Breaking News
December 14, 2017 - Living Lyme disease bacteria found months after antibiotic treatment
December 14, 2017 - These annual checkups help seniors not only survive but thrive
December 14, 2017 - Study reveals impact of diabetes during pregnancy on baby’s heart
December 14, 2017 - Huntington’s disease drug clears initial hurdles
December 14, 2017 - TPU researchers create 3D-printed models of children’s hearts
December 14, 2017 - Brain responses of children with inherited dyslexia risk predict their future reading speed
December 14, 2017 - Study: New Furosemide Formulation Simplifies Administration for HF
December 14, 2017 - Discrimination harms your health—and your partner’s
December 14, 2017 - Having older brothers may increase the likelihood of being gay
December 14, 2017 - New scientific yardstick released to help early detection of Alzheimer’s disease
December 14, 2017 - New finding demonstrates what happens at cellular level during onset of type2 diabetes
December 14, 2017 - Study identifies potassium as key to circadian rhythms in red blood cells
December 14, 2017 - Good friends might be your best brain booster as you age
December 14, 2017 - NIH expected to award up to $70 million to launch Alzheimer’s Clinical Trials Consortium
December 14, 2017 - Pitting pathogens against each other could prevent drug resistance emerging
December 14, 2017 - Study provides new insights into development of Sonic Hedgehog medulloblastoma
December 14, 2017 - Dr. Reddy’s Announces Approval of Impoyz (clobetasol propionate) Cream for Plaque Psoriasis
December 14, 2017 - Gene Screens Can Alter Perception, Behavior
December 14, 2017 - Can Scrotal Vein Condition Hike Heart Risks?: MedlinePlus Health News
December 14, 2017 - Molecules in spit may be able to diagnose and predict length of concussions
December 14, 2017 - Children’s Colorado and RxRevu partner to help prescribers better meet needs of pediatric patients
December 14, 2017 - Researchers discover new way to attack drug-resistant prostate cancer cells
December 14, 2017 - Scientists develop new, high resolution method for identifying microbial species and strains
December 14, 2017 - Declining trend of salmonellosis cases has leveled off in the EU
December 14, 2017 - Death receptors in the blood can help measure risk of cardiovascular diseases, type 2 diabetes
December 14, 2017 - How to Perk Up the Holidays for Hospital Patients
December 14, 2017 - Prolonged Sedation May be Bad for Baby’s Brain
December 14, 2017 - The pediatric submersion score predicts children at low risk for injury following submersions
December 14, 2017 - Video game helps doctors to quickly recognize trauma patients who need high levels of care
December 14, 2017 - Younger persons newly-diagnosed with type 2 diabetes have poorer health than older patients
December 14, 2017 - Clinician re-examines evidence on re-use of catheters and UTIs in people with spinal cord injuries
December 14, 2017 - UK and Russian researchers join forces against AMR
December 14, 2017 - Results of Bariatric Surgery Hold Up Over Time
December 14, 2017 - High-intensity exercise delays Parkinson’s progression
December 14, 2017 - Protein structure could pave way for effective drugs to treat cystic fibrosis
December 14, 2017 - Minority people less likely to see dermatologist for psoriasis treatment
December 14, 2017 - Study indicates decline in use of chemotherapy for early stage breast cancer patients
December 14, 2017 - Chagas disease presents real public health problem to Canadians
December 14, 2017 - Experts call for rigorous clinical trials in use of experimental fetal therapy
December 14, 2017 - Lactic acid bacteria can offer protection against subtypes of influenza A virus
December 14, 2017 - Tapeworm drug could provide new hope for patients with Parkinson’s disease
December 14, 2017 - Parkinson’s progression delayed through high-intensity exercise, study says
December 14, 2017 - Researchers discover potential regulator essential for killer T cells to reside in tumors
December 14, 2017 - Tailor-made protein combats several kinds of pathogenic bacteria
December 14, 2017 - Hidden genes hold blueprints for designing new anti-cancer drugs
December 14, 2017 - Male virgins still at risk for acquiring HPV, study finds
December 14, 2017 - Study reveals novel molecular targets to improve chemotherapy’s efficiency against leukemia
December 14, 2017 - Talazoparib Significantly Extends Progression-Free Survival in Phase 3 EMBRACA Trial of Patients with Metastatic Breast Cancer
December 14, 2017 - AHA: Hospital QI Initiative Fails to Budge Outcomes in India
December 14, 2017 - Scientists observe tremors associated with Parkinson’s disease in fruit flies
December 14, 2017 - Newly discovered molecular chaperones may soon be part of therapies for Huntington’s disease
December 14, 2017 - Performing surgery on virtual patient could provide valuable insight into consequences
December 13, 2017 - New insights into mosquito sex protein could provide strategies to control diseases
December 13, 2017 - Lilly’s Taltz (ixekizumab) Receives U.S. FDA Approval for the Treatment of Active Psoriatic Arthritis
December 13, 2017 - Step Into Sunshine | Medpage Today
December 13, 2017 - Poor Prognosis for Diabetic Foot Sores: MedlinePlus Health News
December 13, 2017 - Exercise alone does not lead to weight loss in women—in the medium term
December 13, 2017 - Researchers use new approach to identify casual mechanisms in depression
December 13, 2017 - Genetic Analysis and Bio-Rad enter into supply and distribution agreement for GA-map clinical test
December 13, 2017 - Study finds barriers to stem cell transplant use among multiple myeloma patients from minority groups
December 13, 2017 - Scientists discover how axons in developing visual system stabilize their connections
December 13, 2017 - Novel compound inhibits mycomembrane biosynthesis and kills tuberculosis bacteria
December 13, 2017 - FDA Launches New Tool for Sharing Information That Allows Doctors to Better Manage Antibiotic Use
December 13, 2017 - Evolocumab Wins FDA Approval for Stand-Alone CVD Prevention
December 13, 2017 - Powerful Clot-Busting Drugs Not Useful After Leg Blockages: Study: MedlinePlus Health News
December 13, 2017 - The fight against obesity: To tax or not to tax?
December 13, 2017 - Isolation during holidays can impact health of seniors
December 13, 2017 - Specialized physiotherapy provides many benefits for patients with Parkinson’s disease
December 13, 2017 - Pairing immunotherapy drug with chemotherapy proves beneficial for relapsed acute myeloid leukemia
December 13, 2017 - Researchers find link between brain structure and hallucination proneness, musical aptitude
December 13, 2017 - Radiation responsive molecules derived from horse chestnuts aid cancer imaging
December 13, 2017 - New Gene Therapy May Be Cure for ‘Bubble Boy’ Disease
December 13, 2017 - MorningBreak: Insurance Driving Drug Prices? Crunch Time for ACA; The ‘Other’ Drug Problem
December 13, 2017 - Are Stents Really Useless After Chest Pain? Cardiologists Not Sure: MedlinePlus Health News
December 13, 2017 - Can you train yourself to develop ‘super senses’?
December 13, 2017 - Cellular self-digestion process plays role in development of autoimmune diseases
December 13, 2017 - E-cigarette use among youth leads to smoking as adults finds study
December 13, 2017 - New nanomaterial could enable new types of chemical processes in pharma, materials and chemical industries
December 13, 2017 - Another CGRP Drug Gains Ground in Migraine
December 13, 2017 - Trigger for most common form of vision loss discovered
Some chemicals in smoke may be even more dangerous than previously thought

