Breaking News
January 19, 2018 - Warm-up program for children cuts soccer injuries by 50%
January 19, 2018 - ‘You’re Old and You Need Tests’: What We Heard This Week
January 19, 2018 - Egg-preserving hysterectomy raises heart risks later: study
January 19, 2018 - GA-map Dysbiosis Test identifies IBS patients who respond to FODMAP diet, study shows
January 19, 2018 - Study explores mortality and health-related habits in former elite athletes and their brothers
January 19, 2018 - New biodegradable sensors could assist doctors
January 19, 2018 - Modular gene enhancers may be suitable target in treatment of blood cancer
January 18, 2018 - New precision medicine trial for metastatic pancreatic cancer
January 18, 2018 - Shire Receives FDA Breakthrough Therapy Designation for Maribavir, an Investigational Treatment for Cytomegalovirus (CMV) Infection in Transplant Patients
January 18, 2018 - Pre-Existing Patient-Valve Mismatch Trips Up ViV Implant
January 18, 2018 - Adolescents: health risks and solutions
January 18, 2018 - US woman delivers baby from embryo frozen for 24 years
January 18, 2018 - Study identifies new target for treatment of depression
January 18, 2018 - LJI study reveals key player that promotes skin inflammation in atopic dermatitis
January 18, 2018 - Study devises efficient and economical strategy to screen breast and ovarian cancer gene mutations
January 18, 2018 - Agile Therapeutics, Inc. Receives a Complete Response Letter from the FDA for Twirla (AG200-15) for the Prevention of Pregnancy
January 18, 2018 - Gene Therapy for Inherited Retinal Dystrophy Gets FDA Clearance
January 18, 2018 - Researchers identify a new chemical pathway that helps the brain detect sweet, savory and bitter flavors
January 18, 2018 - IBV develops platform that helps companies to diagnose wellbeing of their workforce
January 18, 2018 - Study to test new precision medicine approach for metastatic pancreatic cancer
January 18, 2018 - World’s first vaccine relieves grass pollen allergy symptoms by at least 25%, study shows
January 18, 2018 - FDA Approves New Indication for Gilotrif (afatinib) in EGFR Mutation-Positive NSCLC
January 18, 2018 - Oncologists Dish on Top Issues for 2018
January 18, 2018 - Researchers identify new potential drug target for Huntington’s disease
January 18, 2018 - Metrohm USA welcomes employees to new headquarters in Florida
January 18, 2018 - Human waste remains main source of fecal pollution in the river Danube
January 18, 2018 - Expert discusses how to stay healthy during flu season
January 18, 2018 - New biomaterials-based system improves T-cell production
January 18, 2018 - Novel gene expression analysis technique can accurately and quickly measure RNA
January 18, 2018 - Grandparents Help Shape Kids’ Views on Aging
January 18, 2018 - Absolutely Zero Stent Thrombosis at 5 Years With Bioabsorbable MiStent
January 18, 2018 - Safe Sleep for Babies | VitalSigns
January 18, 2018 - Pfizer to launch own little white pill
January 18, 2018 - Aged garlic extract may help obese people fight against inflammation, study shows
January 18, 2018 - Sex steroid hormone fluctuations may have direct effects on eye physiology and AMD
January 18, 2018 - Patients with monoclonal gammopathy at risk of developing cancer even after 30 years
January 18, 2018 - Researchers reveal potential of multivalent antibodies for HIV prevention, treatment and cure
January 18, 2018 - Dying cancer patients receiving assisted hydration live longer
January 18, 2018 - Potential male birth control pill could be developed from arrow poison
January 18, 2018 - Research reveals cost-effectiveness of whole-population screening for breast, ovarian cancer gene mutations
January 18, 2018 - Genes involved in spinal cord repair of lamprey also present in mammals, study reveals
January 18, 2018 - Researchers unravel key molecular mechanism of autoimmune and inflammatory diseases
January 18, 2018 - The State of the Drug Discovery Nation Unveiled as New Report Provides Vital Insights for the Development of New Medicines
January 18, 2018 - Dutch Study Links Implants to Increased Breast-ALCL Risk
January 18, 2018 - Five addiction experts weigh in on future of opioid crisis. Their forecast: grim
January 18, 2018 - EXD2 enzyme facilitates protein production in mitochondria
January 18, 2018 - Kessler Foundation wins $735,000 grant for training rehabilitation researchers
January 18, 2018 - Researchers find new way to halt growth of breast cancer cells
January 18, 2018 - Cantex Pharmaceuticals, Inc. Announces FDA Orphan Drug Designation Has Been Granted to CX-01 for Treatment of Acute Myeloid Leukemia
January 18, 2018 - Civilians Now Getting Flu-Like Illness Afflicting Troops
January 18, 2018 - Discovery brings stem cell therapy for eye disease closer to the clinic
January 18, 2018 - Guts of surfers more likely to be colonized by antibiotic-resistant bacteria, study reveals
January 18, 2018 - Bacteria linked to periodontitis may play role in onset of cancer
January 18, 2018 - Jazz Pharmaceuticals Submits New Drug Application for Solriamfetol (JZP-110) for Excessive Sleepiness Associated with Narcolepsy and Obstructive Sleep Apnea
January 18, 2018 - Early Menarche, Menopause Tied to Higher CVD Risk
January 18, 2018 - Pioneering new technique could boost understanding of causes of heart disease
January 18, 2018 - New brain imaging techniques show how infants’ brains process ‘touch’
January 18, 2018 - GSK Receives FDA Approval for Expanded Indication for Fluarix Quadrivalent (Influenza Vaccine) for Persons 6 Months and Older
January 18, 2018 - Blood Markers Point to Maladaptive LV Remodeling
January 18, 2018 - Effect of gut bacteria on specific immune cells underlies persistent liver inflammation
January 18, 2018 - Study reveals new diabetes gene in families with rare blood sugar conditions
January 18, 2018 - Fewer Hospitals Closed After Obamacare Expanded Medicaid
January 18, 2018 - At-Home Breath Training Improves Asthma Quality of Life
January 18, 2018 - Obesity can add five weeks of asthma symptoms per year in preschoolers
January 18, 2018 - Neuronal loss is very limited in Alzheimer’s disease, shows new study
January 18, 2018 - A new strategy proposed for drug discovery
January 17, 2018 - Lactation May Lower T2D Risk in Younger Women
January 17, 2018 - New Atopic Dermatitis Yardstick provides practical guidance and management insights
January 17, 2018 - New biodegradable pressure sensor could help monitor serious health conditions
January 17, 2018 - HSS orders Sectra’s 3D pre-operative planning solution for improving patient outcomes
January 17, 2018 - Study identifies six new genes regions associated with diabetes
January 17, 2018 - Women do not receive timely diagnosis for heart disease
January 17, 2018 - AbbVie’s Upadacitinib Shows Positive Results as Monotherapy in Phase 3 Rheumatoid Arthritis Study, Meeting All Primary and Key Secondary Endpoints
January 17, 2018 - Should President Trump’s Physical Include a Cognitive Screen?
January 17, 2018 - Could gene therapy someday eliminate HIV?
January 17, 2018 - Researchers identify new anti-inflammatory drug target
January 17, 2018 - Loxo Oncology Initiates Rolling Submission of New Drug Application to U.S. Food and Drug Administration for Larotrectinib for the Treatment of TRK Fusion Cancers
January 17, 2018 - Trunk Imaging Tied to Higher Nephrectomy Risk
January 17, 2018 - Campaigners incensed at failings in Africa AIDS war
January 17, 2018 - Research opens door to development of new treatment for type 2 diabetes
Freezing Metastatic Lung Tumors Feasible

