Breaking News
June 21, 2018 - Christiana Care Health System opens first Epilepsy Monitoring Unit in Delaware
June 21, 2018 - CDC: Obesity Prevalence Higher in Non-Metropolitan Counties
June 21, 2018 - Youths Treated for Non-Suicidal Self Harm at Increased Risk of Suicide Within a Year
June 21, 2018 - Pediatric kidney recipients often have subclinical inflammation
June 21, 2018 - OHSU Knight Cancer Institute Director wins 2018 Tang Prize in Biopharmaceutical Science
June 21, 2018 - Researchers study broader effects of neonics on wildlife
June 21, 2018 - Study provides new insight on how antibiotics affect the gut microbiome
June 21, 2018 - InHealth Technologies becomes exclusive distributor of RENÚ Voice, RENÚ Gel in the United States
June 21, 2018 - New analysis links higher BMI to lower breast cancer risk for younger women
June 21, 2018 - Interactive preclinical PET-MR workshop demonstrates benefits of multi-modality imaging
June 21, 2018 - Gene signature could improve early diagnosis of TB
June 21, 2018 - Psychiatric Drug Lithium Tied to Birth Defect Risk
June 21, 2018 - Preclinical study suggests ARID1a may be useful biomarker for immunotherapy
June 21, 2018 - Risks of cancer and mortality found to be lowest in light drinkers
June 21, 2018 - Fetal immune cells are fast-acting first responders to microbes in adulthood
June 21, 2018 - Researchers invent medical device for proliferation, differentiation of neural stem cells
June 21, 2018 - Study explores current understanding of human physiology, pathology, trauma and surgery in space
June 21, 2018 - Scientists explore interactions between chromosomes 12 and 17
June 21, 2018 - People with severe obesity constantly try to reduce or control their weight
June 21, 2018 - Recovery and Treatment | NIH MedlinePlus the Magazine
June 21, 2018 - Study finds cell-free DNA profiling as versatile method to monitor UTIs
June 21, 2018 - ‘Hidden’ driver discovered that helps prime the anti-tumor immune response
June 21, 2018 - Groundbreaking discovery could be key to preventing cancer metastasis
June 21, 2018 - Impulse control disorders found to be more common in people taking Parkinson’s drugs
June 21, 2018 - Study finds possible link between Type 2 diabetes and common white pigment
June 21, 2018 - Most emergency department patients wish to be involved in medical decision-making
June 21, 2018 - Study highlights growing problem of ‘iPad neck’ among young adults and women
June 21, 2018 - UT Southwestern scientists identify gene mutation linked with perplexing brain condition
June 21, 2018 - Probiotics could cut age-related bone loss in elderly women
June 21, 2018 - New study sheds light on role of vitamin D in healthy pregnancy
June 21, 2018 - Teva Provides Update on Clinical Trial of Fremanezumab for Use in Chronic Cluster Headache
June 21, 2018 - Unlocking the secrets of HIV’s persistence
June 21, 2018 - New guidelines recommend newborns with Down’s syndrome to receive leukemia test
June 21, 2018 - BetterYou’s new Magnesium Bone Lotion helps maximize bone health
June 21, 2018 - UH scientist receives grant to examine understudied part of glaucoma
June 21, 2018 - Lifestyle intervention could normalize unhealthy behaviors that lead to cancer, chronic disease
June 21, 2018 - Combining two anti-malarial vaccines could greatly reduce number of infections
June 21, 2018 - By 2030, prostate and lung cancers expected to be most common cancers among HIV population
June 21, 2018 - Researchers evaluate patient satisfaction and well-being after breast reconstruction
June 21, 2018 - Combining stem cell technology and artificial intelligence to diagnose genetic cardiac diseases
June 21, 2018 - Monash study reveals why older people have reduced immune responses to cancer therapy
June 21, 2018 - Researchers develop new microscope system that can image living tissue in real time
June 21, 2018 - Long-term estrogen therapy alters microbial composition and activity in the gut
June 21, 2018 - Study points to dangers of feeding non-dairy drink to infants
June 21, 2018 - Cannabis Use Linked to Psychosis Symptoms in Adolescents
June 21, 2018 - Inadequate sleep could cost countries billions
June 21, 2018 - Inhibiting epigenetic proteins with drugs could prevent development of breast cancer
June 21, 2018 - Study identifies factors that contribute to vaginal dryness
June 21, 2018 - Researchers employ nucleotide-based gene silencing to mitigate common ataxia
June 21, 2018 - New tool determines best treatment plan for adults with severe asthma
June 21, 2018 - Identifying gene variants that contribute to ovarian reserve may improve female fertility
June 21, 2018 - Religious involvement has no significant effect on misuse of prescription opioids, study finds
June 21, 2018 - Researchers characterize key signaling network that drives growth of triple negative breast cancers
June 21, 2018 - AHA: Big Weight Gain in 1st Pregnancy Could Boost Preeclampsia Risk
June 21, 2018 - How vaping helps even hardened smokers quit
June 21, 2018 - Gaming disorder an official disease condition says WHO
June 21, 2018 - Oxygen consumption in human BAT increases after a meal, shows research
June 21, 2018 - Research finds addictions to be diseases of the brain, not criminal behavior or personality disorders
June 21, 2018 - New study is testing safety and efficacy of glycoside in breaking up kidney stones
June 21, 2018 - Biosimilar competition may offer hope for cheaper, better psoriasis treatments in the future
June 21, 2018 - Cells form cage-like structures that trap viruses
June 21, 2018 - Wound protector use linked to significant reduction in surgical site infection
June 21, 2018 - African Americans and Latinos are more likely to be at risk for depression than Whites
June 21, 2018 - Genome study presents new way to track historical demographics of US populations
June 20, 2018 - Study sheds light on the early stages of tumorigenesis
June 20, 2018 - Quick adoption of new diagnostic tests could help NHS to save nearly £7 billion
June 20, 2018 - Mayo Clinic researchers find genetic mutations that increase person’s risk for pancreatic cancer
June 20, 2018 - Chemists invent new method for remote chiral induction
June 20, 2018 - Methadone or buprenorphine associated with reductions in opioid related mortality
June 20, 2018 - New simulation approach predicts efficacy of HIV-prophylaxis medications
June 20, 2018 - Rhythm Pharmaceuticals Completes Pivotal Enrollment in Two Ongoing Phase 3 Clinical Trials Evaluating Setmelanotide in Rare Genetic Disorders of Obesity
June 20, 2018 - Threat of malaria left its mark on the immune system in people with African ancestry
June 20, 2018 - Recent-onset type 2 diabetes may be early expression of pancreatic cancer
June 20, 2018 - Why are vaccines less effective in the developing world?
June 20, 2018 - Study opens new window into cellular events that occur in the brain during absence seizures
June 20, 2018 - Humana and Walgreens to provide easier access to primary care and other services for seniors
June 20, 2018 - ANU research could help find life in Mars and other planets
June 20, 2018 - Multidisciplinary Human-Focused Research
June 20, 2018 - ‘Mind-minded’ parents contribute greatly to development of infants’ emotion regulation capacity
June 20, 2018 - New study finds increase in use of alternative medicines among children
Ibuprofen intake could be leading to male infertility