Some chemicals in smoke may be even more dangerous than previously thought

image_pdfDownload PDFimage_print
Alison Bauer, PhD, and colleagues show that while single chemicals in combustion may not cause cancer, combinations can be dangerous. Credit: University of Colorado Cancer Center

It’s no surprise that chemicals in smoke cause cancer, but a new study published in the Archives of Toxicology shows that some chemicals in cigarette smoke and industrial processes may be more dangerous than previously thought. Though most “low molecular weight polycyclic aromatic hydrocarbons” (LMW PAHs) have not been shown to cause cancer alone, the study shows that in common combinations, these chemicals can help to spark the disease.

“What we show is that testing each chemical in isolation may not give a complete picture of its danger,” says Alison Bauer, PhD, investigator at the CU Cancer Center and assistant professor in Department of Environmental and Occupational Health at the Colorado School of Public Health. Bauer collaborated with colleagues at the Institute for Prevention and Occupational Medicine, Institute of the Ruhr-University Bochum (IPA) in Bochum, Germany.

The International Agency for Research on Cancer places possible carcinogens into four groups, depending on their degree of risk. Group 1, labeled “carcinogenic to humans”, includes 120 known carcinogens such as benzene, radon and asbestos. It also includes the high molecular weight PAH benzo[a]pyrene or B[a]P, which has become known as one of the standard carcinogenic components associated with combustion. However, most LMW PAHs that are known components of combustion are not listed in Group 1. For example, the LMW PAHs fluoranthene and anthracene are currently listed in Group 3, titled “not classifiable as to its carcinogenicity to humans”. Other LMW PAHs found in combustion such as 1-methylanthracene are not even listed.

In this study, Bauer and colleagues added fluoranthene and 1-methylanthracene to B[a]P and introduced the mixture to mouse cells. Of course, B[a]P alone was enough to cause cellular changes associated with the development of cancer. However, the researchers observed that these cellular changes were dramatically magnified when B[a]P was combined with fluoranthene and 1-methylanthracene, clearly indicating that these previously imprecisely categorized chemicals were acting as co-carcinogens with B[a]P.

“The effect was impressive,” Bauer says.

The tested combination of PAHs (and many more like it) is not a hypothetical construct of the lab. Mixes of B[a]P with LMW PAHs are seen in many industrial processes such as coal gasification, paving and roofing work, vehicle emissions and cigarette smoke, among others.

“The goal is to prevent cancers associated with exposure to mixtures of these chemicals, through increased awareness leading to protective behaviors or to additional regulation of these chemicals,” Bauer says.

The group’s next step is to explore carcinogenicity of this and other combinations of LMW PAHs in human cells.


Explore further:
Study details cancer-promoting mechanisms of overlooked components in secondhand smoke

More information:
Alison K. Bauer et al, Environmentally prevalent polycyclic aromatic hydrocarbons can elicit co-carcinogenic properties in an in vitro murine lung epithelial cell model, Archives of Toxicology (2017). DOI: 10.1007/s00204-017-2124-5

Provided by:
CU Anschutz Medical Campus

Tagged with:

About author

Related Articles