Breaking News
January 18, 2018 - New precision medicine trial for metastatic pancreatic cancer
January 18, 2018 - Shire Receives FDA Breakthrough Therapy Designation for Maribavir, an Investigational Treatment for Cytomegalovirus (CMV) Infection in Transplant Patients
January 18, 2018 - Pre-Existing Patient-Valve Mismatch Trips Up ViV Implant
January 18, 2018 - Adolescents: health risks and solutions
January 18, 2018 - US woman delivers baby from embryo frozen for 24 years
January 18, 2018 - Study identifies new target for treatment of depression
January 18, 2018 - LJI study reveals key player that promotes skin inflammation in atopic dermatitis
January 18, 2018 - Study devises efficient and economical strategy to screen breast and ovarian cancer gene mutations
January 18, 2018 - Agile Therapeutics, Inc. Receives a Complete Response Letter from the FDA for Twirla (AG200-15) for the Prevention of Pregnancy
January 18, 2018 - Gene Therapy for Inherited Retinal Dystrophy Gets FDA Clearance
January 18, 2018 - Researchers identify a new chemical pathway that helps the brain detect sweet, savory and bitter flavors
January 18, 2018 - IBV develops platform that helps companies to diagnose wellbeing of their workforce
January 18, 2018 - Study to test new precision medicine approach for metastatic pancreatic cancer
January 18, 2018 - World’s first vaccine relieves grass pollen allergy symptoms by at least 25%, study shows
January 18, 2018 - FDA Approves New Indication for Gilotrif (afatinib) in EGFR Mutation-Positive NSCLC
January 18, 2018 - Oncologists Dish on Top Issues for 2018
January 18, 2018 - Researchers identify new potential drug target for Huntington’s disease
January 18, 2018 - Metrohm USA welcomes employees to new headquarters in Florida
January 18, 2018 - Human waste remains main source of fecal pollution in the river Danube
January 18, 2018 - Expert discusses how to stay healthy during flu season
January 18, 2018 - New biomaterials-based system improves T-cell production
January 18, 2018 - Novel gene expression analysis technique can accurately and quickly measure RNA
January 18, 2018 - Grandparents Help Shape Kids’ Views on Aging
January 18, 2018 - Absolutely Zero Stent Thrombosis at 5 Years With Bioabsorbable MiStent
January 18, 2018 - Safe Sleep for Babies | VitalSigns
January 18, 2018 - Pfizer to launch own little white pill
January 18, 2018 - Aged garlic extract may help obese people fight against inflammation, study shows
January 18, 2018 - Patients with monoclonal gammopathy at risk of developing cancer even after 30 years
January 18, 2018 - Researchers reveal potential of multivalent antibodies for HIV prevention, treatment and cure
January 18, 2018 - Dying cancer patients receiving assisted hydration live longer
January 18, 2018 - Potential male birth control pill could be developed from arrow poison
January 18, 2018 - Research reveals cost-effectiveness of whole-population screening for breast, ovarian cancer gene mutations
January 18, 2018 - Genes involved in spinal cord repair of lamprey also present in mammals, study reveals
January 18, 2018 - Researchers unravel key molecular mechanism of autoimmune and inflammatory diseases
January 18, 2018 - The State of the Drug Discovery Nation Unveiled as New Report Provides Vital Insights for the Development of New Medicines
January 18, 2018 - Dutch Study Links Implants to Increased Breast-ALCL Risk
January 18, 2018 - Five addiction experts weigh in on future of opioid crisis. Their forecast: grim
January 18, 2018 - EXD2 enzyme facilitates protein production in mitochondria
January 18, 2018 - Kessler Foundation wins $735,000 grant for training rehabilitation researchers
January 18, 2018 - Researchers find new way to halt growth of breast cancer cells
January 18, 2018 - Cantex Pharmaceuticals, Inc. Announces FDA Orphan Drug Designation Has Been Granted to CX-01 for Treatment of Acute Myeloid Leukemia
