Breaking News
June 19, 2018 - Study combines gene editing and stem cell technologies to predict person’s risk for heart disease
June 19, 2018 - Weight loss of 20% or greater results in better outcomes for overweight, obese adults with knee osteoarthritis
June 19, 2018 - Alnylam Reports Updated Positive Results from Phase 1/2 Study of Lumasiran in Patients with Primary Hyperoxaluria Type 1 (PH1)
June 19, 2018 - Study predicts most people with earliest Alzheimer’s signs won’t develop dementia associated with the disease
June 19, 2018 - Abnormal sleep duration linked to metabolic syndrome in new study
June 19, 2018 - Researchers develop new method to preserve fertility in boys with prepubertal cancer
June 19, 2018 - Late onset of diabetes could be indicative of pancreatic cancer
June 19, 2018 - Skin tone makes big difference in diagnosis and treatment of dermatologic conditions
June 19, 2018 - After addiction, the long road back to good health
June 19, 2018 - High blood pressure could be an early sign of dementia
June 19, 2018 - Innovative drugs and new European treatment guidelines refine, improve MS therapy
June 19, 2018 - BIDMC scientists develop new tool to benefit patients with HCV-associated liver failure
June 19, 2018 - Diabetes diagnosis may come with increased risk of pancreatic cancer for African-Americans, Latinos
June 19, 2018 - Personalized Goals, Cash Motivate Heart Patients to Exercise
June 19, 2018 - Nipah Virus (NiV) | CDC
June 19, 2018 - Genomics offers new treatment options for infants with range of soft tissue tumors
June 18, 2018 - Study shows how moderate consumption of alcohol can protect the heart
June 18, 2018 - Gene editing technology predicts heart disease risk
June 18, 2018 - Who Will and Who Won’t Get the Flu?
June 18, 2018 - Research shows effective responses to online feedback
June 18, 2018 - Scientists to focus on big data and genetics to identify risk factors for dementia
June 18, 2018 - Ultrasound-based technology for assessing overweight adolescents with liver disease
June 18, 2018 - Osteochondral knee defect treated using cell technology
June 18, 2018 - New clinical trial finds no evidence to support use of tamsulosin for kidney stones
June 18, 2018 - Study demonstrates increased levels of gum disease in people at risk of rheumatoid arthritis
June 18, 2018 - Ebola & Marburg | NIH: National Institute of Allergy and Infectious Diseases
June 18, 2018 - Brains, eyes, testes: off-limits for transplants?
June 18, 2018 - Drug used to treat myelofibrosis can awaken ‘dormant’ lymphomas in the bone marrow
June 18, 2018 - New study focuses on best, cost effective practices to bridge treatment gap for brain disorders
June 18, 2018 - New study highlights predictors that prevent from achieving remission in early RA
June 18, 2018 - Neuroscientists map feeling of cool touch to the brain’s insula in mouse model
June 18, 2018 - Study highlights potential use of blood biomarkers as diagnostic tool for sleep apnea
June 18, 2018 - Eating plant-based diet can reduce risk for heart problems in people with type 2 diabetes
June 18, 2018 - Lenabasum has acceptable safety and tolerability in diffuse cutaneous systemic sclerosis
June 18, 2018 - Study shows link between risky opioid prescriptions and increased odds of death
June 18, 2018 - Bone density scans could help determine likelihood of cardiovascular disease
June 18, 2018 - Mechanical thrombectomy appears to be important therapy for acute stroke in very old patients
June 18, 2018 - Novel compound as effective as FDA-approved antibiotics for treating deadly infections
June 18, 2018 - Ironwood Pharmaceuticals Announces FDA Orphan Drug Designation for Olinciguat for the Treatment of Sickle Cell Disease
June 18, 2018 - Surgical outcomes equivalent whether physician anesthesiologist assisted by nurse anesthetist or AA
June 18, 2018 - Studies provide insight into molecular changes prior to onset of arthritis
June 18, 2018 - Dyaco unveils specialist medical and rehabilitation equipment range in the UK
June 18, 2018 - Engineers develop algorithm to monitor joints of patients with arthritis
June 18, 2018 - Women with higher vitamin D blood levels have lower risk for breast cancer
June 18, 2018 - New studies help elucidate role of sleep in chronic pain
June 18, 2018 - Researchers link red meat sensitivity spread by ticks with heart disease
June 18, 2018 - Research explores role of autopsy in cardiovascular medicine
June 18, 2018 - Motif Bio Submits NDA for Iclaprim
June 18, 2018 - NIH-funded researchers identify target for chikungunya treatment
June 18, 2018 - Negative emotions are murkier, less distinct in adolescence
June 18, 2018 - Gut microbiome may be potential contributor to depression, anxiety in people with obesity
June 18, 2018 - Canakinumab reduces gout rate by more than half in atherosclerosis patients, study shows
June 18, 2018 - What Does the Future Hold?
June 18, 2018 - FDA Approves Keytruda (pembrolizumab) for Treatment of Refractory or Relapsed Primary Mediastinal Large B-Cell Lymphoma (PMBCL)
June 18, 2018 - School cliques don’t always click
June 18, 2018 - Three experts from The Tinnitus Clinic contribute to major review on pulsatile tinnitus
June 18, 2018 - Unwieldy health costs often stand between teachers and fatter paychecks
June 18, 2018 - Link between frailty and mortality remains unchanged despite lower death rates, study finds
June 18, 2018 - Sleep disorders appear to be first sign of serious neurological diseases
June 18, 2018 - Childhood, adult obesity raise risk of developing hip and knee osteoarthritis
June 18, 2018 - Study unravels ‘blood stem cell niche’ puzzle
June 18, 2018 - People with heart problems do not take enough exercise, shows study
June 18, 2018 - Strong Link Identified Between T2DM and Parkinson’s Disease
June 18, 2018 - Early childhood interventions show mixed results on child development
June 18, 2018 - Chronic use of opioids related to increased risk of fracture nonunion
June 18, 2018 - AHA: Family Perseveres After Losing Father to Heart Attack
June 18, 2018 - Oral propranolol seems safe for infantile hemangioma
June 18, 2018 - New study gives explanation for food’s prominence in memory
June 18, 2018 - First photoactive drug to fight Parkinson’s disease
June 18, 2018 - Patient’s self-evaluation of personality disorders not as far off as previously perceived
June 18, 2018 - Upadacitinib Monotherapy Meets All Primary and Ranked Secondary Endpoints Versus Methotrexate in a Phase 3 Study in Rheumatoid Arthritis
June 18, 2018 - Vitamin B3 has a positive effect on damaged nerve cells in Parkinson’s patients
June 17, 2018 - Sunovion Announces FDA Acceptance of New Drug Application for Apomorphine Sublingual Film (APL-130277)
June 17, 2018 - Bid to beat obesity focuses on fat that keeps us warm
June 17, 2018 - Work Stress May Increase Risk of Developing Atrial Fibrillation
June 17, 2018 - New Zealand’s secret recipe for active school travel: The neighborhood built environment
June 17, 2018 - New Medscape report reveals sexual harassment rate of physicians
June 17, 2018 - Surgical Blood Transfusions Tied to Clot Risk
June 17, 2018 - CDC chief makes $375K, far exceeding his predecessors’ pay
June 17, 2018 - Education linked to higher risk of short-sightedness
Largest clinical specialty database powers studies that yield key insights

