Breaking News
September 26, 2018 - DFG establishes nine new Research Units
September 26, 2018 - Companies stepping up efforts to ensure medicine supply post Brexit
September 26, 2018 - Extracellular RNA in urine may provide useful biomarkers for muscular dystrophy
September 26, 2018 - Horwitz Prize Awarded for Work on Hormones
September 26, 2018 - Study reveals structure of potential drug target in neurological conditions
September 26, 2018 - Micronic introduces better alternative to traditional cryo tubes
September 26, 2018 - Epidural stimulation and locomotor training helps patients with spinal cord injury to walk
September 26, 2018 - RTI’s TETRAfuse 3D Technology wins 2018 Spine Technology Award
September 26, 2018 - Researchers discover novel targeting agents to prevent cancer metastasis
September 26, 2018 - Researchers develop molecule that makes cancer cells sensitive to radiotherapy
September 26, 2018 - American Cancer Society releases new cookbook for cancer patients
September 26, 2018 - Relmada Therapeutics Provides Enrollment Update in Phase 2 Study of REL-1017 (dextromethadone) in Patients with Major Depressive Disorder
September 26, 2018 - Many doctors in India miss TB signs: study
September 26, 2018 - Horwitz Prize Awarded for Work on Hormones
September 26, 2018 - Genomic ‘islands’ evolved from viruses can be converted into ‘anti-bacterial drones’
September 26, 2018 - Who is Your Possible Self?
September 26, 2018 - Most running injuries may be influenced by simple technique errors, finds study
September 26, 2018 - Optimizing dopaminergic treatment improves non-motor symptoms and quality of life
September 26, 2018 - NIRS-IVUS imaging identifies patients and plaques vulnerable to subsequent adverse cardiac events
September 26, 2018 - New insights into what drives organ transplant rejection
September 26, 2018 - Tiny Device Is a ‘Huge Advance’ for Treatment of Severe Heart Failure
September 26, 2018 - Research shows possibility to postpone cumbersome treatment for low-risk MDS patients
September 26, 2018 - CSU chemists may help in making extracorporeal life support devices more effective
September 26, 2018 - Brain marker linked with aggression in toddlers identified
September 26, 2018 - Blood-brain barrier can be important biomarker for early diagnosis of Alzheimer’s disease
September 26, 2018 - PCORI, AHRQ announce awards to support patient-centered outcomes research in learning health systems
September 26, 2018 - Scientists discover and characterize human skeletal stem cells
September 26, 2018 - Repeat CT Common in Peds Traumatic Epidural Hematoma
September 26, 2018 - Genetics Home Reference: bunion
September 26, 2018 - Increase observed in hearts from drug-intoxicated donors
September 26, 2018 - For Heart Failure Patients, Mitral Valve Procedure Improved Outcomes
September 26, 2018 - TINY cancer detection device shows promise as point-of-care detector of KSHV
September 26, 2018 - Women with non-small cell lung cancers live longer than their male counterparts
September 26, 2018 - KTU researchers engineer experimental bone to help treat osteoarthritis patients
September 26, 2018 - Foundation for a Smoke-Free World calls for proposals to implement Smoke-Free Index
September 26, 2018 - Functional Imagery Training helps lose five times more weight than talking therapy
September 26, 2018 - Fewer American Teens Having Sex, Most Using Birth Control
September 26, 2018 - We are predisposed to forgive, new research suggests
September 26, 2018 - Insomnia Exacts Heavy Toll on Quality of Life
September 26, 2018 - Clinical study shows efficacy, safety of novel drug-eluting stent with improved radiographic visibility
September 26, 2018 - Cytox, AIBL announce expanded agreement to assess genetic risk for Alzheimer’s
September 26, 2018 - Study finds persistent rate of lawnmower injury-related emergency department visits
September 26, 2018 - Researchers find molecule that halts, reverts neurodegeneration caused by Parkinson’s disease
September 26, 2018 - Novartis announces winners of 2018 eXcellence in Ophthalmology Vision Award
September 26, 2018 - New spinout company to tackle drug-resistant infections with novel antibiotics
September 26, 2018 - In depression the brain region for stress control is larger
September 26, 2018 - Smuggling RNA into cells can activate the immune system to fight cancer
September 26, 2018 - Special Focus Issue takes wide view of complementary and integrative medicine in cancer
September 26, 2018 - Researchers now confirm that genome duplication drives evolution of species
September 25, 2018 - Study provides evidence of beta lactamase producing, antimicrobial resistant E. coli in U.S. retail meat
September 25, 2018 - UCI study finds new cause of cerebral microbleeds
September 25, 2018 - Researchers propose mechanism by which ASTN2 protein defects lead to brain disorders
September 25, 2018 - Chinese and German researchers to cooperate more closely in future for better food
September 25, 2018 - Recent study helps predict probability of pregnant mothers to have child with autism
September 25, 2018 - New online, sound matching tool offers tinnitus sufferers potential treatment options
September 25, 2018 - UC Davis researchers take critical step in developing more effective Salmonella vaccine
September 25, 2018 - Antibiotics best paediatric treatment for children’s chronic wet cough
September 25, 2018 - Looking beyond opioids: Stanford pain psychologist briefs Congress
September 25, 2018 - Organs actively fighting back against autoimmune diseases, finds study
September 25, 2018 - Lancaster professor aims to understand how genes affect smoking cessation
September 25, 2018 - Human-oriented perspective needed to better understand Parkinson’s disease
September 25, 2018 - Physical activity may have beneficial effects for people with rare Alzheimer’s disease
September 25, 2018 - FDA Updates on Valsartan Recalls
September 25, 2018 - 3-D-printed tracheal splints used in groundbreaking pediatric surgery
September 25, 2018 - Who is the designated driver, or proxy, for your health decisions?
September 25, 2018 - New chemo-optogenetic method enables multi-directional activity control of cellular processes
September 25, 2018 - Study explores link between genetic predisposition to Alzheimer’s and cardiometabolic risk factors
September 25, 2018 - NeoTract presents new clinical data from studies of UroLift System for patients with BPH
September 25, 2018 - Patients with paralysis manage to walk thanks to new technology
September 25, 2018 - Statins Improve Long-Term Survival After AAA Repair
September 25, 2018 - Novel brain network linked to chronic pain in Parkinson’s disease
September 25, 2018 - Researchers reassess negative pressure wound therapy as its benefit and harm remain unclear
September 25, 2018 - Older adults with ‘fall plan of care’ less likely to suffer fall-related hospitalizations
September 25, 2018 - FDA lifts partial clinical hold that paused enrollment of new patients in tazemetosta clinical trials
September 25, 2018 - IME Medical Electrospinning establishes state-of-the-art manufacturing lab facilities
September 25, 2018 - Phase 1 and 2 clinical trials of entrectinib drug in ROS1-positive NSCLC show promising results
September 25, 2018 - How to Protect Your Eyesight
September 25, 2018 - Novel approach allows researchers to define how cells in the retina respond to diabetes
September 25, 2018 - Columbia University announces winners of 2018 Louisa Gross Horwitz Prize
September 25, 2018 - New model enables anyone to run powerful simulations, complex calculations easily
Shorter courses of radiation effective for treatment of slow-growing skin cancers

