Breaking News
January 19, 2019 - FDA Approves Ontruzant (trastuzumab-dttb), a Biosimilar to Herceptin
January 19, 2019 - Tobacco use linked with higher use of opioids and sedatives
January 19, 2019 - Study delves deeper into developmental dyslexia
January 19, 2019 - Anti-vaccination movement one of the top health threats in 2019 says WHO
January 19, 2019 - Newly developed risk score more effective at identifying type 1 diabetes
January 19, 2019 - Highly effective protocol to prepare cannabis samples for THC/CBD analysis
January 19, 2019 - Prinston Pharmaceutical Inc. Issues Voluntary Nationwide Recall of Irbesartan and Irbesartan HCTZ Tablets Due to Detection of a Trace Amount of Unexpected Impurity, N-Nitrosodiethylamine (NDEA) in the Products
January 19, 2019 - How does solid stress from brain tumors cause neuronal loss, neurologic dysfunction?
January 19, 2019 - $14.7 million partnership to supercharge vaccine development
January 19, 2019 - Ian Fotheringham receives Charles Tennant Memorial Lecture award
January 19, 2019 - Brain vital signs detect neurophysiological impairments in players with concussions
January 19, 2019 - Lack of job and poor housing conditions increased likelihood of people attending A&E
January 19, 2019 - Novel targeted drug delivery system improves conventional cancer treatments
January 19, 2019 - Rutgers study finds gene responsible for spread of prostate cancer
January 19, 2019 - Complications Higher Than Expected for Invasive Lung Tests
January 19, 2019 - 3-D printed implant promotes nerve cell growth to treat spinal cord injury
January 19, 2019 - Automated texts lead to improved outcomes after total knee or hip replacement surgery
January 19, 2019 - Poor cardiorespiratory fitness could increase risk of future heart attack, finds new study
January 19, 2019 - Drinking soft drinks while exercising in hot weather may increase risk of kidney disease
January 19, 2019 - Formlabs 3D prints anatomical models
January 19, 2019 - Heart-Healthy Living Also Wards Off Type 2 Diabetes
January 19, 2019 - Teaching Kids to Be Smart About Social Media (for Parents)
January 19, 2019 - Metabolite produced by gut microbiota from pomegranates reduces inflammatory bowel disease
January 19, 2019 - Researchers examine how spray from showers and toilets expose us to disease causing bacteria
January 19, 2019 - Behavioral experiments confirm that additional neurons improve brain function
January 19, 2019 - New study compares performance of real-time infectious disease forecasting models
January 19, 2019 - Obesity can be risk factor for developing renal cell carcinoma, confirms study
January 19, 2019 - New regulation designs on cigarette packs direct smokers’ attention to health warnings
January 19, 2019 - QIAGEN receives first companion diagnostic approval in Japan
January 19, 2019 - Study explores role of Dunning-Kruger effect in anti-vaccine attitudes
January 19, 2019 - Newly identified subset of immune cells may be key to fighting chronic inflammation
January 19, 2019 - New immune response regulators discovered
January 18, 2019 - Poor blood oxygenation during sleep predicts chance of heart-related death
January 18, 2019 - First international consensus on the diagnosis and management of fibromuscular dysplasia
January 18, 2019 - Rapid resistance gene sequencing technology can hasten identification of antibiotic-resistant bacteria
January 18, 2019 - Researchers develop artificial enzymatic pathway for synthesizing isoprenoids in E. coli
January 18, 2019 - Scientists advise caution in immunotherapy research
January 18, 2019 - How children across the world develop language
January 18, 2019 - Columbia Medical Student Receives McDonogh Scholarship
January 18, 2019 - Secretive ‘Rebate Trap’ Keeps Generic Drugs For Diabetes And Other Ills Out Of Reach
January 18, 2019 - Plant based diet could be the best option for the planet says commission
January 18, 2019 - New conservation practice could reduce nitrogen from agricultural drainage, study shows
January 18, 2019 - UIC researchers receive $1.7 million NCI grant to study Southeast Asian fruit
January 18, 2019 - New study determines the fate of DNA derived from genetically modified food
January 18, 2019 - Scientists develop new gene therapy that prevents axon destruction in mice
January 18, 2019 - Study finds critically low HPV vaccination rates among younger adolescents in the U.S.
January 18, 2019 - Brain cells involved in memory play key role in reducing future eating behavior
January 18, 2019 - Risk for Conversion of MS Varies With Different Therapies
January 18, 2019 - Investigational cream may help patients with inflammatory skin disease
January 18, 2019 - Medical school news office receives six writing awards | News Center
January 18, 2019 - County By County, Researchers Link Opioid Deaths To Drugmakers’ Marketing
January 18, 2019 - Research reveals risk for developing more than one mental health disorder
January 18, 2019 - Scientists discover a dramatic pattern of bone growth in female mice
January 18, 2019 - Study finds link between lengthy periods of undisturbed maternal sleep and stillbirths
January 18, 2019 - New nuclear medicine method could improve detection of primary and metastatic melanoma
January 18, 2019 - Combination therapy shows high efficacy in treating people with leishmaniasis and HIV
January 18, 2019 - Health Tip: Don’t Ignore Changes in Skin Color
January 18, 2019 - Dietary Recommendations for Healthy Children
January 18, 2019 - Eliminating the latent reservoir of HIV
January 18, 2019 - Pain From The Government Shutdown Spreads. This Time It’s Food Stamps
January 18, 2019 - Newly discovered regulatory mechanism helps control fat metabolism
January 18, 2019 - New rapid blood tests could speed up TB diagnosis, save the NHS money
January 18, 2019 - Researchers develop intelligent system for ‘tuning’ powered prosthetic knees
January 18, 2019 - Monoclonal antibody pembrolizumab prolongs survival in patients with squamous cell carcinoma
January 18, 2019 - Maintaining an active lifestyle in older age could prevent dementia
January 18, 2019 - New research detects mosquito known to transmit malaria for the first time in Ethiopia
January 18, 2019 - Researchers identify new genes linked to development of age-related macular degeneration
January 18, 2019 - Computerized method helps better protect pharma patents
January 18, 2019 - New guidelines to make swallowing safer for people in Australian nursing homes
January 18, 2019 - Lumex Instruments’ RA-915AM monitor installed at Hg treatment plant in Almadén, Spain
January 18, 2019 - ACCC survey finds multiple threats to growth of cancer programs
January 18, 2019 - Meeting the challenge of engaging men in HIV prevention and treatment
January 18, 2019 - Furloughed Feds’ Health Coverage Intact, But Shutdown Still Complicates Things
January 18, 2019 - Experts discuss various aspects on health risks posed by fumigated containers
January 18, 2019 - Researchers use gene-editing tool CRISPR/Cas9 to limit impact of parasitic diseases
January 18, 2019 - Alpha neurofeedback training could be a means of enhancing learning success
January 18, 2019 - Innovative ‘light’ method demonstrates positive results in fight against malignant tumors
January 18, 2019 - The cytoskeleton of neurons found to play role in Alzheimer’s disease
January 18, 2019 - New resource-based approach to improve HIV care in low- and middle-income countries
January 18, 2019 - Bedfont appoints Dr Jafar Jafari as first member of the Gastrolyzer Medical Advisory Board
Extra Body Fat May Raise Breast Cancer Risk, No Matter Your Weight

