Breaking News
February 23, 2018 - Tobacco Kills, No Matter How It’s Smoked: Study
February 23, 2018 - Q&A: Avindra Nath, MD | Medpage Today
February 23, 2018 - Adherence to sleep apnea treatment affects risk of hospital readmission
February 23, 2018 - Zika virus could be alternative for treatment of aggressive brain cancer
February 23, 2018 - Carbon monoxide enhances efficacy of antibiotic against stomach infection
February 23, 2018 - MSD and Ferring Pharmaceuticals Complete Largest Ever Clinical Trial in Postpartum Haemorrhage
February 23, 2018 - Postnova AF2000 system offers reliable characterization of trace metal colloid distribution in the environment
February 23, 2018 - Pioneering study may pave way for effective painkillers to treat neuropathic pain
February 23, 2018 - Research opens up new avenue to minimize risks of transplants
February 22, 2018 - Cabozantinib Active in Advanced Thyroid Cancer
February 22, 2018 - Polluted air may pollute our morality
February 22, 2018 - New data from VOYAGE 2 trial shows promising results for Janssen’s guselkumab treatment
February 22, 2018 - Bank loans signed in the hospital leave patients vulnerable
February 22, 2018 - Researchers identify new nanostructure inside sperm tails
February 22, 2018 - Catheter-based procedure increases treatment options for mitral valve disease
February 22, 2018 - Sage Therapeutics Receives FDA Breakthrough Therapy Designation for SAGE-217 for the Treatment of Major Depressive Disorder
February 22, 2018 - Larger Endocarditis Vegetations More Likely to Embolize, Kill
February 22, 2018 - Parenting behavior in adoptive families
February 22, 2018 - Researchers discover new weakness in sleeping sickness parasites
February 22, 2018 - Research project aims to find new ways to identify and treat most aggressive brain cancers
February 22, 2018 - Researchers explore how people with Alzheimer’s disease use end-of-life medical services
February 22, 2018 - Stroke survivors and carers feel marginalized due to lack of support from primary care
February 22, 2018 - Neuroscientists discover novel mechanism of action behind schizophrenia
February 22, 2018 - After shooting, ‘honor how kids want to deal with their feelings’
February 22, 2018 - U.S., EU and Japan Health Authorities Accept Regulatory Submissions For Review Of Pfizer’s Third-generation ALK Inhibitor Lorlatinib
February 22, 2018 - At-Home Genetic Test Might Change Medicine
February 22, 2018 - Many second hand plastic toys could pose a risk to children’s health, study suggests
February 22, 2018 - Study shows that two different brain systems cooperate during learning
February 22, 2018 - Liquefied brain tissue after stroke may harm surviving brain, UA study finds
February 22, 2018 - New intervention improves communication behaviors in couples affected by dementia
February 22, 2018 - Clinical trial shows safety of promising TSRI stroke drug
February 22, 2018 - Researchers discover new interaction mechanism of unstructured proteins
February 22, 2018 - A Patient’s Journey: Can I Kill the Glucose Monster?
February 22, 2018 - The Problem That Piles Up
February 22, 2018 - Kids can roll up their sleeves—again—for mumps protection
February 22, 2018 - Scientists find significant amounts of toxic metals in e-cigarette vapors
February 22, 2018 - 3D Signatures reports positive results of new Telo-HL test for Hodgkin’s lymphoma
February 22, 2018 - Scientists reveal development of improved medicine to fight addiction
February 22, 2018 - USC-led researchers release dataset of brain scans from stroke patients
February 22, 2018 - Antibiotic-producing bacterium releases more metabolites than assumed
February 22, 2018 - Flu Season Shows First Signs of Slowing
February 22, 2018 - Nonstick Chemicals May Disrupt Metabolic Function in Women
February 22, 2018 - Calcium may play a role in the development of Parkinson’s disease
February 22, 2018 - Scientists visualize insulin receptor activation for the first time
February 22, 2018 - UC San Diego Health now offers new treatment option for people with refractory epilepsy
February 22, 2018 - First African child vaccinated with new typhoid conjugate vaccine
February 22, 2018 - BetterYou named as ‘Most Innovative Brand’ at FGB Awards 2018
February 22, 2018 - Assaults Among Young People Fall to Lowest Rate in 15 Years
February 22, 2018 - What do you know about Parkinson’s disease?
February 22, 2018 - Researchers discover five new genetic changes that may increase pancreatic cancer risk
February 22, 2018 - Gout medication may help improve heart function in adult patients
February 22, 2018 - Bioactive compound limits collateral damage in the kidneys after heart attack
February 22, 2018 - Study reveals HCT as effective treatment for NHL patients regardless of age
February 22, 2018 - Father’s age can affect offspring lifespan, mice study shows
February 22, 2018 - Opiant Pharmaceuticals Announces Publication of New Pre-Clinical Data Supporting Potential of OPNT005 as a Heroin Vaccine
February 22, 2018 - Make the Diagnosis: Strange Rash Surfaces
February 22, 2018 - Isolated sulfite oxidase deficiency – Genetics Home Reference
February 22, 2018 - Scientists identify weight loss ripple effect
February 22, 2018 - Smoking at record lows in New York
February 22, 2018 - Scientists pinpoint fertility hormone that could support early pregnancy
February 22, 2018 - Aggressive cancer stem cells can now be isolated successfully in a scientific breakthrough
February 22, 2018 - Researchers find high risk of suicide among unaccompanied refugee minors
February 22, 2018 - Protein levels linked to posture and gait problems in Parkinson’s
February 22, 2018 - Biomedical engineers create 3D hydrogel scaffolds  to transform cells into muscle
February 22, 2018 - Study employs novel approach to uncover new biomarker for CHD
February 22, 2018 - Study finds strong connection between midwifery and birth outcomes
February 22, 2018 - Verastem Submits NDA to FDA for Duvelisib for the Treatment of Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Follicular Lymphoma
February 22, 2018 - Low BP Associated With Risk in HFpEF
February 22, 2018 - More U.S. women obese before pregnancy, experts sound the alarm
February 22, 2018 - Study aims to examine effects of PTSD symptoms in police officers
February 22, 2018 - Study reveals increased disease risk after early heart surgery
February 22, 2018 - Women with Type 1 diabetes come across unique challenges
February 22, 2018 - Researchers target abnormal epigenetic mechanisms involved in childhood cancers
February 22, 2018 - Wine polyphenols may be good for oral health
February 22, 2018 - Moderate and severe exacerbations associated with decline in physical activity of COPD patients
February 22, 2018 - FDA Approves Osmolex ER (amantadine) for the treatment of Parkinson’s Disease and Drug-Induced Extrapyramidal Reactions
February 22, 2018 - Morning Break: NSCLC Approval; School Nurses; ‘Human-Sheep Hybrids’?
February 22, 2018 - Penn study sheds new light on immune cell identity
February 22, 2018 - From a novel support group to a book, learning from seven widowed fathers
February 22, 2018 - Researcher makes breakthrough discovery in process of fear relapse
Lemur study offers new insights into role of diet in shaping gut microbes

