Breaking News
January 20, 2018 - MSU scientists seek to identify brain mechanisms related to psychosis
January 20, 2018 - Syndax Pharmaceuticals Announces Clinical Collaboration to Evaluate Entinostat in Combination with anti-PD-L1 Cancer Immunotherapy in Breast Cancer
January 20, 2018 - Endoscopes Over Microscopes in Retinal Surgery: Ophthalmology Times
January 20, 2018 - Technology not taking over children’s lives despite screen-time increase
January 20, 2018 - Study finds extensive contamination around lead battery recycling plants in 7 African countries
January 20, 2018 - Flu may pass to others through exhaled breath, study shows
January 20, 2018 - Neuronal loss very limited in Alzheimer’s disease, new study shows
January 20, 2018 - Novel robot can aid treatment of rare birth defect
January 19, 2018 - TherapeuticsMD Announces Submission of New Drug Application for TX-001HR
January 19, 2018 - Fighting Infant Mortality | Medpage Today
January 19, 2018 - Researchers offer new evidence on four-year-old children’s knowledge about ecology
January 19, 2018 - Analysis finds overlooked crucial factor in determining prognosis for DIPGs
January 19, 2018 - Review explores consequences of genetic testing and cancer risk-reducing surgery
January 19, 2018 - Morning Break: HHS Div. of Religious Freedom; Trump’s Heart Health; Minister of Loneliness
January 19, 2018 - Parkinson’s disease ‘jerking’ side effect detected by algorithm
January 19, 2018 - New analysis finds dramatic increases in maternal mortality rates
January 19, 2018 - Weight-Loss Surgery’s Benefits Wane Over Time for Diabetics
January 19, 2018 - Cath Lab Recap: Sapien 3 Delivery System Recall; Transatlantic PCI Smackdown
January 19, 2018 - Parkinson’s treatment could be more effective, student finds
January 19, 2018 - New vaccine approach offers effective protection against tuberculosis
January 19, 2018 - Home care agencies often wrongly deny Medicare help to the chronically ill
January 19, 2018 - One hundred percent fruit juice does not alter blood sugar levels
January 19, 2018 - Prebiotics could enhance learning and memory skills in infants
January 19, 2018 - CMS May Cover MRI With Cardiac Devices Across the Board
January 19, 2018 - As income rises, women get slimmer—but not men
January 19, 2018 - Researchers develop adhesive materials to prevent bracket stains on teeth
January 19, 2018 - Flu can be spread without coughs and sneezes
January 19, 2018 - AMSBIO’s new recombinant protein shows great promise for organoid culture
January 19, 2018 - AbbVie’s Upadacitinib Granted Breakthrough Therapy Designation from the U.S. Food and Drug Administration for Atopic Dermatitis
January 19, 2018 - ASH: Pomalidomide Dose Escalation Improves Response
January 19, 2018 - Is your child’s school an obesity risk?
January 19, 2018 - Scientists describe groundbreaking training effect on the innate immune system
January 19, 2018 - MAST announces new AmpC, ESBL & Carbapenemase Detection Set
January 19, 2018 - Signaling molecules likely involved in concussions, rodent studies show
January 19, 2018 - Mast introduces Carba plus for CPE and OXA-48 confirmation
January 19, 2018 - Paleolithic diet helps overweight women maintain weight loss
January 19, 2018 - Agios Submits New Drug Application to the FDA for Ivosidenib for the Treatment of Patients with Relapsed/Refractory AML and an IDH1 Mutation
January 19, 2018 - This Flu Season, Don’t Forget About Tamiflu
January 19, 2018 - Amsterdam wins battle to host EU medicines agency after Brexit
January 19, 2018 - Study suggests movement as accurate method to diagnose neurodevelopmental disorders
