Breaking News
July 23, 2018 - No Outcome Differences Based on Anesthesia Team Make-Up
July 23, 2018 - Getting to the heart of congenital cardiac defects
July 23, 2018 - Healthy behaviors are not effective in preventing gestational diabetes in obese women
July 23, 2018 - Top of Teachers’ To-Do List: Focus on the Positives
July 23, 2018 - LDL quality is a novel, modifiable cardiovascular risk marker
July 22, 2018 - Researchers identify enzyme as potential new drug target for blood disorders
July 22, 2018 - Research shows that neurons can encode more than one signal at a time
July 22, 2018 - Exposure to secondhand smoke increases the risk of stillbirth
July 22, 2018 - Skin conditions by the numbers
July 22, 2018 - Brain tumour chemotherapy now available to even more NHS patients
July 22, 2018 - Researchers find mugwort pollen as major source of airborne endotoxins
July 22, 2018 - Occupational safety and health at workplace
July 22, 2018 - Pfizer And Lilly Announce Positive Top-Line Results From Phase 3 Trial Of Tanezumab For The Treatment Of Osteoarthritis (OA) Pain
July 22, 2018 - Early supper associated with lower risk of breast and prostate cancer
July 22, 2018 - Survey results identify major inequalities in acute stroke treatment across Europe
July 22, 2018 - Researchers discover promising treatment for genetic form of autism spectrum disorder
July 22, 2018 - Prenatal Depression More Common in Young Moms Today
July 22, 2018 - What helps adults with autism get and keep a job?
July 22, 2018 - Pediatric NEXUS Head CT DI guides selective imaging decisions in blunt trauma patients
July 22, 2018 - Novel tool predicts genes that cause disease due to production of truncated proteins
July 22, 2018 - AHA: Vaping Tied to Blood Clots — in Mice
July 22, 2018 - Study finds therapy dogs effective in reducing symptoms of ADHD
July 22, 2018 - Scientists find reason why malarial parasites are faster than immune cells
July 22, 2018 - Researchers gain more insight into how FUS protein causes ALS and FTLD
July 22, 2018 - Frequency of joint replacements halved in rheumatoid arthritis patients between 1997-2010
July 22, 2018 - QUT researcher highlights growing impact of non-prescription antibiotics supply in pharmacies
July 22, 2018 - UK health communication researcher seeks solutions for disposing leftover medicine
July 22, 2018 - Pfizer Initiates Pivotal Phase 3 Program for Investigational Hemophilia B Gene Therapy Fidanacogene Elaparvovec
July 22, 2018 - Mutation discovered to protect against Alzheimer’s disease in mice
July 22, 2018 - Researchers reveal how patients in urban areas develop multiple, long-term conditions
July 22, 2018 - Replacing conventional cancer treatment with complementary therapy linked to increased risk of death
July 22, 2018 - Study uncovers molecular key for delaying progression of multiple sclerosis
July 22, 2018 - Availability of athletic trainer in high school reduces injury rates in girls’ sports, shows study
July 22, 2018 - FDA Approves Krintafel (tafenoquine) for the Radical Cure of Plasmodium vivax Malaria
July 22, 2018 - Novel nuclear medicine probe will help assess new drugs for neurodegenerative diseases
July 22, 2018 - Physical activity even during exposure to air pollution can reduce risk of heart attack
July 22, 2018 - Scientists discover protein regulator of myelin production
July 22, 2018 - Sleep disturbances associated with higher dementia risk
July 22, 2018 - Scientists move one step further in developing eye drops to treat age-related macular degeneration
July 22, 2018 - Five-Year Stroke Rates Lower After PCI Versus CABG
July 21, 2018 - Alopecia areata – Genetics Home Reference
