Breaking News
September 23, 2018 - New research hub to drive radical change in development and manufacturing of vaccines
September 23, 2018 - AHA: For Hispanics, Neighborhood May Be Key Factor in Heart Disease Risk
September 23, 2018 - Excessive airway nerves tied to more severe asthma symptoms, study finds
September 23, 2018 - Study highlights need to remain vigilant in maintaining key infection control processes
September 23, 2018 - Novel therapeutic strategy for blood vessel related disorders, such as cancer and retinopathy
September 23, 2018 - New naturally occurring antibiotic found effective against Mycobacterium tuberculosis
September 23, 2018 - First-in-human phase 0 study shows clinically-relevant activity of new drug in glioblastoma
September 23, 2018 - Removing tobacco product display from shops reduced number of children buying cigarettes
September 23, 2018 - Random fraction of specialized immune cells leads the charge in battling invaders
September 23, 2018 - Few minutes of sprinting exercise may be as effective as longer exercise sessions
September 23, 2018 - Researchers use neutrons to make first direct observations of water in lipid bilayers
September 23, 2018 - Researchers demonstrate pre-clinical success for universal flu vaccine in new paper
September 23, 2018 - Study reveals surprising gaps in some HIV medical providers’ knowledge of ACA
September 23, 2018 - Oxehealth secures European medical device accreditation for vital signs measurement software
September 23, 2018 - HTN Tx Intensification Common Upon Discharge in U.S. Vets
September 23, 2018 - Fibre can strengthen the intestinal barrier
September 23, 2018 - New platform examines infectious pathogens that may spread from animals to humans
September 23, 2018 - Demographers create detailed color map of population aging in Europe
September 23, 2018 - New type of fatty acid can slow down overreactive immune system
September 23, 2018 - Innovative procedure could provide breakthrough in treating early-stage lung cancer
September 23, 2018 - Research finds drop in number of measles cases in the EU/EEA since March 2018
September 23, 2018 - Researchers acquire new insights into DNA polymerases
September 23, 2018 - Alzheimer’s diagnosis might become simpler with new brain imaging method
September 23, 2018 - Reports Warn of Growing Opioid Crisis Among Seniors
September 23, 2018 - Researchers unravel why people with HIV suffer from more neurologic diseases
September 23, 2018 - Human brain structured to make best possible decision with limited resources
September 23, 2018 - KHN’s ‘What the Health?’ Health on the hill
September 23, 2018 - Bad air and inadequate data prove an unhealthy mix
September 23, 2018 - Regular bedtime and wake time important for heart, metabolic health even among adults
September 23, 2018 - HIV and a tale of a few cities
September 23, 2018 - NIH launches clinical trial to test infusions of combination antibodies in people with HIV
September 23, 2018 - Researchers develop new system to detect consumption of synthetic cannabinoids
September 23, 2018 - Vax-Hub to influenze radical change in development and manufacturing of vaccines
September 23, 2018 - People who have slept lesser than seven hours have higher risks of car crashes
September 23, 2018 - an ancient art may work best to prevent falls in old age
September 23, 2018 - Consumption of foods with lower nutritional quality related to increased cancer risk
September 23, 2018 - Patient Health Information Often Shared Electronically
September 23, 2018 - Can machine learning bring more humanity to health care?
September 23, 2018 - Body organs undergo structural changes in response to diet
September 23, 2018 - Genetic polymorphisms linked with muscle injury and stiffness
September 23, 2018 - As states try to rein in drug spending, feds slap down one bold Medicaid move
September 22, 2018 - Why Eczema Is Tougher to Treat for Black Patients
September 22, 2018 - Team reveals that human genome could contain up to 20 percent fewer genes
September 22, 2018 - USC research uncovers previously unknown genetic risk factor for Alzheimer’s disease
September 22, 2018 - Novel method achieves accurate and precise temperature estimation in fat-containing tissues
September 22, 2018 - BSI accredits Oxehealth’s vital signs measurement software as Class IIa medical device
September 22, 2018 - Evolution of psychiatric disorders and human personality traits
September 22, 2018 - Obesity in early puberty doubles asthma risk for boy’s future offspring
September 22, 2018 - World’s most advanced real-time patient monitoring platform receives key US patent
September 22, 2018 - Study explores connection between sexuality and cognitive status in older adults
September 22, 2018 - LSTM partners with TB Alliance to develop novel TB drug regimens
September 22, 2018 - Annual wellness visits improve delivery of preventive services in elderly population
September 22, 2018 - CHMP provides positive opinion to Cabometyx for previously-treated patients with hepatocellular carcinoma
September 22, 2018 - Hispanic communities with high proportions of Hispanics face more cardiovascular-related death
September 22, 2018 - Vici syndrome – Genetics Home Reference
September 22, 2018 - Single-dose drug can shorten flu symptoms by about a day, studies suggest
September 22, 2018 - AMSBIO launches circulating tumor DNA Reference Standards
September 22, 2018 - Sandalwood mimicking odorant could stimulate hair growth in humans
September 22, 2018 - Overlooked immune cells could play a key role in cancer immunotherapy, claims new study
September 22, 2018 - Study reveals prevalence of diagnosed type 1 and type 2 diabetes among American adults
September 22, 2018 - Researchers develop fast detection strategy to know type of virus acquired by patients
September 22, 2018 - Global Prevalence of Insufficient Activity 27.5 Percent
September 22, 2018 - Strategies to protect bone health in hematologic stem cell transplant recipients
September 22, 2018 - Brigham Genomic Medicine program unravels 30 medical mysteries
September 22, 2018 - New system harnesses power of bubbles to destroy dangerous biofilms
September 22, 2018 - Inflammation plays crucial role in preventing heart attacks and strokes, study reveals
September 22, 2018 - Calorie dense, nutrient deficient meals common across the world
September 22, 2018 - Researchers develop technology to study behavior of implants without animal testing
September 22, 2018 - First gut bacteria in newborns may have lasting effect on ability to ward off chronic diseases
September 22, 2018 - Detection of BFD virus in parrots in 8 new countries raises concerns for threatened species
September 22, 2018 - Insulin treatment shows great potential against chronic bowel inflammation
September 22, 2018 - ‘Liking Gap’ Might Stand in Way of New Friendships
September 22, 2018 - Simple factors that can avoid harmful side effects in type 2 diabetes
September 22, 2018 - ALSAM Foundation invests additional $2 million for drug discovery and development projects
September 22, 2018 - Study findings may advance discussion of how to effectively curb human-wildlife conflict
September 22, 2018 - Dopamine neurons may involve in conditions ranging from Parkinson’s disease to schizophrenia
September 22, 2018 - Protein C and Protein S Tests: MedlinePlus Lab Test Information
September 22, 2018 - Obesity and diabetes—two reasons why we should be worried about the plastics that surround us
September 22, 2018 - Concern over fussy eating prompts parents to use non-responsive feeding practices
September 22, 2018 - Novel mathematical approach uncovers existence of unsuspected biological cycles
Developing highly specific computer models to better diagnose concussions in real time

