Breaking News
February 23, 2018 - Patients who achieve short-term weight loss before bariatric surgery have better outcomes
February 23, 2018 - Beetroot may reduce kidney failure risk after heart x-ray, research reveals
February 23, 2018 - Sleep disruptions in menopause correlated with hot flashes and depression
February 23, 2018 - Scientists discover new treatment approach to curb severe myocarditis
February 23, 2018 - ‘Click chemistry’ approach may improve disease-fighting properties of drugs
February 23, 2018 - NIGHTSEA and EMS team up to offer KEY Award in fluorescence stereo microscopy
February 23, 2018 - Tobacco Kills, No Matter How It’s Smoked: Study
February 23, 2018 - Q&A: Avindra Nath, MD | Medpage Today
February 23, 2018 - Adherence to sleep apnea treatment affects risk of hospital readmission
February 23, 2018 - Zika virus could be alternative for treatment of aggressive brain cancer
February 23, 2018 - Carbon monoxide enhances efficacy of antibiotic against stomach infection
February 23, 2018 - MSD and Ferring Pharmaceuticals Complete Largest Ever Clinical Trial in Postpartum Haemorrhage
February 23, 2018 - Portable ultrasound can help better detect fluid in the lungs of patients with end-stage kidney disease
February 23, 2018 - Postnova AF2000 system offers reliable characterization of trace metal colloid distribution in the environment
February 23, 2018 - Pioneering study may pave way for effective painkillers to treat neuropathic pain
February 23, 2018 - Research opens up new avenue to minimize risks of transplants
February 22, 2018 - Cabozantinib Active in Advanced Thyroid Cancer
February 22, 2018 - Polluted air may pollute our morality
February 22, 2018 - New data from VOYAGE 2 trial shows promising results for Janssen’s guselkumab treatment
February 22, 2018 - Bank loans signed in the hospital leave patients vulnerable
February 22, 2018 - Researchers identify new nanostructure inside sperm tails
February 22, 2018 - Catheter-based procedure increases treatment options for mitral valve disease
February 22, 2018 - Sage Therapeutics Receives FDA Breakthrough Therapy Designation for SAGE-217 for the Treatment of Major Depressive Disorder
February 22, 2018 - Larger Endocarditis Vegetations More Likely to Embolize, Kill
February 22, 2018 - Parenting behavior in adoptive families
February 22, 2018 - Researchers discover new weakness in sleeping sickness parasites
February 22, 2018 - Research project aims to find new ways to identify and treat most aggressive brain cancers
February 22, 2018 - Researchers explore how people with Alzheimer’s disease use end-of-life medical services
February 22, 2018 - Stroke survivors and carers feel marginalized due to lack of support from primary care
February 22, 2018 - Neuroscientists discover novel mechanism of action behind schizophrenia
February 22, 2018 - After shooting, ‘honor how kids want to deal with their feelings’
February 22, 2018 - U.S., EU and Japan Health Authorities Accept Regulatory Submissions For Review Of Pfizer’s Third-generation ALK Inhibitor Lorlatinib
February 22, 2018 - At-Home Genetic Test Might Change Medicine
February 22, 2018 - Many second hand plastic toys could pose a risk to children’s health, study suggests
February 22, 2018 - Study shows that two different brain systems cooperate during learning
February 22, 2018 - Liquefied brain tissue after stroke may harm surviving brain, UA study finds
February 22, 2018 - New intervention improves communication behaviors in couples affected by dementia
February 22, 2018 - Clinical trial shows safety of promising TSRI stroke drug
February 22, 2018 - Researchers discover new interaction mechanism of unstructured proteins
February 22, 2018 - A Patient’s Journey: Can I Kill the Glucose Monster?
February 22, 2018 - The Problem That Piles Up
February 22, 2018 - Kids can roll up their sleeves—again—for mumps protection
February 22, 2018 - Scientists find significant amounts of toxic metals in e-cigarette vapors
February 22, 2018 - 3D Signatures reports positive results of new Telo-HL test for Hodgkin’s lymphoma
February 22, 2018 - Scientists reveal development of improved medicine to fight addiction
February 22, 2018 - USC-led researchers release dataset of brain scans from stroke patients
February 22, 2018 - Antibiotic-producing bacterium releases more metabolites than assumed
February 22, 2018 - Flu Season Shows First Signs of Slowing
February 22, 2018 - Nonstick Chemicals May Disrupt Metabolic Function in Women
February 22, 2018 - Calcium may play a role in the development of Parkinson’s disease
February 22, 2018 - Scientists visualize insulin receptor activation for the first time
February 22, 2018 - UC San Diego Health now offers new treatment option for people with refractory epilepsy
February 22, 2018 - First African child vaccinated with new typhoid conjugate vaccine
February 22, 2018 - BetterYou named as ‘Most Innovative Brand’ at FGB Awards 2018
February 22, 2018 - Assaults Among Young People Fall to Lowest Rate in 15 Years
February 22, 2018 - What do you know about Parkinson’s disease?
February 22, 2018 - Researchers discover five new genetic changes that may increase pancreatic cancer risk
February 22, 2018 - Gout medication may help improve heart function in adult patients
February 22, 2018 - Bioactive compound limits collateral damage in the kidneys after heart attack
February 22, 2018 - Study reveals HCT as effective treatment for NHL patients regardless of age
February 22, 2018 - Father’s age can affect offspring lifespan, mice study shows
February 22, 2018 - Opiant Pharmaceuticals Announces Publication of New Pre-Clinical Data Supporting Potential of OPNT005 as a Heroin Vaccine
February 22, 2018 - Make the Diagnosis: Strange Rash Surfaces
February 22, 2018 - Isolated sulfite oxidase deficiency – Genetics Home Reference
February 22, 2018 - Scientists identify weight loss ripple effect
February 22, 2018 - Smoking at record lows in New York
February 22, 2018 - Scientists pinpoint fertility hormone that could support early pregnancy
February 22, 2018 - Aggressive cancer stem cells can now be isolated successfully in a scientific breakthrough
February 22, 2018 - Researchers find high risk of suicide among unaccompanied refugee minors
February 22, 2018 - Protein levels linked to posture and gait problems in Parkinson’s
February 22, 2018 - Biomedical engineers create 3D hydrogel scaffolds  to transform cells into muscle
February 22, 2018 - Study employs novel approach to uncover new biomarker for CHD
February 22, 2018 - Study finds strong connection between midwifery and birth outcomes
February 22, 2018 - Verastem Submits NDA to FDA for Duvelisib for the Treatment of Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Follicular Lymphoma
February 22, 2018 - Low BP Associated With Risk in HFpEF
February 22, 2018 - More U.S. women obese before pregnancy, experts sound the alarm
February 22, 2018 - Study aims to examine effects of PTSD symptoms in police officers
February 22, 2018 - Study reveals increased disease risk after early heart surgery
February 22, 2018 - Women with Type 1 diabetes come across unique challenges
February 22, 2018 - Researchers target abnormal epigenetic mechanisms involved in childhood cancers
Innovative technique makes low-grade gliomas visible

