Breaking News
March 20, 2018 - New mutation linked to ovarian cancer can be passed down through dad
March 20, 2018 - Scotland study aims to offer precise diagnoses for people with rare genetic diseases
March 20, 2018 - Stem cell treatment may help rejuvenate ovaries, avoid effects of premature menopause
March 20, 2018 - FDA Approves Hizentra (Immune Globulin Subcutaneous [Human] 20% Liquid) for the Treatment of Patients With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)
March 20, 2018 - Death Strikes Young in RA
March 20, 2018 - Quiescent cells also mutate
March 20, 2018 - Stem cell-derived ocular cells treat severe AMD
March 20, 2018 - Mediterranean diet appears to be good for postmenopausal women’s bones and muscles
March 20, 2018 - Scientists discover rare childhood liver cancer’s ability to metastasize to the brain
March 20, 2018 - Treating metastatic breast cancer with immunotherapy
March 20, 2018 - The 5:2 diet could have beneficial impact on important risk markers for cardiovascular disease
March 20, 2018 - Congress tackles the opioid epidemic. But how much will it help?
March 20, 2018 - Neanderthals Just Part of the Evolutionary Puzzle
March 20, 2018 - Higher Mortality With Surgery for Early NSCLC
March 20, 2018 - Researchers go skin deep to explore what causes wrinkles
March 20, 2018 - E-cigarette use linked to fat accumulation in the liver
March 20, 2018 - Fearful worms provide new clues about human anxiety
March 20, 2018 - Oral micronized progesterone may reduce hot flashes, night sweats in perimenopausal women
March 20, 2018 - Newer treatment for type 2 diabetes reduces liver fat in patients with NAFLD
March 20, 2018 - I.D. Break: PrEP Map; Faulty Flu Meds; Better Zika Test?
March 20, 2018 - Bronchial thermoplasty can improve severe asthmatic cough
March 19, 2018 - Speeding up wound healing using nanofiber dressings
March 19, 2018 - Summit Announces New Analysis Showing Ezutromid Significantly Reduced Muscle Inflammation in Phase 2 Clinical Trial in DMD
March 19, 2018 - Optimizing Sham Acupuncture: That’s Improbable!
March 19, 2018 - Women who have gestational diabetes in pregnancy are at higher risk of future health issues
March 19, 2018 - Viagra cuts colorectal cancer risk in animal model
March 19, 2018 - Vitamin B12 supplementation could postpone disease progression in Parkinson’s patients
March 19, 2018 - Study shows that omega-6 fatty acids could protect against premature death
March 19, 2018 - TherapeuticsMD Announces FDA Acceptance of New Drug Application (NDA) and Prescription Drug User Fee Act (PDUFA) Date for TX-001HR
March 19, 2018 - Minorities More Sensitive To Pain? Pain Medicine News Report
March 19, 2018 - Low blood sugar poses unaddressed threat to people with type 2 diabetes
March 19, 2018 - ACEA goes live with exhaustive, searchable library of NovoCyte publications
March 19, 2018 - Consumption of low-calorie sweeteners could promote metabolic syndrome, increase diabetes risk
March 19, 2018 - Wearable medical patch shows promise for early detection of hypoglycemia in type 1 diabetes
March 19, 2018 - High-energy breakfast leads to better diabetes control and weight loss
March 19, 2018 - D.C. Week: Community Health Centers Get Azar’s Love
March 19, 2018 - Younger siblings of SIDS victims have four-fold increased risk of sudden death
March 19, 2018 - Toothpaste alone does not prevent dental erosion or hypersensitivity
March 19, 2018 - Discovery aids understanding of amyotrophic lateral sclerosis
March 19, 2018 - Hormone imbalance may be reason for higher diabetes rates among men with insufficient sleep
