Breaking News
October 21, 2018 - Report reveals growing impact of cannabis on young people
October 21, 2018 - NSF awards $5 million grant to help scientists magnify societal impact of research
October 21, 2018 - Fertility Rates Down for Each Urbanization Level 2007 to 2017
October 21, 2018 - Genetically engineered 3-D human muscle transplant in a murine model
October 21, 2018 - Moms’ tight work schedules may affect their children’s sleep
October 21, 2018 - AHA: No Direct Link Between Preeclampsia and Cognitive Impairment, Study Finds
October 21, 2018 - Weight loss success linked with active self-control regions of the brain
October 21, 2018 - Scripps researchers successfully test potential new smoking-cessation treatment in rodents
October 21, 2018 - More accurate and less stressful way to measure a baby’s heartbeat
October 21, 2018 - Researchers show better cardiorespiratory fitness leads to longer life
October 21, 2018 - Healthy candies for diabetic patients
October 21, 2018 - Environment impact of microplastics remains unclear
October 21, 2018 - Antibiotics for appendicitis? Surgery often not needed
October 21, 2018 - AHA and AMA recognize more than 800 medical practices, health systems for blood pressure control
October 21, 2018 - Scientists obtain clearest ever image of Ebola virus protein
October 21, 2018 - Study reveals connection between two proteins known to be hyperactive in cancer
October 21, 2018 - Gabapentin Beats Pregabalin for Chronic Sciatica
October 21, 2018 - Cosmetic surgeons offering incomplete information for breast augmentation customers
October 21, 2018 - Chronic sleep disruption in early adult life accelerates AD-related tau pathology
October 21, 2018 - Take 10 for Mindfulness – Drugs.com MedNews
October 21, 2018 - Length of breathing disruption in OSA may be better predictor of mortality risk
October 21, 2018 - ApoE4 gene linked with chronic inflammation increases risk for Alzheimer’s disease
October 21, 2018 - Mother-daughter conflict associated with suicide risk in abused adolescent girls
October 21, 2018 - Scientists molding bacteria into unnatural shapes
October 21, 2018 - High diet quality associated with lower risk of death in colorectal cancer patients
October 21, 2018 - Discharged mental health patients ‘at greater risk of dying’
October 21, 2018 - Research provides insight into neurobiology of aggression and bullying
October 21, 2018 - As billions in tax dollars flow to private Medicaid plans, Who’s minding the store?
October 21, 2018 - Neuroscientists identify brain region that appears to be related to food preference decisions
October 21, 2018 - Deaths related to air pollution in the U.S. decreased by 47% between 1990 and 2010
October 21, 2018 - Study shows correlation between spatial memory and the sense of smell
October 21, 2018 - Increased cardiorespiratory fitness associated with reduced long-term mortality
October 21, 2018 - IU researchers receive $1.55 million from NIH to improve chronic-disease management
October 21, 2018 - Income and wealth affect the mental health of Australians, study shows
October 21, 2018 - Patients with hypertension and psoriasis more often require cardiovascular interventions
October 20, 2018 - Leading hip-hop videos depict use of tobacco and marijuana products, study finds
October 20, 2018 - Dose Range of IV Ketamine for Adjunct Tx of Depression Tested
October 20, 2018 - Infants can distinguish between leaders and bullies, study finds
October 20, 2018 - Mad Cow disease found on Aberdeenshire farm
October 20, 2018 - Study identifies factors associated with prescription opioid misuse among students
October 20, 2018 - Scientists uncover key regulator of mTORC1 in cancer growth
October 20, 2018 - Pounds Regained After Weight-Loss Op Can Tell Your Doc a Lot
October 20, 2018 - Sending parents letters to fight childhood obesity doesn’t work
October 20, 2018 - Supervised aerobic exercise can support major depression treatment
October 20, 2018 - Mindfulness-based program effective for reducing stress in infertile women
October 20, 2018 - Molecule capable of halting and reverting neurodegeneration caused by Parkinson’s disease identified
October 20, 2018 - Midazolam-mediated alterations of PER2 expression may have functional consequences during myocardial ischemia
October 20, 2018 - Sweat bees are ideal for studying the genes underlying social behavior
October 20, 2018 - Weight loss success associated with brain areas involved in self-control
October 20, 2018 - KHN’s ‘What the Health?’ Republicans’ preexisting political problem
October 20, 2018 - Research provides a more complete picture of suffering caused by terrorist attacks
October 20, 2018 - Eradicating Helicobacter pylori infections may be a key treatment for Parkinson’s disease
October 20, 2018 - Breast Cancer as a Dynamic Disease
October 20, 2018 - University of Pittsburgh wins NSF grant for big data research to prevent complications from anesthesia
October 20, 2018 - Skin-to-skin contact may promote attachment between parents and preterm infants
October 20, 2018 - Recommendations Developed to Verify NGT Placement in Children
October 20, 2018 - Weight loss can be boosted fivefold thanks to novel mental imagery technique
October 20, 2018 - Children with autism are more likely to be overweight, obese
October 20, 2018 - Nurses making conscientious objections to ethically-relevant policies lack support
October 20, 2018 - Prion strain diversity may be greater than previously thought
October 20, 2018 - Antidepressant treatment may lead to improvements in sleep quality of patients with depression
October 20, 2018 - Study reports increased risk of death in children with inflammatory bowel disease
October 20, 2018 - Number of Autism Genes Now Tops 100
October 20, 2018 - Total diet replacement programmes are effective for treating obesity
October 20, 2018 - CLARIOstar used for fluorescence measurements on CSIRO’s purpose-built research vessel
October 20, 2018 - People with more copies of AMY1 gene digest starchy carbohydrates faster
October 20, 2018 - Case Comprehensive Cancer Center wins NIH grant to study health disparities
October 20, 2018 - Newly discovered compound shows potential for treating Parkinson’s disease
October 20, 2018 - High rate of non-adherence to hormonal therapy found among premenopausal early breast cancer patients
October 20, 2018 - Immunotherapy medicine found to be effective in treating uveitis
October 20, 2018 - The Pistoia Alliance Calls for Greater Collaboration to Realise Benefits of Innovation and Announces Winners of the 2018 President’s Startup Challenge
October 20, 2018 - Female internists consistently earn less than men
October 20, 2018 - Stanford team looks at dangers of teens’ vaping habits
October 20, 2018 - New approach to understanding cancers will accelerate development of better treatments
October 20, 2018 - LJI and UC San Diego awarded $ 4.5 million as part of NCI’s Cancer Moonshot initiative
October 20, 2018 - School-based HPV vaccination did not increase risky sexual behaviors among adolescent girls
October 20, 2018 - Eye discovery to pave way for more successful corneal transplants
October 20, 2018 - New analysis examines the importance of location in the opioid crisis
October 20, 2018 - Green filters increase reading speed for children with dyslexia
October 19, 2018 - Bariatric Sx Cuts Macrovascular Complications in Obesity, T2DM
Experimental therapy may enhance recovery for stroke patients

