Breaking News
July 17, 2018 - Women Often Unaware of Their Hospital’s Religious Affiliation
July 17, 2018 - CRISPR editing reduces repetitive behavior in mice with a form of autism
July 17, 2018 - Scientists use magnets to detect cancer
July 17, 2018 - Microfluidic chip to detect sepsis proves successful in clinical study
July 17, 2018 - Research provides better understanding of mechanisms underlying memory storage
July 17, 2018 - A Multi-Modal Approach for the Early Detection of Breast Cancer
July 17, 2018 - Mailing colorectal cancer tests to patients increases screening rates, report researchers
July 17, 2018 - Scientists find possible sources of medicinal and antimicrobial drugs
July 17, 2018 - Molecules formed when the body metabolizes omega-3 fatty acids may inhibit cancer
July 17, 2018 - Efficient communication between hospitals improves patient safety and reduces mortality
July 17, 2018 - Study highlights potential of fetal gene therapy to prevent lethal neurodegenerative disease
July 17, 2018 - For Americans, in Science They Trust
July 17, 2018 - Combating HIV/AIDS | NIH MedlinePlus the Magazine
July 17, 2018 - Study shows minorities widely underrepresented in autism diagnoses
July 17, 2018 - Multigene testing replacing BRCA tests for breast cancer risk | News Center
July 17, 2018 - Pre-clinical pilot study shows promising results of ‘concussion pill’
July 17, 2018 - Researchers reduce size of tumors in mice by artificially activating the brain’s reward system
July 17, 2018 - New study documents symptoms of people before they acquire multiple sclerosis
July 17, 2018 - Researchers discover why CRISPR gene editing sometimes fails
July 17, 2018 - New finding may hold key to better understand the complexities of neurological disorders
July 17, 2018 - The Current issue of “The view from here” is concerned with Novel Targets.
July 17, 2018 - Fighting the Flu with a Universal Vaccine
July 17, 2018 - Key social reward circuit in the brain impaired in kids with autism | News Center
July 17, 2018 - Insight into causes, types and treatment of aphasia
July 16, 2018 - Quark Pharmaceuticals, Inc Announces First Patient Dosed in Phase 3 Clinical Trial of QPI-1002 for Prevention of Acute Kidney Injury Following Cardiac Surgery
July 16, 2018 - NSAIDs shown to have causal role in cardiovascular risk of patients with osteoarthritis
July 16, 2018 - PET scan tracer predicts success of cancer ‘vaccine’ | News Center
July 16, 2018 - Parents struggle with what to do when their child has headache, shows study
July 16, 2018 - Outrageous or overblown? HHS announces another round of ACA navigator funding cuts
July 16, 2018 - Weight loss surgery may impact individual’s risk of developing cancer, shows study
July 16, 2018 - Alexion Submits Application for Priority Review and Approval of ALXN1210 as a Treatment for Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) in the U.S.
July 16, 2018 - Restoring epigenetic balance reinstates memory in flies with Alzheimer’s disease symptoms
July 16, 2018 - Magnetized wire could be used to detect cancer in people | News Center
July 16, 2018 - Non-surgical management found to be feasible option for penetrating kidney trauma
July 16, 2018 - California clinic screens asylum seekers for honesty
July 16, 2018 - FDA Approves Xtandi (enzalutamide) for the Treatment of Men with Non-Metastatic Castration-Resistant Prostate Cancer (CRPC)
July 16, 2018 - Can nanotechnology help treat Alzheimer’s?
July 16, 2018 - Researchers identify protein essential for making stem cells | News Center
July 16, 2018 - Severe childhood infections linked with lower school achievement in adolescence
July 16, 2018 - Radiologist discusses causes, treatments of varicose veins