January 19, 2018 - Maximize resolution in deep imaging for neuroscience research with Olympus TruResolution objectives
January 19, 2018 - Bilingualism may benefit children with ASD
January 19, 2018 - FDA Alert: Levofloxacin in 5 Percent Dextrose 250mg/50mL by AuroMedics: Recall
January 19, 2018 - USPSTF Not Backing Ankle-Brachial Index, CRP, or Coronary Calcium
January 19, 2018 - Higher omega-3 fatty acid intake tied to lower glaucoma risk
January 19, 2018 - Findings reveal conventional cancer therapy as double-edged sword
January 19, 2018 - Health Highlights: Jan. 16, 2018
January 19, 2018 - Morning Break: Anti-Emetic Warning; Uninsured Rate Jumps; Flu Worsens Saline Shortage
January 19, 2018 - Increased use of ambulatory surgery centers for cataract surgery
January 19, 2018 - Not-for-profit hospitals coming up with their own generic medicines to combat shortages
January 19, 2018 - $500 cancer detection blood tests may soon become reality
January 19, 2018 - Chronic traumatic encephalopathy may start early even without signs of concussions
January 19, 2018 - Warm-up program for children cuts soccer injuries by 50%
January 19, 2018 - ‘You’re Old and You Need Tests’: What We Heard This Week
January 19, 2018 - Egg-preserving hysterectomy raises heart risks later: study
January 19, 2018 - GA-map Dysbiosis Test identifies IBS patients who respond to FODMAP diet, study shows
January 19, 2018 - Study explores mortality and health-related habits in former elite athletes and their brothers
January 19, 2018 - New biodegradable sensors could assist doctors
January 19, 2018 - Modular gene enhancers may be suitable target in treatment of blood cancer
January 18, 2018 - New precision medicine trial for metastatic pancreatic cancer
January 18, 2018 - Shire Receives FDA Breakthrough Therapy Designation for Maribavir, an Investigational Treatment for Cytomegalovirus (CMV) Infection in Transplant Patients
January 18, 2018 - Pre-Existing Patient-Valve Mismatch Trips Up ViV Implant
January 18, 2018 - Adolescents: health risks and solutions
January 18, 2018 - US woman delivers baby from embryo frozen for 24 years
January 18, 2018 - Study identifies new target for treatment of depression
January 18, 2018 - LJI study reveals key player that promotes skin inflammation in atopic dermatitis
January 18, 2018 - Study devises efficient and economical strategy to screen breast and ovarian cancer gene mutations
January 18, 2018 - Agile Therapeutics, Inc. Receives a Complete Response Letter from the FDA for Twirla (AG200-15) for the Prevention of Pregnancy
January 18, 2018 - Gene Therapy for Inherited Retinal Dystrophy Gets FDA Clearance
January 18, 2018 - Researchers identify a new chemical pathway that helps the brain detect sweet, savory and bitter flavors
January 18, 2018 - IBV develops platform that helps companies to diagnose wellbeing of their workforce
January 18, 2018 - Study to test new precision medicine approach for metastatic pancreatic cancer
January 18, 2018 - World’s first vaccine relieves grass pollen allergy symptoms by at least 25%, study shows
January 18, 2018 - FDA Approves New Indication for Gilotrif (afatinib) in EGFR Mutation-Positive NSCLC
January 18, 2018 - Oncologists Dish on Top Issues for 2018
January 18, 2018 - Researchers identify new potential drug target for Huntington’s disease
January 18, 2018 - Metrohm USA welcomes employees to new headquarters in Florida
January 18, 2018 - Human waste remains main source of fecal pollution in the river Danube
January 18, 2018 - Expert discusses how to stay healthy during flu season
January 18, 2018 - New biomaterials-based system improves T-cell production
Adult-Onset Type 1 Diabetes Not Uncommon in China

