Breaking News
February 19, 2018 - Morning Break: Transgender Breast Feeding; Brazilian ‘Pro-Vaxxers’; Post-Stroke Exercise
February 19, 2018 - Meningitis vaccination strategy in Africa found to be effective, economical
February 19, 2018 - Researchers uncover how excess calcium may influence development of Parkinson’s disease
February 19, 2018 - Psoriasis drug also effective at reducing aortic inflammation
February 19, 2018 - Excess emissions can make serious contributions to air pollution, study shows
February 19, 2018 - Diabetes Drugs Differ on HF; School-Based Obesity Program Flop; Plaque Type in ACS
February 19, 2018 - Surgical infections linked to drug-resistant bugs, study suggests
February 19, 2018 - Poor awareness may hinder a child’s early dental care
February 19, 2018 - FDA Approves Apalutamide (Erleada) to Help Curb a Tough-to-Treat Prostate Cancer
February 19, 2018 - Educational Tool Boosts Cervical Length Screening
February 19, 2018 - Spider’s web inspires removable implant that may control type 1 diabetes
February 19, 2018 - Scientists develop fluorescent probe to identify cancer stem cells
February 19, 2018 - University Hospital of Santiago de Compostela participates in large pancreatic cancer study
February 19, 2018 - New blood test shows promise to revolutionize diagnosis of tick-borne diseases
February 19, 2018 - Report: Use, Not Price, Drives State Health Costs
February 19, 2018 - Emergency services crews often unprepared for diabetic crises
February 19, 2018 - Scientists in Sweden create DNA nanowires that offer hope for treatment of diseases
February 19, 2018 - ID Break: Clean Hands, Fewer Abx; $11 Million HIV Cure?; MenB Vax for Kids
February 19, 2018 - Patient exposure to X-rays depends on how dentists are paid
February 19, 2018 - Study reveals parents’ views toward children’s tanning bed use
February 19, 2018 - Shot may help reduce risk of shingles
February 19, 2018 - FDA approves first treatment to reduce risk of NSCLC progression
February 19, 2018 - FDA Expands Approval of Imfinzi (durvalumab) to Reduce the Risk of Non-Small Cell Lung Cancer Progressing
February 19, 2018 - D.C. Week: Congress Passes Spending Bill
February 19, 2018 - Heart-muscle patches made with human cells improve heart attack recovery
February 19, 2018 - FDA Approves First Blood Test to Detect Concussions
February 19, 2018 - Survival Bump in Bladder Cancer with Keytruda
February 18, 2018 - Scientists describe the mechanism of heart regeneration in the zebrafish
February 18, 2018 - Scientists uncover the structure of microtubule motor proteins
February 18, 2018 - Light-activated cancer drugs without toxic side effects are closer to becoming reality
February 18, 2018 - Pioneering research could provide novel insight into how genomic information is read
February 18, 2018 - Pearls From: David Putrino, PhD
February 18, 2018 - Researchers uncover how cancer stem cells drive triple-negative breast cancer
February 18, 2018 - Morning Break: Anti-Anti-Vaxxers; Private Piercings Prohibited; A Case for Pelvic Massage
February 18, 2018 - Lower-dose radiation effective, safe for HPV+ head and neck cancer after induction chemo
February 18, 2018 - Specialist residential service for adults with autism opens in Swansea
February 18, 2018 - FDA Moves to Limit Loperamide Doses per Package
February 18, 2018 - Alcohol use disorder – Genetics Home Reference
February 18, 2018 - Autism might be better detected using new two-minute questionnaire
February 18, 2018 - Hand hygiene-intervention practices may reduce risk of infection among nursing home patients
February 18, 2018 - Researchers develop most sophisticated mini-livers to date
February 18, 2018 - Obamacare Helped More Young Women Get Prenatal Care: Study
February 18, 2018 - School-Based Program Fails to Dent Kids’ Obesity
February 18, 2018 - Research compares neural activity in children with and without autism spectrum disorder
February 18, 2018 - Poor fitness levels increase the risk dementia, concludes study
February 18, 2018 - Risk Score May Reveal if Kids are Victims of Ill-Treatment
February 18, 2018 - Adding Folic Acid to Corn Masa Flour May Prevent Birth Defects
February 18, 2018 - Acute treatment suppresses posttraumatic arthritis in ankle injury
February 18, 2018 - A Role for Budesonide in Autoimmune Hepatitis?
February 18, 2018 - Lupus patients exhibit altered cell proteins, a discovery with potential implications for diagnostics
February 18, 2018 - Muscle plays vital role in regulating heat loss from the hands
February 18, 2018 - High-tech brain scans can provide new way to define intelligence
February 18, 2018 - Study reveals the association between ultra-processed foods and cancer
February 18, 2018 - Prescription Opioid Use Tied to Higher Pneumonia Risk
February 18, 2018 - A non-invasive method to detect Alzheimer’s disease
February 18, 2018 - Deletion of specific enzyme leads to improvement in memory and cognitive functions
February 18, 2018 - Amyloid protein may be transmitted through neurosurgical instruments, study suggests
February 18, 2018 - Electric brain signals of males and females show differences
February 18, 2018 - American Heart Association commends McDonald’s for offering healthier menu in kids’ meals
February 18, 2018 - Parents Find Kids’ Weight Report Cards Hard to Swallow
February 18, 2018 - Does a Financial Conflict of Interest Ever Expire?
February 18, 2018 - Exercise can improve Alzheimer’s symptoms
February 18, 2018 - Scientists develop green chemistry method to improve pharmaceutical manufacturing efficiency
February 17, 2018 - ‘A Time Clock to a Tissue Clock’ for Acute Stroke Care
February 17, 2018 - Cancer Care Gets Personal | NIH News in Health
February 17, 2018 - Do more youth use or do youth use more?
February 17, 2018 - Eating faster linked to obesity
February 17, 2018 - Who’s Still Smoking? ACS Report Highlights Most Vulnerable Adults
February 17, 2018 - Study of smoking and genetics illuminates complexities of blood pressure
February 17, 2018 - Study reveals new link between bone cells and blood glucose level
February 17, 2018 - Children with reading challenges may have lower than expected binocular vision test results
February 17, 2018 - Mass Shootings Trigger Change for Emergency Medicine
February 17, 2018 - ECMO helps revive woman thought to be drowned
February 17, 2018 - Learning stress-reducing techniques may benefit people with epilepsy
February 17, 2018 - Shedding Pounds Before Weight-Loss Surgery a Smart Move
February 17, 2018 - FDA Approves New Cystic Fibrosis Drug Combo
February 17, 2018 - Augmented Reality helps surgeons to ‘see through’ tissue and reconnect blood vessels
February 17, 2018 - Emotional state affects operation of the entire brain instead of being restricted to specific regions
February 17, 2018 - Apalutamide Slows Metastasis in Prostate Cancer
February 17, 2018 - Kids’ well visits linked to lower appendicitis complications
Civilians Now Getting Flu-Like Illness Afflicting Troops

