Breaking News
January 16, 2019 - Questions to ask your doctor about post pregnancy care: MedlinePlus Medical Encyclopedia
January 16, 2019 - Neurons with good housekeeping are protected from Alzheimer’s
January 16, 2019 - Is mindfulness worthy of all the hype?
January 16, 2019 - Physical Activity, Any Type or Amount, Cuts Health Risk from Sitting
January 16, 2019 - New understanding in the evolution of human feet
January 15, 2019 - AHA: New Cholesterol Guidelines Put Ethnicity in the Spotlight
January 15, 2019 - Different brain areas linked to smoking and drinking
January 15, 2019 - Henry Marsh shares insights into neurosurgery and more at Dean’s Lecture Series
January 15, 2019 - Want to Live Longer? For Just 30 Minutes a Day, Do Anything Else But Sit
January 15, 2019 - The Current issue of “The view from here” is concerned with Targets
January 15, 2019 - Plain packaging sparked tobacco price rises, new study finds
January 15, 2019 - Sedentary lifestyles can be unhealthy, physical activity can lower risk
January 15, 2019 - Gut microbiome may help prevent development of cow’s milk allergy
January 15, 2019 - Lesbian, gay and bisexual individuals more likely to suffer severe substance use disorders
January 15, 2019 - New England Journal of Medicine Publishes Positive Results of the Pivotal Trial of Cablivi (caplacizumab) for Rare Blood Clotting Disorder
January 15, 2019 - Levels of inflammatory marker (CRP) linked to housing type and tenure
January 15, 2019 - Three gifts I’m glad I gave myself in 2018
January 15, 2019 - Columbia’s Pediatrics Department Names New Vice Chairs, Expands Leadership
January 15, 2019 - US FDA Accepts Regulatory Submissions for Review of Tafamidis to Treat Transthyretin Amyloid Cardiomyopathy
January 15, 2019 - Staying fit can cut your risk of heart attack by half
January 15, 2019 - Vitamin D supplements are of no gain to those over 70, study shows
January 15, 2019 - Scientists create comprehensive new method to predict breast cancer risk
January 15, 2019 - Research shows connection between social media use and impaired risky decision-making
January 15, 2019 - FDA Approves Expanded Use of Adacel (Tdap) Vaccine for Repeat Vaccination
January 15, 2019 - Treating spinal pain with replacement discs made of ‘engineered living tissue’ moves closer to reality
January 15, 2019 - Providers Walk ‘Fine Line’ Between Informing And Scaring Immigrant Patients
January 15, 2019 - Outcomes Poorer for Medicaid Beneficiaries With STEMI
January 15, 2019 - Decorative Products on Foods Can Be Unsafe
January 15, 2019 - A dream of sustainable surgery in Uganda
January 15, 2019 - Study shows how herpes viruses and tumors have learned to manipulate the same ancient RNA
January 15, 2019 - Common Heart, Diabetes Meds May Help Ease Mental Illness
January 15, 2019 - Stress and trauma in earliest years linked to reduced hippocampal volume in adolescence
January 15, 2019 - Scientists identify endogenous activator of sigma-1 receptors in human cells
January 15, 2019 - MAR treatments unlikely to be cause of premature or low birth weight babies
January 15, 2019 - Parental CPTSD increases transmission of trauma to offspring of Tutsi genocide survivors
January 15, 2019 - High-fat diets shown to increase blood pressure
January 15, 2019 - New institute for food safety to be established in Netherlands
January 15, 2019 - Keele University researchers receive £2.4 million grant to help reduce overprescribing of opioids
January 15, 2019 - Synthetic compound reverses mutant p53 aggregate accumulation, study shows
January 15, 2019 - First elder care robot tested in a WSU smart home apartment
January 15, 2019 - Oxford researchers explore relationship between technology use and adolescent mental health
January 15, 2019 - From microbiome research to healthier and sustainable foods
January 15, 2019 - How coaching moms and dads improves infants’ language skills
January 15, 2019 - Precision health approach tapped to identify causes of poverty
January 14, 2019 - DNA origami can accurately measure how antibodies interact with several antigens
January 14, 2019 - Researchers identify multiple new subtypes of most common childhood cancer
January 14, 2019 - Total Fertility Rates Vary by State
January 14, 2019 - Elevated blood lead level in early childhood associated with increased risk of academic problems in school-aged children
January 14, 2019 - Superior technique identified that can block CRISPR gene editing
January 14, 2019 - Turning breast cancer cells into fat cells prevents the formation of metastases
January 14, 2019 - Review examines what influences HIV-positive patients to stay on antiretroviral drugs in Africa
January 14, 2019 - Identifying genetic factors that lead to squamous cell carcinoma
January 14, 2019 - Virtual video visits can replace office visits without compromising quality of care
January 14, 2019 - Health Highlights: Jan. 10, 2019
January 14, 2019 - Molecular hallmarks of tumor hypoxia across 19 cancer types discovered
January 14, 2019 - Scientists uncover how protein clumps damage cells in Parkinson’s
January 14, 2019 - Physician-scientist’s “indomitable spirit” prevails over personal adversity
January 14, 2019 - King’s researchers receive £1.25 million to investigate fatal eating disorder
January 14, 2019 - UCR researchers uncover how plants sense temperature
January 14, 2019 - Scientists find link between colitis and colon cancer
January 14, 2019 - New skin patch provides long-acting contraceptive protection
January 14, 2019 - Asparagine synthetase deficiency – Genetics Home Reference
January 14, 2019 - Improved stem cell approach could aid fight against Parkinson’s
January 14, 2019 - New class of sleeping pill preserves ability to wake in response to danger signals
January 14, 2019 - Cancer patients are four times more likely to commit suicide
January 14, 2019 - The human brain works in reverse order to retrieve memories
January 14, 2019 - Simple tips can lead to better food choices
January 14, 2019 - Meth’s Resurgence Spotlights Lack Of Meds To Combat The Addiction
January 14, 2019 - TARA Biosystems and Insilico Medicine collaborate to discover novel therapies for cardiac disease
January 14, 2019 - Early life stress in mice affects their offspring behavior
January 14, 2019 - Depression Tied to Worse Asthma Outcomes in Urban Teens
January 14, 2019 - Santa calorie counting
January 14, 2019 - Opiod prescriptions for pet dogs misused by their masters
January 14, 2019 - People with ASD could be better at recognizing regret and relief in others finds study
January 14, 2019 - Conducting ChIP-Seq with Low Cell Numbers
January 14, 2019 - Study explores support and social networks of family carers of people with dementia
January 14, 2019 - At Risk for an Opioid OD? There’s an App for That
January 14, 2019 - Single national electronic health record will help improve care in Canadian hospitals
January 14, 2019 - Study unearths Britain’s first speech therapists
January 14, 2019 - Study reveals nuances of racial inequalities in breast cancer prevention
Lactation May Lower T2D Risk in Younger Women