March 19, 2018 - Docs worry there’s ‘nowhere to send’ new and expectant moms with depression
March 19, 2018 - Obesity linked to increased DNA damage in breast epithelium of BRCA mutation carriers
March 19, 2018 - Heart rate increases with higher alcohol consumption
March 19, 2018 - Template produced for clinically validated DIY stethoscope
March 19, 2018 - Experts highlight nocturia as most common cause of poor night’s sleep
March 19, 2018 - Fit Middle-Aged Women May Fend Off Dementia Later
March 19, 2018 - Fake Insta Doc; Humana’s Weird Pay Bump Tax Trick; Few NPDB Searches
March 19, 2018 - Guidelines for fluoride intake—are they appropriate?
March 19, 2018 - Race and pre-pregnancy BMI may be key predictors of maternal weight gain
March 19, 2018 - Telediabetes program improves blood sugar control for veterans
March 19, 2018 - Research suggests breastfeeding as protective factor against obesity in high-birthweight infants
March 19, 2018 - Morning Break: House Nixes ‘Right-to-Try’ Bill; Purdue’s PR Makeover; Air in the Brain
March 19, 2018 - Heart researchers develop a new, promising imaging technique for cardiac arrhythmias
March 19, 2018 - Mice study shows how BPA exposure during pregnancy can lead to altered brain development
March 19, 2018 - Breastfeeding mothers who overeat may increase risk of health problems in offspring
March 19, 2018 - New mobile application can detect atrial fibrillation that causes strokes
March 19, 2018 - Study finds low rates of preconception counseling among women of childbearing age with diabetes
March 19, 2018 - Vitl Life Science Solutions announces launch of new Lu-mini at analytica 2018
March 19, 2018 - ObsEva SA Reports Positive Topline Results from IMPLANT2 Phase 3 Clinical Trial of Nolasiban in IVF
March 19, 2018 - D.C. Week: States Plead for Federal $$ in Opioid Fight
March 19, 2018 - Polycystic ovary syndrome – Genetics Home Reference
March 19, 2018 - Reducing co-payments improves patient, physician adherence to guideline-recommended treatment post-MI
March 19, 2018 - Normalizing estrogen levels can benefit female athletes with irregular menstrual periods
March 19, 2018 - Fitness trackers and virtual coaches motivate patients to exercise post cardiac rehab
March 19, 2018 - Atrial fibrillation patients could reduce risk of dementia by taking stroke prevention drugs
March 19, 2018 - Low sperm count more prevalent with other health problems finds study
March 19, 2018 - Male birth control pill taken once a day shows success
March 19, 2018 - AcelRx Announces Receipt of Type A FDA Meeting Minutes and Plans to Resubmit the DSUVIA New Drug Application in Q2 2018
March 19, 2018 - Eye Docs Adopt EHRs Despite Reservations
March 19, 2018 - CRISPR enhances cancer immunotherapy
March 19, 2018 - Study finds first evidence of delayed aging among Americans
March 19, 2018 - Aussies unaware of sun protection rules to prevent skin cancer
March 19, 2018 - Essential oils linked to abnormal breast development in boys
March 19, 2018 - ‘Tummy Tuck’ Relieved Postpartum Back Pain/Incontinence
March 19, 2018 - New biomarkers for neuroblastoma, a type of cancer in children
March 19, 2018 - Hookah Smoking Carries a Poisoning Risk
March 19, 2018 - Do Mood and Anxiety Affect MS Disability?
March 19, 2018 - Mean depth of ultrasonographic penetration greater in autism
March 19, 2018 - Platypus milk may help combat antibiotic resistance
March 19, 2018 - U.S. IDE study of THERMOCOOL SMARTTOUCH SF Catheter completes patient enrollment
What Not to Do If You Have Asthma and Want to Get Pregnant