Lemur study offers new insights into role of diet in shaping gut microbes

image_pdfDownload PDFimage_print

A study of the bacteria in the guts of three lemur species offers new insights into the role of diet in shaping these microbial ecosystems – and how these microbes may relate to primate health.

“We wanted to know which microbes were present and what they were doing,” says Erin McKenney, a postdoctoral researcher at North Carolina State University and lead author of a paper on the work. “We found, among other things, some similarities between lemurs and humans – their distant primate cousins – which raise questions about microbes we have associated with health problems in humans.”

The researchers looked at three species of lemur: ruffed lemurs (Varecia variegata) and ringtail lemurs (Lemur catta), which eat an identical diet of fruits and vegetables at the Duke Lemur Center (where the study animals were located); and sifakas (Propithecus coquereli), which eat leaves.

The researchers collected data on the nutritional composition of each species’ diet in captivity. They then used genetic sequencing techniques to identify the bacterial makeup of the gut microbiome, based on fecal samples taken from representatives of each species.

The researchers also used nuclear magnetic resonance spectroscopy on fecal samples to determine which chemical products were produced in the gut. By analyzing the bacteria present and the chemicals being produced, the researchers could determine how the gut microbes were making use of each lemur’s diet.

To put this work in context, it’s important to know that ruffed and ringtail lemurs have very different guts, physically. Ruffed lemurs have very simple guts – they’re pretty much a straight line. Ringtails have guts that resemble human intestines – lots of twists and turns. But both species have identical diets in captivity. And researchers found that they also had almost identical gut microbiomes.

“We already knew that humans, all of whom have similar gut systems, could have very different gut microbiomes if they ate different diets,” McKenney says. “But this study tells us that primates with very different gut systems can have very similar gut microbiomes if they eat identical diets. That highlights the importance of diet in shaping these microbial ecosystems.”

In addition, the researchers found that the ruffed and ringtail lemurs, with their high-sugar diets, also have five enriched metabolic pathways in common with humans who have inflammatory bowel disease (IBD). In other words, the lemurs and humans with IBD had abundant suites of microbial machinery that were able to perform five specific functions in common.

“In humans, it’s thought that these metabolic pathways may be contributing to intestinal health problems,” McKenney says. “But those same metabolic pathways in lemurs don’t appear to harm the animal’s health. This raises – but does not answer – some interesting questions about the role of those metabolic pathways in humans. For example, are the relevant microbes actually harmful? Or is this a case of there being a correlation with IBD, but no causation.”

Source:

Lemur Study Highlights Role of Diet in Shaping Gut Microbiome

Tagged with:

About author

Related Articles