Breaking News
February 23, 2019 - FDA Adds Boxed Warning for Increased Risk of Death with Gout Medicine Uloric (febuxostat)
February 23, 2019 - Phone-based intervention aids rheumatoid arthritis care
February 23, 2019 - Opioid epidemic makes eastern inroads and targets African-Americans
February 23, 2019 - New identified biomarker predicts patients who might benefit from HER2-targeted agents
February 23, 2019 - Study offers new insights into mechanisms of changes in erythrocytes under stress
February 23, 2019 - Antipsychotic polypharmacy may be beneficial for schizophrenia patients
February 23, 2019 - Patients with diabetes mellitus have high risk of stable ischemic heart disease
February 23, 2019 - Transparency on healthcare prices played key role in Arizona health system’s turnaround
February 23, 2019 - A comprehensive, multinational review of peppers around the world
February 23, 2019 - Study finds modest decrease in burnout among physicians
February 23, 2019 - A simple change can drastically reduce unnecessary tests for urinary tract infections
February 23, 2019 - Deep Learning-Enhanced Device Detects Diabetic Retinopathy
February 23, 2019 - Researchers discover new binding partner for amyloid precursor protein
February 23, 2019 - Modest decrease seen in burnout among physicians, researchers say | News Center
February 23, 2019 - Transplanting bone marrow of young mice into old mice prevents cognitive decline
February 23, 2019 - Mogrify to accelerate novel IP and cell therapies using $3.7m USD funding
February 23, 2019 - Johns Hopkins study describes cells that may help speed bone repair
February 23, 2019 - Scientists demonstrate influence of food odors on proteostasis
February 23, 2019 - Researchers unlock the secret behind reproduction of fish called ‘Mary’
February 23, 2019 - Acupuncture Could Help Ease Menopausal Symptoms
February 23, 2019 - Researchers use AI to detect early signs of Alzheimer’s
February 23, 2019 - On recovery, vulnerability and ritual: An exhibit in white | News Center
February 23, 2019 - Memory Stored in Unexpected Region of the Brain
February 23, 2019 - Several health experts worldwide gather at EUDONORGAN event
February 23, 2019 - Discovery of potent compound in native California shrub may lead to treatment for Alzheimer’s
February 22, 2019 - Researchers create new map of the brain’s own immune system
February 22, 2019 - ICHE’s reviews on surgical infections, unnecessary urine tests, and nurses’ role in antibiotic stewardship
February 22, 2019 - UK Research and Innovation invests £200 million to create new generation of AI leaders
February 22, 2019 - Takeda collaboration to boost fight against Alzheimer’s and other neurodegenerative diseases
February 22, 2019 - Heavy drinking may change DNA, leading to increased craving for alcohol
February 22, 2019 - U.S. opioid deaths jump fourfold in 20 years; epidemic shifts to Eastern states | News Center
February 22, 2019 - 5 Questions with William Turner on Diversity in Medicine
February 22, 2019 - HHS Finalizes Rule Seeking To Expel Planned Parenthood From Family Planning Program
February 22, 2019 - Researchers uncover biochemical pathway that may help identify drugs to treat Alzheimer’s
February 22, 2019 - Biologist uses new grant to find ways to eliminate schistosomiasis
February 22, 2019 - Bag-mask ventilation to help patients breathe during intubation prevents complications
February 22, 2019 - AbbVie Announces New Drug Application Accepted for Priority Review by FDA for Upadacitinib for Treatment of Moderate to Severe Rheumatoid Arthritis
February 22, 2019 - Nature versus nurture and addiction
February 22, 2019 - New website connects researchers with data experts, resources | News Center
February 22, 2019 - Today’s Concerns About Drug Prices Echo The Past
February 22, 2019 - CT and Doppler equipment have low accuracy in detecting cerebral vasospasm and ischemia
