Breaking News
October 21, 2018 - Antibiotics for appendicitis? Surgery often not needed
October 21, 2018 - AHA and AMA recognize more than 800 medical practices, health systems for blood pressure control
October 21, 2018 - Scientists obtain clearest ever image of Ebola virus protein
October 21, 2018 - Study reveals connection between two proteins known to be hyperactive in cancer
October 21, 2018 - Gabapentin Beats Pregabalin for Chronic Sciatica
October 21, 2018 - Cosmetic surgeons offering incomplete information for breast augmentation customers
October 21, 2018 - Chronic sleep disruption in early adult life accelerates AD-related tau pathology
October 21, 2018 - Take 10 for Mindfulness – MedNews
October 21, 2018 - Length of breathing disruption in OSA may be better predictor of mortality risk
October 21, 2018 - ApoE4 gene linked with chronic inflammation increases risk for Alzheimer’s disease
October 21, 2018 - Mother-daughter conflict associated with suicide risk in abused adolescent girls
October 21, 2018 - Scientists molding bacteria into unnatural shapes
October 21, 2018 - Discharged mental health patients ‘at greater risk of dying’
October 21, 2018 - As billions in tax dollars flow to private Medicaid plans, Who’s minding the store?
October 21, 2018 - Deaths related to air pollution in the U.S. decreased by 47% between 1990 and 2010
October 21, 2018 - Study shows correlation between spatial memory and the sense of smell
October 21, 2018 - Increased cardiorespiratory fitness associated with reduced long-term mortality
October 21, 2018 - IU researchers receive $1.55 million from NIH to improve chronic-disease management
October 21, 2018 - Income and wealth affect the mental health of Australians, study shows
October 21, 2018 - Patients with hypertension and psoriasis more often require cardiovascular interventions
October 20, 2018 - Leading hip-hop videos depict use of tobacco and marijuana products, study finds
October 20, 2018 - Dose Range of IV Ketamine for Adjunct Tx of Depression Tested
October 20, 2018 - Infants can distinguish between leaders and bullies, study finds
October 20, 2018 - Mad Cow disease found on Aberdeenshire farm
October 20, 2018 - Study identifies factors associated with prescription opioid misuse among students
October 20, 2018 - Scientists uncover key regulator of mTORC1 in cancer growth
October 20, 2018 - Pounds Regained After Weight-Loss Op Can Tell Your Doc a Lot
October 20, 2018 - Sending parents letters to fight childhood obesity doesn’t work
October 20, 2018 - Supervised aerobic exercise can support major depression treatment
October 20, 2018 - Mindfulness-based program effective for reducing stress in infertile women
October 20, 2018 - Molecule capable of halting and reverting neurodegeneration caused by Parkinson’s disease identified
October 20, 2018 - Midazolam-mediated alterations of PER2 expression may have functional consequences during myocardial ischemia
October 20, 2018 - Sweat bees are ideal for studying the genes underlying social behavior
October 20, 2018 - Weight loss success associated with brain areas involved in self-control
October 20, 2018 - KHN’s ‘What the Health?’ Republicans’ preexisting political problem
October 20, 2018 - Research provides a more complete picture of suffering caused by terrorist attacks
October 20, 2018 - Eradicating Helicobacter pylori infections may be a key treatment for Parkinson’s disease
October 20, 2018 - Breast Cancer as a Dynamic Disease
October 20, 2018 - University of Pittsburgh wins NSF grant for big data research to prevent complications from anesthesia
October 20, 2018 - Skin-to-skin contact may promote attachment between parents and preterm infants
October 20, 2018 - Recommendations Developed to Verify NGT Placement in Children
October 20, 2018 - Weight loss can be boosted fivefold thanks to novel mental imagery technique
October 20, 2018 - Children with autism are more likely to be overweight, obese
October 20, 2018 - Nurses making conscientious objections to ethically-relevant policies lack support
October 20, 2018 - Prion strain diversity may be greater than previously thought
October 20, 2018 - Antidepressant treatment may lead to improvements in sleep quality of patients with depression
October 20, 2018 - Study reports increased risk of death in children with inflammatory bowel disease
October 20, 2018 - Number of Autism Genes Now Tops 100
October 20, 2018 - Total diet replacement programmes are effective for treating obesity
October 20, 2018 - CLARIOstar used for fluorescence measurements on CSIRO’s purpose-built research vessel
October 20, 2018 - People with more copies of AMY1 gene digest starchy carbohydrates faster
October 20, 2018 - Case Comprehensive Cancer Center wins NIH grant to study health disparities
October 20, 2018 - Newly discovered compound shows potential for treating Parkinson’s disease
October 20, 2018 - High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients
October 20, 2018 - Immunotherapy medicine found to be effective in treating uveitis
October 20, 2018 - The Pistoia Alliance Calls for Greater Collaboration to Realise Benefits of Innovation and Announces Winners of the 2018 President’s Startup Challenge
October 20, 2018 - Female internists consistently earn less than men
October 20, 2018 - Stanford team looks at dangers of teens’ vaping habits
October 20, 2018 - New approach to understanding cancers will accelerate development of better treatments
October 20, 2018 - LJI and UC San Diego awarded $ 4.5 million as part of NCI’s Cancer Moonshot initiative
October 20, 2018 - School-based HPV vaccination did not increase risky sexual behaviors among adolescent girls
October 20, 2018 - Eye discovery to pave way for more successful corneal transplants
October 20, 2018 - New analysis examines the importance of location in the opioid crisis
October 20, 2018 - Green filters increase reading speed for children with dyslexia
October 19, 2018 - Bariatric Sx Cuts Macrovascular Complications in Obesity, T2DM
October 19, 2018 - Better assessments for early age-related macular degeneration
October 19, 2018 - Visible and valued: Stanford Medicine’s first-ever LGBTQ+ Forum | News Center
October 19, 2018 - Understanding of metal-free enzymes used by bacteria could lead to new effective antibiotics
October 19, 2018 - Beckman Coulter Life Sciences announces new research-focused website
October 19, 2018 - Study finds link between refined soluble fibers, gut microbiota and liver cancer
October 19, 2018 - Social media reduces risk of depression among seniors with pain
October 19, 2018 - Newly developed synthetic DNA molecule may one day be used as ‘vaccine’ for prostate cancer
October 19, 2018 - Preoperative weight loss may not provide health benefits after surgery
October 19, 2018 - U.S. Birth Rates Continue to Drop as Age of New Moms Rises
October 19, 2018 - New technology can keep an eye on babies’ movements in the womb
October 19, 2018 - Juul e-cigarettes pose addiction risk for young users | News Center
October 19, 2018 - Gene sequencing reveals crucial molecular aspects of Trypanosoma brucei
October 19, 2018 - New DNA vaccine strategy protects mice against lethal challenge by multiple H3N2 viruses
October 19, 2018 - Study shows close link between cytokine interleukin-1ß and obesity-promoted colon cancer
October 19, 2018 - Muscle mass plays a critical role in health, shows research
Dear drug using up Medicare expenditures with out proof of better efficacy