Experimental therapy may enhance recovery for stroke patients

image_pdfDownload PDFimage_print

An experimental therapy being tested by University of Alberta scientists that targets the spinal cord may one day be key to spurring on enhanced recovery for stroke victims.

By injecting a drug called chondroitinase ABC (ChABC) into the spinal cord of rats 28 days after they suffered a stroke, researchers found they were able to enhance recovery by inducing amplified rewiring of circuits connecting the brain to the spinal cord. When they also combined the spinal therapy with rehabilitative training, recovery amplified further.

“This gives us real evidence that there are things we can do for people with a permanent physical disability–such as paralysis or having difficulty controlling movements–after a stroke,” said Ian Winship, an associate professor of psychiatry at the U of A. “There is hope that eventually we might have a therapy that can help somebody with a deficit that is really affecting their quality of life, even years after the stroke.”

“These are deficits that previously have been thought to be untreatable and people just learned to live with them,” added Anna Wiersma, lead author of the study and a recent PhD graduate at the U of A’s Neuroscience and Mental Health Institute. “The fact that these might not actually be untreatable and that we have an opportunity to help patients who are in the chronic stages of stroke is really exciting.”

Stroke is the most common cause of adult disability in Canada. Currently more than 400,000 Canadians are living with the effects of stroke. The typical path of recovery involves intensive rehabilitation therapy. In the first few weeks following a stroke, patients experience gains as the brain rewires itself, but they will eventually plateau and rarely regain full capacity–even with ongoing rehabilitation.

In the study, the scientists explored the impact of injecting ChABC into the spinal cord. The drug acts on components that surround the cells of the nervous system and prevent growth of new connections. It also removed the inhibition of growth, allowing for new connections between the unaffected motor areas in the brain and the spinal networks that control movement.

The researchers found that injecting ChABC a month after suffering a stroke and without rehabilitative training led to moderate improvements of sensorimotor deficits. When combining both spinal therapy and rehabilitative therapy, they found that their subjects recovered better and were able to perform some sensorimotor tasks at pre-stroke levels.

“The idea here is there is still something we can potentially do for people that would give them a second wave of recovery,” said Winship. “That’s pretty exciting because (rehabilitation efforts) have a ceiling effect. You can only achieve so much recovery. This drug could remove that ceiling.”

The researchers acknowledge there are barriers to overcome before the work could be tested and applied in humans. The major drawback is that injected ChABC only extends a small distance and acts for a finite period of time–both of which would be challenging in a human spinal cord, which is much larger than that of a rat. Time of recovery in a human is also much longer, meaning multiple injections would likely be needed, increasing the risk of infection or injury.

Winship and Wiersma speculate one solution may be to introduce the drug through another way than through injection. They believe using a viral vector could make cells genetically express ChABC instead of having it injected directly. The solution would allow for longer-lasting expression and greater spread within the spinal cord.

“The potential is there but at this point we need a lot more evidence that this is going to be something that is truly effective,” said Winship. “This approach is still a long way from the clinic, but this gives us real evidence that there are things we can do for people with permanent disability after a stroke.”

Source:

https://www.ualberta.ca/medicine/

Tagged with:

About author

Related Articles