Breaking News
January 23, 2018 - New long-acting, less-toxic HIV drug suppresses virus in humanized mice
January 23, 2018 - Findings provide better understanding of cognitive inflexibility in Fragile X Syndrome
January 23, 2018 - Powerful anti-oxidant can stop progression of fatty liver disease in young mice
January 23, 2018 - Study shows value of occupational therapy in the lives of young adults with diabetes
January 23, 2018 - Researchers seek to understand effect of very low birth weight on the brain
January 23, 2018 - Be a Savvy Supermarket Shopper
January 23, 2018 - NIH Striving to Avoid False Hope in Chronic Fatigue
January 23, 2018 - ClinicalTrials.gov: Occupational Stress
January 23, 2018 - PrEP could make US easily hit its 2020 HIV prevention goal, study finds
January 23, 2018 - Study finds considerable variation in hip fracture rates across nursing homes
January 23, 2018 - Evidence-based approach to preventing or treating caries could transform dental care
January 22, 2018 - TAVR Discharge Timing; Stentreiver Anesthesia; New Valve Depression
January 22, 2018 - Could sugar be responsible for the obesity and diabetes epidemics?
January 22, 2018 - Mallinckrodt Completes Stannsoporfin New Drug Application Filing
January 22, 2018 - ACOG Backs ‘Cascade Testing’ for Cancer-Related Mutations
January 22, 2018 - The terrible toll tennis can take on top players who play too much
January 22, 2018 - KAIST scientists identify cellular mechanism for severe viral hepatitis
January 22, 2018 - New genomic tools provide better understanding of the human immune system
January 22, 2018 - Improving QoL with an App?
January 22, 2018 - Researchers identify virus as likely cause of mystery polio-like paralysis
January 22, 2018 - First step toward CRISPR cure of Lou Gehrig’s disease
January 22, 2018 - Scientists uncover the proteins responsible for movement
January 22, 2018 - New clinical practice guideline provides recommendations for use of anticoagulants during heart surgery
January 22, 2018 - Depressive symptoms associated with poorer survival in patients with head and neck cancer
January 22, 2018 - Restaurant Bans Have Big Impact on Smoking Rates
January 22, 2018 - D.C. Week: CMS Outlines Path for Medicaid Work Mandate
January 22, 2018 - Study identifies new loci associated with asthma enriched in epigenetic marks
January 22, 2018 - Researchers explore impact of smart rollator in motivating seniors to increase physical activity
January 22, 2018 - New bug may reduce misery of hay fever sufferers
January 22, 2018 - Specially prepared supplement helps women to run faster, study shows
January 22, 2018 - 3-D Stent Retriever with Aspiration Proves Mettle in AIS
January 22, 2018 - Public health research seeks to understand how natural disasters impact spread of Zika
January 22, 2018 - Research reveals role of nanophenomenon in stimulating bone-repair process
January 22, 2018 - Drinking during late adolescence could be first step to liver problems in adulthood
January 22, 2018 - Epilepsy associated with volume and thickness differences in brain matter
January 22, 2018 - Trevena Announces FDA Acceptance for Review of New Drug Application for Olinvo (oliceridine) Injection
January 22, 2018 - A Noteworthy Margin of Error
January 22, 2018 - Firm advances human trials of revolutionary vaccine
January 22, 2018 - Many Indians put away treating orthopedic problems
January 22, 2018 - Cherwell releases new pocket guide to prepared culture media
January 22, 2018 - Huron earns ISO 13485 certification for quality management system
January 22, 2018 - Avion Pharmaceuticals Announces FDA Approval of Balcoltra (levonorgestrel and ethinyl estradiol tablets and ferrous bisglycinate tablets) Oral Contraceptive
January 22, 2018 - Multi-Gene Test For Early CVD; Neighborhood HF Risk; Novel Testosterone Drugs
January 22, 2018 - Skipping breakfast disrupts ‘clock genes’ that regulate body weight
January 22, 2018 - Creativity May Rely on ‘Teamwork’ in the Brain
January 22, 2018 - NeuroBreak: Alzheimer’s Germ Contest; High Salt Diet May Be Bad for Brain
January 22, 2018 - Diabetics may often fare poorly in hospice care
January 22, 2018 - Performance enhancing benefits of caffeine more apparent for infrequent tea, coffee drinkers
January 22, 2018 - HHS Unveils Framework for Interoperability
January 22, 2018 - More dentists to discuss risks of HPV-related cancers with their patients
January 21, 2018 - Research shows how Zika virus damages placenta to cause malformations in babies
January 21, 2018 - Achaogen Announces FDA Acceptance of New Drug Application with Priority Review for Plazomicin for Treatment of Complicated Urinary Tract Infections and Bloodstream Infections
January 21, 2018 - Drug Allergies: Time to Re-Test?
January 21, 2018 - Mitochondrial protein in cardiac muscle cells linked to heart failure, study finds
January 21, 2018 - Women more likely than men to die from a heart attack
January 21, 2018 - Next generation genomic sequencing can help detect pathogens after joint replacement
January 21, 2018 - Gov’t Shutdown Looms as Senate Debates Spending Bill
January 21, 2018 - Emergency Readiness for Older Adults and People with Disabilities
January 21, 2018 - Heart health at risk for Latinas over worries about deportation
January 21, 2018 - Scientists methodically identify genes related to blood feeding and non-biting mosquitoes
January 21, 2018 - Researchers discover potential target genes to halt thyroid cancer progression
January 21, 2018 - Youth with shared residency after parents’ divorce have less mental issues
January 21, 2018 - Sleep Better, Lose Weight? – Drugs.com MedNews
January 21, 2018 - More $$ Needed for Health Emergencies, Senators Told
January 21, 2018 - Gene test to predict breast cancer recurrence less cost effective in real world practice
January 21, 2018 - Study finds rise in number of adolescents receiving psychiatric or neurodevelopmental diagnosis
January 21, 2018 - Reminders can improve immunization rates
January 21, 2018 - A More Personalized Approach to PSA Screening in 2017
January 21, 2018 - T-cells engineered to outsmart tumors induce clinical responses in relapsed Hodgkin lymphoma
January 21, 2018 - Tetraphase Pharmaceuticals Announces Submission of New Drug Application to FDA for Eravacycline for the Treatment of Complicated Intra-Abdominal Infections (cIAI)
January 21, 2018 - Have Robotics Had a Detrimental Effect on Surgical Residency?
January 21, 2018 - Being bilingual may help autistic children
January 21, 2018 - Metrics Are Not Widespread in Rheumatoid Care
January 21, 2018 - Neuroanatomic abnormalities ID’d in those at risk for autism
January 21, 2018 - Children born with Down’s syndrome have superior genome that compensates for disability
January 21, 2018 - Study finds higher risks for asymptomatic paroxysmal AF patients
January 21, 2018 - The Second Stage of Diet Resolutions
January 21, 2018 - CT Scans Reduce Lung Cancer Deaths … But Among Whom?
January 21, 2018 - ADHD drug use soars among young women
January 21, 2018 - Researchers propose new regulation mechanism linked to action of SirT6 on chromatin
Epigenetic editing in healthy breast cells can set off chain reaction for tumor initiation

