Breaking News
November 19, 2017 - Don’t Fret Delays in Treating Colon Cancer, Study Suggests
November 19, 2017 - Yeast Infection Test: MedlinePlus Lab Test Information
November 19, 2017 - Video of blood clot contraction reveals how platelets naturally form unobtrusive clots
November 19, 2017 - UNN researchers explore modeling of cognitive dissonance phenomenon
November 19, 2017 - Verseon presents second anticoagulation candidate for clinical trials at AHA 2017
November 19, 2017 - Pregnant Asian women who develop high blood pressure at highest risk for heart failure hospitalization
November 19, 2017 - Medicare seeks comment on ways to cut costs of Part D drugs
November 19, 2017 - Tree cover linked to fewer asthma cases in polluted urban neighborhoods
November 19, 2017 - Make the Diagnosis: Hair Care Conundrum
November 19, 2017 - New techniques give blood biopsies greater promise
November 19, 2017 - Researchers identify possible genetic basis for coronary artery disease
November 19, 2017 - Stress experienced by emergency call handlers has negative impact on psychological health
November 18, 2017 - New cancer cell screening is improving childhood leukaemia treatment
November 18, 2017 - Groundbreaking study identifies protein as potential factor in cancer metastasis
November 18, 2017 - New model to test effectiveness of existing and potential CF therapies
November 18, 2017 - Staying Active May Lower Odds for Glaucoma
November 18, 2017 - Potential new autism drug shows promise in mice
November 18, 2017 - Some states roll back ‘retroactive Medicaid,’ a buffer for the poor — and for hospitals
November 18, 2017 - Selectively deleting stem cell factor promotes recovery after TBI in mice
November 18, 2017 - Breakthrough research brings new procedure closer to helping patients with blood cancer
November 18, 2017 - Dr Peter Simpson Appointed to SLAS Board of Directors
November 18, 2017 - Friendships between young children can protect against ADHD
November 18, 2017 - Old World monkeys could hold key to stop progression of rheumatoid arthritis
November 18, 2017 - Harris Health System RNs named among 20 Outstanding Nurses for 2017
November 18, 2017 - Old World monkeys could be key to a new, powerful rheumatoid arthritis therapy
November 18, 2017 - Mount Sinai researchers identify new therapeutic target for ER+ breast cancer
November 18, 2017 - Age, CRP levels predict success in tapering of biologics in rheumatoid arthritis patients
November 18, 2017 - New dye could be used to observe electrical activity of neurons in the brain
November 18, 2017 - New study further validates use of vaginal progesterone to decrease risk of preterm birth
November 18, 2017 - Russian researcher determined range of reference values for boron in the human body
November 18, 2017 - ‘What the Health?’ Tax bill or health bill?
November 18, 2017 - Could Your Cat Give You ‘Bird Flu?’
November 18, 2017 - Vitamin D Linked to Fertility Outcomes in ART
November 18, 2017 - Neuroscientists identify genetic changes in microglia in a mouse model of neurodegeneration and Alzheimer’s disease
November 18, 2017 - Tax reform proposal could impact care for older Americans
November 18, 2017 - PCSK9 inhibitor offers clinical benefit to patients with peripheral artery disease
November 18, 2017 - Researchers receive £1.3 million to develop sight-saving imaging technology
November 18, 2017 - Novel buckypaper sensor could pave way for high-performance, affordable wearable technology
November 18, 2017 - Despite ACA cost protections, most adolescents skip regular checkups
November 18, 2017 - Stem cell treatment allows paraplegic rats to walk and regain sensory perception
November 18, 2017 - HTC analytical conference comes to the UK