July 21, 2018 - Study identifies overdose risk factors in youth with substance use disorders
July 21, 2018 - Drug in clinical trials for Parkinson’s disease offers hope for treating heart failure
July 21, 2018 - Coupling free malaria tests with diagnosis-dependent vouchers can improve rational use of ACTs
July 21, 2018 - Sweetness depends on molecular interactions between specific sugars and water in saliva
July 21, 2018 - Muscle fitness is strongly associated with improved rate of ageing in the brain
July 21, 2018 - Resetting E-Prescriptions for Opioids Helps Curb Use: Study
July 21, 2018 - Overuse of antibiotics not what the doctor ordered
July 21, 2018 - Bundled-payment system did not lower costs for serious medical conditions, shows study
July 21, 2018 - Therapy dogs found to be effective in reducing ADHD symptoms in children
July 21, 2018 - Could rotating multiple therapists better treat PTSD patients?
July 21, 2018 - Binge drinking impairs working memory in adolescent brain
July 21, 2018 - Dying at home could be beneficial for terminally ill cancer patients and their relatives
July 21, 2018 - Researchers identify subtypes of retinal ganglion cells using single-cell RNA sequencing
July 21, 2018 - Study uncovers opportunities to reduce death by suicide among cancer patients
July 21, 2018 - Genetic sequencing reveals new clues to aggressiveness of prostate cancer
July 21, 2018 - BioSight Launches a Phase 2b Clinical Trial of BST-236 as a First-Line Treatment of Acute Myeloid Leukemia
July 21, 2018 - First major study comparing robotic to open surgery published in The Lancet
July 21, 2018 - ADHD medications may fail to improve cognition in healthy college students, study shows
July 21, 2018 - Intervention program that includes a personalized app could benefit teens with suicidal thoughts
July 21, 2018 - Researchers identify new compound that protects against neurodegeneration
July 21, 2018 - Gene therapy may hold potential to treat people with spinal cord injuries
July 21, 2018 - FDA Approves Nivestym (filgrastim-aafi), a Biosimilar to Neupogen
July 21, 2018 - Surgeons have substantial impact on genetic testing in breast cancer patients who need it
July 21, 2018 - Species diversity can have positive and negative impacts on disease transmission
July 21, 2018 - Genome research suggests presence of enteric fever in medieval Europe
July 21, 2018 - Risk of Sensory Deficits Drops With Rising Gestational Age
July 21, 2018 - Mum’s sleep matters—the effect of sleep on an unborn baby
July 21, 2018 - UC San Diego researchers awarded two grants for investigating stem cell-based therapies
July 21, 2018 - Cellular ‘garbage disposal’ may actually work on some of the proteins to neuronal development
July 21, 2018 - More Pregnant Women Having Heart Attacks
July 21, 2018 - Acne Breakouts | NIH News in Health
July 21, 2018 - Change health messaging to focus on potential impact to help stop the next pandemic
July 21, 2018 - Frailty associated with poor survival rates in young heart patients
July 21, 2018 - New discovery could save millions of lives from fatal fungal infections
July 21, 2018 - OBD presents latest data on the use of EpiSwitch™ in predicting patient response to immunotherapy and identifying lymphoma subtypes
July 21, 2018 - Childhood adversity increases susceptibility to addiction via immune response
July 21, 2018 - Scientists identify potential target for the treatment of binge eating
July 21, 2018 - Whole-brain LIPUS therapy improves cognitive dysfunction in mice simulating dementia, Alzheimer’s
July 21, 2018 - Digital media use raising risk of ADHD symptoms among the young
Many Sufferers Denied Pricey New Ldl cholesterol Medication