Innovative technique makes low-grade gliomas visible

image_pdfDownload PDFimage_print

Gliomas are a type of brain tumor characterized by a poor prognosis. In order to improve this prognosis, as much of the tumor as possible must be removed safely during the neurosurgical operation. However, especially in the case of slow-growing, low-grade gliomas, it is often difficult to distinguish diseased tissue from healthy tissue. In a joint project, MedUni Vienna, the University of California in San Francisco and the Dartmouth-Hitchcock Medical Center (both USA) have now trialed a technique designed to make low-grade gliomas visible. The technique involved using an innovative probe together with 5-ALA as a fluorescence marker during the operation. 5-ALA fluorescence specialist Georg Widhalm, Department of Neurosurgery and member MedUni Vienna/Vienna General Hospital Comprehensive Cancer Center was heavily involved in the project.

In Austria, around 450 people a year develop a glioma. Nowadays, fluorescence marker 5-ALA, which accumulates in the cancerous tissue, is routinely used during surgical resection of fast-growing gliomas (glioblastomas) to help differentiate between diseased tissue and healthy tissue. A special surgical microscope that emits blue light, thereby making the brain tumor glow red, is used during the operation. This shows the surgeon exactly which parts of the brain are diseased, so he/she is better able to resect the tumor.

New probe visualizes gliomas

Normally it is not possible to see slow-growing, low-grade gliomas intraoperatively using the 5-ALA fluorescence technique. Dartmouth-Hitchcock Medical Center has now developed a special probe that is able to measure the concentration of 5-ALA fluorescence during the operation. This innovative technique has now been used for the first time in a larger cohort of patients with low-grade gliomas at the University of California, San Francisco.

“The initial results are very promising,” says CCC expert Georg Widhalm, who, as an internationally recognized specialist in 5-ALA fluorescence, was heavily involved in the trial. Widhalm adds: “We therefore have reason to hope that this innovative technique will also help us to visualize primary non-fluorescing, low-grade gliomas more accurately during surgery so that we can remove them more completely in future. This should improve the prognosis for these patients.” The new technique could therefore be an additional aid for neurosurgeons, helping them to differentiate between cancerous tissue and healthy brain tissue in low-grade gliomas.

International collaboration

In this trial, around 40 patients underwent surgery at the University of California, San Francisco. Because of his expertise in the field of 5-ALA fluorescence, once the probe had been developed at Dartmouth-Hitchcock Medical Center (David W. Roberts), neurosurgeon Georg Widhalm was invited to conduct this trial with Mitchel S. Berger, Head of the Division of Neurosurgery of the University of California, San Francisco. Says Widhalm: “The Comprehensive Cancer Center at MedUni Vienna/Vienna General Hospital has an internationally unique level of expertise in exactly this area: with more than 1,000 5-ALA-fluorescence-guided operations since its introduction, we are one of the world’s leading centres.” 5-ALA has been licensed in Europe for use in neurosurgery since 2007. The technique has been licensed in the USA since the summer of 2017 – data from MedUni Vienna played a crucial role in obtaining FDA (US Food and Drug Administration) approval for 5-ALA for use in neurosurgery in the USA. As a world expert, Georg Widhalm was heavily involved in this approval process.

The preliminary findings of the assessment were presented at this year’s Meetings of the Society of Neuro-Oncology (SNO). The conference, which is the world’s largest neuro-oncology congress, took place in San Francisco on 16 – 19th November.

Source:

https://www.meduniwien.ac.at/web/en/about-us/news/detailseite/2017/news-im-dezember-2017/innovative-probe-visualises-tumours/

Tagged with:

About author

Related Articles