Ibuprofen intake could be leading to male infertility

image_pdfDownload PDFimage_print

According a new study that appeared this week in the journal Proceedings of the National Academy of Sciences, simple pain reliever, Ibuprofen, could be having a problematic effect on the testes of young men. Ibuprofen is taken almost routinely by young athletes for injuries and pain.

Image Credit: R.Classen / Shutterstock

Image Credit: R.Classen / Shutterstock

This study finds that doses that are routinely taken by athletes when taken by a group of young men, change and alter the hormonal balance and leads to infertility as the person ages.

Ibuprfoen is available over-the-counter for pain and fever and this is the first time that such an effect of this long used medication has been noted. Bernard Jégou, co-author and director of the Institute of Research in Environmental and Occupational Health in France said that this study was part of another ongoing study that was looking at effects of this drug on pregnant women.  

Jégou along with his French and Danish colleagues were looking at the effects of aspirin, acetaminophen or paracetamol and Ibuprofen on pregnant mothers around the world. They have found that these drugs have an impact on the testes of the male babies that the mothers were carrying in their wombs. David M. Kristensen, study co-author and a senior scientist in the Department of Neurology at Copenhagen University Hospital explained that these drugs were damaging the sperm production in the testes and also acting against the male hormone testosterone and thus could be called “antiandrogenic”. He added that these male babies could likely be born with congenital deformities and problems.

As a follow up from this study, the team went on to look at the effects of Ibuprofen on young men, explained Jégou. This is a routine agent that is used as a pain reliever by many. They included 31 male volunteers aged between 18 and 35 years. Of these, 14 were given daily doses of ibuprofen 600 milligrams twice a day – a dose commonly taken by athletes and soccer players for injuries and pain and dose that is directed by the labels of the generic version of the drug. The other 17 participants received placebo or inert pills posing as the drug.

On analyzing the effects, the team found that in the men who were taking Ibuprofen, within 14 days of use, the levels of the luteinizing hormone was fluctuating according to the Ibuprofen levels in blood. Luteinizing hormone or LH, is secreted by the pituitary gland and it is the key hormone that stimulates the testes to produce the male hormone testosterone. It was noted that the ratio of testosterone to LH plummeted with Ibuprofen use. This meant that the testes were not functioning adequately. This eventually lead to infertility or “hypogonadism” and other associated conditions such as increased risk of heart disease, stroke, heart failure and depression.

Jégou said, in these men these hormonal imbalances would be reversible as it was given for a short period of time. However, long term effects of long term use of Ibuprofen may not be reversible he added. He went on to explain that they also followed up this experiment with a laboratory exercise using donated testicular tissues from organ donors. They had the Leydig and Sertoli cells from the testes that produce testosterone normally. Ibuprofen showed an inhibitory effect on testosterone production in these cells too.

According to researchers, this is a small study but more extensive studies in future can shed more light on these deleterious effects of Ibuprofen on male fertility.

Source:

http://www.pnas.org/content/early/2018/01/03/1715035115

Tagged with:

About author

Related Articles