Shorter courses of radiation effective for treatment of slow-growing skin cancers

image_pdfDownload PDFimage_print

A recent Penn State College of Medicine physician’s study review suggests that shorter courses of radiation are preferable to longer ones for older patients receiving treatment for slow-growing skin cancers.

Skin basal and squamous cell cancers are common among patients over 60 years old and are rarely fatal. These cancers-;which look like moles, freckles or skin tags-;can be removed surgically but in some cases radiation therapy is preferred. Doctors often recommend radiation when these cancers appear in areas such as near the eyes, ears, nose or lips, or in patients on blood thinners or with other health problems that rule out surgery.

Radiation therapy for these skin cancers is delivered in a series of treatments over anywhere from one to six weeks. Shorter-course therapy requires larger doses per treatment, which are expected to cause more damage to the skin that appears years later. Yet, no large study has actually compared the results of different-length courses of radiation therapy for these cancers.

To reduce the risk of long-term damage, the standard approach has been small, daily doses over the course of weeks. But this drawn-out therapy can be costly and is inconvenient, especially for elderly patients who may have transportation or mobility issues.

“The way I think of radiation is it’s like building a brick wall,” said study co-lead author Dr. Nicholas G. Zaorsky, a radiation oncologist and assistant professor of radiation oncology at Penn State College of Medicine. “We know how big the wall has to be to kill the cancer cells, but the question is how big do we make the bricks? Historically, we’ve made the bricks tiny-;so if it’s over six weeks, five days a week, it’s about 30 treatments. We could also make the bricks bigger and get the treatment done faster. The problem for skin cancer is we don’t know how big we can make the bricks and still deliver a safe treatment, where the cosmetic result is good.”

In a new systematic review and meta-analysis, Zaorsky and colleagues looked at 21 international studies of radiation treatment for slow-growing skin cancers published between 1986 and 2016. The studies included almost 10,000 patients aged 62 to 84 years old who were followed up for anywhere from a year to more than six years after their therapy ended.

The researchers found no difference in long-term cosmetic outcomes between shorter- and longer-course therapies. About 80 percent of patients receiving high-dose, short-course therapies had good cosmetic results, similar to longer-course treatments with smaller radiation doses. The most common types of long-term skin damage reported across the studies were discoloration and the appearance of spider veins. Skin cancer recurrence at the same site was rare among all the regimens, and there were no deaths related to the treatments.

Based on this, the researchers recommend short courses of five, seven or 15 treatments-;all adding up to around the same amount of total radiation exposure-;for patients over 70 years old, especially if they have trouble traveling for treatments. Younger patients who are 60-70 years old can also consider these regimens, but they may live to see more skin damage from the treatments.

The meta-analysis was recently published in the journal Radiotherapy and Oncology.

“The takeaway is that most elderly patients, and most patients with skin cancer, can get a short course of radiation-;just a few treatments-;instead of coming in for radiation almost every day for six weeks, and the cosmetic result will be just as good,” Zaorsky said.

Source:

Short-course radiation treatment is safe and effective for skin cancer

Tagged with:

About author

Related Articles