Breaking News
January 18, 2018 - New precision medicine trial for metastatic pancreatic cancer
January 18, 2018 - Shire Receives FDA Breakthrough Therapy Designation for Maribavir, an Investigational Treatment for Cytomegalovirus (CMV) Infection in Transplant Patients
January 18, 2018 - Pre-Existing Patient-Valve Mismatch Trips Up ViV Implant
January 18, 2018 - Adolescents: health risks and solutions
January 18, 2018 - US woman delivers baby from embryo frozen for 24 years
January 18, 2018 - Study identifies new target for treatment of depression
January 18, 2018 - LJI study reveals key player that promotes skin inflammation in atopic dermatitis
January 18, 2018 - Study devises efficient and economical strategy to screen breast and ovarian cancer gene mutations
January 18, 2018 - Agile Therapeutics, Inc. Receives a Complete Response Letter from the FDA for Twirla (AG200-15) for the Prevention of Pregnancy
January 18, 2018 - Gene Therapy for Inherited Retinal Dystrophy Gets FDA Clearance
January 18, 2018 - Researchers identify a new chemical pathway that helps the brain detect sweet, savory and bitter flavors
January 18, 2018 - IBV develops platform that helps companies to diagnose wellbeing of their workforce
January 18, 2018 - Study to test new precision medicine approach for metastatic pancreatic cancer
January 18, 2018 - World’s first vaccine relieves grass pollen allergy symptoms by at least 25%, study shows
January 18, 2018 - FDA Approves New Indication for Gilotrif (afatinib) in EGFR Mutation-Positive NSCLC
January 18, 2018 - Oncologists Dish on Top Issues for 2018
January 18, 2018 - Researchers identify new potential drug target for Huntington’s disease
January 18, 2018 - Metrohm USA welcomes employees to new headquarters in Florida
January 18, 2018 - Human waste remains main source of fecal pollution in the river Danube
January 18, 2018 - Expert discusses how to stay healthy during flu season
January 18, 2018 - New biomaterials-based system improves T-cell production
January 18, 2018 - Novel gene expression analysis technique can accurately and quickly measure RNA
January 18, 2018 - Grandparents Help Shape Kids’ Views on Aging
January 18, 2018 - Absolutely Zero Stent Thrombosis at 5 Years With Bioabsorbable MiStent
January 18, 2018 - Safe Sleep for Babies | VitalSigns
January 18, 2018 - Pfizer to launch own little white pill
January 18, 2018 - Aged garlic extract may help obese people fight against inflammation, study shows
January 18, 2018 - Patients with monoclonal gammopathy at risk of developing cancer even after 30 years
January 18, 2018 - Researchers reveal potential of multivalent antibodies for HIV prevention, treatment and cure
January 18, 2018 - Dying cancer patients receiving assisted hydration live longer
January 18, 2018 - Potential male birth control pill could be developed from arrow poison
January 18, 2018 - Research reveals cost-effectiveness of whole-population screening for breast, ovarian cancer gene mutations
January 18, 2018 - Genes involved in spinal cord repair of lamprey also present in mammals, study reveals
January 18, 2018 - Researchers unravel key molecular mechanism of autoimmune and inflammatory diseases
January 18, 2018 - The State of the Drug Discovery Nation Unveiled as New Report Provides Vital Insights for the Development of New Medicines
January 18, 2018 - Dutch Study Links Implants to Increased Breast-ALCL Risk
January 18, 2018 - Five addiction experts weigh in on future of opioid crisis. Their forecast: grim
January 18, 2018 - EXD2 enzyme facilitates protein production in mitochondria
January 18, 2018 - Kessler Foundation wins $735,000 grant for training rehabilitation researchers
January 18, 2018 - Researchers find new way to halt growth of breast cancer cells
January 18, 2018 - Cantex Pharmaceuticals, Inc. Announces FDA Orphan Drug Designation Has Been Granted to CX-01 for Treatment of Acute Myeloid Leukemia
