Breaking News
January 18, 2019 - Let’s map our DNA and save billions each year in health costs
January 18, 2019 - AI demonstrates potential to identify irregular heart rhythms as well as humans
January 17, 2019 - Study shows link between air pollution and increased risk of sleep apnea
January 17, 2019 - Neck-strengthening exercises can protect athletes from concussions
January 17, 2019 - Computer model shows how to better control MRSA outbreaks
January 17, 2019 - Pain is unpleasant, and now scientists have identified the set of responsible neurons
January 17, 2019 - CUIMC Celebrates 2018-2019
January 17, 2019 - Study reveals potential pathway for endothelial cells to avoid apoptosis
January 17, 2019 - Hamilton Storage launches LabElite DeCapper SL to expand LabElite product family
January 17, 2019 - Location of epigenetic changes co-locate with genetic signal causing psychartric disorder
January 17, 2019 - Researchers awarded 6.1 million euros to address female fertility problems
January 17, 2019 - Counseling appointments fail to reduce weight gain during pregnancy, shows study
January 17, 2019 - Contraceptive patch that could provide 6 months of contraception within seconds
January 17, 2019 - Yeast model may pave way for development of novel therapies for metabolic disorders
January 17, 2019 - Study determines impact of antibiotic perturbation of the gut microbiome on skeletal health
January 17, 2019 - Cardiometabolic Risk Up With Tourette, Chronic Tic Disorder
January 17, 2019 - Hong Kong scientists claim ‘broad-spectrum’ antiviral breakthrough
January 17, 2019 - Researchers discover the brain cells that make pain unpleasant | News Center
January 17, 2019 - Hepatitis Is Common in New Cancer Patients
January 17, 2019 - Podcast: KHN’s ‘What The Health?’ Drug Prices Are Rising Again. Is Someone Going To Do Something About It?
January 17, 2019 - Smoking significantly increases your biological age, study shows
January 17, 2019 - B-group vitamins may be beneficial for people with first episode psychosis
January 17, 2019 - Researchers demonstrate how manganese produces parkinsonian syndrome
January 17, 2019 - Researchers suggest link between personality type and attitude towards others’ bodies
January 17, 2019 - Mutant mice administered with cocaine failed to exhibit hyperactivity, shows study
January 17, 2019 - Health Tip: Understanding a Heart Murmur
January 17, 2019 - Gut protein mutations shield against spikes in glucose
January 17, 2019 - Engineered immune cells target broad range of pediatric solid tumors in mice | News Center
January 17, 2019 - Study finds link between high pesticide exposure and poor sense of smell among farmers
January 17, 2019 - Many cancer patients have undiagnosed hepatitis
January 17, 2019 - New study finds only 13% of outpatient antibiotic prescriptions to be appropriate
January 17, 2019 - Stem cell-based approach to diabetes offers hope for treatment
January 17, 2019 - New project receives €8.65 million from EU and Canada to ease genomic, health data sharing
January 17, 2019 - Improvements in pharmacological study to fight cognitive impairment in schizophrenia
January 17, 2019 - Study looks at trends over time in oral antibiotic prescribing by dermatologists
January 17, 2019 - Most substance use disorder treatment facilities do not offer medication treatment
January 17, 2019 - Multiple sclerosis could benefit from stem cell therapy
January 17, 2019 - Researchers manipulate T cells to improve transplant success
January 17, 2019 - Put away your rulers and reach for your phone
January 17, 2019 - Mindfulness linked with fewer menopausal symptoms
January 17, 2019 - Integrated care to women with PMADs offered at several levels
January 17, 2019 - Researchers identify MANF as a rejuvenating factor in parabiosis
January 17, 2019 - Truncal mutations study suggests new direction in origins of cancer
January 17, 2019 - Beckman Coulter launches new ClearLLab 10C System for clinical flow cytometry lab
January 17, 2019 - Effects of linoleic acid on the body are largely dependent on genes, shows study
January 17, 2019 - Pre-injury exercise reduces damage to both muscles and nerves, study finds
January 17, 2019 - Minimizing Antibody Size to Maximize Research Potential
January 17, 2019 - Research finds large genome in tiny forest defoliator
January 17, 2019 - Technology helps reduce the yearning for unhealthy food
January 17, 2019 - Imec develops prototype cardiovascular device
January 17, 2019 - New Drug Application for Insomnia Disorder Treatment Lemborexant Submitted in the United States
January 17, 2019 - What you should know about teeth whitening
January 17, 2019 - Why Older Adults Should Eat More Protein (And Not Overdo Protein Shakes)
January 17, 2019 - Colorectal cancer mortality rates predicted to increase globally
January 17, 2019 - Scientists discover mutational signatures of tumor hypoxia
January 17, 2019 - New evidence shows how fever alters immune cells
January 17, 2019 - Researchers find new class of blood pressure-regulating peptides in vampire bat venom
January 17, 2019 - Promega to exhibit new Maxwell RSC48 platform at 2019 Festival of Genomics
January 17, 2019 - Study pinpoints immune cells that could be key to tackling hypertension
January 17, 2019 - Couples Intervention May Aid Partners of Diabetes Patients
January 17, 2019 - Your weight history may predict your heart failure risk
January 17, 2019 - Explore a cornucopia of accomplishments in prematurity research
January 17, 2019 - New study identifies four characteristics that predict severity of postpartum depression
January 17, 2019 - AHF urges United Nations to follow own mandate for protecting Ebola response efforts
January 17, 2019 - New, scalpel-free treatment for reducing Parkinson’s tremor gets FDA approval
January 17, 2019 - Neurobiologists uncover key component of how the human brain marks time
January 17, 2019 - LifeTime receives fund to develop a plan to embed its vision for healthier future
January 17, 2019 - WTC first responders at higher risk for head and neck cancers, study finds
January 17, 2019 - New NSF funded study may help physicians decrease brain injury deaths
January 17, 2019 - Ham bones contain peptides that could have cardioprotective effects
January 17, 2019 - Research finds how Candida albicans adapt to low oxygen levels to cause infection
January 17, 2019 - Cobra Biologics announces appointment of Dr Darrell Sleep as Director of Innovation
January 17, 2019 - Cellular protein that interacts with viruses appears to enable infection process of Zika virus
January 17, 2019 - Opioids Now More Deadly for Americans Than Traffic Accidents
January 17, 2019 - Women who start periods early are at greater risk of cardiovascular problems
January 17, 2019 - The brain-circuitry clash that keeps you from diving into that plate of ribs when you’re dining with royalty
January 17, 2019 - Poo transplant can successfully treat patients with ulcerative colitis
January 17, 2019 - Study suggests key role for glial cells in Parkinson’s disease
January 17, 2019 - Educational videos in clinical settings increase HPV vaccination rates among adolescents
January 17, 2019 - Better understanding of aggressive brain tumour
Cocaine de-addiction breakthrough shows promise

