Breaking News
July 21, 2018 - Bundled-payment system did not lower costs for serious medical conditions, shows study
July 21, 2018 - Therapy dogs found to be effective in reducing ADHD symptoms in children
July 21, 2018 - Could rotating multiple therapists better treat PTSD patients?
July 21, 2018 - Binge drinking impairs working memory in adolescent brain
July 21, 2018 - Dying at home could be beneficial for terminally ill cancer patients and their relatives
July 21, 2018 - Researchers identify subtypes of retinal ganglion cells using single-cell RNA sequencing
July 21, 2018 - Study uncovers opportunities to reduce death by suicide among cancer patients
July 21, 2018 - Genetic sequencing reveals new clues to aggressiveness of prostate cancer
July 21, 2018 - BioSight Launches a Phase 2b Clinical Trial of BST-236 as a First-Line Treatment of Acute Myeloid Leukemia
July 21, 2018 - First major study comparing robotic to open surgery published in The Lancet
July 21, 2018 - ADHD medications may fail to improve cognition in healthy college students, study shows
July 21, 2018 - Intervention program that includes a personalized app could benefit teens with suicidal thoughts
July 21, 2018 - Researchers identify new compound that protects against neurodegeneration
July 21, 2018 - Gene therapy may hold potential to treat people with spinal cord injuries
July 21, 2018 - FDA Approves Nivestym (filgrastim-aafi), a Biosimilar to Neupogen
July 21, 2018 - Surgeons have substantial impact on genetic testing in breast cancer patients who need it
July 21, 2018 - Species diversity can have positive and negative impacts on disease transmission
July 21, 2018 - Genome research suggests presence of enteric fever in medieval Europe
July 21, 2018 - Risk of Sensory Deficits Drops With Rising Gestational Age
July 21, 2018 - Mum’s sleep matters—the effect of sleep on an unborn baby
July 21, 2018 - UC San Diego researchers awarded two grants for investigating stem cell-based therapies
July 21, 2018 - Cellular ‘garbage disposal’ may actually work on some of the proteins to neuronal development
July 21, 2018 - More Pregnant Women Having Heart Attacks
July 21, 2018 - Acne Breakouts | NIH News in Health
July 21, 2018 - Change health messaging to focus on potential impact to help stop the next pandemic
July 21, 2018 - Frailty associated with poor survival rates in young heart patients
July 21, 2018 - New discovery could save millions of lives from fatal fungal infections
July 21, 2018 - OBD presents latest data on the use of EpiSwitch™ in predicting patient response to immunotherapy and identifying lymphoma subtypes
July 21, 2018 - Childhood adversity increases susceptibility to addiction via immune response
July 21, 2018 - Scientists identify potential target for the treatment of binge eating
July 21, 2018 - Whole-brain LIPUS therapy improves cognitive dysfunction in mice simulating dementia, Alzheimer’s
July 21, 2018 - Digital media use raising risk of ADHD symptoms among the young
July 21, 2018 - Phase 3 study of tanezumab in patients with osteoarthritis pain meets all three co-primary endpoints
July 21, 2018 - Restoring mitochondrial function to reverse aging-related skin wrinkles, hair loss in mice
July 21, 2018 - SP PennTech introduces RW-500 rotary vial washer for biotech, pharmaceutical applications
July 21, 2018 - Researchers to study molecular mechanisms behind susceptibility of males to autism
July 21, 2018 - Scientists create wearable device that measures cortisol in sweat
July 21, 2018 - Researchers study efficacy and safety of new treatment for OUD
July 21, 2018 - Fourth Published Clinical Trial Confirms Long-Term Safety of Niagen Supplementation at High Doses and Shows Potential for Improvement in Liver Health
July 21, 2018 - Study examines effects of a two-day intermittent calorie restriction diet for patients with type 2 diabetes
July 21, 2018 - Greening vacant urban land reduces feelings of depression for surrounding residents
July 21, 2018 - Parents say intense gun violence in PG-13 movies appropriate for teens 15 and older
July 21, 2018 - Collaborative study to assess effects of exercise training for cognitive deficits in MS
July 21, 2018 - FAU researchers find possible cause of Parkinson’s disease in the patients’ immune system
July 21, 2018 - Protective qualities of ‘good cholesterol’ reduce after menopause
July 21, 2018 - Researchers develop new way to uncover hidden breast cancer tumors
July 21, 2018 - FDA approves first drug for treatment of adult AML patients with specific genetic mutation
July 21, 2018 - Top AI companies join hands to discover novel drugs for DMD
July 21, 2018 - Ferring announces FDA approval of ZOMACTON for injection in four new pediatric indications
July 20, 2018 - Researchers design proteins that can self-assemble into complex structures
July 20, 2018 - AVITA Medical expands management team to support launch of RECELL device to treat burns
July 20, 2018 - FDA Approves Tibsovo (ivosidenib) for Relapsed or Refractory Acute Myeloid Leukemia with an IDH1 Mutation
July 20, 2018 - Developmental screening and surveillance rates remain low, new study suggests
July 20, 2018 - TGen opens tissue donation portal to advance DIPG research
July 20, 2018 - Health impact of highly processed summertime staples
July 20, 2018 - Exergaming can improve health in overweight and obese children, study shows
July 20, 2018 - Postmenopausal factors may impact heart-protective qualities of ‘good cholesterol’
July 20, 2018 - MRI and blood test combination results in improved prostate cancer diagnosis
July 20, 2018 - Update Health Professional and Consumer on Recent Recalled Products
July 20, 2018 - Researchers trace Parkinson’s damage in the heart
July 20, 2018 - Wearable device designed to measure cortisol in sweat
July 20, 2018 - Scientists demonstrate a new regulation mechanism for skeletal muscles
July 20, 2018 - Exposure to mobile phone radiation may negatively impact memory performance in adolescents
July 20, 2018 - SUSU scientists find alternative method to treat post-traumatic stress disorder syndrome
July 20, 2018 - Gestational diabetes may increase offspring’s heart disease risk
July 20, 2018 - New vaccine could protect unborn babies from Zika virus
July 20, 2018 - Researchers find high mercury and methylmercury concentrations in traditional Tibetan medicine
July 20, 2018 - Brief Safety Plan Intervention in ER Can Cut Suicidal Behavior
July 20, 2018 - The Mount Sinai Hospital receives accreditation as geriatric emergency department
July 20, 2018 - Toward a better understanding of Parkinson’s disease
July 20, 2018 - Med school communications office wins four national awards | News Center
July 20, 2018 - Professional baseball players with faster hand-eye coordination may have better batting performance
July 20, 2018 - Study looks into mechanisms that control sleep and wakefulness
July 20, 2018 - Scientists identify melanoma biomarkers that could help tailor immunotherapy treatments
July 20, 2018 - Research reveals long-term efficacy of drug used to treat common cause of kidney failure
July 20, 2018 - Timing of dinner associated with breast and prostate cancer risks
July 20, 2018 - Health Tip: Performing the Heimlich Maneuver
July 20, 2018 - Nearly all adolescents have eating, activity or weight-related issues
July 20, 2018 - Sage launches new web-based tool that helps explore curated genomic analyses of Alzheimer’s
July 20, 2018 - High-performance porous polymeric material for chromatography applications
Researchers uncover new magnificence of molecules that can offer protection to mind from damage or sicknesses

