Breaking News
December 19, 2018 - FDA Approves Genentech’s Tecentriq in Combination With Avastin and Chemotherapy for the Initial Treatment of Metastatic Non-Squamous Non-Small Cell Lung Cancer
December 19, 2018 - Mediterranean Diet for Osteoarthritis | About OA
December 19, 2018 - Successful bladder repair using silk fibroid scaffolds
December 19, 2018 - Quidel receives CE mark to use Sofia 2 Lyme+ Fluorescent Immunoassay with Sofia 2 analyzer
December 19, 2018 - Horizon Discovery partners with C4XD to validate novel synthetic lethal oncology targets
December 19, 2018 - Research suggests a promising therapeutic target to treat or prevent metabolic disorders
December 19, 2018 - Split liver transplants could save children on wait list finds study
December 19, 2018 - Michigan-based food manufacturer ordered to discontinue operations after recurrent food safety violations
December 19, 2018 - Incorrect prescribing warnings in electronic prescribing systems
December 19, 2018 - New $1.6 million NIH grant supports study on a gene vital to circadian rhythms
December 19, 2018 - Racial Disparities Seen Among Teens Undergoing Flu Vaccination
December 19, 2018 - To resolve inflammation, location matters
December 19, 2018 - Dancing could help older women to perform their daily tasks
December 19, 2018 - Research identifies new therapeutic target for cancer treatment and tissue regeneration
December 19, 2018 - Energy costs, social isolation contribute to health risk of older adults in extreme weather
December 19, 2018 - Potential combination therapy against rare disease of the bone marrow could improve treatment
December 19, 2018 - Researchers aim to improve cognition, reverse weight gain in schizophrenia
December 19, 2018 - UC San Diego Health offers new DRG stimulation device for phantom limb pain
December 19, 2018 - Study examines relationship between growth restriction and risk of childhood mortality
December 19, 2018 - New study provides insights on increased risk of suicide in young patients visiting ED
December 19, 2018 - AHA: Thyroid Problems Linked to Worsening Heart Failure
December 19, 2018 - World-first coeliac disease vaccine enters Phase 2 trials
December 19, 2018 - RNA sequencing offers novel insights into the microbiome
December 19, 2018 - A promising, effective vaccine for common respiratory disease
December 19, 2018 - Protein may slow progression of emphysema, study finds
December 19, 2018 - Studying atrial fibrillation — and exploring new frontiers in precision health
December 19, 2018 - A New Way To Get College Students Through A Psychiatric Crisis — And Back To School
December 19, 2018 - Optum, UnitedHealthcare take action to help people affected by North Carolina winter storms
December 18, 2018 - Weight change in middle-aged, elderly Chinese Singaporeans related to increased risk of death
December 18, 2018 - Immune cells sacrifice themselves to protect us from invading bacteria
December 18, 2018 - Watching brain cells fire, with a twist of gravitational waves
December 18, 2018 - 2018 in Review
December 18, 2018 - Getting the Most Out of the CLARITY Technique
December 18, 2018 - NVF shoes provide a viable option for track and road racing
December 18, 2018 - CRISPR may restore effectiveness of chemotherapies used to treat lung cancer
December 18, 2018 - New app accurately measures and charts progression of skin wounds
December 18, 2018 - Persistent Discrimination ID’d Among Physician Mothers
December 18, 2018 - Cellphone technology developed to detect HIV
December 18, 2018 - A Stanford doctor hits the field with the 49ers — as their airway management physician
December 18, 2018 - The Rise of Anxiety Baking
December 18, 2018 - Just one night of sleep deprivation increases the urge to eat
December 18, 2018 - Study reveals mechanism behind failed remyelination in MS
