Breaking News
January 17, 2018 - Lactation May Lower T2D Risk in Younger Women
January 17, 2018 - New Atopic Dermatitis Yardstick provides practical guidance and management insights
January 17, 2018 - New biodegradable pressure sensor could help monitor serious health conditions
January 17, 2018 - HSS orders Sectra’s 3D pre-operative planning solution for improving patient outcomes
January 17, 2018 - Study identifies six new genes regions associated with diabetes
January 17, 2018 - Women do not receive timely diagnosis for heart disease
January 17, 2018 - AbbVie’s Upadacitinib Shows Positive Results as Monotherapy in Phase 3 Rheumatoid Arthritis Study, Meeting All Primary and Key Secondary Endpoints
January 17, 2018 - Should President Trump’s Physical Include a Cognitive Screen?
January 17, 2018 - Could gene therapy someday eliminate HIV?
January 17, 2018 - Researchers identify new anti-inflammatory drug target
January 17, 2018 - Loxo Oncology Initiates Rolling Submission of New Drug Application to U.S. Food and Drug Administration for Larotrectinib for the Treatment of TRK Fusion Cancers
January 17, 2018 - Trunk Imaging Tied to Higher Nephrectomy Risk
January 17, 2018 - Campaigners incensed at failings in Africa AIDS war
January 17, 2018 - Research opens door to development of new treatment for type 2 diabetes
January 17, 2018 - Bariatric surgery extends lifespan in obese patients, shows study
January 17, 2018 - Bristol-Myers Squibb Receives FDA Approval for Opdivo (nivolumab) as Adjuvant Therapy in Patients with Completely Resected Melanoma with Lymph Node Involvement or Metastatic Disease
January 17, 2018 - Ewww Moments in the ER: That’s Improbable!
January 17, 2018 - Methods from optogenetics, machine learning should help improve treatment options for stroke patients
January 17, 2018 - Booze may help or harm the heart, but income matters
January 17, 2018 - Three-dimensional organization of genome plays key role in gene expression, cell fate
January 17, 2018 - Scientists identify six new gene regions that may help treat type 1 diabetes
January 17, 2018 - Top nutrients needed to boost mood and energy levels on Blue Monday
January 17, 2018 - Scientists develop unique technique to map elasticity of cell components
January 17, 2018 - Obesity surgery reduces the risk of death by half finds new study
January 17, 2018 - Raw Meat Not the Safest Choice for Your Dog or for You
January 17, 2018 - Men who lack HSD17B4 gene may be more susceptible to treatment-resistant prostate cancer
January 17, 2018 - High-Dose Aspirin Preferred for Kawasaki’s
January 17, 2018 - Study suggests risk management approach to combat EMS fatigue
January 17, 2018 - A new therapy against obesity
January 17, 2018 - Doctors warn against holding your nose and closing your mouth to contain a sneeze
January 17, 2018 - Measles outbreak alarms public health officials
January 17, 2018 - FDA Slaps Class Warning on Gadolinium Contrast Agents
January 17, 2018 - Distinct human mutations can alter the effect of medicine
January 17, 2018 - ASIT biotech’s new article presents clinical results of gp
January 17, 2018 - Alternative tobacco use by adolescents associated with greater odds of future cigarette smoking
January 17, 2018 - A High-Salt Diet Produces Dementia In Mice
January 17, 2018 - Scientists provide insights into crucial interaction for DNA repair
January 17, 2018 - Sanofi and Regeneron Announce Positive Topline Pivotal Results for PD-1 Antibody Cemiplimab in Advanced Cutaneous Squamous Cell Carcinoma
January 17, 2018 - Morning Break: Pfizer Kills AD/PD Pipeline; Trump Affirms His Mental Health; Humira Pricing Strategy
January 17, 2018 - Researchers see gene influencing performance of sleep-deprived people
January 17, 2018 - Fast food triggers the immune system making it hyperactive
January 17, 2018 - Scientists find increased risk of HIV outbreaks in Ukraine due to war-related migration
January 17, 2018 - New universal flu vaccine moves to clinical trial phase and could be a reality soon
January 17, 2018 - Cocaine de-addiction breakthrough shows promise
January 17, 2018 - FDA Accepts New Drug Application for Seysara (sarecycline) for the Treatment of Moderate to Severe Acne
January 17, 2018 - Robotic Telestenting; BP Cuff Smartwatch; Medicare Bundled Care
January 17, 2018 - New cellular approach found to control progression of chronic kidney disease
January 17, 2018 - Lamprey genes provide clues to repair spinal cord damage, finds study
January 17, 2018 - Tissue-based soft robot could lead to advances in bio-inspired robotics
January 17, 2018 - Mostly the healthy and wealthy Americans use mobile phone apps to track sleep habits
January 17, 2018 - FDA Alert: Varubi (rolapitant) Injectable Emulsion: Health Care Provider Letter
January 16, 2018 - NeuroBreak: Rough Days for Neuroscience Research; Another Migraine Drug Advances
January 16, 2018 - The ‘greatest pandemic in history’ was 100 years ago – but many of us still get the basic facts wrong
January 16, 2018 - Serena Williams Shares Childbirth Ordeal
January 16, 2018 - The Artificial Brain as Doctor
January 16, 2018 - Type 2 diabetes has hepatic origins
January 16, 2018 - Expert discusses how to identify, support individuals with drug or alcohol addiction in workplace
January 16, 2018 - Starting menstruation early increases risk of cardiovascular disease and stroke in later life
January 16, 2018 - CapsoVision receives CE Mark approval for use of CapsoCam Plus System in pediatric patients
January 16, 2018 - Researchers develop new dynamic statistical model to follow gene expressions over time
January 16, 2018 - Alzheimer’s ‘looks like me, it looks like you’
January 16, 2018 - By the Numbers: Physicians’ Economic Impact
January 16, 2018 - Sound Health | NIH News in Health
January 16, 2018 - Modifying baby formula doesn’t prevent type 1 diabetes in children
January 16, 2018 - Energy drinks dangerous for kids
January 16, 2018 - When you need a breast screening, should you get a 3-D mammogram?
January 16, 2018 - Johns Hopkins gets approval to perform HIV positive to HIV positive living donor kidney transplants
January 16, 2018 - The Salk Institute and Indivumed collaborate for cutting-edge cancer research
January 16, 2018 - Study reveals negative long-term effects of heavy cannabis use on brain function and behavior
January 16, 2018 - Many gym-goers injure themselves by pushing harder to be better than friends
January 16, 2018 - Risankizumab Meets All Primary Endpoints Reporting Positive Results in Fourth Pivotal Phase 3 Psoriasis Study
January 16, 2018 - Federal Junk Food Tax Feasible, Study Says
January 16, 2018 - Do girls have stronger teeth than boys?
January 16, 2018 - New high-sensitivity blood tests could aid faster diagnosis and treatment for heart attack
January 16, 2018 - How fatal mitochondrial diseases may strike offspring of families with no history of the conditions
January 16, 2018 - TherapeuticsMD Announces FDA Acceptance of New Drug Application and Prescription Drug User Fee Act (PDUFA) Date for TX-004HR
January 16, 2018 - Morning Break: Food Pharmacies; Obamacare Sign-ups Dip; Top Pot Studies
January 16, 2018 - Blood pressure declines 14 to 18 years before death
January 16, 2018 - ViLim Ball technology helps reduce uncontrollable shaking hands
January 16, 2018 - Researchers use immune-mimicking biomaterial scaffolds to fast track T cell therapies