January 18, 2018 - Civilians Now Getting Flu-Like Illness Afflicting Troops
January 18, 2018 - Discovery brings stem cell therapy for eye disease closer to the clinic
January 18, 2018 - Guts of surfers more likely to be colonized by antibiotic-resistant bacteria, study reveals
January 18, 2018 - Bacteria linked to periodontitis may play role in onset of cancer
January 18, 2018 - Jazz Pharmaceuticals Submits New Drug Application for Solriamfetol (JZP-110) for Excessive Sleepiness Associated with Narcolepsy and Obstructive Sleep Apnea
January 18, 2018 - Early Menarche, Menopause Tied to Higher CVD Risk
January 18, 2018 - Pioneering new technique could boost understanding of causes of heart disease
January 18, 2018 - New brain imaging techniques show how infants’ brains process ‘touch’
January 18, 2018 - GSK Receives FDA Approval for Expanded Indication for Fluarix Quadrivalent (Influenza Vaccine) for Persons 6 Months and Older
January 18, 2018 - Blood Markers Point to Maladaptive LV Remodeling
January 18, 2018 - Effect of gut bacteria on specific immune cells underlies persistent liver inflammation
January 18, 2018 - Study reveals new diabetes gene in families with rare blood sugar conditions
January 18, 2018 - Fewer Hospitals Closed After Obamacare Expanded Medicaid
January 18, 2018 - At-Home Breath Training Improves Asthma Quality of Life
January 18, 2018 - Obesity can add five weeks of asthma symptoms per year in preschoolers
January 18, 2018 - Neuronal loss is very limited in Alzheimer’s disease, shows new study
January 18, 2018 - A new strategy proposed for drug discovery
January 17, 2018 - Lactation May Lower T2D Risk in Younger Women
January 17, 2018 - New Atopic Dermatitis Yardstick provides practical guidance and management insights
January 17, 2018 - New biodegradable pressure sensor could help monitor serious health conditions
January 17, 2018 - HSS orders Sectra’s 3D pre-operative planning solution for improving patient outcomes
January 17, 2018 - Study identifies six new genes regions associated with diabetes
January 17, 2018 - Women do not receive timely diagnosis for heart disease
January 17, 2018 - AbbVie’s Upadacitinib Shows Positive Results as Monotherapy in Phase 3 Rheumatoid Arthritis Study, Meeting All Primary and Key Secondary Endpoints
January 17, 2018 - Should President Trump’s Physical Include a Cognitive Screen?
January 17, 2018 - Could gene therapy someday eliminate HIV?
January 17, 2018 - Researchers identify new anti-inflammatory drug target
January 17, 2018 - Loxo Oncology Initiates Rolling Submission of New Drug Application to U.S. Food and Drug Administration for Larotrectinib for the Treatment of TRK Fusion Cancers
January 17, 2018 - Trunk Imaging Tied to Higher Nephrectomy Risk
January 17, 2018 - Campaigners incensed at failings in Africa AIDS war
January 17, 2018 - Research opens door to development of new treatment for type 2 diabetes
January 17, 2018 - Uniqsis’ novel reactor system for continuous flow synthesis
January 17, 2018 - Bariatric surgery extends lifespan in obese patients, shows study
January 17, 2018 - Genevac offers miVac DNA for efficient concentration of nucleic acids
January 17, 2018 - Bristol-Myers Squibb Receives FDA Approval for Opdivo (nivolumab) as Adjuvant Therapy in Patients with Completely Resected Melanoma with Lymph Node Involvement or Metastatic Disease
January 17, 2018 - Systematic bright light exposure can improve sleep in people treated for cancer
January 17, 2018 - Ewww Moments in the ER: That’s Improbable!
January 17, 2018 - Scientists discover possible cause of colonial-era epidemic in Mexico
January 17, 2018 - Methods from optogenetics, machine learning should help improve treatment options for stroke patients
New instructional find out about unearths true extent of the hyperlink between onerous water and eczema

