Breaking News
October 21, 2018 - Study reveals connection between two proteins known to be hyperactive in cancer
October 21, 2018 - Gabapentin Beats Pregabalin for Chronic Sciatica
October 21, 2018 - Cosmetic surgeons offering incomplete information for breast augmentation customers
October 21, 2018 - Chronic sleep disruption in early adult life accelerates AD-related tau pathology
October 21, 2018 - Take 10 for Mindfulness – Drugs.com MedNews
October 21, 2018 - Length of breathing disruption in OSA may be better predictor of mortality risk
October 21, 2018 - ApoE4 gene linked with chronic inflammation increases risk for Alzheimer’s disease
October 21, 2018 - Mother-daughter conflict associated with suicide risk in abused adolescent girls
October 21, 2018 - Scientists molding bacteria into unnatural shapes
October 21, 2018 - Discharged mental health patients ‘at greater risk of dying’
October 21, 2018 - As billions in tax dollars flow to private Medicaid plans, Who’s minding the store?
October 21, 2018 - Study shows correlation between spatial memory and the sense of smell
October 21, 2018 - Increased cardiorespiratory fitness associated with reduced long-term mortality
October 21, 2018 - IU researchers receive $1.55 million from NIH to improve chronic-disease management
October 21, 2018 - Income and wealth affect the mental health of Australians, study shows
October 21, 2018 - Patients with hypertension and psoriasis more often require cardiovascular interventions
October 20, 2018 - Leading hip-hop videos depict use of tobacco and marijuana products, study finds
October 20, 2018 - Dose Range of IV Ketamine for Adjunct Tx of Depression Tested
October 20, 2018 - Infants can distinguish between leaders and bullies, study finds
October 20, 2018 - Mad Cow disease found on Aberdeenshire farm
October 20, 2018 - Study identifies factors associated with prescription opioid misuse among students
October 20, 2018 - Scientists uncover key regulator of mTORC1 in cancer growth
October 20, 2018 - Pounds Regained After Weight-Loss Op Can Tell Your Doc a Lot
October 20, 2018 - Sending parents letters to fight childhood obesity doesn’t work
October 20, 2018 - Supervised aerobic exercise can support major depression treatment
October 20, 2018 - Mindfulness-based program effective for reducing stress in infertile women
October 20, 2018 - Molecule capable of halting and reverting neurodegeneration caused by Parkinson’s disease identified
October 20, 2018 - Midazolam-mediated alterations of PER2 expression may have functional consequences during myocardial ischemia
October 20, 2018 - Sweat bees are ideal for studying the genes underlying social behavior
October 20, 2018 - Weight loss success associated with brain areas involved in self-control
October 20, 2018 - KHN’s ‘What the Health?’ Republicans’ preexisting political problem
October 20, 2018 - Research provides a more complete picture of suffering caused by terrorist attacks
October 20, 2018 - Eradicating Helicobacter pylori infections may be a key treatment for Parkinson’s disease
October 20, 2018 - Breast Cancer as a Dynamic Disease
October 20, 2018 - University of Pittsburgh wins NSF grant for big data research to prevent complications from anesthesia
October 20, 2018 - Skin-to-skin contact may promote attachment between parents and preterm infants
October 20, 2018 - Recommendations Developed to Verify NGT Placement in Children
October 20, 2018 - Weight loss can be boosted fivefold thanks to novel mental imagery technique
October 20, 2018 - Children with autism are more likely to be overweight, obese
October 20, 2018 - Nurses making conscientious objections to ethically-relevant policies lack support
October 20, 2018 - Prion strain diversity may be greater than previously thought
October 20, 2018 - Antidepressant treatment may lead to improvements in sleep quality of patients with depression
October 20, 2018 - Study reports increased risk of death in children with inflammatory bowel disease
October 20, 2018 - Number of Autism Genes Now Tops 100
October 20, 2018 - Total diet replacement programmes are effective for treating obesity
October 20, 2018 - CLARIOstar used for fluorescence measurements on CSIRO’s purpose-built research vessel
October 20, 2018 - People with more copies of AMY1 gene digest starchy carbohydrates faster
October 20, 2018 - Case Comprehensive Cancer Center wins NIH grant to study health disparities
October 20, 2018 - Newly discovered compound shows potential for treating Parkinson’s disease
October 20, 2018 - High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients
October 20, 2018 - Immunotherapy medicine found to be effective in treating uveitis
October 20, 2018 - The Pistoia Alliance Calls for Greater Collaboration to Realise Benefits of Innovation and Announces Winners of the 2018 President’s Startup Challenge
October 20, 2018 - Female internists consistently earn less than men
October 20, 2018 - Stanford team looks at dangers of teens’ vaping habits
October 20, 2018 - New approach to understanding cancers will accelerate development of better treatments
October 20, 2018 - LJI and UC San Diego awarded $ 4.5 million as part of NCI’s Cancer Moonshot initiative
October 20, 2018 - School-based HPV vaccination did not increase risky sexual behaviors among adolescent girls
October 20, 2018 - Eye discovery to pave way for more successful corneal transplants
October 20, 2018 - New analysis examines the importance of location in the opioid crisis
October 20, 2018 - Green filters increase reading speed for children with dyslexia
October 19, 2018 - Bariatric Sx Cuts Macrovascular Complications in Obesity, T2DM
October 19, 2018 - Better assessments for early age-related macular degeneration
October 19, 2018 - Visible and valued: Stanford Medicine’s first-ever LGBTQ+ Forum | News Center
October 19, 2018 - Understanding of metal-free enzymes used by bacteria could lead to new effective antibiotics
October 19, 2018 - Beckman Coulter Life Sciences announces new research-focused website
October 19, 2018 - Study finds link between refined soluble fibers, gut microbiota and liver cancer
October 19, 2018 - Social media reduces risk of depression among seniors with pain
October 19, 2018 - Newly developed synthetic DNA molecule may one day be used as ‘vaccine’ for prostate cancer
October 19, 2018 - Preoperative weight loss may not provide health benefits after surgery
October 19, 2018 - U.S. Birth Rates Continue to Drop as Age of New Moms Rises
October 19, 2018 - New technology can keep an eye on babies’ movements in the womb
October 19, 2018 - Juul e-cigarettes pose addiction risk for young users | News Center
October 19, 2018 - Gene sequencing reveals crucial molecular aspects of Trypanosoma brucei
October 19, 2018 - New DNA vaccine strategy protects mice against lethal challenge by multiple H3N2 viruses
October 19, 2018 - Study shows close link between cytokine interleukin-1ß and obesity-promoted colon cancer
October 19, 2018 - Muscle mass plays a critical role in health, shows research
October 19, 2018 - Study finds undiagnosed prediabetes in many infertile men
October 19, 2018 - The Current issue of “The view from here” is concerned with Nanotherapeutic strategies
October 19, 2018 - Delay in replacing the Pap smear with HPV screening is costing lives
October 19, 2018 - Physicians battle pediatric diseases of ear, nose, throat in Zimbabwe | News Center
Scientists imitate the Human Blood-retinal barrier on a microfluidic chip

