Breaking News
April 22, 2018 - AYOXXA to develop multiplex immunoassay to support treatment of sepsis patients
April 22, 2018 - New Drug Combo Ups Survival in HER2/neu Uterine Serous Cancer
April 22, 2018 - Researchers chart a new way to look at concussion
April 22, 2018 - Every parent needs to know fundamental red flags for autism
April 22, 2018 - Anatotemp expands anatomic dental implant healing abutments with 4Side anti-rotational connection
April 22, 2018 - Gene Twist Can Make Your Blood Pressure Spike From Salt
April 22, 2018 - Study suggests failed osteoarthritis drug could help treat opioid addiction
April 22, 2018 - More Americans aware of growing problem of opioid addiction
April 22, 2018 - KHN’s ‘What the Health?’ Nothing in health care ever goes away
April 22, 2018 - BGS to promote high-quality sterilization services at Health GB in Manchester
April 22, 2018 - New integrated POC tool detects biomarkers of heart failure rapidly and precisely
April 22, 2018 - Direct electrical current can be delivered to nerves for blocking pain signals
April 22, 2018 - Newly Published Phase 2 Study Found Esketamine Demonstrated Significantly Rapid Improvements in Depressive Symptoms and Suicidality
April 22, 2018 - Healthy red blood cells owe their shape to muscle-like structures
April 22, 2018 - Researchers present case study of management of rheumatic mitral regurgitation in woman contemplating pregnancy
April 22, 2018 - New black Porvair Krystal UV Quartz microplates for Circular Dichroism measurements
April 22, 2018 - Advanced flow chemistry modules enhance control of nanoprecipitation
April 22, 2018 - Look! Down in the petri dish! It’s a superplatelet!
April 22, 2018 - Research reveals why people with tetraplegia more likely to suffer from sleep apnea
April 21, 2018 - New non-invasive nerve stimulation may offer relief for people with hand tremor
April 21, 2018 - Smartphone App May Up Medication Adherence in HTN
April 21, 2018 - Western diet depletes artery-protecting immune cells
April 21, 2018 - Excelitas Technologies launches new powerful LED light source for fluorescence microscopy
April 21, 2018 - Academia and high tech companies join forces to increase production capacity for microfluidic systems
April 21, 2018 - Developing cooking skills as young adult may have long-term health benefits
April 21, 2018 - Study compares survival outcomes of different drugs for type 2 diabetes
April 21, 2018 - More Than 40 Percent of Americans Breathe Dirty Air: Report
April 21, 2018 - Obstructive sleep apnea – Genetics Home Reference
April 21, 2018 - More evidence shows exposure to traffic and outdoor air pollution increases risk of asthma
April 21, 2018 - Novel gold nanoparticle technology could guide cancer treatment in real-time
April 21, 2018 - News coverage of Ebola impacted public’s perception on disease and survivors
April 21, 2018 - S.Africa’s DIY battle against HIV
April 21, 2018 - Children with autism have gastrointestinal and immune system deregulation, research finds
April 21, 2018 - Human brain processes sight and sound in the same way, shows study
April 21, 2018 - Evolutionary history of tumor helps predict severity of prostate cancer
April 21, 2018 - Pepper plant metabolizes antibiotic in personal care products
April 21, 2018 - Tradeshow Talks with Integra
April 21, 2018 - EPFL becomes part of Chan Zuckerberg’s project to develop Human Cell Atlas
April 21, 2018 - Pfizer Announces Positive Topline Results From Phase 3 ATTR-ACT Study Of Tafamidis In Patients With Transthyretin Cardiomyopathy
April 21, 2018 - Breaking through the HIV vaccine ‘logjam’
April 21, 2018 - IntelliCyt introduces new QSol buffer to enable robust, consistent sampling
April 21, 2018 - Scientists publish comprehensive lineage tree of whole adult animal in Science journal
April 21, 2018 - Innovative method based on FluidFM technology could revolutionize biological research
April 21, 2018 - Americans world’s biggest TV addicts, watching four hours a day
April 21, 2018 - Investigational drug may help increase protein levels in babies with spinal muscular atrophy
April 21, 2018 - Study shows distinctions between age groups in predicting and responding to stress at home
April 21, 2018 - Aziyo Biologics, BIOTRONIK enter into US co-distribution agreement
April 21, 2018 - Opiate Use Linked to Early Mortality in IBD Patients
April 21, 2018 - Online ads help pregnant smokers quit
April 21, 2018 - Opioid pain medications may not be safe for hemodialysis patients
April 21, 2018 - Rare variants in non-coding DNA inherited from parents heighten autism risk
April 21, 2018 - A needleless glucose monitor for diabetes patients
April 21, 2018 - BD introduces new informatics and automation solutions for clinical laboratories
April 21, 2018 - Turn Chores Into a Fitness Routine
April 21, 2018 - DNA methylation plays key role in stem cell differentiation
April 21, 2018 - Scientists find link between soil metals and cancer mortality
April 21, 2018 - Experts discuss implications of low calcium intake in global population
April 21, 2018 - GNA Biosolutions to display Pharos V8 Laser PCR instrument at Analytica trade fair
April 21, 2018 - People with vitamin D deficiency may be at greater risk of diabetes
April 21, 2018 - Study findings could open new possibilities for treating cancer with adenovirus
April 21, 2018 - People who use medical marijuana have higher rates of prescription drug use, study finds
April 21, 2018 - Study debunks ‘myth’ that strenuous exercise dampens immunity
April 21, 2018 - FDA approves marijuana based medication for epilepsy treatment
April 21, 2018 - Researchers find novel genes for longevity in mammals
April 21, 2018 - GNA Biosolutions and project partners launch new research project to develop TB diagnostic platform for POC applications
April 21, 2018 - $2 million funding boosts progress of UAB biomedical startup
April 21, 2018 - Scientists identify gene responsible for evolution of recombination rates
April 21, 2018 - UConn researchers develop new composite for healing broken load-bearing bones
April 21, 2018 - Study examines how higher-order gene combinations help maintain normal cell physiology
April 21, 2018 - Study challenges use of whole-brain radiation for small-cell lung cancer patients with brain metastases
April 21, 2018 - Researchers discover blood biomarkers that may help detect, confirm mild traumatic brain injury
April 21, 2018 - People who become physically active after heart attack more likely to live longer, shows research
April 21, 2018 - CPRIT awards $2 million grant to push forward breast cancer research in West Texas
April 21, 2018 - Unhealthy diet damages the development of immature fat cells, study shows
April 21, 2018 - Consumption of protein supplements with meals may provide better weight control
April 21, 2018 - 4 Types of Foods to Help Boost Your Memory
April 21, 2018 - How did gonorrhea become a drug-resistant superbug?
April 21, 2018 - DePuy Synthes announces clinical results related to use of CORAIL Hip System Femoral Stems
April 21, 2018 - New initiative launched to support goals of Human Cell Atlas
April 20, 2018 - Teen patient gets a new lease on life
FDA warning against Kratom strengthened

