Breaking News
November 19, 2017 - Retinal sensitivity linked to cognitive status in T2DM
November 19, 2017 - Dental filling failure linked to smoking, drinking and genetics
November 19, 2017 - Medicaid expansion takes a bite out of medical debt
November 19, 2017 - Study aims to involve parents in early intervention services for children with autism
November 19, 2017 - Don’t Fret Delays in Treating Colon Cancer, Study Suggests
November 19, 2017 - Yeast Infection Test: MedlinePlus Lab Test Information
November 19, 2017 - Video of blood clot contraction reveals how platelets naturally form unobtrusive clots
November 19, 2017 - UNN researchers explore modeling of cognitive dissonance phenomenon
November 19, 2017 - Verseon presents second anticoagulation candidate for clinical trials at AHA 2017
November 19, 2017 - Pregnant Asian women who develop high blood pressure at highest risk for heart failure hospitalization
November 19, 2017 - Medicare seeks comment on ways to cut costs of Part D drugs
November 19, 2017 - Tree cover linked to fewer asthma cases in polluted urban neighborhoods
November 19, 2017 - Make the Diagnosis: Hair Care Conundrum
November 19, 2017 - New techniques give blood biopsies greater promise
November 19, 2017 - Researchers identify possible genetic basis for coronary artery disease
November 19, 2017 - Stress experienced by emergency call handlers has negative impact on psychological health
November 18, 2017 - New cancer cell screening is improving childhood leukaemia treatment
November 18, 2017 - Groundbreaking study identifies protein as potential factor in cancer metastasis
November 18, 2017 - New model to test effectiveness of existing and potential CF therapies
November 18, 2017 - Staying Active May Lower Odds for Glaucoma
November 18, 2017 - Potential new autism drug shows promise in mice
November 18, 2017 - Some states roll back ‘retroactive Medicaid,’ a buffer for the poor — and for hospitals
November 18, 2017 - Selectively deleting stem cell factor promotes recovery after TBI in mice
November 18, 2017 - Breakthrough research brings new procedure closer to helping patients with blood cancer
November 18, 2017 - Dr Peter Simpson Appointed to SLAS Board of Directors
November 18, 2017 - Friendships between young children can protect against ADHD
November 18, 2017 - Old World monkeys could hold key to stop progression of rheumatoid arthritis
November 18, 2017 - Harris Health System RNs named among 20 Outstanding Nurses for 2017
November 18, 2017 - Old World monkeys could be key to a new, powerful rheumatoid arthritis therapy
November 18, 2017 - Mount Sinai researchers identify new therapeutic target for ER+ breast cancer
November 18, 2017 - Age, CRP levels predict success in tapering of biologics in rheumatoid arthritis patients
November 18, 2017 - New dye could be used to observe electrical activity of neurons in the brain
November 18, 2017 - New study further validates use of vaginal progesterone to decrease risk of preterm birth
November 18, 2017 - Russian researcher determined range of reference values for boron in the human body
November 18, 2017 - ‘What the Health?’ Tax bill or health bill?
November 18, 2017 - Could Your Cat Give You ‘Bird Flu?’
November 18, 2017 - Vitamin D Linked to Fertility Outcomes in ART
November 18, 2017 - Neuroscientists identify genetic changes in microglia in a mouse model of neurodegeneration and Alzheimer’s disease
November 18, 2017 - Tax reform proposal could impact care for older Americans
November 18, 2017 - PCSK9 inhibitor offers clinical benefit to patients with peripheral artery disease
November 18, 2017 - Researchers receive £1.3 million to develop sight-saving imaging technology
November 18, 2017 - Novel buckypaper sensor could pave way for high-performance, affordable wearable technology
November 18, 2017 - Despite ACA cost protections, most adolescents skip regular checkups
November 18, 2017 - Stem cell treatment allows paraplegic rats to walk and regain sensory perception
November 18, 2017 - HTC analytical conference comes to the UK
November 18, 2017 - Face It: Drinking, Smoking Takes Toll on Looks: MedlinePlus Health News
November 18, 2017 - New research shows where in the brain the earliest signs of Alzheimer’s occur
November 18, 2017 - Philips announces launch of global movement to raise awareness for COPD
November 18, 2017 - University of Bristol awarded grant to reduce antibacterial drug resistance in Thailand
November 18, 2017 - New oxytocin chemical sensor could be first step towards early diagnosis of autism
November 18, 2017 - Study shows how naïve T-cells may affect tumor immunity and immunotherapy
November 18, 2017 - New studies highlight importance of cardiorespiratory fitness to reduce CVD risk
November 18, 2017 - Study finds medical cannabis is effective at reducing opioid addiction
November 18, 2017 - Specially tailored, ultrafast light pulses can trigger neurons to fire in different patterns
November 18, 2017 - Decrease in sunshine linked to rising incidence of Rickets
November 18, 2017 - Harnessing social media big data to fight against prescription drug crisis
November 18, 2017 - Researchers find way to switch tumor cells between 2D and 3D morphology
November 18, 2017 - Leaf-eating ability of beetle largely due to bacteria inside the insect
November 18, 2017 - FDA Approves Hemlibra (emicizumab-kxwh) for Hemophilia A with Inhibitors
November 18, 2017 - Adolescents underreport amphetamine use, likely unaware that adderall is amphetamine
November 18, 2017 - Study reveals a reduced risk of teenage eczema in breastfed babies
November 18, 2017 - Separating side effects could pave way for safe, effective pain medications
November 18, 2017 - Gut bacteria at young age can contribute to MS disease onset and progression, study suggests
November 18, 2017 - Environmental triggers may play role in development of Lupus
November 18, 2017 - Review looks into conventional versus new treatment modalities in orthodontic pain management
November 17, 2017 - FDA Alert: Diphenoxylate Hydrochloride and Atropine Sulfate Tablets by Greenstone: Recall
November 17, 2017 - For older women, every movement matters
November 17, 2017 - Talking-based therapy could transform aftercare for cancer survivors
November 17, 2017 - Olympus IXplore SpinSR10 imaging system enables researchers to observe fine details in live cells
November 17, 2017 - Study explores reasons for underrepresentation of minorities in genetic cancer research
November 17, 2017 - California firm running physician practices is closing down as scrutiny ramps up
November 17, 2017 - BMI not valid measure of obesity in postmenopausal women, study shows
November 17, 2017 - Vaginal progesterone decreases the risk of premature birth in women with short cervix
November 17, 2017 - Pricey ER Tests for Chest Pain Often Unnecessary
November 17, 2017 - ‘Old’ Lungs May Be Good Transplant Options: MedlinePlus Health News
November 17, 2017 - How not to gain weight over the holidays
November 17, 2017 - Researchers map first-ever proteome of healthy human heart
November 17, 2017 - Drug used to prevent and treat malaria may also be effective for Zika virus
November 17, 2017 - One in 20 children still receiving codeine to treat pain despite warning from federal regulators
November 17, 2017 - Improving clinical trials with machine learning
DNA-level biomarker can are expecting general survival for uncommon mind tumors

