Breaking News
March 19, 2018 - ‘Tummy Tuck’ Relieved Postpartum Back Pain/Incontinence
March 19, 2018 - New biomarkers for neuroblastoma, a type of cancer in children
March 19, 2018 - Hookah Smoking Carries a Poisoning Risk
March 19, 2018 - Do Mood and Anxiety Affect MS Disability?
March 19, 2018 - Mean depth of ultrasonographic penetration greater in autism
March 19, 2018 - Platypus milk may help combat antibiotic resistance
March 19, 2018 - U.S. IDE study of THERMOCOOL SMARTTOUCH SF Catheter completes patient enrollment
March 18, 2018 - E-cigarette use exposes adolescents to potentially cancer-causing chemicals
March 18, 2018 - GOP Senator: Solve Opioid Crisis Through Community, Not Policy
March 18, 2018 - Why is ADHD more common in boys than girls?
March 18, 2018 - Measles alert after two passengers with the disease fly into US
March 18, 2018 - FDA looks to remove nicotine from cigarettes
March 18, 2018 - FDA moves to cut nicotine in cigarettes, helping smokers kick habit
March 18, 2018 - Athenex Announces Phase II Clinical Study Results for KX2-391 Ointment for the Treatment of Actinic Keratosis
March 18, 2018 - Surgery Tied to Better Outcomes in Kids with T2D
March 18, 2018 - Scientists use nanotechnology to detect molecular biomarker for osteoarthritis
March 18, 2018 - Research establishes use of chimeric cells as potential therapy for Duchenne muscular dystrophy
March 18, 2018 - Researcher working to develop improved endoscopic probe for colonoscopies
March 18, 2018 - Researchers develop way to sequence entire fetal genome by modifying prenatal testing method
March 18, 2018 - FDA Approves PDUFA Fee Waiver for Gimoti New Drug Application
March 18, 2018 - P2Y12 Tx Subsidy Yields Positive Response from Docs, Patients
March 18, 2018 - Are Proteins in Formula Linked to Type 1 Diabetes?
March 18, 2018 - Exercise does not seem to increase bone marrow edema in healthy people
March 18, 2018 - Researchers delineate architecture of nuclear pore complex in yeast cells
March 18, 2018 - ‘It’s Just Ghetto-izing People’: What We Heard This Week
March 18, 2018 - Alzheimer’s disease: Neuronal loss very limited
March 18, 2018 - Study reveals impact of intense, changing work schedules experienced by medical interns
March 18, 2018 - Jobs That Keep the Mind Sharp … Even Into Retirement
March 18, 2018 - Facial Scarring Improved with Botulinum Toxin
March 18, 2018 - Data detectives shift suspicions in Alzheimer’s to inside villain
March 18, 2018 - Shorter Preventive TB Tx Effective for HIV+ Patients
March 18, 2018 - New technique for identifying alcoholism puts treatment options at patients’ and providers’ fingertips
March 18, 2018 - Researchers uncover four microRNAs as potential biomarkers for atrial fibrillation
March 18, 2018 - IRX Therapeutics Announces Initiation of Phase 2 Clinical Trial of IRX-2 in Squamous Cervical or Vulvar Intraepithelial Neoplasia 3
March 18, 2018 - OncoBreak: Learning from Silence; ‘Rigged’ Drug System; NCCN Guidelines Questioned
March 18, 2018 - The coffee cannabis connection
March 18, 2018 - Novel centrifugal-flow pump for heart failure patients provides improved long-term outcomes
March 18, 2018 - U.S. FDA Accepts New Drug Application for Prucalopride (SHP555) for Chronic Idiopathic Constipation
March 18, 2018 - Cath Lab Recap: iFR vs FFR $$; Ridaforolimus-Eluting Stent
March 18, 2018 - Tree care workers need better training to handle dangers on the job, study finds