FDA warning against Kratom strengthened

image_pdfDownload PDFimage_print

Dr Ananya Mandal, MD

The U.S. Food and Drug Administration (FDA) has amped up its warnings against popular herbal drug kratom. The new warning mentions the deadly risks associated with kratom including a case of a teenager who hanged himself under influence.

Mitragyna speciosa,mitragyna speciosa korth (kratom) a drug from plant to a category 5 in Thailand. Image Credit: sarintra chimphoolsuk / Shutterstock

Mitragyna speciosa,mitragyna speciosa korth (kratom) a drug from plant to a category 5 in Thailand. Image Credit: sarintra chimphoolsuk / Shutterstock

The new warning statement issued by the FDA states that the effects of this herbal concoction is yet to be understood clearly. The effects of kratom in the cases of fatalities are being investigated to see the extent of damage this drug can cause.

FDA Commissioner Scott Gottlieb, in a press release this Tuesday (6th of February 2018), said that this was a reinforcement of an earlier health advisory that was released last November. The earlier advisory stated that there was “clear data on the increasing harms associated” with kratom. This was because of the 36 deaths associated with kratom at the time. In this new statement Gottlieb said that the present death count is up to 44 deaths. He explained that the FDA has classified the substance as an opioid and this would require further “scientific analysis”. He said, “This new data adds to our body of substantial scientific evidence supporting our concerns about the safety and abuse potential of kratom… As the scientific data and adverse event reports have clearly revealed, compounds in kratom make it so it isn’t just a plant — it’s an opioid.”

Kratom is derived from a plant that grows in South east Asia. It is related to coffee and the leaves are used to make the drug. It is available at online portals and websites in the form of powder packaged within capsules or as tea. Kratom can act as a mood enhancer or as a sedative. Its effects as a stimulant or a sedative depend on the variety of the plant or on the dosage taken. It has been claimed to treat long term pain, depression and anxiety disorders effectively. It has also been used by heroin abusers who wish to step down from their addiction. It is being touted as a “non-opioid” alternative to traditional opioids. However, being an unregulated drug available for use and made by multiple manufacturers in a non-standardized manner, the quality of the drug is not assured as it its dosage, composition and packaging. This may lead to adulteration and overdosage on self-medication, says the FDA. The FDA warns that as of now the claims in favour of kratom have not been verified scientifically and the potential harms are known.

Gottlieb added in his statement that kraton has a potential for “abuse, addiction, and serious health consequences; including death.” The 36 death reports earlier, he said were reported in academic research, adverse event reports from Accident and Emergency Departments and from the reports of the Medical Examiners. Reports of the eight new cases are also to be rel;eased shortly, he said. These victims were all on multiple substances at the time of death he said. These were all illicit and harmful drugs. The teenager who hanged himself for example tested positive for kratom, alcohol and several other prescription drugs. Another person who feel out of a window under influence showed high blood levels of mitragynine. This is the main psychoactive substance that is present in kratom. Another middle aged man who died of overdose, was found to have opioids, benzodiazepines as well as kratom in his blood. Only one of the deaths was due to kratom alone states the FDA. Gottlieb said that this case was being investigated and also that it was not an absolute proof that kratom could be causing these deaths alone.

“Many of the cases received could not be fully assessed because of limited information provided,” Gottleib said, adding, “a few cases raise concern that kratom is being used in combination with other drugs.” “Cases of mixing kratom, other opioids, and other types of medication is extremely troubling because the activity of kratom at opioid receptors indicates there may be similar risks of combining kratom with certain drugs, just as there are with FDA-approved opioids,” Gottlieb said.

After this statement, kratom could be facing a ban under federal law say experts. FDA sent the Drug Enforcement Administration (DEA) an “8 factor analysis” to place the drug under a schedule and reduce its free availability and increase user awareness.

Tagged with:

About author

Related Articles