Civilians Now Getting Flu-Like Illness Afflicting Troops

image_pdfDownload PDFimage_print

Action Points

  • Human adenovirus type 4, an influenza-like illness usually found in isolated military settings, was detected among the general population, such as college students, other young adults, and residents of long-term care facilities.
  • Note that HAdV-4 plays a leading role in the etiology of outbreaks of febrile respiratory illness and ocular disease in military recruit training facilities, and a vaccine against this virus was exclusively licensed for military use.

Human adenovirus type 4, an influenza-like illness usually found in isolated military settings, was detected among the general population, such as college students, residents of long-term care facilities and other young adults, researchers found.

Thirty-six isolates of human adenovirus type 4, or HAdV-4, were found in adults outside of military facilities, reported Adriana E. Kajon, PhD, of Lovelace Respiratory Research Institute in Albuquerque, New Mexico, and colleagues.

While most of these were the most common genome types found among military recruits, certain novel variants were identified among college students and young adults from upstate New York, the authors wrote in Emerging Infectious Diseases.

HAdV-4 is one cause of acute respiratory disease and ocular disease, the authors said. They noted that a vaccine against this virus was exclusively licensed for military use, although HAdV-4 vaccination protocols were discontinued for 15 years, until they were reinstated in 2011. But the authors said there is no surveillance for the disease outside of the military, which makes it difficult to figure out the burden of disease linked to it among civilians.

“The apparent increased frequency of detection of cases and case clusters of HAdV-4 respiratory infection in the northeastern United States … caught our attention,” they wrote.

Researchers obtained specimens that were positive for HAdV-4. Patients had acute respiratory disease or influenza-like illness characterized by a fever, cough, sore throat and other respiratory symptoms. These cases were identified by the New York State Department of Health as part of the CDC’s influenza-like illness surveillance network or “special HAdv cases” referred to the CDC for investigation.

Identified cases came from an outbreak at a long-term care facility in Boston, adults with severe pneumonia in Connecticut and New York, college students in New York, and additional cases among other adults, including a nursing home patient, a fatal case of a patient at a cancer care center, and acute respiratory disease in a teenager at a pediatric clinic.

Among these 36 cases, authors identified five genomic variants — some of which were associated with outbreaks and others that were “epidemiologically unlinked” cases of acute respiratory disease. Of these, genomic variant 4a1 was isolated from 18 of 36 specimens, while genomic variant 4a2 was isolated from 12 of 36 specimens. Both variants were highly prevalent in basic training facilities prior to the reinstatement of vaccination protocols in 2011, the authors said.

But they also found two previously unreported variants described as “closely related” to 4a1 and 4a2 among certain college students in upstate New York, and one strain that was similar to a vaccine-like strain of the virus in an 18 year-old at a physician’s office.

They speculated on the potential reasons for this virus in the civilian population, either that the public could have been exposed to non-attenuated vaccine strains through fecal shedding from military personnel who were vaccinated from 1971 to 1997, or that these variants were circulating at low prevalence among civilian communities since the 1950s, when they were first identified, the authors said.

They added that due to the severity of clinical presentation in some of these cases, the vaccine licensed for military use against HAdV-4 should be considered “a potentially valuable resource” to prevent disease in closed communities, like college, summer camps, and long-term care facilities.

“Our data and reports of cases of severe [acute respiratory disease] associated with HAdV-4 infection in Italy and Singapore suggest that the role of this HAdV type in the etiology of adult civilian ARD might have been underestimated in the absence of access to molecular…typing resources,” they wrote.

They recommended including human adenovirus in differential diagnostic panels to ensure that patients with influenza-like symptoms, but who test negative for the flu, are not treated with anti-influenza agents.

The study was supported by the CDC.

Kajon disclosed no relevant relationships with industry. One co-author disclosed support from the NIH.

2018-01-11T12:00:00-0500

Tagged with:

About author

Related Articles