Scientists imitate the Human Blood-retinal barrier on a microfluidic chip

image_pdfDownload PDFimage_print

Dr Ananya Mandal, MD.

For years scientists have sought to minimise Animal testing and speed up clinical trials. One alternative is the use of in vitro assays using live cells, but its effectiveness is limited,  since it is difficult to reproduce interaction and interconnection between cells.

Credit: science photo/ Shutterstock.com

In their latest developments, scientists are creating systems that imitate organ functions and tissues under conditions that closely match reality. Microenvironments and microarquitectures are included in these devices, named “Organ-on-a-chip”, to help mimic living tissues and organs.

A microfluidic device that acts as the human blood-retinal barrier has been produced by an extensive team of scientists in Barcelona.

The team comprised of Researchers from the Biomedical Applications Group of the Microelectronics Institute of Barcelona (IMB-CNM) of the Spanish Council for Scientific Research (CSIC), the CIBER-BBN, and from the Diabetes and Metabolism group of the Vall d’Hebron Research Institute (VHIR), CIBERDEM- Institute of Health Carlos III, and the Universitat Autònoma de Barcelona (UAB).

Featured as the cover piece for the journal Lab-on-a chip., the study is referred to by experts as “proof of concept”, meaning it proves the design has practical applicability. Lead author of the study, José Yeste, a CSIC scientist at the IMB-CNM and at the Microelectronics and Electronics Systems Department at the UAB, explained how the team constructed the device.

The device has several compartments parallel to each other, mimicking the structure of the retina. There are three types of cells in these layers, including endothelial cells that line the blood vessels, neuron cells that form tiny nerves and retinal pigmented epithelial cells that form most of the blood retina barrier through which drugs pass.

The compartments are connected with each other via  a system of microgrooves beneath the cells, that cells can use to transfer signal molecules allowing them to communicate. This means a cellular communication and interaction can be generated from substances from cells connecting with other cells, just as would take place in a real organ.

Rosa Villa, a CSIC scientist and leader of the Biomedical Applications Group, explains that “in the living organism, endothelial cells that cover the inner walls of blood vessels are exposed to the mechanical stimulus of the blood stream. In the cell cultures where this condition is not reproduced, we could say the cells are like “sleepy” and do not react as they would do in real conditions”.

The most relevant characteristic of this technology is that mimics what happens ‘in vivo’ in the retina and therefore can be an essential tool to boost the in vitro experimentation. On the device, the cells grow constantly in contact with a fluid, as it happens in the human retina.  Also, the cells keep a close interaction between them by chemical mediators, which makes possible to see what happens in a type of cell when another type of cell nearby is harmed. “

Rafael Simó, the Vall d’Hebron Research Institute (VHIR)

According to the researchers, the impact of harming conditions on the human retina or molecules on the human retina can be observed using this system, as well as understanding the effects of diabetes and hypertension on the retina.

The team at IMB-CNM previously created a microfluidic chamber (Liver-on-a chip) that imitates hepatic microcirculation, and another that emulates the blood-brain barrier.

Source:

https://www.eurekalert.org/pub_releases/2018-01/uadb-set012318.php

Tagged with:

About author

Related Articles