Breaking News
March 20, 2018 - Antibiotics could benefit women suffering from chronic bladder pain
March 20, 2018 - Health Highlights: March 16, 2018
March 20, 2018 - Interventional Radiology Has a Problem of ‘Unseen’ Value
March 20, 2018 - Antibodies show effectiveness for HIV prevention and promise for treatment and cure
March 20, 2018 - 50% of Australians do not brush teeth twice a day
March 20, 2018 - American Gene Technologies receives second immuno-oncology patent
March 20, 2018 - Study finds no link between long-term violent video game play and adult aggression
March 20, 2018 - Weight loss surgery widely underutilized among young patients with severe obesity
March 20, 2018 - Scientists uncover new answers to cell aging in children with rare, fatal disease
March 20, 2018 - The Pistoia Alliance Calls for Greater Life Sciences Collaboration to Build the ‘Lab of the Future’
March 20, 2018 - Morning Break: Psychopathic Thought; Americans Flout Zzz’s; Farm to Pharma
March 20, 2018 - Perceptions of old age change as we age
March 20, 2018 - New standards for public involvement in research launched across the UK
March 20, 2018 - Whole Genome Sequencing used as diagnostic solution for TB
March 20, 2018 - Researchers show how two cancer genes work together to trigger leukemia
March 20, 2018 - Scientists discover basic molecular mechanism that helps understand how ALS works
March 20, 2018 - Multi-center study to evaluate promising new intervention for upper limb dysfunction after SCI
March 20, 2018 - Researchers develop technology to program DNA for delivering cancer drugs
March 20, 2018 - Northwestern scientists bring precision medicine to rheumatoid arthritis
March 20, 2018 - Research suggests possible link between heading a soccer ball and brain imbalance
March 20, 2018 - Robocall increases diabetic retinopathy screening rates among poor minorities
March 20, 2018 - INSYS Therapeutics Initiates Phase 3 Clinical Trial of Cannabidiol (CBD) Oral Solution for Treatment of Infantile Spasms
March 20, 2018 - Little Talk Between Docs and Patients Pre-PSA Screen
March 20, 2018 - Women GPs bring remote care to rural Pakistan
March 20, 2018 - Adults skipping vaccines may miss out on effective new shingles shot
March 20, 2018 - Suppressing emotions appears to reduce negative memories
March 20, 2018 - Epidural stimulation can safely, effectively normalize blood pressure in patients with SCI
March 20, 2018 - ‘Fast track’ project shows promising results in cancer whole genome analyses
March 20, 2018 - Advanced insulin pump system can also manage type 1 diabetes in children, study shows
March 20, 2018 - Flu risk less on flights if in a window seat finds study
March 20, 2018 - Sarepta Therapeutics Announces Plan to Submit a New Drug Application (NDA) for Accelerated Approval of Golodirsen (SRP-4053) in Patients with Duchenne Muscular Dystrophy (DMD) Amenable to Skipping Exon 53
March 20, 2018 - Post-Transplant Fatty Liver Disease on the Rise
March 20, 2018 - New mutation linked to ovarian cancer can be passed down through dad
March 20, 2018 - Alex’s experiences of living with rare genetic disease
March 20, 2018 - Scotland study aims to offer precise diagnoses for people with rare genetic diseases
March 20, 2018 - Stem cell treatment may help rejuvenate ovaries, avoid effects of premature menopause
March 20, 2018 - FDA Approves Hizentra (Immune Globulin Subcutaneous [Human] 20% Liquid) for the Treatment of Patients With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
March 20, 2018 - Death Strikes Young in RA
March 20, 2018 - Quiescent cells also mutate
