Breaking News
January 24, 2018 - Study illustrates role of specific antibodies in protection against influenza
January 24, 2018 - Curcumin could provide meaningful cognitive benefits, study suggests
January 24, 2018 - Tenax Therapeutics Announces Plan to Develop Levosimendan for a Pulmonary Hypertension Indication with No FDA Approved Therapies
January 24, 2018 - EndoBreak: Obesity in 2018; Diabetes Risks in Pregnancy
January 24, 2018 - Recommendations to improve the quality of ultrasound imaging in obstetrics and gynecology
January 24, 2018 - Sensory feedback facilitates enhanced brainwave control of portable hand-exoskeleton
January 24, 2018 - Innovative system helps medical staff to accurately evaluate patients’ risk of falling
January 24, 2018 - Porvair Sciences to showcase microplate and chromatography products at Analytica 2018
January 24, 2018 - Children with cochlear implant learn words faster than kids with normal hearing
January 24, 2018 - Ionis’ Inotersen NDA Accepted for Priority Review by the FDA
January 24, 2018 - Abuse-Deterrent Opioid No Help in Australia
January 24, 2018 - Maternal mortality rates are on the rise, but more accurate estimates are needed
January 24, 2018 - New essential oil inhaler facilitates pain management
January 24, 2018 - USPSTF: Insufficient Evidence to Screen Kids for Scoliosis
January 24, 2018 - Team develops method to identify seizure-causing regions in the brain
January 24, 2018 - New report takes comprehensive look at health effects of e-cigarettes
January 24, 2018 - Researchers develop new indicator for assessing active aging
January 24, 2018 - Research highlights decreasing trend in traditional hysterectomy
January 24, 2018 - Computer-based speech analysis has potential to improve prediction of psychosis
January 24, 2018 - New family of FFPE reagent kits launched by Beckman Coulter Life Sciences
January 24, 2018 - Researchers use epigenetic signatures to advance diagnosis for neurodevelopmental disorders
January 24, 2018 - EPI report reveals air quality as major environmental threat to public health
January 23, 2018 - How to Fight the Flu This Season
January 23, 2018 - Mixed Data for Fatty Acid Intake and Glaucoma
January 23, 2018 - The brains of jazz and classical pianists work differently
January 23, 2018 - Scientists identify protein biomarkers to track patients with Hutchinson-Gilford progeria syndrome
January 23, 2018 - Exercise could extend the life expectancy of breast cancer survivors, study states
January 23, 2018 - Researchers show association between microbiome and cancer-related blood infections
January 23, 2018 - Cancer.com Site Sat Dormant for 10 Years. Now It’s Live Again.
January 23, 2018 - FDA’s program to speed up drug approval shaved nearly a year off the process
January 23, 2018 - Study reveals key challenges and frustrations associated with current RTSM/IRT solutions
January 23, 2018 - Researchers unravel function of protein ‘smallish’
January 23, 2018 - Infants born in withdrawal due to opioid exposure in utero show abnormalities
January 23, 2018 - Researchers block common siren call of glioblastoma and metastatic breast cancer
January 23, 2018 - FDA Accepts New Drug Applications for Merck’s Doravirine, the Company’s Investigational Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI), for Treatment of HIV-1 Infection
January 23, 2018 - Six Concerns About Practice Consolidation
January 23, 2018 - How Alzheimer’s Changes the Brain
January 23, 2018 - Pharmaceutical stirs outrage over price hike for brain tumor drug
January 23, 2018 - University under fire for off-the-grid herpes vaccine experiments
January 23, 2018 - Gastric environment permanently changes in the presence of Helicobacter pylori infection
January 23, 2018 - Scientists take tissue-engineering approach to improve healing related to skeletal system
January 23, 2018 - Consumption of dietary fiber can prevent obesity and metabolic syndrome, study shows
January 23, 2018 - FDA Alert: Multiple Drug Products by Flawless Beauty: Recall
January 23, 2018 - Rhymes with Amyloid: That’s Improbable!
January 23, 2018 - CLCN2-related leukoencephalopathy – Genetics Home Reference
January 23, 2018 - Can road salt and other pollutants disrupt our circadian rhythms?
January 23, 2018 - ‘Depression literacy’ program encourages many teens to seek adult help
January 23, 2018 - New initiative seeks to transform the way people live with dementia
January 23, 2018 - Isosec introduces first Virtual Smartcard for NHS Trusts and clinicians
January 23, 2018 - New report reveals rapid growth in Vietnam pharmaceutical market
January 23, 2018 - Obamacare Led to Rise in Breast Cancer Screening
January 23, 2018 - Bariatric Tx Bests Usual Care for Long-Term Health
January 23, 2018 - Keep Your Dogs and Cats Safe From Holiday Hazards
January 23, 2018 - New AI technology significantly improves human kidney analysis
January 23, 2018 - In Trump’s first year, anti-abortion forces make strides despite setbacks
January 23, 2018 - Small PFS Bump in Gastric/GEJ Cancer
January 23, 2018 - Defending against environmental stressors may shorten lifespan
January 23, 2018 - Researchers create cavitation bubbles to remove dental plaque
January 23, 2018 - Discovery offers fresh perspective on how the brain keeps its balance
January 23, 2018 - Opioid exposure linked to physical abnormalities in newborns
January 23, 2018 - Study identifies genes involved in latent asymptomatic state of breast cancer metastases
January 23, 2018 - Kala Pharmaceuticals Announces New Drug Application for Inveltys (KPI-121 1%) Has Been Accepted for Review by the U.S. Food and Drug Administration
January 23, 2018 - Closer Look at Household Contacts Finds More TB Cases
January 23, 2018 - Type 1 IFNs may mediate Zika pregnancy complications
January 23, 2018 - Anti-inflammatory pill could help make vaccines more effective for the elderly
January 23, 2018 - New discovery sheds light on iron-restricted anemia that causes fatigue in millions
January 23, 2018 - BMG LABTECH’s Australian office celebrates 20 years of innovation and growth in APAC region
January 23, 2018 - FDA Alert: Basic Drugs Brand of Senna Laxative by Magno-Humphries Laboratories: Recall
January 23, 2018 - Chronic Opioid Use High Among IBD Patients
January 23, 2018 - New long-acting, less-toxic HIV drug suppresses virus in humanized mice
January 23, 2018 - Findings provide better understanding of cognitive inflexibility in Fragile X Syndrome
January 23, 2018 - Powerful anti-oxidant can stop progression of fatty liver disease in young mice
January 23, 2018 - Marijuana use does not lower probability of conception, study shows
January 23, 2018 - Study shows value of occupational therapy in the lives of young adults with diabetes
January 23, 2018 - Chinese researchers develop multifunctional vehicle to transport gene therapeutics
January 23, 2018 - Researchers seek to understand effect of very low birth weight on the brain
January 23, 2018 - Be a Savvy Supermarket Shopper
January 23, 2018 - NIH Striving to Avoid False Hope in Chronic Fatigue
January 23, 2018 - ClinicalTrials.gov: Occupational Stress
January 23, 2018 - PrEP could make US easily hit its 2020 HIV prevention goal, study finds
Lowered glucose metabolism in medial prefrontal spaces related w/ dietary standing in sufferers Alzheimer's illness