July 16, 2018 - Researchers develop nanostructured surface to accelerate wound healing after dental implants
July 16, 2018 - New non-invasive procedure to reposition kidney stones could benefit astronauts
July 16, 2018 - Attending Surgeon Influences Genetic Testing in Breast Cancer
July 16, 2018 - Medical doctors with addictions fear professional repercussions if they seek treatment
July 16, 2018 - 5 Questions: John Ioannidis calls for more rigorous nutrition research | News Center
July 16, 2018 - University of Illinois buys 3D-Bioplotter for regenerative biology, tissue engineering research
July 16, 2018 - Charité’s researchers integrate open-source platform into the ‘Human Brain Project’
July 16, 2018 - SUSU scientists develop rehabilitation device for people with lower limbs injuries
July 16, 2018 - Researchers find definite increase in scooter-related injuries
July 16, 2018 - Researchers solve mystery of final blood group system
July 16, 2018 - Researchers develop near-infrared fluorophores-based PDT to cure cancer with less side effects
July 16, 2018 - Traumatic brain injury biomarker could help predict patient prognosis
July 16, 2018 - Researchers to investigate role of hormones in mosquito’s ability to use human blood for egg production
July 16, 2018 - AHA: Doctor Makes Lifesaving House Call in His Own Home
July 16, 2018 - Nearsightedness – Genetics Home Reference
July 16, 2018 - Study shows biomarker panel boosts lung cancer risk assessment for smokers
July 16, 2018 - Researchers find link between bereavement during pregnancy, child’s mental health | News Center
July 16, 2018 - Legalizing same-sex marriage has meaningful effects on health care access for sexual-minority men
July 16, 2018 - New York to allow medical marijuana as substitute to opioids
July 16, 2018 - Reducing tapeworm infection could improve academic performance, reduce poverty | News Center
July 16, 2018 - Researchers describe key role of enzyme in regulating immune response against Chagas disease parasite
July 16, 2018 - Johnson & Johnson Announces Publication in The Lancet Highlighting Robust Immune Response to Janssen’s Mosaic-based Preventive Vaccine Regimen for HIV
July 16, 2018 - Do Racial and Gender Disparities Exist in Newer Glaucoma Treatments?
July 16, 2018 - Antibodies may predict transplant rejection risk
July 16, 2018 - New center sets out to stop disease before it starts | News Center
July 16, 2018 - FDA warns consumers about criminals sending fake warning letters
July 16, 2018 - Residential segregation linked with racial disparities in firearm homicide fatalities
July 16, 2018 - UW-Madison researchers develop new method to track Parkinson’s damage in the heart
July 16, 2018 - New approach to cultivate hypoallergenic tomato and strawberry varieties
July 16, 2018 - Smoking associated with delayed shinbone healing
July 16, 2018 - Sheila Dolezal, ‘team player extraordinaire,’ wins 2018 Amy J. Blue Award | News Center
July 16, 2018 - Advanced Prostate Cancer Variant More Common Than Thought
July 16, 2018 - New ways to conquer sleep apnea compete for place in bedroom
July 16, 2018 - Renowned microbe hunter Stanley Falkow dies at 84 | News Center
July 15, 2018 - FDA Slaps Stronger Warnings on Potent Class of Antibiotics, Fluoroquinolones
July 15, 2018 - Don’t let depression keep you from exercising
July 15, 2018 - Student research symposium showcases curiosity and scholarship | News Center
July 15, 2018 - Heavy smokers have increased risk of heart rhythm disorder, shows study
July 15, 2018 - Parents who had severe trauma, stresses in childhood more likely to have kids with behavioral health problems
July 15, 2018 - At colloquium, a range of views on value of predictive algorithms | News Center
Rigidity makes the guts develop more potent