How Zika Virus Went From Delicate to Devastating

image_pdfDownload PDFimage_print

THURSDAY, Sept. 28, 2017 — A unmarried genetic mutation only some years again gave the Zika virus the facility to motive serious neurological beginning defects like microcephaly, a brand new learn about in mice suggests.

Scientists have identified concerning the Zika virus since 1947, when it was once came upon in a monkey from the Zika Woodland in Uganda. At that time, it was once simplest connected to delicate signs.

It wasn’t till the Zika epidemic of 2015 in Central and South The us that Zika become referred to as a reason for microcephaly, a devastating situation by which a new child’s mind and cranium are critically underdeveloped.

How did that occur?

One explicit genetic exchange, which most likely befell in 2013, boosted Zika’s skill to wreck the neural stem cells that function development blocks for a fetus’ creating mind, Chinese language researchers record.

“The proof suggests this actual mutation someway greater the facility of the virus to get into those neural progenitor cells,” mentioned Dr. Joseph McCormick, regional dean on the College of Texas College of Public Well being in Brownsville. McCormick wasn’t concerned within the new learn about.

This discovery is hectic as it means that the virus may have extra unwelcome surprises in retailer for humanity, mentioned Michael Osterholm, director of the College of Minnesota’s Middle for Infectious Illness Analysis and Coverage.

“The mutation that probably brought about this well being result in people is going on in an endemic the place further mutations may just nonetheless happen, which might deliver us different new well being demanding situations,” mentioned Osterholm, who had no position within the analysis.

Zika is transmitted basically by means of inflamed mosquitoes. It will also be unfold by means of having intercourse with an inflamed individual.

The Chinese language group, whose first writer is Ling Yuan of the Chinese language Academy of Sciences in Beijing, when compared 3 present Zika traces in opposition to an older pressure remoted in Cambodia in 2010.

The 3 present traces killed all lab mice uncovered to it, generating a chain of neurological signs. Then again, the 2010 pressure simplest killed about 17 % of mice.

Evaluating the traces, researchers discovered a important mutation that altered a key protein within the protecting coating of more moderen Zika viruses. This unmarried exchange a great deal enhanced Zika’s skill to contaminate, injury and spoil human precursor mind cells, they mentioned.

An evolutionary research published that this variation most likely arose someday in 2013, only some months sooner than an explosive outbreak of Zika in French Polynesia. That timing coincides with the primary reviews linking Zika to microcephaly and Guillain-Barre syndrome, a neural dysfunction that reasons muscle weak point and paralysis in adults.

“They have concluded it looks as if the fresh virus is extra virulent than its ancestors,” mentioned Dr. Richard Temes, director of the Middle for Neurocritical Care at North Shore College Health center in Manhasset, N.Y. “When sufferers are inflamed, it is much more likely to result in neurological illness than the previous traces.”

Even though the research “is in some ways an excellent clarification of what took place,” it must be each showed and expanded upon, Osterholm mentioned. Analysis on animals does now not all the time produce the similar leads to people.

McCormick agreed. As an example, he mentioned, the conclusions go away open the likelihood genetic trait in some people would possibly go away them extra liable to the danger posed by means of this Zika mutation.

“Obviously a large number of other folks were given inflamed with this, and much more pregnant ladies were given inflamed than had microcephalic kids,” McCormick mentioned. “Is there a human aspect of this that can make some other folks with the fitting genetic background extra at risk of this actual mutation?”

The findings have been printed Sept. 28 within the magazine Science.

Additional information

For extra on Zika, consult with the U.S. Facilities for Illness Keep watch over and Prevention.

Posted: September 2017

Really useful for you

Tagged with:

About author

Related Articles