January 18, 2018 - Civilians Now Getting Flu-Like Illness Afflicting Troops
January 18, 2018 - Discovery brings stem cell therapy for eye disease closer to the clinic
January 18, 2018 - Guts of surfers more likely to be colonized by antibiotic-resistant bacteria, study reveals
January 18, 2018 - Bacteria linked to periodontitis may play role in onset of cancer
January 18, 2018 - Jazz Pharmaceuticals Submits New Drug Application for Solriamfetol (JZP-110) for Excessive Sleepiness Associated with Narcolepsy and Obstructive Sleep Apnea
January 18, 2018 - Early Menarche, Menopause Tied to Higher CVD Risk
January 18, 2018 - Pioneering new technique could boost understanding of causes of heart disease
January 18, 2018 - New brain imaging techniques show how infants’ brains process ‘touch’
January 18, 2018 - GSK Receives FDA Approval for Expanded Indication for Fluarix Quadrivalent (Influenza Vaccine) for Persons 6 Months and Older
January 18, 2018 - Blood Markers Point to Maladaptive LV Remodeling
January 18, 2018 - Effect of gut bacteria on specific immune cells underlies persistent liver inflammation
January 18, 2018 - Study reveals new diabetes gene in families with rare blood sugar conditions
January 18, 2018 - Fewer Hospitals Closed After Obamacare Expanded Medicaid
January 18, 2018 - At-Home Breath Training Improves Asthma Quality of Life
January 18, 2018 - Obesity can add five weeks of asthma symptoms per year in preschoolers
January 18, 2018 - Neuronal loss is very limited in Alzheimer’s disease, shows new study
January 18, 2018 - A new strategy proposed for drug discovery
January 17, 2018 - Lactation May Lower T2D Risk in Younger Women
January 17, 2018 - New Atopic Dermatitis Yardstick provides practical guidance and management insights
January 17, 2018 - New biodegradable pressure sensor could help monitor serious health conditions
January 17, 2018 - HSS orders Sectra’s 3D pre-operative planning solution for improving patient outcomes
January 17, 2018 - Study identifies six new genes regions associated with diabetes
January 17, 2018 - Women do not receive timely diagnosis for heart disease
January 17, 2018 - AbbVie’s Upadacitinib Shows Positive Results as Monotherapy in Phase 3 Rheumatoid Arthritis Study, Meeting All Primary and Key Secondary Endpoints
January 17, 2018 - Should President Trump’s Physical Include a Cognitive Screen?
January 17, 2018 - Could gene therapy someday eliminate HIV?
January 17, 2018 - Researchers identify new anti-inflammatory drug target
January 17, 2018 - Loxo Oncology Initiates Rolling Submission of New Drug Application to U.S. Food and Drug Administration for Larotrectinib for the Treatment of TRK Fusion Cancers
January 17, 2018 - Trunk Imaging Tied to Higher Nephrectomy Risk
January 17, 2018 - Campaigners incensed at failings in Africa AIDS war
January 17, 2018 - Research opens door to development of new treatment for type 2 diabetes
January 17, 2018 - Uniqsis’ novel reactor system for continuous flow synthesis
January 17, 2018 - Bariatric surgery extends lifespan in obese patients, shows study
January 17, 2018 - Genevac offers miVac DNA for efficient concentration of nucleic acids
January 17, 2018 - Bristol-Myers Squibb Receives FDA Approval for Opdivo (nivolumab) as Adjuvant Therapy in Patients with Completely Resected Melanoma with Lymph Node Involvement or Metastatic Disease
January 17, 2018 - Systematic bright light exposure can improve sleep in people treated for cancer
January 17, 2018 - Ewww Moments in the ER: That’s Improbable!
January 17, 2018 - Scientists discover possible cause of colonial-era epidemic in Mexico
January 17, 2018 - Methods from optogenetics, machine learning should help improve treatment options for stroke patients
Defining optimum opioid ache drugs prescription period following surgical operation

