Breaking News
November 18, 2018 - Using light to control crucial step in embryonic development
November 18, 2018 - Unusual case of father-to-son HIV transmission reported
November 18, 2018 - FDA Approves Aemcolo (rifamycin) to Treat Travelers’ Diarrhea
November 18, 2018 - Poverty blamed on widening north-south gap in young adult deaths in England
November 18, 2018 - Progress in meningitis lags far behind other vaccine-preventable diseases, analysis shows
November 18, 2018 - Consensus Statement Issued on Management of Foot, Ankle Gout
November 18, 2018 - Fine particle air pollution is a public health emergency hiding in plain sight
November 18, 2018 - In-hospital mortality higher among patients with drug-resistant infections
November 17, 2018 - Research shines new, explanatory light on link between obesity and cancer
November 17, 2018 - FIND explores new diagnostic assays for confirmatory HCV diagnosis in community settings
November 17, 2018 - Tracking Preemies’ Head Size May Yield IQ Clues
November 17, 2018 - Scientists call for unified standards in 3-D genome and epigenetic data
November 17, 2018 - Lab Innovations 2018 has beaten all records by attracting 3,113 attendees
November 17, 2018 - Sexuality education before age 18 may reduce risk of sexual assault in college
November 17, 2018 - New model of FSHD could be useful to study effectiveness of experimental therapeutics
November 17, 2018 - FDA approves antibacterial drug to treat travelers’ diarrhea
November 17, 2018 - Lab Innovations 2018 confirmed as a major hit with visitors, exhibitors and speakers
November 17, 2018 - Largest parasitic worm genetic study hatches novel treatment possibilities
November 17, 2018 - UCLA biologists uncover how head injuries can lead to serious brain disorders
November 17, 2018 - Static and dynamic physical activities offer varying protection against heart disease
November 17, 2018 - Obesity significantly increases risk of Type 2 diabetes and coronary artery disease
November 17, 2018 - People with rare cancers can benefit from genomic profiling, shows research
November 17, 2018 - NIH awards over $1.8 million to husband-and-wife doctors to test new breast cancer approach
November 17, 2018 - Four-in-one antibody used to fight flu shows promise in mice
November 17, 2018 - New approach allows pathogens to be starved by blocking important enzymes
November 17, 2018 - Higher body mass index could cause depression even without health problems
November 17, 2018 - Protein which plays role in sensing cell damage serves as new target to treat pulmonary hypertension
November 17, 2018 - FDA Approves Adcetris (brentuximab vedotin) in Combination with Chemotherapy for Adults with Previously Untreated Systemic Anaplastic Large Cell Lymphoma or Other CD30-Expressing Peripheral T-Cell Lymphomas
November 17, 2018 - ID specialist input improves outcomes for outpatient parenteral antimicrobial therapy
November 17, 2018 - UT Southwestern scientists selected to receive 2019 Edith and Peter O’Donnell Awards
November 17, 2018 - New clinical algorithm to help individuals manage type 2 diabetes when fasting during Ramadan
November 17, 2018 - Researchers identify LZTR1 as evolutionarily conserved component of RAS pathway
November 17, 2018 - Heart Disease Leading Cause of Death in Low-Income Counties
November 17, 2018 - Estrogen Levels Test: MedlinePlus Lab Test Information
November 17, 2018 - Research reveals link between immunity, diabetes
November 17, 2018 - Research shows how to achieve improved smoking cessation outcomes within California’s Medicaid population
November 17, 2018 - New study finds less understanding and implementation of patient engagement
November 17, 2018 - New shoe insole technology could help diabetic ulcers heal better while walking
November 17, 2018 - New method to extend cell division and immortalization of avian-derived cells
November 17, 2018 - Australian Academy of Science urges parents to vaccinate children against meningococcal disease
November 17, 2018 - Hot water treatment may help improve inflammation and metabolism in sedentary people
November 17, 2018 - Researchers produce 3D chemical maps of small biological samples
November 17, 2018 - Must Blood Pressure Rise Wth Age? Remote Tribes Hold Clues
November 17, 2018 - Noonan Syndrome
November 17, 2018 - Interventions to delay and prevent type 2 diabetes are underused, researchers say
November 17, 2018 - Hackathon prize winner seeks to remotely monitor patient skin conditions
November 17, 2018 - Research team identifies Ashkenazi Jewish founder mutation for Leigh syndrome
November 17, 2018 - Gene editing could be used to halt kidney disease in patients with Joubert syndrome
November 17, 2018 - Study uncovers link between gut disruption and aging
November 17, 2018 - Teens more likely to pick up smoking after exposure from friends and family
November 17, 2018 - Nicoya designate the Institute for Stem Cell Biology and Regenerative Medicine as the OpenSPR Centre of Excellence
November 17, 2018 - new horizon in dental, oral and craniofacial research
November 17, 2018 - How does poor air quality affect your health?
November 17, 2018 - New device can regulate children’s blood glucose more like natural pancreas
November 17, 2018 - Game-Changers in Western Blotting and Protein Analysis
November 17, 2018 - FDA announces new actions to limit sale of e-cigarettes to youth
November 17, 2018 - Warmer winter temperatures related to higher crime rates
November 17, 2018 - MCO places increasing emphasis on helping people find and access healthy food
November 17, 2018 - Group of students aim to improve malaria diagnosis using old smartphones
November 17, 2018 - Transplantation of feces may protect preterm children from deadly bowel disease
November 17, 2018 - Researchers explore whether low-gluten diets can be recommended for people without allergies
November 17, 2018 - New and better marker for assessing patients after cardiac arrest
November 17, 2018 - For 7-year-old with failing bone marrow, a life-saving transplant | News Center
November 17, 2018 - New first-line treatment for peripheral T-cell lymphoma approved by FDA
November 17, 2018 - Artificial intelligence could be valuable tool to help young victims disclose traumatic testimony
November 17, 2018 - Breakthrough in the treatment of Restless Legs Syndrome
November 16, 2018 - FDA Approves Keytruda (pembrolizumab) for the Treatment of Patients with Hepatocellular Carcinoma (HCC) Who Have Been Previously Treated with Sorafenib
November 16, 2018 - Eagle Books | Native Diabetes Wellness Program
November 16, 2018 - Patients with common heart failure more likely to have lethal heart rhythms
November 16, 2018 - How AI could help veterinarians code their notes | News Center
November 16, 2018 - Bias-based bullying does more harm to students than generalized bullying
November 16, 2018 - Researchers find first direct evidence that cerebellum plays role in cognitive functions
November 16, 2018 - Non-coding genetic variant plays key role in endothelial function and disease incidence
November 16, 2018 - EMA recommends first all-oral treatment to tackle deadly sleeping sickness
November 16, 2018 - Drug used to treat dizziness may slow down growth of triple-negative breast cancer
November 16, 2018 - AHA: Icosapent Ethyl Cuts CV Risk From Elevated Triglycerides
November 16, 2018 - ‘Orphan’ RNAs make cancer deadlier, but potentially easier to diagnose
November 16, 2018 - Air Cube touches down at hospital | News Center
November 16, 2018 - CRISPR-based tool shown to enhance cell-based immunotherapy
November 16, 2018 - Mechanisms that govern HIV latency differ in the gut and blood, finds study
Developing highly specific computer models to better diagnose concussions in real time

