Breaking News
December 16, 2017 - Research uncovers mechanism implicated in defective function of tumor-associated dendritic cells
December 16, 2017 - OncoBreak: Stubborn Racial Disparities; Paid Medical Leave & Chemo; DIY Gene Tests
December 16, 2017 - Critical link between obesity and diabetes has been identified
December 16, 2017 - Transfusion dependence reduces access to high-quality end-of-life care for leukemia patients
December 16, 2017 - Porvair and Suzhou Tianlong Bio to develop epigenetic analysis technologies
December 16, 2017 - FDA Approves Ixifi (infliximab-qbtx), a Biosimilar to Remicade
December 16, 2017 - Morning Break: Trump to Get Check-Up; Cancerous Transplant; Death Knell for MIPS?
December 16, 2017 - First transcatheter implant for diastolic heart failure successful
December 16, 2017 - ‘Sushi-like’ nanodiscs provide structural snapshots of misfolding proteins
December 16, 2017 - Inherited gene variation may be to blame for poor survival of patients with early-onset breast cancer
December 16, 2017 - Sign-up deadline is Friday, but some people may get extra time
December 16, 2017 - Higher Booze Taxes Might Pay Off for Public Health
December 16, 2017 - Regular Activity in Midlife Spares Joints in Women
December 16, 2017 - Rain May Not Cause Achy Joints After All: MedlinePlus Health News
December 16, 2017 - MedDiet adherence doesn’t affect acute heart failure mortality
December 16, 2017 - HKBU experts develop new generation of smart anti-cancer drug molecules
December 16, 2017 - Chronic Kidney Disease Audit finds wide variations in coding of CKD patients in primary care
December 16, 2017 - Scientists use nanoparticles to fight Mucoviscidosis
December 16, 2017 - Increasing physical activity decreases risk of death from lymphoma
December 16, 2017 - Fear compromises the health, well-being of immigrant families, survey finds
December 16, 2017 - Rejected antibiotic candidate could be worth a second look, research finds
December 16, 2017 - Is Nation on the Right Track to Combat Opioid Crisis?
December 16, 2017 - Arthritis No Longer Just a Disease of the Old: MedlinePlus Health News
December 16, 2017 - Family members without inherited mutation have increased risk of melanoma
December 16, 2017 - Active surveillance proposed as first-line approach to manage patients with low-risk PMC of the thyroid
December 16, 2017 - Patients’ life values affect their attendance at medical treatment for pelvic-floor dysfunction
December 16, 2017 - Experts consider hazards of antibiotic resistances to be high
December 16, 2017 - Study finds erectile dysfunction as risk factor for early cardiovascular disease
December 16, 2017 - Amber-tinted glasses may reduce insomnia severity
December 16, 2017 - Arthritis Drug Seen Lowering GvHD Risk
December 16, 2017 - Atoh1, a potential Achilles’ heel of Sonic Hedgehog medulloblastoma
December 15, 2017 - Cornell engineers develop new method to measure vital signs using radio waves
December 15, 2017 - Rutgers studies highlight need for salon clients, workers to protect themselves from health risks
December 15, 2017 - FDA Approves Nucala (mepolizumab) for Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss Syndrome)
December 15, 2017 - Morning Break: CVS Buying Aetna; Uterus Transplant Baby; Your Brain on Drugs, Redux
December 15, 2017 - Social phobia linked to autism and schizophrenia
December 15, 2017 - Timestrip technology helping to prevent missed vaccinations
December 15, 2017 - Researchers win NIH grants for Alzheimer’s research on Amish resilience and rapid onset
December 15, 2017 - Mitochondrial error-correction mechanism essential for energy production of cells
December 15, 2017 - New report reveals steep rise in lung disease admissions to emergency departments during winter
December 15, 2017 - Study finds social stigma as barrier to successful treatment of children with HIV in Ethiopia
December 15, 2017 - Health Tip: Keep Gift-Giving Stress Under Wraps
December 15, 2017 - Long Stoppage of Bisphosphonates Tied to More Fractures
December 15, 2017 - Triglycerides Test: MedlinePlus Lab Test Information
December 15, 2017 - Study shows interventions, though few, can be effective for students with high-functioning autism
December 15, 2017 - Higher blood sugar during first trimester of pregnancy increases child’s risk of congenital heart defect
December 15, 2017 - Study tests accuracy of laboratory-developed cancer tests and FDA-approved companion diagnostics
December 15, 2017 - Extracellular vesicles can be used to effectively delay progression of kidney damage
December 15, 2017 - Targeted lung cancer treatments may benefit smokers and non-smokers alike
December 15, 2017 - Sugary-drink warning labels may help decrease obesity and overweight prevalence
December 15, 2017 - Coarse particulate matter exposure linked to increased asthma risk in children
December 15, 2017 - OCT Angio Gains Ground: Ophthalmology Times
December 15, 2017 - Flu Can Have Dangerous Domino Effect on Older Adults: MedlinePlus Health News
December 15, 2017 - A daily cup of hot tea may lower glaucoma risk
December 15, 2017 - New blood test accurately forecasts advanced heart failure patients’ survival after surgery
December 15, 2017 - Study finds improvements in survivals rates of individuals with kidney failure
December 15, 2017 - Rare gene mutation gives rise to low sensitivity to pain
December 15, 2017 - Older Women Do Well with New Breast Cancer Drugs
December 15, 2017 - Joint damage in healthy military recruits may mimic spondyloarthropathies
December 15, 2017 - Researchers examine link between tumor mutational burden and response to immune checkpoint therapy
December 15, 2017 - Nanotextured surfaces kill bacteria without harming mammalian cells
December 15, 2017 - Ketamine more effective than common sedative in reducing suicidal thoughts
December 15, 2017 - Scientists engineer light-emitting plant
December 15, 2017 - Medicare fails to recover hundreds of millions of dollars in lab overcharges
December 15, 2017 - IPM begins first clinical trial of vaginal rings to prevent HIV in women
December 15, 2017 - Telemedicine for addiction treatment? Picture remains fuzzy
December 15, 2017 - Genetic variations may help identify people at high-risk for chronic pain after surgery
December 15, 2017 - Intersect ENT Announces FDA Approval of Sinuva (mometasone furoate) Sinus Implant, a New In-Office Treatment Option for Recurrent Nasal Polyps
December 15, 2017 - Learning the Lessons of FluMist
December 15, 2017 - Study shows brain structures make some people resilient to Alzheimer’s disease
December 15, 2017 - UQ researchers create new and improved version of ‘love hormone’
December 15, 2017 - Anti-stress compounds provide new treatment approach for diabetes and obesity
December 15, 2017 - Survey finds extremely high rate of mortality from sepsis in ICUs
December 15, 2017 - Study provides insights into molecular mechanisms regulating cellular fate of SCCs
December 15, 2017 - Researchers identify previously unknown functions of natural killer cells in the womb
December 15, 2017 - Tech at Bedtime May Mean Heavier Kids
December 15, 2017 - Meta-Analysis: Hearing Loss Linked to Dementia in Elderly
December 15, 2017 - Second Phase 3 study results for LMTX published
December 15, 2017 - Researchers team up to identify vulnerabilities of lethal parasite
December 15, 2017 - Experts call for more action on gambling-related research and treatment
Scientists detect pathological prion protein in skin of CJD patients