November 18, 2017 - Face It: Drinking, Smoking Takes Toll on Looks: MedlinePlus Health News
November 18, 2017 - New research shows where in the brain the earliest signs of Alzheimer’s occur
November 18, 2017 - Philips announces launch of global movement to raise awareness for COPD
November 18, 2017 - University of Bristol awarded grant to reduce antibacterial drug resistance in Thailand
November 18, 2017 - New oxytocin chemical sensor could be first step towards early diagnosis of autism
November 18, 2017 - Study shows how naïve T-cells may affect tumor immunity and immunotherapy
November 18, 2017 - New studies highlight importance of cardiorespiratory fitness to reduce CVD risk
November 18, 2017 - Study finds medical cannabis is effective at reducing opioid addiction
November 18, 2017 - Specially tailored, ultrafast light pulses can trigger neurons to fire in different patterns
November 18, 2017 - Decrease in sunshine linked to rising incidence of Rickets
November 18, 2017 - Harnessing social media big data to fight against prescription drug crisis
November 18, 2017 - Researchers find way to switch tumor cells between 2D and 3D morphology
November 18, 2017 - Leaf-eating ability of beetle largely due to bacteria inside the insect
November 18, 2017 - FDA Approves Hemlibra (emicizumab-kxwh) for Hemophilia A with Inhibitors
November 18, 2017 - Adolescents underreport amphetamine use, likely unaware that adderall is amphetamine
November 18, 2017 - Study reveals a reduced risk of teenage eczema in breastfed babies
November 18, 2017 - Separating side effects could pave way for safe, effective pain medications
November 18, 2017 - Gut bacteria at young age can contribute to MS disease onset and progression, study suggests
November 18, 2017 - Environmental triggers may play role in development of Lupus
November 18, 2017 - Review looks into conventional versus new treatment modalities in orthodontic pain management
November 17, 2017 - FDA Alert: Diphenoxylate Hydrochloride and Atropine Sulfate Tablets by Greenstone: Recall
November 17, 2017 - For older women, every movement matters
November 17, 2017 - Talking-based therapy could transform aftercare for cancer survivors
November 17, 2017 - Olympus IXplore SpinSR10 imaging system enables researchers to observe fine details in live cells
November 17, 2017 - Study explores reasons for underrepresentation of minorities in genetic cancer research
November 17, 2017 - California firm running physician practices is closing down as scrutiny ramps up
November 17, 2017 - BMI not valid measure of obesity in postmenopausal women, study shows
November 17, 2017 - Vaginal progesterone decreases the risk of premature birth in women with short cervix
November 17, 2017 - Pricey ER Tests for Chest Pain Often Unnecessary
November 17, 2017 - ‘Old’ Lungs May Be Good Transplant Options: MedlinePlus Health News
November 17, 2017 - How not to gain weight over the holidays
November 17, 2017 - Researchers map first-ever proteome of healthy human heart
November 17, 2017 - Drug used to prevent and treat malaria may also be effective for Zika virus
November 17, 2017 - One in 20 children still receiving codeine to treat pain despite warning from federal regulators
November 17, 2017 - Improving clinical trials with machine learning
November 17, 2017 - Experts identify mental exercise program that can reduce risk of dementia
November 17, 2017 - Just-in-time 3-D implants set to transform tumor surgery
November 17, 2017 - Skin patch offers hope for people with peanut allergy
November 17, 2017 - Scientists identify biomarkers that predict risk of death in Ebola patients
Blood take a look at might expect medicine results for sufferers with localized NSCLC