Freezing Metastatic Lung Tumors Feasible

image_pdfDownload PDFimage_print

CHICAGO – Researchers here suggested that metastatic tumors that go to the lung can be successfully eradicated using cryotherapy — literally turning the masses into ice balls that are then resorbed by the body.

With more than 21 months of follow-up, the overall recurrence rate of the metastases attacked in the study was 6.2% – with 1.9% within the cryozone and 4.3% outside the cryozone, reported Salah Abdelhadi, MD, a diagnostic radiologist at Wayne State University/Detroit Medical Center.

Central organ tumors tended to recur more frequently in the study — about 8% of the 99 centrally located masses recurred, compared with 5% of the 159 peripherally located masses (P=nonsignificant), Abdelhadi said in an oral presentation at the annual scientific sessions of the Radiological Society of North America.

“Tumors larger than 3 cm had a recurrence rate of 13.6%, compared with 4.7% for the smaller lesions, P<0.05."

The complication rate was also considered low, Abdelhadi said. Overall, 3.7% of the patients treated with cryoablation had a complication — 2.4% in the centrally located tumors and 4.6% in the peripheral ones; 9.6% of the larger tumors carried a complication risk, compared with 2% of the smaller tumors. He reported four grade 3 cases of pneumothorax, all occurring with tumors at the periphery. There was one grade 4 complication — a pleural hemorrhage that occurred post-procedure in a 4 cm mass. That patient required drainage, treatment in the intensive care unit, and blood transfusion.

“The advantages of cryoablation of the lung masses include excellent visualization of the effect of the ice ball that freezes the lesion and the ability to avoid nerves and other structures such as the esophagus. The procedure is associated with little pain, and does not discriminate in tissue types and holds the potential for a cryoimmune response.”

Abdelhadi explained that the cryoablation technique includes a triple-freeze protocol, opposed to double-freeze techniques: The tumor is frozen for 3 minutes, thawed for 6 minutes, frozen for 10 minutes, followed by a 13-minute thaw period, and finally frozen for 20 minutes.

In the study, there were 109 patients who underwent 191 procedures for a total of 258 masses, Abdelhadi said. Most of the metastases came from sarcomas: 103 cases — 56 colorectal metastases and other metastases from numerous cancer types. A total of 66 patients had multiple procedures — as many as six; in 48 procedures multiple tumors were frozen – up to seven different masses.

The average tumor size was 2 cm, and the average ablation zone was 4.3 cm; the mean follow-up has been 21.6 months, with 130 cases for longer than 12 months, and patients have been out as long as 8.3 years, Abdelhadi said. There were 44 tumors larger than 3 cm, and 214 were 3 cm or smaller.

The moderator of the session where the study was presented, Hyun Kim, MD, chief of interventional radiology at Yale School of Medicine in New Haven, Connecticut, told MedPage Today: “We do transcatheter therapy for liver cancer all the time, but doing it for lung cancer is sort of novel. It is not something that is standard of care. But being aware of the lung vasculature, there is very little discomfort in doing this procedure. The lung is a very forgiving organ.

“At the present time there are a lot of niche applications for treatment of these masses. It is really center-specific, and some centers do use cryoablation as well as radiofrequency or microwave ablation procedures.”

Kim said the findings of the Detroit group using cryoablation are about when he would expect: “At the end of the day we will probably have a choice of all these modalities including transcatheter and percutaneous. I think it really depends more on the comfort zone of the practicing doctor as to what method is selected to treat these patients.”

Abdelhadi reported having no disclosures. Two coauthors reported relationships with Galil Medical, CryoMedix, Endo International, and Delphinus Medical Technologies.

Kim reported having no disclosures.


Tagged with:

About author

Related Articles