Largest clinical specialty database powers studies that yield key insights

image_pdfDownload PDFimage_print

The American Academy of Ophthalmology today announced key milestones and clinical insights from studies powered by its clinical database. The IRIS® Registry (Intelligent Research In Sight) has amassed more than 41.2 million unique patients in its database, representing 166.2 million patient visits, covering 11 percent of the U.S. population. It is the largest clinical specialty database in the world, allowing ophthalmologists to pioneer research based on real-world clinical practice.

Launched in 2014, the IRIS Registry is the nation’s first comprehensive eye disease clinical registry. The Academy developed it as part of the profession’s shared goal of continual improvement in the delivery of eye care. Open to all Academy members in good standing, the IRIS Registry allows ophthalmologists to compare their patient outcomes, professional performance and care processes against other ophthalmologists across the country. A number of key insights are being presented today at AAO 2017, 121st Annual Meeting of the American Academy of Ophthalmology.

Three brands of treatment appear equally effective in patients with age-related macular degeneration

One of the most hotly debated issues in eye care in recent years has been over three similar anti-vascular endothelial growth factor (anti-VEGF) treatments for age-related macular degeneration. To find out if there are differences in their ability to protect sight, researchers reviewed records for 13,859 patients treated with a single drug type – Avastin (bevaci¬zumab: 6,723), Lucentis (ranibizumab: 2,749), or Eylea (aflibercept: 4,387) – for one year. Patients achieved similar improvement in vision regardless of drug type. Mean number of injections were 5.9 with Avastin, 6.4 with Lucentis, and 6.2 with Eylea.

Complication related to macular degeneration treatment less common than previously reported

Previous randomized, controlled trials have shown that close to 10 percent of patients who received anti-VEGF therapy for retinal diseases experience a pressure rise inside the eye that could be damaging. To learn more, researchers conducted a review of 23,776 patients with age-related macular degeneration, diabetic macular edema, or branch or central retinal vein occlusion who received bevaci¬zumab, ranibizumab, or aflibercept injections. The rate of clinically significant pressure rise was small, at 2.8 percent for both ranibizumab and bevaci¬zumab. The rate was even smaller for aflibercept, at 1.9 percent, which is considered insignificant. It’s unclear why aflibercept was not associated with sustained pressure rise.

Many patients with diabetic macular edema go untreated

A review of 13,410 patients shows that 60 percent received no treatment within the first year after their diagnosis of diabetic macular edema. For those who were treated, anti-VEGFs were the treatment of choice: 23.5 percent received an anti-VEGF while 13.7 percent received laser treatment and 1.8 percent received corticosteroids. Almost half of those receiving an anti-VEGF treatment had 3 or fewer injections. Data suggest future studies should investigate possible barriers preventing patients from receiving care.

Return trip to the operating room after macular surgery linked to significantly worse visual outcomes

An evaluation of patients who underwent macular surgery from 2013 to 2016 showed that about 6 percent of patients had to go back to the operating room for a second macular surgery. Patients who required another surgery experienced significantly worse visual outcomes, compared with patients who did not require a second surgery.

Promise of using the IRIS Registry to study patients with glaucoma

The IRIS Registry currently includes data on 5.4 million glaucoma patients, representing 8.6 million eyes. Data collected include disease type and severity, as well as age, sex, race, and types of surgical procedures performed. Currently there are 2 million patients with suspected primary open-angle glaucoma and 1.3 million with primary open-angle glaucoma.

“The holy grail of health care is to improve value by enhancing patient outcomes, improving the process and experience of health care, and reducing unnecessary or ineffective care,” said William L. Rich III, M.D., medical director of Health Policy for the American Academy of Ophthalmology. “The IRIS Registry has proven to be a valuable tool for patients, physicians, and the health care system as a whole.”

Tagged with:

About author

Related Articles