Many Sufferers Denied Pricey New Ldl cholesterol Medication

image_pdfDownload PDFimage_print

HealthDay news image

THURSDAY, Sept. 28, 2017 (HealthDay Information) — Dear new drugs be offering hope to sufferers with out of control “dangerous” ldl cholesterol, however the top charge assists in keeping many sufferers from getting them, a brand new learn about says.

The injectable medicine — licensed to be used in america in 2015 — are referred to as PCSK9 inhibitors. They come with Praluent (alirocumab) and Repatha (evolocumab).

However, researchers discovered, of tens of hundreds of sufferers prescribed the medication, just about part had been denied insurance plans. And top copays gave the impression to save you many others from filling their prescriptions.

“We had been shocked through how little medical components — like how top your ldl cholesterol used to be — mattered as to whether or now not you were given licensed,” mentioned learn about lead creator Dr. Ann Marie Navar.

“We are hoping that this research activates a larger review of ways restricted affected person get right of entry to is to new remedies,” added Navar, an assistant professor of cardiology at Duke Scientific Analysis Institute in Durham, N.C.

Increased LDL levels of cholesterol are a big possibility issue for middle illness and stroke. The brand new medicine are advisable for sufferers who are not successfully handled through statins, the normal cholesterol-lowering drugs. In step with researchers, PCSK9 inhibitors paintings through serving to the liver flush the “dangerous” ldl cholesterol out of the bloodstream through focused on a protein referred to as PCSK9.

The medicine charge up to $14,000 a 12 months, alternatively. And a learn about revealed in August puzzled their cost-effectiveness.

This new learn about used to be funded through Repatha’s maker, Amgen Inc., primarily based in Thousand Oaks, Calif.

The findings are “severely essential,” mentioned Dr. Kim Williams Sr., professor and leader of cardiology at Rush College College of Drugs in Chicago.

“Many affected person are statin-intolerant because of opposed results,” mentioned Williams, who wasn’t concerned with the learn about. “We want to have PCSK9 inhibitors in our armamentarium when indicated, now not simply when indicated and reasonably priced.”

For the learn about, Navar’s workforce tracked greater than 45,000 sufferers in america who had been prescribed the medication from mid-2015 to mid-2016. Greater than part had been 65 years or older and had govt insurance coverage like Medicare.

Insurers simplest licensed the drugs 47 p.c of the time. And simply 1 in five sufferers were given the approval at the first day, consistent with the learn about.

“What mattered essentially the most used to be who your insurance coverage corporate used to be, what form of pharmacy you used, or who the drugstore receive advantages supervisor used to be,” Navar mentioned.

Of the sufferers whose prescriptions had been in truth licensed, about one-third by no means crammed them.

Price did not appear to be a subject for everybody who did not fill their prescriptions: About eight p.c had a copay of 0. However greater than three-quarters of the ones with copays of greater than $350 by no means were given their medicine, the learn about discovered.

Navar put it in differently: “The majority of those that needed to pay lower than $20 a month crammed the prescription. As soon as copays reached about $300 per 30 days, this had dropped to lower than 25 p.c.”

It’s not transparent what the medication charge total. “Price for medicine is actually a shifting goal,” Navar mentioned. “The sticky label value is nearly by no means what’s in truth paid.”

That is as a result of pharmacy receive advantages managers and insurance coverage corporations steadily negotiate reductions and rebates with the drug producers, Navar mentioned. “Pharmacy receive advantages managers can, however would not have to, cross alongside the ones reductions to insurers. There is no option to actually understand how a lot is being paid for those medicine nor how a lot of the cut price is getting again to sufferers,” she defined.

Navar added there may be additionally a “burden on suppliers, who’ve already taken time to speak to sufferers in regards to the dangers and advantages of recent treatment.” Then there may be bureaucracy to get it during the gadget, all of which delays remedy, she added.

The learn about additionally highlights demanding situations in drug innovation, Navar mentioned. “On one hand, we would like new remedies and we hail the improvement of recent remedies. However however, we’ve but to increase a gadget to comprise prices, so get right of entry to to new remedies is restricted,” she famous.

In step with Williams, the learn about “issues to a gadget this is damaged, and threatens to extend the well being care inequalities that we’ve got been running to lower.”

The learn about used to be revealed Sept. 27 in JAMA Cardiology.

SOURCES: Ann Marie Navar, M.D., Ph.D., assistant professor, cardiology, Duke Scientific Analysis Institute, Durham, N.C.; Kim Allan Williams Sr., M.D., professor and leader, cardiology, Rush College College of Drugs, Chicago; Sept. 27, 2017, JAMA Cardiology

Information tales are written and equipped through HealthDay and don’t replicate federal coverage, the perspectives of MedlinePlus, the Nationwide Library of Drugs, the Nationwide Institutes of Well being, or the U.S. Division of Well being and Human Services and products.

Tagged with:

About author

Related Articles