Developing highly specific computer models to better diagnose concussions in real time

image_pdfDownload PDFimage_print
Songbai Ji, associate professor of biomedical engineering at Worcester Polytechnic Institute, is researching how injuries affect functionally important neural pathways and specific areas of the brain. Credit: Worcester Polytechnic Institute

As fall sports seasons get under way and concerns related to concussions in contact sports continue to grow, a Worcester Polytechnic Institute (WPI) biomedical engineering professor is developing better tools to understand the mechanics of traumatic brain injuries in athletes.

With two grants from the National Institutes of Health, Songbai Ji is using advanced neuroimaging to develop highly specific computer models of the head and brain to better diagnose concussions in real time.

Ji, whose research integrates neuroimaging into existing brain injury research, focuses on how injuries affect functionally important neural pathways and specific areas of the brain. While there are numerous studies that essentially view the brain as a single unit to determine injury, Ji says, certain components like white matter neural tracts (tissue that helps coordinate communication between different regions of the brain) deep within the brain are more vulnerable and thus may be better indicators of injury.

Ji is developing a sophisticated head injury computer model to produce a strain map as part of a four-year $1.5 million NIH grant, titled “Accumulated white matter fiber strain from repetitive head impacts in contact sports.” Co-principal investigators include colleagues from Dartmouth College, Indiana University School of Medicine, and medical device developer Simbex. In a separate two-year, $461,545 NIH grant, titled “Model-based cumulative analysis of on-field head impacts in contact sports,” Ji is working to make the model simulation in real time.

“Typically it would take hours to produce a detailed strain map for each impact to determine if someone has a concussion,” said Ji. “But we are developing a model simulation in real time.”

Sports concussions have been a growing concern for years. According to the most current data from the Centers for Disease Control and Prevention, in 2012, nearly 330,000 children aged 19 or younger were treated in emergency rooms across the United States for sports and recreation-related injuries that included a diagnosis of concussion or traumatic brain injury.

Ji envisions that, in the future, an athlete on the field could be wearing protective gear, such as a helmet or mouthguard, equipped with an impact sensor. When an athlete’s head is struck, the sensor would record the acceleration, which would provide input to the computer model.

Because Ji will have pre-computed various strain maps into a computer, athletic trainers could quickly retrieve a strain map of the blow that could be used to assess injury risk.

“But the computational cost is now too high for real-world applications,” Ji said, “and that’s why we are also developing a real-time simulation technique.”

Ji added that many current concussion studies are looking at acceleration magnitudes, much like a “hit count” – the number of times an athlete’s head has been hit – rather than considering how many times a specific brain region experiences a certain level of strain and deformation, which is likely more related to the extent of the actual injury. Ji’s lab is looking at the role such repeated straining plays in the severity of concussions.

In a recently published paper in Biomechanics and Modeling in Mechanobiology, Ji and his research associates found that, in addition to the findings about deep white matter, a rigorous cross-validation of injury prediction performance has been lacking in brain injury studies. They proposed a general framework to address this issue in future studies.

“I am very encouraged by the research and think that we can make an impact in this crucial health area,” Ji says. “My research team understands just how important it is to advance concussion research for athletes of both genders and of all ages.”


Explore further:
Researchers test new technique to help with concussion diagnosis

More information:
Wei Zhao et al. Injury prediction and vulnerability assessment using strain and susceptibility measures of the deep white matter, Biomechanics and Modeling in Mechanobiology (2017). DOI: 10.1007/s10237-017-0915-5

Provided by:
Worcester Polytechnic Institute

Tagged with:

About author

Related Articles