December 18, 2018 - New genetic testing method increases the precision of biomarker analysis
December 18, 2018 - Simple technique to effectively treat underdiagnosed cause of debilitating chest pain
December 18, 2018 - Barbershop-based medical intervention can successfully lower blood pressure, new data shows
December 18, 2018 - Food labels have caused changes in consumers’ intake and industry’s use of key additives
December 18, 2018 - Sickest children could benefit from split liver transplants
December 18, 2018 - Scientists create patient-specific model to identify most effective treatment for appendix cancer
December 18, 2018 - ‘Little Foot’ endocast reveals a small brain combining ape-like and human-like features
December 18, 2018 - New therapy for childhood blindness shows ‘very promising’ results
December 18, 2018 - Researchers discover promising new compound against Buruli ulcer
December 18, 2018 - Study finds significant use of traditional, complementary and alternative medicines in Sub-Saharan Africa
December 18, 2018 - California Farm Implicated in Outbreak of E. coli Tied to Romaine Lettuce
December 18, 2018 - Mobile health has power to transform HIV/AIDS nursing
December 18, 2018 - Celiac Vaccine in Clinical Trials at Columbia
December 18, 2018 - Research into mental health first aid prompts practical guidance and resources for workplace
December 18, 2018 - Researcher conducts study to investigate peripheral blood markers of Alzheimer’s disease
December 18, 2018 - Researchers identify link between mucus in the small airways and pulmonary fibrosis
December 18, 2018 - EU Commission’s Health Policy Platform to host EKHA program on transplantation
December 18, 2018 - Survivors of childhood Hodgkin lymphoma have high risk of developing solid tumors
December 18, 2018 - Small changes to cafeteria design can get kids to eat healthier, new assessment tool finds
December 18, 2018 - From Machines to Cyclic Compounds
December 18, 2018 - New study reveals best assessment tools to establish delirium severity
December 18, 2018 - Rice University scientists develop synthetic protein switches to control electron flow
December 18, 2018 - Home-based pulmonary function monitoring for teens with Duchenne muscular dystrophy
December 18, 2018 - Researchers identify potential target for new breast cancer treatments
December 18, 2018 - National Biofilms Innovation Centre award grant to Neem Biotech for novel anti-biofilm drug development
December 18, 2018 - Artificial intelligence and the future of medicine
December 18, 2018 - Montana State doctoral student receives grant for her work to improve neuroscience tool
December 18, 2018 - Early postpartum initiation of opioids associated with persistent use
December 18, 2018 - Russian scientists identify molecular ‘switch’ that could be target for treatment of allergic asthma
December 18, 2018 - Surgeons make more mistakes in the operating room during stressful moments, shows study
December 18, 2018 - Immune cells explode themselves to inform about the danger of invading bacteria
December 18, 2018 - Malnutrition in children with Crohn’s disease linked with increased risk of surgical complications
December 18, 2018 - FDA Approves Motegrity (prucalopride) for Adults with Chronic Idiopathic Constipation (CIC)
December 18, 2018 - The long and short of CDK12
December 18, 2018 - Hologic’s Cynosure division introduces TempSure Surgical RF technology in North America
December 18, 2018 - CMR Surgical partners with Nicholson Center to launch U.S.-based training program for Versius
December 18, 2018 - Findings reinforce guidelines for cautious use of antipsychotics in younger populations
December 18, 2018 - Study finds new strains of hepatitis C virus in sub-Saharan Africa
Being Breastfed May Lower Eczema Risk for Teens