Developing highly specific computer models to better diagnose concussions in real time

image_pdfDownload PDFimage_print
Songbai Ji, associate professor of biomedical engineering at Worcester Polytechnic Institute, is researching how injuries affect functionally important neural pathways and specific areas of the brain. Credit: Worcester Polytechnic Institute

As fall sports seasons get under way and concerns related to concussions in contact sports continue to grow, a Worcester Polytechnic Institute (WPI) biomedical engineering professor is developing better tools to understand the mechanics of traumatic brain injuries in athletes.

With two grants from the National Institutes of Health, Songbai Ji is using advanced neuroimaging to develop highly specific computer models of the head and brain to better diagnose concussions in real time.

Ji, whose research integrates neuroimaging into existing brain injury research, focuses on how injuries affect functionally important neural pathways and specific areas of the brain. While there are numerous studies that essentially view the brain as a single unit to determine injury, Ji says, certain components like white matter neural tracts (tissue that helps coordinate communication between different regions of the brain) deep within the brain are more vulnerable and thus may be better indicators of injury.

Ji is developing a sophisticated head injury computer model to produce a strain map as part of a four-year $1.5 million NIH grant, titled “Accumulated white matter fiber strain from repetitive head impacts in contact sports.” Co-principal investigators include colleagues from Dartmouth College, Indiana University School of Medicine, and medical device developer Simbex. In a separate two-year, $461,545 NIH grant, titled “Model-based cumulative analysis of on-field head impacts in contact sports,” Ji is working to make the model simulation in real time.

“Typically it would take hours to produce a detailed strain map for each impact to determine if someone has a concussion,” said Ji. “But we are developing a model simulation in real time.”

Sports concussions have been a growing concern for years. According to the most current data from the Centers for Disease Control and Prevention, in 2012, nearly 330,000 children aged 19 or younger were treated in emergency rooms across the United States for sports and recreation-related injuries that included a diagnosis of concussion or traumatic brain injury.

Ji envisions that, in the future, an athlete on the field could be wearing protective gear, such as a helmet or mouthguard, equipped with an impact sensor. When an athlete’s head is struck, the sensor would record the acceleration, which would provide input to the computer model.

Because Ji will have pre-computed various strain maps into a computer, athletic trainers could quickly retrieve a strain map of the blow that could be used to assess injury risk.

“But the computational cost is now too high for real-world applications,” Ji said, “and that’s why we are also developing a real-time simulation technique.”

Ji added that many current concussion studies are looking at acceleration magnitudes, much like a “hit count” – the number of times an athlete’s head has been hit – rather than considering how many times a specific brain region experiences a certain level of strain and deformation, which is likely more related to the extent of the actual injury. Ji’s lab is looking at the role such repeated straining plays in the severity of concussions.

In a recently published paper in Biomechanics and Modeling in Mechanobiology, Ji and his research associates found that, in addition to the findings about deep white matter, a rigorous cross-validation of injury prediction performance has been lacking in brain injury studies. They proposed a general framework to address this issue in future studies.

“I am very encouraged by the research and think that we can make an impact in this crucial health area,” Ji says. “My research team understands just how important it is to advance concussion research for athletes of both genders and of all ages.”


Explore further:
Researchers test new technique to help with concussion diagnosis

More information:
Wei Zhao et al. Injury prediction and vulnerability assessment using strain and susceptibility measures of the deep white matter, Biomechanics and Modeling in Mechanobiology (2017). DOI: 10.1007/s10237-017-0915-5

Provided by:
Worcester Polytechnic Institute

Tagged with:

About author

Related Articles