DNA-level biomarker can are expecting general survival for uncommon mind tumors

image_pdfDownload PDFimage_print

MGMT promoter methylation standing—knowledge accumulated at a DNA-level—can lend a hand are expecting general survival for sufferers with a unprecedented type of mind most cancers referred to as anaplastic astrocytoma, in keeping with a brand new research from The Ohio State College Complete Most cancers Heart – Arthur G. James Most cancers Sanatorium and Richard J. Solove Analysis Institute (OSUCCC – James).

The objective of this learn about used to be to decide the choice of sufferers with sure MGMT promoter methylation standing and its importance as a way of predicting survival results for sufferers with anaplastic astrocytomas. Erica Bell, PhD, assistant professor of radiation oncology served as first writer of the learn about. Arnab Chakravarti, MD, chair of radiation oncology on the OSUCCC – James, used to be senior writer and major investigator.

MGMT is a famous DNA restore gene and identified biomarker in grade four glioblastoma mind tumors, on the other hand, knowledge on its prognostic worth in different grade 2 and grade three kinds of mind tumors has been unclear. MGMT promoter methylation used to be calculated the use of the MGMT-STP27 style on this learn about.

“The scientific neighborhood has suspected that MGMT standing may well be used as a biomarker for predicting general survival in those sufferers, however get entry to to a big set of well-controlled scientific knowledge and paired specimens to verify this used to be missing,” says Bell. “Our learn about represents the primary knowledge confirming that MGMT promoter methylation standing can be utilized as an unbiased biomarker for predicting general survival in grade three tumors.”

She notes that this data will lend a hand oncologists determine sufferers much less most probably to reply to remedy according to the biology in their tumors and design higher scientific trials.

Bell will provide the findings (Summary No. 2781) on Sept. 26, 2017, at the once a year assembly of the American Society for Radiation Oncology (ASTRO) in San Francisco, the place she may also obtain some of the 2017 “Very best of ASTRO” awards.

Find out about Design and Effects

For this learn about, researchers analyzed knowledge from a countrywide cooperative staff trial (RTOG 9813) that enrolled 196 high-risk sufferers with anaplastic astrocytoma. Sufferers had been randomized into certainly one of two remedy hands: radiation treatment plus nitrosourea or radiation treatment and temozolomide.

MGMT promoter methylation standing used to be calculated for 58 sufferers – 62 % of sufferers examined sure for the biomarker. Bell and co-workers then particularly analyzed MGMT promoter methylation in correlation with general and progression-free survival results. Sufferers who had the MGMT biomarker additionally had upper general survival when compared with sufferers whose tumors didn’t raise this biomarker. No vital distinction in progression-free survival used to be noticed, even supposing there used to be a pattern towards importance.

Bell says your next step is to broaden higher predictive biomarker fashions that incorporate all identified markers, now not simply MGMT.

“This may increasingly lend a hand us higher perceive which explicit sufferers don’t seem to be doing effectively on standard-of-care and sign up the ones sufferers to scientific trials that can give us the most productive probability of most cancers keep watch over,” she provides. “If we perceive which sufferers don’t seem to be doing effectively on usual of care, we will be able to in point of fact focal point on designing explicit scientific trials to lend a hand the ones sufferers reach higher general survival.”

Discover additional:
A brand new prognostic classification would possibly lend a hand scientific decision-making in glioblastoma

Equipped through:
Ohio State College Clinical Heart

Tagged with:

About author

Related Articles