Breaking News
February 19, 2018 - Study sheds light on biology that guides behavior across different stages of life
February 19, 2018 - Morning Break: Transgender Breast Feeding; Brazilian ‘Pro-Vaxxers’; Post-Stroke Exercise
February 19, 2018 - Meningitis vaccination strategy in Africa found to be effective, economical
February 19, 2018 - Researchers uncover how excess calcium may influence development of Parkinson’s disease
February 19, 2018 - Psoriasis drug also effective at reducing aortic inflammation
February 19, 2018 - Excess emissions can make serious contributions to air pollution, study shows
February 19, 2018 - Diabetes Drugs Differ on HF; School-Based Obesity Program Flop; Plaque Type in ACS
February 19, 2018 - Surgical infections linked to drug-resistant bugs, study suggests
February 19, 2018 - Poor awareness may hinder a child’s early dental care
February 19, 2018 - FDA Approves Apalutamide (Erleada) to Help Curb a Tough-to-Treat Prostate Cancer
February 19, 2018 - Educational Tool Boosts Cervical Length Screening
February 19, 2018 - Spider’s web inspires removable implant that may control type 1 diabetes
February 19, 2018 - Scientists develop fluorescent probe to identify cancer stem cells
February 19, 2018 - University Hospital of Santiago de Compostela participates in large pancreatic cancer study
February 19, 2018 - New blood test shows promise to revolutionize diagnosis of tick-borne diseases
February 19, 2018 - Report: Use, Not Price, Drives State Health Costs
February 19, 2018 - Emergency services crews often unprepared for diabetic crises
February 19, 2018 - Scientists in Sweden create DNA nanowires that offer hope for treatment of diseases
February 19, 2018 - ID Break: Clean Hands, Fewer Abx; $11 Million HIV Cure?; MenB Vax for Kids
February 19, 2018 - Patient exposure to X-rays depends on how dentists are paid
February 19, 2018 - Study reveals parents’ views toward children’s tanning bed use
February 19, 2018 - Shot may help reduce risk of shingles
February 19, 2018 - FDA approves first treatment to reduce risk of NSCLC progression
February 19, 2018 - FDA Expands Approval of Imfinzi (durvalumab) to Reduce the Risk of Non-Small Cell Lung Cancer Progressing
February 19, 2018 - D.C. Week: Congress Passes Spending Bill
February 19, 2018 - Heart-muscle patches made with human cells improve heart attack recovery
February 19, 2018 - FDA Approves First Blood Test to Detect Concussions
February 19, 2018 - Survival Bump in Bladder Cancer with Keytruda
February 18, 2018 - Scientists describe the mechanism of heart regeneration in the zebrafish
February 18, 2018 - Scientists uncover the structure of microtubule motor proteins
February 18, 2018 - Light-activated cancer drugs without toxic side effects are closer to becoming reality
February 18, 2018 - Pioneering research could provide novel insight into how genomic information is read
February 18, 2018 - Pearls From: David Putrino, PhD
February 18, 2018 - Researchers uncover how cancer stem cells drive triple-negative breast cancer
February 18, 2018 - Morning Break: Anti-Anti-Vaxxers; Private Piercings Prohibited; A Case for Pelvic Massage
February 18, 2018 - Lower-dose radiation effective, safe for HPV+ head and neck cancer after induction chemo
February 18, 2018 - Specialist residential service for adults with autism opens in Swansea
February 18, 2018 - FDA Moves to Limit Loperamide Doses per Package
February 18, 2018 - Alcohol use disorder – Genetics Home Reference
February 18, 2018 - Autism might be better detected using new two-minute questionnaire
February 18, 2018 - Hand hygiene-intervention practices may reduce risk of infection among nursing home patients
February 18, 2018 - Researchers develop most sophisticated mini-livers to date
February 18, 2018 - Obamacare Helped More Young Women Get Prenatal Care: Study
February 18, 2018 - School-Based Program Fails to Dent Kids’ Obesity
February 18, 2018 - Research compares neural activity in children with and without autism spectrum disorder
February 18, 2018 - Poor fitness levels increase the risk dementia, concludes study
February 18, 2018 - Risk Score May Reveal if Kids are Victims of Ill-Treatment
February 18, 2018 - Adding Folic Acid to Corn Masa Flour May Prevent Birth Defects
February 18, 2018 - Acute treatment suppresses posttraumatic arthritis in ankle injury
February 18, 2018 - A Role for Budesonide in Autoimmune Hepatitis?
February 18, 2018 - Lupus patients exhibit altered cell proteins, a discovery with potential implications for diagnostics
February 18, 2018 - Muscle plays vital role in regulating heat loss from the hands
February 18, 2018 - High-tech brain scans can provide new way to define intelligence
February 18, 2018 - Study reveals the association between ultra-processed foods and cancer
February 18, 2018 - Prescription Opioid Use Tied to Higher Pneumonia Risk
February 18, 2018 - A non-invasive method to detect Alzheimer’s disease
February 18, 2018 - Deletion of specific enzyme leads to improvement in memory and cognitive functions
February 18, 2018 - Amyloid protein may be transmitted through neurosurgical instruments, study suggests
February 18, 2018 - Electric brain signals of males and females show differences
February 18, 2018 - American Heart Association commends McDonald’s for offering healthier menu in kids’ meals
February 18, 2018 - Parents Find Kids’ Weight Report Cards Hard to Swallow
February 18, 2018 - Does a Financial Conflict of Interest Ever Expire?
February 18, 2018 - Exercise can improve Alzheimer’s symptoms
February 18, 2018 - Scientists develop green chemistry method to improve pharmaceutical manufacturing efficiency
February 17, 2018 - ‘A Time Clock to a Tissue Clock’ for Acute Stroke Care
February 17, 2018 - Cancer Care Gets Personal | NIH News in Health
February 17, 2018 - Do more youth use or do youth use more?
February 17, 2018 - Eating faster linked to obesity
February 17, 2018 - Who’s Still Smoking? ACS Report Highlights Most Vulnerable Adults
February 17, 2018 - Study of smoking and genetics illuminates complexities of blood pressure
February 17, 2018 - Study reveals new link between bone cells and blood glucose level
February 17, 2018 - Children with reading challenges may have lower than expected binocular vision test results
February 17, 2018 - Mass Shootings Trigger Change for Emergency Medicine
February 17, 2018 - ECMO helps revive woman thought to be drowned
February 17, 2018 - Learning stress-reducing techniques may benefit people with epilepsy
February 17, 2018 - Shedding Pounds Before Weight-Loss Surgery a Smart Move
February 17, 2018 - FDA Approves New Cystic Fibrosis Drug Combo
February 17, 2018 - Augmented Reality helps surgeons to ‘see through’ tissue and reconnect blood vessels
February 17, 2018 - Emotional state affects operation of the entire brain instead of being restricted to specific regions
February 17, 2018 - Apalutamide Slows Metastasis in Prostate Cancer
Oncologists Dish on Top Issues for 2018