February 22, 2019 - Study finds out similarity in function between healthy retina cell and tumor cell
February 22, 2019 - CWRU awarded NIH grant to identify effective treatments for intimate partner violence
February 22, 2019 - Oncotype DX Not Cost-Effective for Low-Risk Breast Cancer
February 22, 2019 - Scientists discover new type of immune cells that are essential for forming heart valves
February 22, 2019 - Talk About Déjà Vu: Senators Set To Re-Enact Drug Price Hearing Of 60 Years Ago
February 22, 2019 - Genetic defect linked to pediatric liver disease identified
February 22, 2019 - New cellular atlas could provide a deeper insight into blinding diseases
February 22, 2019 - Growing number of cancer survivors, fewer providers point to challenge in meeting care needs
February 22, 2019 - Innovative compound offers a new therapeutic approach to treat multiple sclerosis
February 22, 2019 - $1.5 million grant to develop opioid treatment program for jail detainees
February 22, 2019 - FDA’s new proposed rule would update regulatory requirements for sunscreen products in the U.S
February 22, 2019 - Most Hip, Knee Replacements Last Decades, Study Finds
February 22, 2019 - Wellness problems prevalent among ob-gyn residents
February 22, 2019 - In the Spotlight: “The world is your oyster in geriatrics”
February 22, 2019 - Successful testing of multi-organ “human-on-a-chip” could replace animals as test subjects
February 22, 2019 - Analysis of cervical precancer shows decline in two strains of HPV
February 22, 2019 - Sugary stent eases suturing of blood vessels
February 22, 2019 - From surgery to psychiatry: A medical student reevaluates his motivations
February 22, 2019 - Is New App From Feds Your Answer To Navigating Medicare Coverage? Yes And No
February 22, 2019 - New pacemakers powered by heartbeats could reduce need for surgery
February 22, 2019 - The United States records highest drug overdose death rates
February 22, 2019 - Heart attacks more likely to be fatal in women and rates are rising
February 22, 2019 - Morning walks could be better than drugs at lowering blood pressure
February 22, 2019 - Phase 1 data reinforce safety profile of new drug for treating Duchenne muscular dystrophy
February 22, 2019 - Vitamin D supplementation less effective in the presence of obesity, shows study
February 22, 2019 - Novostia raises CHF 6.5 million to advance its aortic, mitral heart valve to clinical trials
February 22, 2019 - CPRIT awards nearly $20 million to The University of Texas MD Anderson Cancer Center
February 22, 2019 - Sarepta Announces FDA Acceptance of Golodirsen (SRP-4053) New Drug Application for Patients with Duchenne Muscular Dystrophy Amenable to Skipping Exon 53
February 22, 2019 - An institutional effort to reduce the amount of opioids prescribed following lumbar surgery
February 22, 2019 - Family-history-based models perform better than non-family-history based models
February 22, 2019 - Failure to take statins leads to higher mortality rates | News Center
February 22, 2019 - New study explains why some patients report phantom sensations after limb amputation
February 22, 2019 - First motor-controlled heart valves implanted by Mainz University Medical Center
February 22, 2019 - Novel preclinical model mimics persistent interneuron loss seen in preterm infants
February 22, 2019 - Global health burden of glaucoma has increased, study reveals
February 22, 2019 - A holistic approach key to minimize treatment complexity in patients with interstitial lung disease
February 22, 2019 - 1 in 10 middle-aged Chinese adults are at high risk for heart disease, finds study
February 22, 2019 - More than half a million breast cancer patient’s lives saved by improvements in treatment
February 22, 2019 - Study finds no evidence that tougher policies prevent teenage cannabis use
Biotechnology startup receives FDA clearance for synthetic bone graft substitute