Adult-Onset Type 1 Diabetes Not Uncommon in China

image_pdfDownload PDFimage_print

Action Points

  • The majority of newly diagnosed type 1 diabetes (T1D) cases in China are diagnosed in adulthood, according to a population-based study of Chinese patients followed between 2010-2013.
  • Note that most epidemiological studies of T1D have focused on childhood onset T1D, and although it most often develops in children T1D can occur at any age, and adult onset is not rare in China.

The majority of newly diagnosed type 1 diabetes cases in China are diagnosed in adulthood, researchers said.

The population-based study identified 5,018 new cases of type 1 diabetes among a Chinese cohort followed from 2010 to 2013 — 65.3% of whom were diagnosed at age 20 or older, reported Jianping Weng, PhD, of The Third Affiliated Hospital of Sun Yat-Sen University in Guangzhou, China, and colleagues.

Still, estimated incidence of type 1 diabetes was highest among those 14 and younger (incidence 1.93 per 100,000, 95% CI 0.83-3.03), appearing online in The BMJ.

Point estimates for the incidence of newly diagnosed type 1 diabetes tapered off among older age groups: 1.23 per 100,000 person years at 15-29 (95% CI 0.45-2.11) and 0.69 among those 30 and older (95% CI 0.00-1.51).

“[M]ost epidemiological studies of type 1 diabetes focused on childhood onset type 1 diabetes. Although type 1 diabetes most often develops in children, it can occur at any age,” the group wrote. “Our previous study also indicated that the onset of type 1 diabetes in adulthood is not rare in China. Yet little is known about its incidence in adults aged more than 20 years,” Weng’s group added.

These findings echo the results of another recent study from the U.K., which found roughly 42% of people with type 1 diabetes were diagnosed between 31 to 60 years of age.

Weng’s group analyzed nearly 10% of the Chinese population, spanning 13 areas in China with 505 hospitals. Type 1 diabetes was diagnosed using American Diabetes Association and the World Health Organization criteria by endocrinologists and/or pediatricians.

The overall estimated incidence among all age groups across China was 0.93 per 100,000 person years (95% CI 0.90-0.95). This was also slightly higher among males compared to females (0.95 for males, 95% CI 0.91-0.99, vs 0.81 for females, 95% CI 0.78-0.85, P<0.001.)

However, among the youngest age group of 0 to 14 years, females had a significantly higher estimated incidence of type 1 diabetes compared to males (2.21 for females, 95% CI 2.05-2.39 versus 1.72 for males, 95% CI 1.58-1.86, P<0.001).

For newly diagnosed cases, those 0 to 14 years of age were more commonly had the following clinical characteristics with the onset of type 1 diabetes:

  • Immediate initiation of insulin: 98.4% (0-14 years) versus 91.5% (≥30 years)
  • Diabetic ketosis <6 mo. of diagnosis: 92.9% versus 83.8%
  • Diabetic ketoacidosis <6 mo. of diagnosis: 51.4% versus 30.8%
  • ≥1 positive result for diabetes autoantibody <6 mo. of diagnosis: 73.5% versus 55.4%

A fasting C peptide of 0.2 ng/mL or higher at the onset of type 1 diabetes was slightly more common among the older age group (27.5% for those 30 and older versus 22.5% at age 10-14).

Compared to the similar DiaMond study conducted in China back in 1998, incidence of type 1 diabetes among those under 15 years of age has risen 3.8-fold — “equal to a roughly 6.5% annual increase,” the group wrote. The prior study estimated the incidence of type 1 diabetes in this age group to be 0.51 per 100,000 person years in 1985-1994.

“Our study confirms that the incidence of type 1 diabetes remains low in China, even after a 3.8-fold increase of what was reported by the DiaMond Project two decades ago,” they highlighted, adding, “Although the underlying mechanism is not completely known, the low incidence in China is probably attributed to genetic, environmental, and behavioural factors.”

Click here for the American Association of Clinical Endocrinologists’ clinical practice guideline for developing a diabetes mellitus comprehensive care plan.

The study was funded by the China International Medical Foundation, national key R&D programme of China, and National Natural Science Foundation of China.

None of the authors reported any relevant conflicts of interest.

2018-01-04T15:00:00-0500

Tagged with:

About author

Related Articles