Oncologists Dish on Top Issues for 2018

image_pdfDownload PDFimage_print

MedPage Today asked physicians in several specialties to predict the news that will dominate their specialties during 2018.

Number one for oncologists could probably have been predicted at the start of 2017: immunotherapies and their impact on routine clinical practice.

Last year saw the first approvals of CAR T-cell therapies, and the roles of drugs targeting the PD-1 checkpoint on immune cells, allowing them to attack tumor cells, became clearer and larger in 2017.

In 2018, nearly all the oncologists we contacted mentioned immunotherapies, although many were not glowing expectations that patients will see dramatic improvements in outcomes.

Daniel Hayes, MD, University of Michigan; past president, American Society of Clinical Oncology: I think the biggest issue in the field of oncology will be ongoing advances in immunotherapy and precision medicine, with the former including both new targets and drugs as well as delivering them more precisely and the latter including better tests for all the new targeted drugs we use to treat cancers.

John W. Sweetenham, MD, University of Utah: In my opinion, the biggest clinical issue for oncology in 2018 is evaluating the true clinical impact of immunologic therapies including checkpoint inhibitors and CAR-T cell therapy from the perspective of outcomes and cost.

Ross Camidge, MD, University of Colorado-Denver: Recognition of the cost implications (financial and medical) of a one-size-fits-all approach to immunotherapy in lung cancer.

Sagar Lonial, MD, Emory University: I think that the biggest issue in our field will be how to more effectively pair immune therapy with genomic subtyping and sequencing data. Both separately are only effective in the minority of patients, but marrying these two ideas in a more coherent combination approach has the potential to yield greater benefits for all.

Howard Alan Fine, MD, Weill Cornell Medicine: One of the biggest clinical issues in this upcoming year in neuro-oncology in general, and malignant gliomas specifically, will be the maturation and release of clinical trial data on the efficacy of immunotherapeutic strategies in GBM. To date, the early data regarding immunotherapeutic strategies in the treatment of GBM (such as the highly touted anti-PD-1/PD-1L and anti-CTL4 so effective in melanoma, along with a plethora of vaccine approaches) have largely been negative (except for the approximate 1% of GBM patients that have tumor genomics that demonstrate DNA mismatch repair). The negative results are early, but it is likely that a number of these trials will become mature this year with the release of longer term follow-up data that will suggest whether this strategic approach for brain tumors has some clinical efficiency (e.g., proof of principle) or whether significantly more basic and translational research will need to be done in order to try and get this type of treatment to benefit patients.

But for some oncologists, other issues came to the fore.

Sidney Winawer, MD, Memorial Sloan Kettering Cancer Center: If the ACS [American Cancer Society] can reach its goal of screening 80% of Americans for colorectal cancer in 2018, approximately 200,000 lives can be saved over the next 20 years.

David Crawford, MD, University of Colorado-Denver: The indication of a PSA cutoff of 1.5 [ng/mL] for family practice doctors [to act on increased prostate cancer risk].

Herbert Lepor, MD, New York University: Using molecular and genetic testing to better define aggressiveness of prostate cancer.

Ed Kim, MD, Carolinas Healthcare: Balancing the increasing effectiveness of cancer drugs and the increasing costs of drugs.

And our favorite:

Derek Raghavan, MD, PhD, Carolinas Healthcare: The biggest clinical issue in oncology will be to create magic that allows oncologists to provide state of art care for the indigent and under-insured in this harsh political environment.


Tagged with:

About author

Related Articles