Lactation May Lower T2D Risk in Younger Women

image_pdfDownload PDFimage_print

Longer duration of breastfeeding was associated with a lower risk of diabetes among mothers later in life, according to a 30-year observational study.

Among more than 1,200 young white and black women (mean age 24.2), increasing lactation duration was associated with a graded 25% to 47% relative reduction in the incidence of diabetes, even after accounting for factors such as prepregnancy biochemical measures, clinical and demographic risk factors, gestational diabetes (GD), and lifestyle behaviors, reported Erica P. Gunderson, PhD, MPH, of Kaiser Permanente in Northern California in Oakland, and colleagues, in JAMA Internal Medicine.

Gunderson’s group found a strong inverse association between diabetes incidence and lactation duration compared with 0 days:

  • >0 to 6 months: relative hazards 0.75 (95% CI0.51-1.09, P=01)
  • >6 months to <12 months: RH 0.52 (95% CI 0.31-0.87, P=01)
  • ≥12 months: RH 0.53 (95% CI 0.29-0.98, P=01)

“Our findings in young black and white women are consistent with studies in high-risk women with GD that re-screened women systematically for diabetes after pregnancy,” the authors stated. “This strong graded, protective association is strikingly similar in magnitude to our 30-year follow-up risk reduction in healthy CARDIA women.”

They explained that lactation is a natural biological process, which had the potential to provide long-term benefits to maternal health, “but has been underappreciated as a potential key strategy for early primary prevention of metabolic diseases in women across the childbearing years and beyond.”

Gunderson’s group collected data on 1,238 women from the Coronary Artery Risk Development in Young Adults (CARDIA) study of young black (n=615) and white women, ages 18-30 year,s without diabetes at baseline (1985-1986). The community-based sampling occurred in four geographic areas in the country: Birmingham, Alabama; Chicago; Minneapolis; and Oakland.

All women had one or more live births after baseline, reported lactation duration, and were screened for diabetes up to seven times during 30 years after baseline (1986-2016).

Gunderson’s group reported 182 incident diabetes cases during 27,598 person-years for an overall incidence rate of 6.6 cases per 1,000 person-years (95% CI 5.6-7.6). Of this group, there were 132 cases (73.0%) in 13,369 person-years for black women and 50 cases in 14,229 person-years for white women.

Diabetes incidence per 1,000 person-years was higher in black women (9.9. 95% CI 8.2-11.6, P<0.001) than white women (3.5, 95% CI 2.5-4.5, P<0.001) and the rate was 18.0 (95% CI 13.3-22.8, P<0.001) for women with gestational diabetes and 5.1 (95% CI 4.2-6.0, P<0.001) for women without.

There was no evidence of effect modification by race, gestational diabetes, or parity, the researchers added.

They explained that there are several mechanisms that might explain the link between lactation duration and lower risk of diabetes, including that lactating women have lower circulating glucose in both fasting and post-absorptive states, as well as lower insulin secretion, despite increased glucose production rates.

The researchers concluded that their findings may have implications for social policies. For example, the findings support extending paid maternity leave to achieve a longer duration of breastfeeding, as well as an increased allocation of healthcare resources to increase breastfeeding rates in order to help prevent chronic disease in women, and prevent obesity-related diseases.

Study imitations included self-report of pregnancy complications and the inability to explain the reasons behind the association.

The study was supported by the National Institute of Diabetes, Digestive, and Kidney Disease. CARDIA is supported by multiple institutions including the National Heart, Lung, and Blood Institute.

Gunderson disclosed funding from Janssen Pharmaceuticals. One co-author disclosed relevant relationships with Takeda, Merck, Sanofi-Aventis, Lilly, Genentech, Valeant, and Pfizer.

2018-01-16T15:45:00-0500

Tagged with:

About author

Related Articles