March 20, 2018 - Stem cell-derived ocular cells treat severe AMD
March 20, 2018 - Mediterranean diet appears to be good for postmenopausal women’s bones and muscles
March 20, 2018 - Scientists discover rare childhood liver cancer’s ability to metastasize to the brain
March 20, 2018 - Treating metastatic breast cancer with immunotherapy
March 20, 2018 - The 5:2 diet could have beneficial impact on important risk markers for cardiovascular disease
March 20, 2018 - Congress tackles the opioid epidemic. But how much will it help?
March 20, 2018 - Neanderthals Just Part of the Evolutionary Puzzle
March 20, 2018 - Higher Mortality With Surgery for Early NSCLC
March 20, 2018 - Researchers go skin deep to explore what causes wrinkles
March 20, 2018 - E-cigarette use linked to fat accumulation in the liver
March 20, 2018 - Fearful worms provide new clues about human anxiety
March 20, 2018 - Oral micronized progesterone may reduce hot flashes, night sweats in perimenopausal women
March 20, 2018 - Newer treatment for type 2 diabetes reduces liver fat in patients with NAFLD
March 20, 2018 - I.D. Break: PrEP Map; Faulty Flu Meds; Better Zika Test?
March 20, 2018 - Bronchial thermoplasty can improve severe asthmatic cough
March 19, 2018 - Speeding up wound healing using nanofiber dressings
March 19, 2018 - Summit Announces New Analysis Showing Ezutromid Significantly Reduced Muscle Inflammation in Phase 2 Clinical Trial in DMD
March 19, 2018 - Optimizing Sham Acupuncture: That’s Improbable!
March 19, 2018 - Women who have gestational diabetes in pregnancy are at higher risk of future health issues
March 19, 2018 - Viagra cuts colorectal cancer risk in animal model
March 19, 2018 - Vitamin B12 supplementation could postpone disease progression in Parkinson’s patients
March 19, 2018 - Study shows that omega-6 fatty acids could protect against premature death
March 19, 2018 - TherapeuticsMD Announces FDA Acceptance of New Drug Application (NDA) and Prescription Drug User Fee Act (PDUFA) Date for TX-001HR
March 19, 2018 - Minorities More Sensitive To Pain? Pain Medicine News Report
March 19, 2018 - Low blood sugar poses unaddressed threat to people with type 2 diabetes
March 19, 2018 - ACEA goes live with exhaustive, searchable library of NovoCyte publications
March 19, 2018 - Consumption of low-calorie sweeteners could promote metabolic syndrome, increase diabetes risk
March 19, 2018 - Wearable medical patch shows promise for early detection of hypoglycemia in type 1 diabetes
March 19, 2018 - High-energy breakfast leads to better diabetes control and weight loss
March 19, 2018 - D.C. Week: Community Health Centers Get Azar’s Love
March 19, 2018 - Younger siblings of SIDS victims have four-fold increased risk of sudden death
March 19, 2018 - Toothpaste alone does not prevent dental erosion or hypersensitivity
March 19, 2018 - Discovery aids understanding of amyotrophic lateral sclerosis
March 19, 2018 - Hormone imbalance may be reason for higher diabetes rates among men with insufficient sleep
March 19, 2018 - Docs worry there’s ‘nowhere to send’ new and expectant moms with depression
March 19, 2018 - Obesity linked to increased DNA damage in breast epithelium of BRCA mutation carriers
March 19, 2018 - Heart rate increases with higher alcohol consumption
March 19, 2018 - Template produced for clinically validated DIY stethoscope
March 19, 2018 - Experts highlight nocturia as most common cause of poor night’s sleep
March 19, 2018 - Fit Middle-Aged Women May Fend Off Dementia Later
March 19, 2018 - Fake Insta Doc; Humana’s Weird Pay Bump Tax Trick; Few NPDB Searches
Epigenetic 'fingerprint' identifies diabetes threat