Scientists detect pathological prion protein in skin of CJD patients

image_pdfDownload PDFimage_print

Researchers have found that it was possible to detect abnormal prion protein in the skin of 23 people who died from Creutzfeldt-Jakob Disease (CJD). They also found that exposing mice to skin tissue taken from the CJD patients caused them to develop prion disease.

The brain of a patient who died from sporadic Creutzfeldt-Jacob disease (CJD) seems to be nearly identical to that of a mouse inoculated with the infectious prions extracted from the skin of patients who died from CJD. Credit: Case Western Reserve University

The study has raised questions about the possibility of prion diseases being transmitted during medical procedures that involve the skin, as well as the possibility of using skin samples to detect the diseases.

The study was conducted by scientists from the National Institute of Allergy and Infectious Diseases (NIAID) and various other collaborating groups.

Generally, people associate prion diseases with the brain, although it has been shown that clusters of the abnormal prion protein, which cause sponge-like holes in the brain, can accumulate in other organs including the liver, spleen, lungs and kidney. It is known that Sporadic CJD, which is the most common human prion disease, can be transmitted via invasive medical procedures involving the central nervous system and cornea, but transmission via the skin has not generally been considered a concern.

For the study, Byron Caughey, senior investigator at NIAID’s Rocky Mountain Laboratories (RML) and colleagues used a prion disease test called Real-Time Quaking-Induced Conversion (RT-QuIC) to analyse skin extracts taken from 38 patients, 23 of whom who had died from CJD, and 15 of whom died from other causes. They also tested brain tissue taken from the CJD patients and from seven patients who had died from other causes.

As reported in Science Translational Medicine, the RT-QuIC test correctly identified the abnormal prion protein in all samples taken from the CJD patients and detected none in the patients who did not have CJD.

The team then inoculated 12 mice with brain tissue and 12 with skin tissue from two of the CJD patients and found that all of them developed prion disease, although it took approximately twice as long for the mice exposed to skin tissue to develop the disease.

The authors say the study should trigger discussion about the risk of surgical instruments becoming contaminated and the risk associated with procedures that involve CJD patients, as well as the possibility of using the RT-QuIC as a skin-based diagnostic test for prion diseases in both humans and animals

Our objective has always been to facilitate RT-QuIC testing using the most broadly available and least-invasive sample possible, whether that is blood, skin, nasal brushings, or other samples,”

Byron Caughey, Senior Investigator, NIAID’s Rocky Mountain Laboratories

The team is continuing to develop RT-QuIC applications, including research into when and where the abnormal prion protein appears in the skin, as well as how its infectious forms can be inactivated.

Source:

https://eurekalert.org/pub_releases/2017-11/nioa-nsa112217.php

Tagged with:

About author

Related Articles