Extra Body Fat May Raise Breast Cancer Risk, No Matter Your Weight

image_pdfDownload PDFimage_print

FRIDAY, Jan. 26, 2018 — Older women who carry some extra body fat may face a heightened risk of breast cancer — even if their weight is normal, a new study finds.

“This suggests women should not just concentrate on weight,” said Mia Gaudet, strategic director of breast and gynecologic cancer research for the American Cancer Society.

“Instead, they should focus on doing things that can help reduce body fat levels — like a healthy diet and regular exercise,” said Gaudet, who was not involved in the study.

Past research has found that overweight and obese women generally have a higher risk of developing breast cancer after menopause.

But doctors have long relied on body mass index (BMI) to tell whether people are normal weight or not.

The problem is, BMI does not distinguish between fat, muscle and bone. So, it’s an imprecise gauge of body composition — and disease risks, recent studies have shown.

It’s now “fairly well established” that BMI is not the best indicator of a person’s risk of conditions like type 2 diabetes and heart disease, said lead researcher Dr. Neil Iyengar.

And now it seems that may also be true for breast cancer, said Iyengar, a medical oncologist at Memorial Sloan Kettering Cancer Center, in New York City.

The findings are based on 3,460 women aged 50 to 79 who were part of a large study called the Women’s Health Initiative. The women all had a normal BMI at the outset, and all had their body fat measured with dual energy X-ray absorptiometry, or DXA.

DXA is a whole-body scan that gives a snapshot of a person’s body composition.

Over 16 years, 182 women developed breast cancer; most had tumors that were estrogen receptor-positive — which means estrogen helps fuel their growth.

On average, the study found, women with higher body fat levels had a greater risk of developing ER-positive breast cancer: Women whose fat levels were in the top 25 percent were twice as likely to develop the cancer, compared to women in the bottom 25 percent.

The findings do not prove definitively that body fat caused the cancers, according to Iyengar. But his team accounted for many other factors — including the women’s family history of breast cancer, use of hormone therapy, and their exercise and drinking habits.

And still, extra body fat was a risk factor.

Why would body fat matter? Fat is “active tissue,” Iyengar explained, and when it accumulates in excess, it outgrows its blood supply and fat cells start to die. When that happens, he said, there is inflammation, and substances called growth factors are churned out.

“Those growth factors can potentially support cancers,” Iyengar said.

On top of that, fat is a source of continued estrogen production in postmenopausal women, said Dr. Graham Colditz, of the Siteman Cancer Center at Barnes-Jewish Hospital, in St. Louis.

Colditz, who was not involved in the study, said the findings make sense.

But practically speaking, he added, it will still be much easier for women to monitor their weight on the bathroom scale, versus having their body fat levels tracked.

Colditz echoed Gaudet’s advice: Even if women have a normal BMI, they should still strive for a healthy diet and regular exercise — including, he said, resistance exercises to maintain and build muscle.

In fact, Iyengar said, study participants with higher body fat levels did generally exercise less often than other women did.

The study looked only at postmenopausal women, so the findings do not necessarily apply to breast cancer in younger women, Iyengar said.

In general, he noted, premenopausal breast cancer differs from cases that arise later in life — and it’s not clear whether weight or body composition have any bearing on that risk.

The findings were to be presented Friday at an American Association for Cancer Research conference in Austin, Texas. Such research is considered preliminary until published in a peer-reviewed journal.

More information

The American Cancer Society has more on body weight and cancer risk.

© 2018 HealthDay. All rights reserved.

Posted: January 2018

Tagged with:

About author

Related Articles