Epigenetic 'fingerprint' identifies diabetes threat

image_pdfDownload PDFimage_print
Professor Leigh Ackland (left), Director of Deakin’s Centre for Mobile and Molecular Biology, and Deputy Director of the Molecular and Clinical Analysis SRC and Ms Bronwyn Halfpenny (proper), Victorian Govt Well being Ambassador for Diabetes. Credit score: Deakin College

Deakin researchers have recognized an epigenetic marker that predicts threat of sort 2 diabetes in girls with gestational diabetes.

Scientists at Deakin College have found out that particular epigenetic markers can distinguish girls with gestational diabetes who broaden sort 2 diabetes from girls with gestational diabetes who don’t broaden sort 2 diabetes after being pregnant.

Gestational diabetes is expanding considerably in Australia. Its prevalence has nearly doubled since 2013 – expanding by way of 8 consistent with cent all through 2016.

“Previously yr in Australia over 37,000 girls have been recognized with gestational diabetes, that is 103 girls each day,” stated undertaking chief Professor Leigh Ackland, Director of Deakin’s Centre for Mobile and Molecular Biology, and Deputy Director of the Molecular and Clinical Analysis SRC.

“Gestational diabetes is a sturdy inhabitants predictor of next construction of sort 2 diabetes, with a better than seven-fold build up in threat of construction of sort 2 diabetes, when put next with girls with customary blood glucose ranges in being pregnant,” Professor Ackland stated.

A Deakin group, with colleagues from a number of different universities, examined 39 Australian girls within the overdue phases of being pregnant for glucose intolerance and Kind 2 diabetes – retesting the ladies at 20 weeks post-partem. In girls with gestational diabetes, other epigenetic profiles have been discovered within the staff of girls who evolved sort 2 diabetes, when put next with girls who didn’t.

The Victorian Govt Well being Ambassador for Diabetes, Ms Bronwyn Halfpenny, lately visited Deakin’s Centre for Mobile and Molecular Biology, and the Molecular and Clinical Analysis Strategic Analysis Centre (SRC) to be informed concerning the analysis. Ms Halfpenny is Member for Thomastown and Govt Whip within the Victorian Legislative Meeting.

“It’s superb to be informed concerning the science at the back of diabetes,” Ms Halfpenny stated. “I’m very enthusiastic about the potential for this analysis. It is specifically thrilling that we will be able to goal explicit teams – as a significantly better manner of allocating our assets.”

Professor Ackland defined that girls with a historical past of gestational diabetes are at greater threat of heart problems and their offspring are at greater threat of metabolic syndrome, diabetes and heart problems.

Professor Trish Livingston, Affiliate Dean (Analysis) within the College of Well being, defined that the brand new box of epigenetics has remarkable attainable for progressing well being remedy in lots of spaces. Made conceivable by way of refined analytic era akin to three-D imaging and genome sequencing, it addresses adjustments in organisms brought about by way of amendment of gene expression, moderately than alteration of the genetic code itself.

“Epigenetics presentations us how environmental components can have an effect on the human frame and will exchange our body structure,” stated Professor Livingston. “The adjustments to gene expression may also be transmitted throughout generations.”

Professor Ackland famous that, till now, epigenetics has been extra of a lab-based science.

“It hasn’t been taken up prior to now in public well being spaces like gestational diabetes, nevertheless it has large attainable,” she stated.

The Deakin researchers are lately searching for investment to broaden the following analysis section as a collaborative undertaking throughout Victorian areas with well being suppliers akin to Western Well being and Monash Well being, to validate their learn about on a bigger scale over a five-year, post-partum length.

They hope the brand new learn about will permit them to broaden a predictive check – permitting way of life interventions to extra successfully goal at-risk girls. It might additionally display if epigenetic adjustments may also be reversed by way of remedy akin to vitamin and workout, and disclose epigenetic variations throughout ethnic teams.

The Affiliate Director of the World Weight problems Centre at Deakin, Professor Anna Peeters, defined that the obese and weight problems epidemic is a big explanation for the rise within the nationwide prevalence of diabetes, among different stipulations like center illness.

“This epidemic is developing an enormous burden of long run illness for Australia. In 1980, once we started gathering obesity-related knowledge, one in ten Australian adults have been obese or overweight,” stated Professor Peeters.

“Now, nearly 30 consistent with cent of Australian adults are compatible that class, however the distribution isn’t equivalent. In poorer neighbourhoods as many as 40 consistent with cent of adults may also be obese or overweight. Indigenous Australians are specifically in peril.

“Then again, we have now superb knowledge concerning the luck of interventions, which will cut back the prevalence of diabetes by way of 50 consistent with cent. It’s obviously more economical to intrude with the ones at absolute best threat.”

Professor Bodil Rasmussen, Chair in Nursing (Western Well being) added: “Over the years, folks might revert to their older behavior, however even delaying the onset of diabetes a couple of years would give folks higher possibilities of having an extended existence.”

Discover additional:
Diabetes related to adjustments in gene behaviour pushed by way of atmosphere

Additional information:
Agnes A. Michalczyk et al. Epigenetic Markers to Expect Conversion From Gestational Diabetes to Kind 2 Diabetes, The Magazine of Scientific Endocrinology & Metabolism (2016). DOI: 10.1210/jc.2015-4206

Magazine reference:
Magazine of Scientific Endocrinology & Metabolism

Supplied by way of:
Deakin College

Tagged with:

About author

Related Articles