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Microbiologists find deadly cryptococcal fungi in public spaces in South Africa

Microbiologists find deadly cryptococcal fungi in public spaces in South Africa

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Large populations of potentially deadly cryptococcal fungi have been found on woody debris collected from old trees in two public areas in the center of Cape Town and the Northern Cape, South Africa.

After tuberculosis, cryptococcal meningitis is the leading cause of death in HIV/AIDS patients in Sub-Saharan Africa. In 2016, South Africa launched the world’s largest national screening programme to detect cryptococcal meningitis in patients living with HIV. People become infected when they inhale the airborne microscopic spores produced by pathogenic cryptococci occurring in the environment.

The fungi were found and identified by PhD student 2011) have reported the presence of these pathogens in the South African environment. C. neoformans causes a severe form of meningitis, mostly in individuals with a compromised immune system. Generally, healthy people’s immune systems are able to ward off the infection. C. gattii, on the other hand, can lead to meningitis in healthy individuals.

But while pathogenic cryptococci have been thoroughly researched from a clinical perspective, there is very little information available about their ecology and how they interact with the environment. This type of information can aid in curbing their spread from trees (their host) to the general public.

More than a decade of searching

His research group has been working closely with Prof Teun Boekhout from the Westerdijk Fungal Biodiversity Institute in The Netherlands to ensure that the collected cryptococci are identified and characterized according to the most modern taxonomic methods.

Vreulink says initially they were looking for pathogenic cryptococci in woody debris sampled from pristine areas in South Africa, but with very little success. In 2007, as it became more and more evident worldwide that these fungi are found in areas where there is a combination of pigeons, old trees and large numbers of people, she changed tack and started looking in public spaces.

To her surprise the very first samples collected from a public park in the center of Cape Town, delivered more colonies than she could handle.

“It was late on a Friday afternoon and I was working alone. I decided to check on the petri dishes that I prepared from the samples collected in Cape Town. On most of the dishes brown colonies – typical of these cryptococcal pathogens – were growing. This was such a rare occasion that I started working immediately to transfer the colonies to new petri dishes for identification. I was scared to death that the colonies will be overgrown by other microorganisms if I left it over the weekend,” she recalls.

As part of her MSc and later PhD studies, her research efforts have been focused on understanding the biology and ecology of the single-celled yeasts that make up these brown colonies. She compared their genetic makeup to that of pathogens isolated from patients in South Africa, as well as to that of pathogenic cryptococci found elsewhere. She also looked at their resistance to commonly used antifungals and how environmental factors affect their survival in trees.

While Vreulink only collected samples from the two public spaces, she believes these pathogens are everywhere: “Methods used to isolate these fungi are simply not sensitive enough.”

But there is still a lot that needs to be understood: “For now, I’m focusing on the ecology of these yeasts. I want to understand the population dynamics, the genetics and how these it interacts with their environment. If we can understand how they survive out there, we can use this knowledge to better predict how they can survive in their human host.

“At the moment, my research is generating more questions than answers. But that makes it even more exciting!”

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