Researchers uncover new magnificence of molecules that can offer protection to mind from damage or sicknesses

image_pdfDownload PDFimage_print

Analysis led through Nicolas Bazan, MD, PhD, Boyd Professor and Director of the Neuroscience Heart of Excellence at LSU Well being New Orleans, has came upon a brand new magnificence of molecules within the mind that synchronize cell-to-cell conversation and neuroinflammation/immune task according to damage or sicknesses. Elovanoids (ELVs) are bioactive chemical messengers constructed from omega-Three very lengthy chain polyunsaturated fatty acids (VLC-PUFAs,n-Three). They’re launched on call for when cells are broken or stressed out.

“Even if we knew about messengers from omega-Three fatty acids comparable to neuroprotectin D1 (22 carbons) prior to, the newness of the current discovery is that elovanoids are product of 32 to 34 carbon atoms in period,” notes Nicolas Bazan, MD, PhD, Boyd Professor and Director of the Neuroscience Heart of Excellence at LSU Well being New Orleans. “We predict that those constructions will profoundly build up our figuring out of cell move communicate to maintain neuronal circuitry and specifically to revive mobile equilibrium after pathological insults.”

Running in neuronal mobile cultures from the cerebral cortex and from the hippocampus and a type of ischemic stroke, the researchers discovered that elovanoids now not most effective secure neuronal cells and promoted their survival, however helped care for their integrity and balance. The paintings is printed in Science Advances, to be had http://advances.sciencemag.org/content material/Three/nine/e1700735 .

“Our findings constitute a leap forward within the figuring out of the way the complexity and resiliency of the mind are sustained when faced with adversities comparable to stroke, Parkinson’s or Alzheimer’s and neuroprotection signaling must be activated,” says Dr. Bazan. “A key issue is how neurons keep up a correspondence amongst themselves. Those novel molecules take part in speaking messages to total synaptic group to verify a correct waft of data thru neuronal circuits. We know the way neurons make synaptic connections with different neurons, alternatively those connections should be malleable to modify energy as it should be. Elovanoids would possibly play a central position as synaptic organizers, particularly vital in stipulations on account of synaptic disorder comparable to autism or amyotropic lateral sclerosis, for which we don’t have any healing solutions.”

Even if the incidence of very lengthy chain polyunsaturated fatty acids has been smartly documented, what has now not been recognized is their importance and attainable to be transformed into biochemical triggers to get to the bottom of damage, irritation and different threats to neuronal conversation and mobile survival.

The researchers came upon the construction and traits of 2 elovanoids – ELV-N32 and ELV-N34 – within the mind. Beginning with neuron mobile cultures after which an experimental type of stroke, they discovered that elovanoids had been activated when cells underwent both oxygen/glucose deprivation or excitotoxicity – early occasions related to stroke, epilepsy, Parkinson’s, nerve-racking mind damage and different neurodegenerative sicknesses. They made up our minds the concentrations and healing home windows at which elovanoids conferred neuroprotection. The workforce discovered that elovanoids overcame the dangerous results and toxicity of those early occasions. Within the stroke type, elovanoids lowered the dimensions of the broken mind house, initiated restore mechanisms and stepped forward neurological/behavioral restoration.

“Our findings supply a significant conceptual advance of vast relevance for neuronal mobile survival and mind serve as, specifically with regard to ischemic stroke,” provides Bazan. “Within the close to long term, we are hoping to use this data to forestall nerve-racking mind damage, continual nerve-racking encephalopathy, stroke and neurodegenerative sicknesses. Elovanoids might be offering a solution to be examined as a possible remedy.”

Supply:

http://www.lsuhsc.edu/newsroom/New%20Elegance%20of%20Molecules%20Would possibly%20Give protection to%20Mind%20from%20Stroke,%20Neurodegenerative%20Illnesses.html

Tagged with:

About author

Related Articles