Cocaine de-addiction breakthrough shows promise

image_pdfDownload PDFimage_print

Researchers have successfully created a way by which cocaine craving could be reduced. This could help in the de-addiction of thousands of users feel experts. The team of researchers neutralized a protein molecule that is commonly seen among cocaine users in their blood and brain.

The team found that the protein granulocyte-colony stimulating factor (G-CSF), can affect the reward centres of the brain. Neutralizing it would be one of the safest methods by which cocaine craving could be reduced among addicts. The research comes from Mont Sinai Medical Centre in New York. The results of the study appeared in the latest issue of the journal Nature Communications.

Lead researcher Dr Drew Kiraly, assistant professor of psychiatry at Icahn School of Medicine at Mount Sinai said that the results of this study are “exciting” because this is the first time an alternative to routine de-addiction programs is found. The regular traditional approaches include psychotherapy and “no medication-assisted therapy” that are used to treat the drug seeking behavior.

They found that since G-CSF is capable of producing a positive signal at the reward centres of the brain, it could be injected directly into the brain’s reward centres called the “nucleus acumbens”. This led to a significant rise in the cocaine seeking behavior as well as cocaine consumption among the mice that were tested. As the mice were treated with the G-CSF, they worked harder to look for and consume cocaine in the experiments.

Dr Kiraly said that medical science had already created safe drugs that could neutralize G-CSF. These drugs are commonly used to stimulate the production of the white blood cells or the immunity cells after rounds of chemotherapy. Chemotherapy typically suppresses the white blood cells. G-CSF stimulates the production of these WBCs. The team then administered drugs that could neutralize the G-CSF among the test mice. The mice then showed a lost motivation to seek out the cocaine. These drugs used are all approved by the Food and Drugs Administration (FDA), United States of America, the authors explain.

One of the most interesting findings was that these mice lost interest only in seeking out cocaine and not other food treats such as sugar water. Sugar water also stimulates the pleasure and reward centres of the brain. These results thus show that if the G-CSF could be neutralized in the brain, the animal would effectively just stop seeking cocaine and it would not alter other behaviors.

Authors write that the feasibility of using the new medications remains a problem. They write that the problems include, “side effects, routes of delivery, or abuse potential of agents tested.” Once these hurdles are overcome, a potential new area of medications for de-addiction could be developed. They conclude, “Treatment with a G-CSF modulator would have the distinct advantage that it may be harnessed to reduce drug taking while ostensibly having no abuse potential on its own—a known confound in many previous trials for psychostimulant use disorders.” Dr Kiraly says more studies and research is necessary before this could become a reality.

Reference: https://www.nature.com/articles/s41467-017-01881-x

30bc23a0-4f43-445f-953a-eb97fc12d22e|0|.0

Posted in: Medical Research News

Tags: Addiction, Blood, Brain, Chemotherapy, Drugs, Molecule, Nucleus, Protein, Psychiatry, Psychotherapy, Research

Tagged with:

About author

Related Articles