Blood take a look at might expect medicine results for sufferers with localized NSCLC

image_pdfDownload PDFimage_print

A brand new learn about demonstrates blood take a look at to come across most cancers might expect medicine results for sufferers with localized non-small cellular lung most cancers (NSCLC) and come up with the money for physicians further lead time to personalize medicine for recurrent illness. Sufferers within the learn about with detectable ranges of circulating tumor DNA (ctDNA) in a while after medicine all had recurrences inside of two years, whilst all however one of the vital sufferers with out detectable ctDNA in a while after medicine remained disease-free and survived long-term. Typical imaging, conversely, was once no longer prognostic for recurrence or survival. Findings will probably be offered as of late on the 59th Annual Assembly of the American Society for Radiation Oncology (ASTRO).

The competitive nature of lung most cancers could make long-term control particularly difficult. As a result of NSCLC has a tendency to development, even following medicine, common tracking for recurrence is essential. The CT scans in most cases used for tracking, then again, are steadily not able to come across microscopic tumor deposits or to tell apart standard tissue adjustments led to via medicine from adjustments led to via recurrent illness.

“Blood exams that may come across minute lines of most cancers that stay after medicine may just make stronger recurrence tracking and probably be offering physicians months of extra lead time to tailor therapies and make stronger our sufferers’ results and high quality of lifestyles,” stated Aadel Chaudhuri, MD, PhD, lead writer of the learn about and a major resident in radiation oncology at Stanford College in Palo Alto, California.

“Our findings recommend that ctDNA research, in contrast to CT scans, can determine in a while after medicine of completion if a affected person with localized lung most cancers has most probably been cured via radiation or surgical operation or if she or he nonetheless has most cancers cells provide of their frame. Whilst we anticipated that ctDNA detection of molecular residual illness would expect deficient scientific results, we had been shocked via how strongly predictive the take a look at was once for recurrence and survival.”

Presence of ctDNA was once measured as a marker of molecular residual illness (MRD) in sufferers with degree I-III NSCLC instantly earlier than medicine and in a while after medicine was once finished. ctDNA ranges additionally had been measured mid-treatment (reasonable = Three weeks, vary = 1.Four-Three.7 weeks) for part of the sufferers receiving chemoradiation (n = 13 of 27 sufferers). Most cancers Customized Profiling via Deep Sequencing (CAPP-Seq) was once used to evaluate whether or not ctDNA was once provide. Surveillance scans the use of CT imaging had been evaluated the use of the Reaction Analysis Standards In Forged Tumors (RECIST).

The median affected person age was once 67 years (vary 47-91 years), and maximum sufferers (67%) had been male. All 41 sufferers had been handled with healing intent, together with with chemoradiation remedy (66%), radiation remedy on my own (27%) and surgical operation on my own (7%). Median follow-up for the learn about was once 35 months (vary 7-56 months).

Researchers detected ctDNA pretreatment in 38 of the 41 sufferers (93%). Thirty-four of those 38 sufferers had blood drawn inside of 4 months of medicine of completion (the prespecified MRD landmark) and had been eligible for next research.

A few of the 34 sufferers with ctDNA MRD pretreatment, greater than part (56%, n = 19) had detectable residual illness after medicine. All of those sufferers therefore evolved recurrent lung most cancers, in comparison with most effective one of the vital 15 sufferers with out detectable ctDNA MRD.

Sufferers with detectable ctDNA MRD after medicine had worse freedom from development and survival than sufferers with out detectable ctDNA MRD (freedom from development Danger Ratio (HR) = 44.zero, p < zero.0001; disease-specific survival HR = 27.7, p < zero.0001). CT imaging on the identical time was once no longer prognostic for survival. ctDNA ranges earlier than medicine additionally weren't related to survival results.

In 8 of the 13 sufferers assessed mid-treatment, ctDNA accounted for zero.1 p.c or extra of all cell-free DNA. For those sufferers, mid-treatment ctDNA ranges predicted eventual illness development (HR = 2.7, p = zero.006). Sixty p.c of the sufferers with not up to zero.1 p.c ctDNA mid-treatment had been progression-free at two years following medicine, in comparison to not one of the sufferers with zero.1 p.c or upper ranges of ctDNA (HR = Four.Four, p = zero.037).

“Someday, clinicians could possibly use ctDNA research to spot sufferers who may just get pleasure from further medicine after first-line remedy,” stated Maximilian Diehn, MD, PhD, senior writer of the learn about and an assistant professor of radiation oncology at Stanford.

“In a similar learn about additionally offered at this yr’s ASTRO Annual Assembly, we discovered that ctDNA research detected illness recurrence a mean five.five months previous than standard-of-care CT imaging for localized lung most cancers and helped with interpretation of equivocal follow-up imaging. This implies that ctDNA research may just open a window to regard sufferers with residual most cancers early, whilst illness burden is minimum.”​

Tagged with:

About author

Related Articles