensitivity blood test could be used to predict which patients are at risk of a heart attack according to new research funded by the British Heart Foundation (BHF).

The study, published in the Journal of the American College of Cardiology, shows the troponin test – currently used to help diagnose a heart attack – could also be a more effective way of assessing future heart disease risk than blood pressure or cholesterol.

As a result, the researchers say the test could more precisely identify people who will benefit from statins, and assess the impact that statins are having in lowering someone\’s heart disease risk.

Coronary heart disease – the cause of heart attacks – is the UK\’s single biggest killer, accounting for nearly 70,000 deaths in the UK each year. When heart muscle is damaged it leaks a protein called troponin in to the blood stream. Patients suspected of suffering a heart attack will often be given a troponin test to aide diagnosis, but until now the test has not been used to assess future heart attack risk.

In this study of over 3,000 men with high cholesterol but no history of heart disease, the team found that changes in blood levels of a high-sensitivity troponin test from Abbott Diagnostics accurately predicted the risk of a person suffering a heart attack or dying of coronary heart disease up to 15 years later.

Troponin improved the prediction of coronary heart disease risk adding to traditional markers, such as cholesterol levels and blood pressure. If borne out in larger, more diverse, studies, doctors may be able to use the troponin test to determine which patients are most likely to develop coronary heart disease.

The researchers from the University of Edinburgh and University of Glasgow also found that by measuring levels of troponin in the blood they could tell which patients were responding to the statins used to treat them.

Remarkably, taking a statin reduced troponin levels. Those whose troponin levels decreased the most had a 5-fold lower risk of heart attack or death from coronary heart disease compared with those who troponin levels were unchanged or increased. A decrease in troponin could indicate treatment is effective, whereas any increases in blood troponin could prompt a change in treatment strategy.

Statins are used to prevent coronary heart disease in people who are considered high-risk, but more accurate risk assessment could help doctors to target treatment to those who need it most. Statins are currently recommended for patients considered at high risk of cardiovascular disease based on traditional clinical indicators. Higher levels of troponin may reflect \’silent\’ coronary artery disease, and identify those at greatest risk who could benefit from targeted therapy.

While encouraging, these results were obtained in a population of middle-aged men with high blood cholesterol. Further work to see whether the same effects are seen in women and men with lower cholesterol levels will need to take place before the test can be used in clinical practice.

Professor Nicholas Mills, BHF Senior Clinical Research Fellow at the University of Edinburgh, who led the research, said:
\”These results are tremendously exciting, and could revolutionise the way we manage patients at risk of coronary heart disease.\”

\”Whilst blood cholesterol levels and blood pressure are important and associated with the risk of developing heart disease, troponin is a direct measure of injury to the heart. Troponin testing will help doctors to identify apparently healthy individuals who have silent heart disease so we can target preventative treatments to those who are likely to benefit most.\”

Professor Sir Nilesh Samani, Medical Director at the British Heart Foundation, said:
\”Thanks in part to research funded by the BHF the use of troponin tests to determine whether or not a person has had a heart attack when they first arrive at hospital is now firmly established in clinical practice.
\”Now, the hope from this new research is that we may be able to use this simple test earlier on to identify people at higher risk of suffering from a heart attack. Those found to be at higher risk could have their preventative treatments intensified.

\”Before the findings from this research can be clinically applied, the usefulness of measuring troponin findings need to be demonstrated in a wider group of patients. If this confirms its value, the test could easily be administered by GPs during standard check-ups, and could ultimately save lives.\”

Article: High-Sensitivity Cardiac Troponin, Statin Therapy, and Risk of Coronary Heart Disease, Ian Ford, Anoop S.V. Shah, Ruiqi Zhang, David A. McAllister, Fiona E. Strachan, Muriel Caslake, David E. Newby, Chris J. Packard, Nicholas L. Mills, Journal of the American College of Cardiology, doi: 10.1016/j.jacc.2016.10.020, published 25 December 2016.

[ad_2]

About author