Epigenetic editing in healthy breast cells can set off chain reaction for tumor initiation

image_pdfDownload PDFimage_print

Changing the epigenetic code of a single gene is enough to cause a healthy breast cell to begin a chain reaction and become abnormal, according to research by Queen Mary University of London (QMUL).

The findings could lead to earlier cancer diagnosis and the potential for new therapeutics in the form of gene editing.

Epigenetic changes are a hallmark of cancer, but up until now, it has not been known whether these changes on their own are sufficient to push healthy cells down the cancer path.

Using a CRISPR-dCas9 epigenetic editing tool, the researchers methylated different genes in healthy breast cells and found that those changes were sufficient to cause the cells to undergo ‘hyperproliferation’ – abnormally rapid cell division which is an early stage of tumor initiation.

The research, using cells from the Breast Cancer Now Tissue Bank and due to be published in Nature Communications, also shows that the epigenetic changes are inherited as long as the cell divides, and that the team’s manipulations permanently and negatively affected the biology of a normal breast cell from a healthy individual.

Lead researcher Dr Gabriella Ficz from QMUL’s Barts Cancer Institute said: “It’s surprising that cells from several healthy individuals are so permissive to gaining this epigenetic change and that one ‘hit’ from an epigenetic editing tool is sufficient to set off this chain reaction of epigenetic inheritance and establish a cancer cell-like gene expression signature.”

The findings may help scientists to better understand the earliest epigenetic changes which can initiate abnormal cell processes, and the transition between the pre-disease state and cancer. This could help with the development of new biomarkers for earlier diagnosis.

In the future, epigenetic editing could also be used to design novel therapies by initiating permanent changes to cell biology. This may be a more viable or alternative way forward for gene editing as any potential mistakes would be less damaging than directly editing the DNA sequence, and epigenetic editing would be more easily reversible if needed.

Dr Ficz also explains that the findings could have an impact on our knowledge of aging and cancer: “Epigenetic fluctuations happen all the time in our cells. We know that, during aging, our epigenome is progressively distorted – so called ‘epigenetic drift’. It will, therefore, be exciting to find out if this drift is responsible for initiating or accelerating aging-associated diseases. Age is the biggest risk in cancer so our work highlights the importance of understanding the mechanism of epigenetic drift.”

6837829c-d195-4dea-8759-573b4cff94e0|0|.0

Posted in: Device / Technology News | Medical Science News | Medical Research News | Medical Condition News

Tags: Ageing, Breast Cancer, Cancer, Cancer Diagnosis, Cell, CRISPR, DNA, Gene, Gene Expression, Genes, therapeutics

Tagged with:

About author

Related Articles