New instructional find out about unearths true extent of the hyperlink between onerous water and eczema

image_pdfDownload PDFimage_print
Credit score: CC0 Public Area

Onerous water damages our protecting pores and skin barrier and may give a contribution to the improvement of eczema, a brand new find out about has proven.

Researchers from the College of Sheffield and King’s Faculty London have found out that exposing the outside to onerous water damages the outside barrier – which is our defence towards outdoor threats comparable to micro organism or solar burn – and will increase the sensitivity of the outside to attainable irritants present in on a regular basis wash merchandise comparable to cleaning soap or washing powder.

Onerous water comprises prime ranges of calcium and magnesium ions that bind to surfactants comparable to sodium lauryl sulfate (SLS) and sodium lauryl ether sulfate (SLES) – which act as detergents or wetting brokers – making them insoluble, so that they precipitate onto the outside.

Pores and skin pH is usually acidic however onerous water has prime alkalinity this means that it will possibly elevate the outside floor pH. A shift in opposition to alkaline pH disturbs the outside’s herbal serve as as a bodily barrier and leaves it liable to colonization by way of doubtlessly pathogenic micro organism which will motive an infection.

Lead creator of the find out about, Dr Simon Danby from the College of Sheffield’s Division of An infection, Immunity and Cardiovascular Illness, mentioned: “Via harmful the outside barrier, washing with onerous water might give a contribution to the improvement of eczema – a prolonged pores and skin situation characterized by way of an intensely itchy pink rash.

“Sufferers with eczema are a lot more delicate to the consequences of onerous water than other people with wholesome pores and skin. This build up in sensitivity is related to a genetic predisposition to a pores and skin barrier defect led to by way of mutations within the gene encoding filaggrin. Filaggrin is a structural protein essential for the formation of our pores and skin’s barrier to the outdoor setting. As much as part of all other people with eczema lift a filaggrin gene.”

Credit score: College of Sheffield

“This new find out about unearths the mechanism in which calcium and magnesium ions in onerous water, surfactants, and filaggrin engage to break the outside barrier unlocking new details about how publicity to onerous water may doubtlessly give a contribution to the improvement of eczema.”

Signs of eczema (also referred to as ‘atopic eczema’ or ‘atopic dermatitis’) come with infected, dry pores and skin and continuously secondary pores and skin infections, which will have an effect on any a part of the frame and each side of an individual’s lifestyles – each bodily and emotionally.

The brand new find out about, which Harvey Water Softeners was once requested to fund, was once revealed this week (16 September 2017) within the Magazine of Investigative Dermatology. The workforce of researchers tested whether or not getting rid of the calcium and magnesium ions the use of an ion-exchange water softener may mitigate the uncomfortable side effects of onerous water at the pores and skin. They discovered that the use of a water softener reduces the dangerous results of surfactants, doubtlessly lowering the chance of creating eczema.

Managing director of Harvey Water Softeners, Martin Hurworth, mentioned: “The hyperlink between onerous water and eczema has been reported anecdotally for years – now for the primary time there is instructional evidence. We have been happy to offer business improve to this find out about within the type of onerous water samples and the twin-cylinder water softeners that equipped the softened water that was once wanted.”

Co-senior creator of the find out about, Dr Carsten Flohr from the St John’s Institute of Dermatology at Man’s and St Thomas’ NHS Basis Accept as true with and King’s Faculty London, mentioned: “One in 5 kids and one in 12 adults in the United Kingdom be afflicted by eczema, costing the NHS smartly over £500 million once a year.

“It’s all through the primary few days and months of lifestyles that our pores and skin is maximum prone to harm and maximum susceptible to creating eczema.

“For this reason we at the moment are embarking on a pilot trial to analyze whether or not set up of a home water softener across the time of beginning can save you pores and skin barrier breakdown and eczema in the ones residing in onerous water spaces.”

Discover additional:
Onerous water related to possibility of eczema in babies

Additional info:
The Impact of Water Hardness on Surfactant Deposition Following Washing an Next Pores and skin Inflammation in Atopic Dermatitis Sufferers and Wholesome Controls. Magazine of Investigative Dermatology. DOI: 10.10.16/j.jid2017.08.037

Magazine reference:
Magazine of Investigative Dermatology

Supplied by way of:
College of Sheffield

Tagged with:

About author

Related Articles