March 18, 2018 - Dementia patients do not undergo diagnostic evaluation at onset of disease, study finds
March 18, 2018 - Transplanting enhanced interneurons restores brain rhythms in mouse model of Alzheimer’s
March 18, 2018 - Gene Therapy Flops for Critical Limb Ischemia
March 17, 2018 - Study spotlights risks in anesthesiologist handoffs
March 17, 2018 - Verb fluency test may be useful tool for differential diagnosis of cognitive failure
March 17, 2018 - Health Tip: Suggestions to Improve Your Cholesterol
March 17, 2018 - Fructans Suspect in Non-Celiac Gluten Sensitivity
March 17, 2018 - Aspirin therapy appears safe before thyroid surgery
March 17, 2018 - Minimally invasive surgical device may one day provide lasting heart repair
March 17, 2018 - UIH and RaySearch enter into new partnership
March 17, 2018 - Is BMI Too Inexact? | Medpage Today
March 17, 2018 - Sleep apnea study finds male-female differences in cerebral cortex thickness, symptoms
March 17, 2018 - Leicester research could help identify people with asthma of different severities
March 17, 2018 - Biosense Webster enrolls and treats first AF patient in clinical study of new RF balloon catheter
March 17, 2018 - Participants in rogue herpes vaccine research take legal action
March 17, 2018 - Imara Doses First Patient in Phase 2a Clinical Trial of IMR-687 for Sickle Cell Disease
March 17, 2018 - AAP: Prevent Medication Errors by Improving Processes
March 17, 2018 - Severe sleep apnea during REM sleep tied to acute CV events
March 17, 2018 - Alzheimer’s disease also affects small blood vessels
March 17, 2018 - Jazz Pharmaceuticals Announces FDA Acceptance of NDA for Solriamfetol (JZP-110) for Excessive Sleepiness Associated with Narcolepsy or Obstructive Sleep Apnea
March 17, 2018 - Switching Biologics in Psoriasis Care
March 17, 2018 - Polygenic risk score may identify alzheimer’s risk in younger populations
March 17, 2018 - Genetic heart mutations account for fewer sudden and unexplained infant deaths
March 17, 2018 - Clinical trial to test efficacy of stem cell transplants in stopping ALS muscle deterioration
March 17, 2018 - Researchers team up to improve life for children with microcephaly
March 17, 2018 - Health guide for young women regarding labiaplasty
March 17, 2018 - Inhaled Nitrite Flops as HFpEF Therapy
March 17, 2018 - California mental health tax providing services to needy in L.A. County, study finds
March 17, 2018 - Cancer survivors become fatigued more quickly than their peers, study finds
March 17, 2018 - Study finds common presence of nightmares among U.S. military personnel
March 17, 2018 - Yellow fever outbreak in Brazil necessitates vaccination for travelers
March 17, 2018 - Health Tip: Waist Size May Help Predict Heart Attack
March 17, 2018 - Low-Dose Combo Pill Successfully Takes Down High BP
March 17, 2018 - Most children with sickle cell anemia not receiving key medication to stay healthy
March 17, 2018 - YCC launches new Yale Center for Immuno-Oncology
March 17, 2018 - My Job Isn’t to Move Patients Quickly
March 17, 2018 - Achoo! Cold, Flu, or Something Else?
March 17, 2018 - For girls who mature early, psychological problems last into adulthood
March 17, 2018 - Researchers find new method to restore movement sensation in patients with prosthetic arms
March 17, 2018 - Older patients with colorectal cancer at increased risk of cardiovascular morbidity
Study provides hope that schizophrenia isn’t as deep-rooted in affected individuals as previously believed