Lowered glucose metabolism in medial prefrontal spaces related w/ dietary standing in sufferers Alzheimer's illness

image_pdfDownload PDFimage_print
An overlay of important advantageous correlation of rCGM with WHtR in prodromal/early AD (n = 34) and CN (n = 55) adjusted for age, intercourse, and schooling. Colour overlays display comparability of correlation of rCGM with WHtR between prodromal/early AD (pink colour overlay) and CN (inexperienced colour overlay). rCGM, regional cerebral glucose metabolism; WHtR, waist to peak ratio; AD, Alzheimer’s illness; CN, cognitively customary. Credit score: Analysis Investment of Longevity Sciences

A brand new learn about from the Multimodal Neuroimaging for AD Prognosis (MULNIAD) learn about, which is a potential learn about carried out on the Nationwide Middle for Geriatrics and Gerontology (NCGG), supplies that hypometabolism within the medial prefrontal spaces is in particular related to Alzheimer’s disease-related dietary issues, and reduce in fats mass can have a key position. This learn about is printed within the Magazine of Alzheimer’s Illness.

Dietary issues, particularly weight reduction, are frequently observed in folks with Alzheimer’s illness (AD); then again, the underlying mechanisms aren’t smartly understood.

“This learn about is a vital learn about to lend a hand perceive the underlying mechanism of weight reduction in sufferers with gentle cognitive impairment and Alzheimer’s illness.”, says Dr. Takashi Sakurai, corresponding writer, head of the Reminiscence Health center on the NCGG.

This present learn about is the primary to explain the associations of dietary standing with AD-related mind adjustments comprehensively by way of the usage of multi imaging modalities together with amyloid-β (Aβ)- positron emission tomography (PET), 18F-fluorodeoxyglucose (FDG)-PET, and structural magnetic resonance imaging.

Topics had been 34 Aβ-positive folks with gentle cognitive impairment or early AD (prodromal/early AD), and 55 Aβ-negative cognitively customary (CN) topics. The associations between dietary standing (frame mass index, waist to peak ratio, fats mass index, and fat-free mass index) and mind adjustments had been tested by way of multipleregression evaluation the usage of statistical parametric mapping.

Within the prodromal/early AD crew, dietary standing was once considerably definitely correlated with regional cerebral glucose metabolism (rCGM) within the medial prefrontal cortices, whilst other topographical associations had been observed within the CN crew. Aβ deposition and grey subject quantity weren’t related to dietary standing. Sub-analysis within the prodromal/early AD crew demonstrated that fats mass index, however now not fat-free mass index, was once definitely correlated with rCGM within the medial prefrontal spaces.

“Those effects recommend that hypometabolism within the medial prefrontal spaces is in particular related to AD-related weight reduction, and reduce in fats mass can have a key position. Then again, this cross-sectional learn about supplies initial effects, so we’d like additional longitudinal investigation bearing in mind the fats tissue metabolism together with adipokines to deepen our working out of AD connected weight reduction”, says Dr. Takashi Sakurai. After adjusting for cognitive serve as, the numerous hyperlink between fat-mass index and rCGM was once preserved.

The learn about findings of diminished glucose metabolism in medial prefrontal spaces in Aβ-positive folks might provide an explanation for the underlying mechanism of weight reduction in AD.


Discover additional:
Alzheimer’s illness biomarker known throughout take a look at websites

Additional information:
Taiki Sugimoto et al, Lowered Glucose Metabolism in Medial Prefrontal Spaces is Related to Dietary Standing in Sufferers with Prodromal and Early Alzheimer’s Illness, Magazine of Alzheimer’s Illness (2017). DOI: 10.3233/JAD-170257

Magazine reference:
Magazine of Alzheimer’s Illness

Supplied by way of:
IOS Press

Tagged with:

About author

Related Articles