What Not to Do If You Have Asthma and Want to Get Pregnant

image_pdfDownload PDFimage_print

Action Points

  • Nulliparous women with asthma who relied on short-acting beta agonist rescue medications alone while trying to conceive took longer to get pregnant than women without asthma and asthmatic women taking preventive medications, in a large international study.
  • Note that the findings suggest that use of preventive medications may protect against impaired fertility, possibly by reducing systemic inflammation, which increases infiltration of inflammatory cells into the uterine mucosal layer, impairing implantation.

Women with asthma who relied on rescue medications alone while trying to conceive took longer to get pregnant than women without asthma and asthmatic women taking preventive medications, researchers report.

In an analysis of data from the international Screening for Pregnancy Endpoints (SCOPE) study, no significant difference in time to conception was seen among non-asthmatic women and asthmatic women taking inhaled corticosteroids with and without long-acting β-agonists.

But women with asthma using short-acting beta agonist drugs alone took, on average, about 20% longer to conceive and were 30% more likely to take more than a year to get pregnant compared with women without asthma.

Findings from the analysis, published online as a Research Letter in the European Respiratory Journal, suggest that use of preventive medications may protect against impaired fertility, possibly by reducing systemic inflammation, wrote Luke Grzeskowiak, PhD, of the University of Adelaide in Australia, and colleagues.

Grzeskowiak told MedPage Today that the findings should reassure women with asthma who are trying to conceive: “A lot of women have concerns about the safety of asthma medications leading into pregnancy, and many stop taking them. We know that poorly controlled asthma during pregnancy is bad for both the mother and her baby, but we haven’t known much about how it affects fertility.”

Participants in the SCOPE study were healthy, nulliparous women recruited between November 2004 and February 2011 in Auckland (New Zealand), Adelaide (Australia), Cork (Ireland), and Manchester and London (United Kingdom).

Asthma was self-reported, and asthmatic women were further divided by asthma symptoms and asthma medication use. They were also classified as having former asthma (i.e., doctor-diagnosed asthma, no symptoms in the previous 12 months, and no use of asthma medications) or current asthma (doctor-diagnosed asthma, symptoms in the previous 12 months, or use of asthma reliever or prevention medications).

Women with current asthma were further divided according to use of intermittent reliever medications only (i.e., short-acting β-agonists (SABA) or additional use of reliever medications (i.e., inhaled corticosteroids (ICS) with or without long-acting β-agonists (LABA). This resulted in three asthmatic subgroups: former asthma, SABA, and ICS±LABA.

Self-reported time to pregnancy was defined as the duration of having sex (in months) without contraception before pregnancy. Subfertility was defined as time to pregnancy of more than 12 months.

Close to 20% of the 5,617 study participants reported doctor-diagnosed asthma, and 656 (11.75) were identified as current asthmatics.

Among the main study findings:

  • Compared with non-asthmatics, current asthmatics managed with SABAs had adjusted fecundity odds radios (FORs) that were 15% lower (0.85, 95% CI, 0.75-0.96); no difference was observed for former asthmatics or current asthmatics using ICS+LABA
  • Point estimates for subfertility were increased among women using SABAs (adjusted OR, 1.30, 95% CI 0.93-1.81), but not for women with previous asthma or current asthma using ICS+LABAs
  • Women with asthma who conceived using assisted reproductive technologies also showed delayed fertility if they took SABAs alone

The researchers noted that while the exact mechanism that may drive asthma’s impact on fertility remains unknown, “it has been hypothesized that asthma reduces uterine blood supply or increases infiltration of inflammatory cells into the decidua (the uterine mucosal layer), which impairs implantation.”

In a 2015 study of Danish women undergoing infertility treatment, asthmatic women showed reduced vascular endothelial growth factor in uterine endometrial secretion, compared with non-asthmatic women. The researchers speculated that this could affect endometrium receptiveness, thereby increasing the time to conception.

A strength of the study, the researchers said, was its large size, with a relatively large number of women with asthma. Limitations cited included the self-reported nature of asthma and medication use during a single time point (15 weeks gestation), and the absence of data on asthma control and lung function during pregnancy. In addition, the recruitment of only nulliparous women makes generalizability of the findings to multiparous women uncertain.

The researchers reported having no relevant relationships with industry related to the study.


Tagged with:

About author

Related Articles