Rigidity makes the guts develop more potent

image_pdfDownload PDFimage_print
Epicardium cells masking the guts regenerate in a wave led by means of huge cells that include more than one nuclei according to cellular (magenta). Those cells are below extra mechanical pressure (aqua streaks) than trailing cells which divide to provide cells with one nucleus each and every. Credit score: Jingli Cao, Duke

By means of taking movies of a tiny beating zebrafish center because it reconstructs its masking in a petri dish, scientists have captured sudden dynamics of cells concerned about tissue regeneration. They discovered that the depleted center tissue regenerates itself in a wave, led by means of a entrance of fast-moving, supersized cells and trailed by means of smaller cells that multiply to provide others.

The character of this wavefront—and the good fortune of the tissue regeneration that follows—is made up our minds by means of mechanical pressure that acts upon the cells. The effects, printed September 25 within the magazine Developmental Cellular, point out a brand new paradigm for the way forces appearing in tissues can direct the choices that cells make to regenerate misplaced tissues.

“Our findings open avenues for the find out about of cellular cycle dynamics in regenerating tissue,” mentioned Jingli Cao, PhD, lead find out about creator and a postdoctoral fellow in Ken Poss’s lab at Duke College Faculty of Medication. “By means of manipulating the mechanical pressure of cells, we additionally may be able to expand new bioengineering or translational approaches.”

Whilst the human center cannot totally heal itself after a center assault, the zebrafish center can simply exchange cells misplaced to wreck or illness. Scientists have spent a few years probing the regenerative powers of this small striped fish within the hopes of uncovering clues that might make stronger remedy for human center illness.

In 2015, Cao confirmed that he may just take away the hearts from zebrafish and develop them in dishes within the laboratory, the place the tiny two-chambered organs endured to overcome and behave as though they had been nonetheless tucked throughout the animal. On this find out about, Cao and his colleagues exploited the program to watch the regeneration of the epicardium, a skinny layer of cells that duvet the guts’s floor.

The researchers destroyed lots of the center’s epicardial layer, after which put the “explanted” organs below the microscope to seize the regeneration in motion. They anticipated to peer a inhabitants of cells that had swiftly replicated their DNA content material and divided into new cells refill the outside of the organ. Whilst those cells certainly performed an element, they weren’t main the rate. As an alternative, regeneration used to be led by means of cells that replicated their DNA with out dividing, successfully developing supersized cells with two occasions the cellular equipment or extra.

“Consider you might have a wound in your pores and skin and you need to hide it once conceivable, however you do not have sufficient cells,” mentioned Cao. “By means of making cells change into better, it’s worthwhile to successfully duvet the wound. We expect this tactic may just build up the regenerative capability of this inhabitants by means of masking the outside in an effective means.”

The researchers measured numerous houses of the cells within the regenerative wavefront. They discovered that the larger chief cells migrated around the floor of the guts at upper speeds than the smaller follower cells. After they measured the degrees of hysteria skilled by means of the cells, they discovered that chief cells recoiled quicker than follower cells when tiny incisions had been implemented, similar to the outside of an inflated balloon retracts after bursting. Poss mentioned that mechanical pressure turns out to stay the cells from dividing after DNA replication.

“This find out about is attempting to know the fundamental selections cells make once they regenerate,” mentioned Poss, professor of cellular biology at Duke College Faculty of Medication and director of the Regeneration Subsequent Initiative at Duke. “If there are ways shall we use to lead their selections, to resolve whether or not they generate better cells or extra cells thru department, it might be one method to affect the power of a tissue to fix.”

The researchers plan to make use of their zebrafish center explant tradition device to display for small molecules that might probably build up the regenerative capability of center tissues. Such chemical substances may just at some point shape the root for brand new medication to fix the wear led to by means of a center assault or different cardiovascular sicknesses.

Discover additional:
Learn about uncovers foundations of center regeneration

Additional information:
“Rigidity Creates an Endoreplication Wavefront That Leads Regeneration of Epicardial Tissue,” Jingli Cao, Jinhu Wang, Christopher P. Jackman, Amanda H. Cox, Michael A. Trembley, Joseph J. Balowski, Ben D. Cox, Alessandro De Simone, Amy L. Dickson, Stefano Di Talia, Eric M. Small, Daniel P. Kiehart, Nenad Bursac, and Kenneth D. Poss. Developmental Cellular, September 25, 2017. DOI: 10.1016/j.devcel.2017.08.024

Magazine reference:
Developmental Cellular

Supplied by means of:
Duke College

Tagged with:

About author

Related Articles