Study provides hope that schizophrenia isn’t as deep-rooted in affected individuals as previously believed

image_pdfDownload PDFimage_print
Functional magnetic resonance imaging (fMRI) and other brain imaging technologies allow for the study of differences in brain activity in people diagnosed with schizophrenia. The image shows two levels of the brain, with areas that were more active in healthy controls than in schizophrenia patients shown in orange, during an fMRI study of working memory. Credit: Kim J, Matthews NL, Park S./PLoS One.

A schizophrenia patient’s own perceptions of their experiences—and confidence in their judgments—may be factors that can help them overcome challenges to get the life they wish, suggests a new paper published in Clinical Psychological Science from researchers at Penn Medicine’s Aaron T. Beck Psychopathology Research Center. The findings buck a commonly-held belief about the relationship between so-called “cognitive insight” and neurocognitive performance (behavioral measures of attention, memory, etc.) that have important implications for treating the disorder.

Cognitive insight, measured using the Beck Cognitive Insight Scale, tested individual’s self-reflectiveness and confidence in their interpretations of experiences.

Participants were asked to rate statements, such as “I have jumped to conclusions too fast,” on a scale from (0) “do not agree at all” to (4) “completely agree.” Neurocognitive performance was assessed with the University of Pennsylvania Computerized Neurocognitive Battery that uses a series of behavioral tasks.

In two separate, prospective studies involving a total of 228 participants diagnosed with schizophrenia or schizoaffective disorder, researchers found that cognitive insight is a significant predictor of neurocognition (and not vice versa, which previous studies have suggested). For example, lower self-reflectiveness and greater overconfidence in judgments (low cognitive insight) are more likely to result in poorer neurocognition in the future. Similarly, improvement in self-reflectiveness and overconfidence predict improved neurocognitive performance in the future. These results suggest that improving cognitive insight may directly improve performances on laboratory and real-world tasks, the authors suggest.

“The relationship between the two is important because it presents a promising opportunity to improve outcomes for individuals diagnosed with schizophrenia, many of whom experience long periods of disability, not to mention the 1.5 million new people who are diagnosed with schizophrenia worldwide every year,” said Paul M. Grant, PhD, a research assistant professor of Psychology in the department of Psychiatry in the Perelman School of Medicine at the University of Pennsylvania, and senior author of the study.

“There’s a lot of effort in the schizophrenia field to help people through what’s called cognitive remediation, which is basically a bottom-up process of learning, memory and attention,” Grant said. “But we think that having interventions that target positive and negative beliefs, along with goals, would be key in terms of helping the individuals have better lives, the lives that they want.” One intervention is called recovery-oriented cognitive therapy (CT-R), a hands-on, active approach that focuses on life aspirations, successful goal achievement, development of resiliency in the face of stressful symptoms and life events, all to promote positive beliefs and neutralize negative attitudes. CT-R was created by Grant, along with Aaron T. Beck, MD, an emeritus professor in the department of Psychiatry at Penn, and co-author on the study.

A June 2017 study in the journal Psychiatric Services, authored by this same team, found that CT-R is effective in individuals with schizophrenia who are functioning poorly. The study was a follow up to a randomized clinical trail and showed that participants who received CT-R for 18 months, as compared to those who received standard treatment (e.g., anti-psychotic medications, case management), showed major improvements in daily functioning, motivation and psychotic symptoms that endured after the therapy was completed. Importantly, those with the longest course of illness showed improvement by the end of the study.

“Some of what produces the disability is related to how individuals think about the disability. And that thinking is quite changeable,” Grant said. “CT-R does indeed adjust beliefs, so that would be one of the main therapies we would suggest practitioners to implement.” The researchers called for further studies to not only replicate these findings but to also examine the clinical ratings of metacognition – higher order thinking involved in learning – and behavioral engagements when investigating the relationship between insight and cognition.

“Often times, individuals think there is something fundamentally wrong with them that can’t be changed,” Grant said. “This paper provides hope that the problem isn’t as entrenched or as stable as it might seem, or that it’s a devastating and unremittable disorder.”

Explore further:
Brain training shows promise for patients with bipolar disorder

Journal reference:
Clinical Psychological Science

Provided by:
Perelman School of Medicine at the University of Pennsylvania

Tagged with:

About author

Related Articles