Being Breastfed May Lower Eczema Risk for Teens

image_pdfDownload PDFimage_print

Action Points

  • Mothers who participated in a breastfeeding intervention trial had teenagers with lower risk of eczema, but not asthma.
  • Note that there was no evidence of an association between the intervention group and either self-reported atopic eczema symptoms or asthma outcomes in the past year.

Mothers who participated in a breastfeeding intervention trial had teenagers with lower risk of eczema, but not asthma, a large Belarusian follow-up study found.

Adolescents whose mothers were part of the breastfeeding intervention group had about a 50% reduction in the risk of flexural eczema compared with those whose mothers received standard care (adjusted OR 0.46, 95% CI 0.25-0.83), reported Carsten Flohr, MD, PhD, of King’s College in London, and colleagues.

But there was no evidence of an association between the intervention group and either self-reported atopic eczema symptoms or asthma outcomes in the past year, the authors wrote in JAMA Pediatrics.

They noted that many allergy organizations and the World Health Organization (WHO) recommend exclusive breastfeeding for the first 4 to 6 months of life “to aid the prevention of allergy and associated illnesses,” but added that these recommendations are based on contradictory results and “inconsistent” findings of cross-sectional studies with methodological shortcomings.

While a trial that examined the impact of a breastfeeding intervention found “marked differences in breastfeeding exclusivity and duration,” the authors saw a unique opportunity to follow-up with these trial participants “to test the long-term effects of breastfeeding on childhood outcomes, including asthma, lung function and atopic eczema.”

This study was a follow-up of the Promotion of Breastfeeding Intervention Trial (PROBIT), a cluster randomized clinical trial of breastfeeding promotion conducted at 34 Belarusian maternity hospitals. Intervention was determined by hospitals who were either randomized to implement an experimental breastfeeding intervention or to implement standard care.

Risk of gastrointestinal tract infection was the primary outcome of the trial, with risk of atopic eczema a secondary outcome. Children were followed up for 12 months from the time of birth, and when they were about age 6 years, using skin-prick tests and the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire to get information about asthma and atopic eczema. There was a third follow-up when the children were almost age 12 years, though this did not include atopy-related outcomes, the authors said.

During this current follow-up, children were physically examined for evidence of flexural dermatitis, reported their atopic eczema and asthma symptoms using the ISAAC questionnaire, and had their lung function measured by spirometry.

Overall, 13,557 participants — about 80% of the original cohort — were followed up at age 16 years. There were 7,064 from the intervention group and 6,493 from the control group. Both groups had about equal representation between boys and girls.

In an intention-to-treat analysis, there were 21 (0.3%) children with signs of flexural eczema in the intervention group compared with 43 (0.7%) of the control group. But when examining secondary outcomes, the authors noted an odds ratio of “similar magnitude, but with lower precision.”

  • Questionnaire-derived flexural eczema in past year: cluster-adjusted OR 0.57 (95% CI 0.27-1.18)
  • Persistent flexural eczema in past year: cluster-adjusted OR 0.48 (95% CI 0.22-1.04)
  • Sleep-disturbed flexural eczema in past year: cluster-adjusted OR 0.54 (95% CI 0.23-1.28)

Similar results were seen for asthma outcomes, where the authors found no protective effect for breastfeeding. Overall, 108 (1.5%) of the intervention group reported “asthma ever” versus 110 of the control group (1.7%), but with similar wide estimates (cluster-adjusted OR 0.66, 95% CI 0.37-1.18).

Researchers also found no significant difference in reported asthma attacks in the past 12 months, and they noted that effect estimates for “asthma ever” and wheezing in the past 12 months were similar after adjustment.

Limitations to the data include unconscious bias in skin examination, if the pediatrician was aware of the child’s treatment allocation, and there was no ability for quality assurance of measured lung function equipment, “due to technical limitations of the equipment used in the field,” the authors said. They also noted that atopic eczema is less common in Belarus compared with North America and Western Europe, and their centralized healthcare system is also different, which could potentially limit the generalizability of the findings.

The study was supported in by EU grants, the Canadian Institutes of Health Research, and the NIH.

Flohr disclosed funding from the National Institute for Health Research (NIHR) and the NIHR Biomedical Research Centre, and no relevant relationships with industry.

  • Reviewed by
    Robert Jasmer, MD Associate Clinical Professor of Medicine, University of California, San Francisco and Dorothy Caputo, MA, BSN, RN, Nurse Planner

2017-11-13T16:00:00-0500

Tagged with:

About author

Related Articles