Defining optimum opioid ache drugs prescription period following surgical operation

image_pdfDownload PDFimage_print
Credit score: CC0 Public Area

A brand new learn about led via researchers on the Heart for Surgical operation and Public Well being at Brigham and Ladies’s Clinic analyzed opioid prescription information from the Division of Protection Army Well being Gadget Knowledge Repository, figuring out greater than 200,000 opioid-naïve people who had gone through certainly one of 8 commonplace surgeries between 2006 and 2014 and had been therefore prescribed opioid ache drugs. Their findings seem in JAMA Surgical operation as a featured article for the week of Sept. 27.

Each day, greater than 90 American citizens die after overdosing on opioids, consistent with the Nationwide Institute on Drug Abuse. Misuse of and habit to opioids has grow to be a public well being disaster with greater than 2 million American citizens affected by substance abuse problems associated with prescription opioid ache drugs. Whilst over-prescription of ache drugs has been implicated as a driving force of this rising opioid epidemic, few tips exist on accurately prescribe opioid ache drugs following surgical operation with the purpose of balancing ache with possibility of habit. There were a number of contemporary governmental efforts to handle the upward thrust in opioid ache drugs prescriptions, which quadrupled between 1999 and 2012. In Mass. and New York, regulation has restricted preliminary prescription lengths to lower than seven days and pushed the improvement of drug tracking systems.

To resolve optimum opioid ache scientific prescribing practices, in particular within the atmosphere of postoperative, outpatient ache control, researchers from the CSPH at BWH investigated opioid ache scientific prescription patterns following commonplace surgeries. The staff sought to spot the appropriateness of the prescription as indicated via the speed of prescription refills and to broaden suggestions.

The usage of a nationally consultant pattern of people that had been opiate naïve present process commonplace procedures, researchers discovered that median prescription period for the first-time prescriptions was once 4 to seven days, and that the quantity of people that required a replenish in their opiate prescription numerous from 11.three p.c to 39.three p.c relying on the kind of process carried out. The length of the prescription additionally numerous relying at the class of process, from 9 days for normal surgical operation procedures to 15 days for musculoskeletal procedures.

“Whilst seven days is also greater than good enough for lots of sufferers present process commonplace normal surgical operation and gynecological procedures, prescription period limits would possibly want to be prolonged to 10 days, spotting that as many as 40 p.c of sufferers would possibly nonetheless require a replenish at a seven-day prohibit for ache control, in particular following many orthopedic and neurosurgical procedures,” stated first creator Rebecca Scully, MD, MPH, a resident within the Division of Surgical operation at BWH who works within the CSPH.

Researchers used information from the Army Well being Gadget Knowledge Repository, which tracks care brought to lively, disabled and retired individuals of the united statesarmed forces and their dependents. Researchers recognized 215,140 folks elderly 18-64 who had gone through certainly one of 8 commonplace surgeries (cholecystectomy, appendectomy, inguinal hernia restore, ACL reconstruction, rotator cuff tear restore, discectomy, mastectomy and hysterectomy) between 2006 and 2014 and had crammed a minimum of one opioid ache drugs prescription within the 14 days following the process. The learn about excluded folks with a previous analysis of power ache, substance dependence or an opioid prescription inside of six months previous the index process. Normal surgical operation procedures had been carried out on 122,435 folks, whilst 47,998 underwent musculoskeletal procedures, and 44,707 gained a mastectomy or hysterectomy.

The usage of a mathematical fashion, researchers decided that the optimum period of opiate prescription was once 4 to 9 days for normal surgical operation procedures, 4 to 13 days for ladies’s well being procedures, and 6 to 15 days for musculoskeletal procedures.

“We acknowledge that the opiate disaster is being addressed on many social, legislative, and coverage ranges,” stated senior creator Louis Nguyen, MD, MBA, MPH. “We are hoping our paper supplies a quantitative research of present prescribing patterns and sheds mild at the optimum prescription in sufferers present process surgeries.”


Discover additional:
Find out about reveals commonplace surgical procedures would possibly function pathway to nonmedical opioid use in kids

Additional info:
JAMA Surgical operation (2017). DOI: 10.1001/jamasurg.2017.3132

Magazine reference:
JAMA Surgical operation

Equipped via:
Brigham and Ladies’s Clinic

Tagged with:

About author

Related Articles