Biotechnology startup receives FDA clearance for synthetic bone graft substitute

image_pdfDownload PDFimage_print

A biotechnology startup enabled by UC Davis, Molecular Matrix Inc., has received Food and Drug Administration clearance for a carbohydrate-based polymer that can help injured bones heal and regrow.

Osteo-PTM, a synthetic bone graft substitute, supports and guides the growth of new bone — such as when there is a loss of bone due to injury or surgery — after which the biomaterial is resorbed and replaced with the patients’ own bone during the healing process. With the 510(k) FDA clearance, Molecular Matrix will now be able to take Osteo-PTM to market.

“This is yet another meaningful milestone for UC Davis and our technology commercialization efforts,” said Dushyant Pathak, associate vice chancellor of Technology Management and Corporate Relations, and executive director of Venture Catalyst at UC Davis. “Our focus on innovation and technology commercialization is a direct reflection of its being one of the most tangible ways in which the university can fulfil its mission of public benefit and societal impact.”

For Charles Lee, the founder of Molecular Matrix and also an assistant adjunct professor in the Department of Cell Biology and Human Anatomy at the UC Davis School of Medicine, the FDA clearance marks an exciting turning point for the company UC Davis helped him found in 2011.

“What began as an idea from UC Davis has reached all the way to FDA clearance,” Lee said.

Lee received his B.S. in microbiology and Ph.D. in comparative pathology and did his postdoctoral work at UC Davis. He became fascinated by stem cells as an undergraduate when he had an internship with Alice Tarantal, professor of pediatrics and cell biology and human anatomy in the UC Davis School of Medicine, and the associate director of the UC Davis School of Medicine Stem Cell Program.

Tarantal gave him a line of stem cells to culture.

“I fell in love with those cells,” Lee said. “That’s how I got into stem cell biology. There was nothing else I wanted to do than study and research them.”

The stem cells he worked with were grown in a single layer, but Lee began thinking about new ways to grow them.

“Stem cells behave much differently when they are grown in an aggregate as opposed to a monolayer,” he said. “But building up stem cells is not easy. It requires a scaffold — a matrix or structure — to help support the cells to grow into an organoid.”

Stem cell substrates did exist, but Lee said none was ideal. “I specifically wanted to use a carbohydrate, a sugar, for scaffolding. I wanted it to be degradable and nontoxic, to not affect stem cells in any way,” Lee said.

The invention he came up with, a hyper-crosslinked carbohydrate polymer technology, provides a platform for stem cells to grow both in vitro and in vivo. Lee explained that the platform is all about cross-linking.

“We chemically crosslink the carbohydrate molecules to build a massive structure. It’s crosslinked so much that it can hold its shape under heat and pressure.”

Helping bones regrow

For its first clinical launch, Molecular Matrix focused on creating a polymer product to help bones regrow without stem cell transplantation.

“Bone is a good place to start,” Lee said. “It is simpler to regenerate than other organic systems.” The polymer platform has potential to be used for other clinical and research applications. “Cartilage or heart tissue, for example,” Lee said.

In its unprocessed form, Osteo-PTM is spongy and porous and can be made in a variety of shapes and sizes. Lee explained that the unique composition of Osteo-P creates an optimal microenvironment for bone precursors such as osteoblasts, leading to the formation of healthy bone.

“The need for bone substitute products is expected to expand,” said Jim Keefer, COO of Molecular Matrix. “The global bone graft and substitutes market was estimated at $2.1 billion in 2013 and is expected to grow to $2.7 billion by 2020.”

The company plans to release the product for single-patient use possibly as early as mid-March. It will be available as large pore granules, sheets, cubes, wedges and cylinders or in custom sizes.

Lee credits the Technology Management and Corporate Relations unit at UC Davis as being essential to Molecular Matrix’s success, helping him navigate the dual roles of innovative researcher and entrepreneur. TMCR provided support for everything from patent processing to incorporation to networking to helping him raise capital.

Starting out, Lee thought he would need to focus primarily on raising capital to grow his startup, but focusing on people turned out to be his best investment.

“I ended up getting more and more people who believed in the technology, and when the people came together, the money followed,” Lee said. “Jim Keefer, our COO, was instrumental in getting broader interest in the company.”

“What is most heartening about how Charles has grown and developed Molecular Matrix is his engagement of UC Davis students as interns and employees within the company,” said Pathak. “Charles could have set up the company anywhere, but he chose to build and grow it in proximity to UC Davis, thereby benefiting from close access to university resources, including Venture Catalyst, while contributing to regional economic impact. Charles’ recognition of the talent pool that UC Davis represents is no small driver of the company’s success.”

Despite the challenges of juggling many roles, Lee never once considered letting another company commercialize the scaffolding technology he developed.

“We scientists have fun developing projects, ideas and concepts into something that can ultimately help patients,” Lee said. “I can’t imagine stopping in the middle and having someone else have all the fun. I want to take it all the way — from benchtop to bedside.”

Source:

https://www.ucdavis.edu/news/startup-receives-fda-clearance-polymer-aid-bone-regrowth

Tagged with:

About author

Related Articles