Dear drug using up Medicare expenditures with out proof of better efficacy

image_pdfDownload PDFimage_print

Medicare spent greater than $1 billion over a five-year duration on a high-priced drug that has no longer been confirmed more practical for a number of inflammatory prerequisites than a lot more economical corticosteroids, analysis by means of the OHSU/OSU School of Pharmacy presentations.

The research additionally signifies relatively small staff of “common prescribers” mix to put in writing prescriptions that result in the majority of Medicare’s expenditures at the drug, repository adrenocorticotropin, or ACTH.

In 2015 on my own, Medicare spending crowned $500 million at the drug, the price of which has soared to $36,000 in line with process treatment.

Recognized by means of the industry identify H.P. Acthar Gel, steadily shortened to simply Acthar, the drug’s number one use is to regard uncommon epileptic spasms in kids beneath age 2.

“The drug has an enchanting again tale,” stated Dan Hartung, lead creator on a analysis letter that used to be revealed as of late in JAMA Inside Medication. “It is a rather outdated drug, first authorized in 1952, previous to most of the FDA laws about scientific efficacy. The bar for what constitutes authorized indications used to be a lot other then, a lot decrease; it has many indications that got here ahead of the present laws have been set in stone within the 1960s.”

The drug, categorized as a “biologic,” used to be to start with authorized for a huge vary of corticosteroid-responsive inflammatory prerequisites.

“It is a hormone produced within the human frame that alerts the discharge of steroids,” Hartung stated. “It does the similar activity as cheap corticosteroids. And it in point of fact wasn’t a lot on somebody’s radar till 2007.”

Questcor Prescribed drugs bought the rights to the in large part forgotten Acthar in 2001 for $100,000 and started often elevating Acthar’s value. In 2007 Questcor greater the cost of the drug, which as soon as bought for $40 for a vial, or process treatment, from $1,650 to $23,000 in a single day.

Questcor, got by means of Mallinckrodt Prescribed drugs in 2017, markets the drug aggressively for slightly not unusual prerequisites comparable to rheumatoid arthritis, a couple of sclerosis and nephrotic syndrome, Hartung stated. The Meals and Drug Management authorized Acthar for the ones sorts of prerequisites a long time in the past when necessities have been much less strict; no scientific trials have been required.

“There are a selection of FDA-approved indications that lack numerous proof that Acthar is even efficient, let on my own higher than reasonably priced corticosteroids,” Hartung stated. “And what lets in for this sort of pricing is that it is a rather complicated molecule and no competition can precisely replica it; they have got a monopoly in this specific molecule.”

In 2015, Acthar generated gross earnings of about $1 billion – greater than part of which got here from Medicare, and far of the remainder coming from Medicaid, Hartung stated, which means public expenditures most probably accounted for just about all the gross sales.

Hartung and the opposite collaborators discovered Medicare spending at the drug greater tenfold and totaled $1.three billion from 2011 to 2015.

In 2014, a complete of one,621 prescribers have been liable for $391.2 million in Acthar spending; amongst the ones, 203 common prescribers – 94 rheumatologists, 55 neurologists and 54 nephrologists, each and every with greater than 10 prescriptions – accounted for $165 million of the entire.

“And on the whole those physicians are prescribing about the similar collection of different medicine in comparison to their peer uniqueness teams, so we suspect they aren’t treating extra significantly unwell sufferers,” Hartung stated. “Mallinckrodt is in point of fact aggressively advertising and marketing in ways in which perhaps topic prescribers to conflicts of pastime. From the payer facet, there may be in point of fact little that little justifies this drug and its exorbitant price over a lot inexpensive choices. If Medicare have been to take a company stand on reimbursements, this would not be going down.”

Discover additional:
Mallinckrodt purchasing Questcor for approximately $five.6B (Replace)

Additional information:
JAMA Inside Medication (2017). DOI: 10.11001/jamainternmed.2017.3631

Magazine reference:
JAMA Inside Medication

Equipped by means of:
Oregon State College

Tagged with:

About author

Related Articles