Breaking News
September 22, 2018 - Finding epigenetic signature appears to predict inflammation risk in serious type of IBD
September 22, 2018 - Researchers develop light-based technique to measure very weak magnetic fields
September 22, 2018 - UAB researchers study dysfunction of the immune system associated with NSAID carprofen
September 22, 2018 - QIAGEN and DiaSorin launch automated, CE-marked workflow for high-throughput TB screening
September 22, 2018 - Cardiac MR With Contrast Feasible in Developing World
September 22, 2018 - Daily low-dose aspirin doesn’t reduce heart-attack risk in healthy people
September 21, 2018 - Children with asthma found to be disadvantaged in education and future occupation
September 21, 2018 - Interaction of chemical slurry and ancient shale in fracking wastewater causes radioactivity
September 21, 2018 - Researchers find that sample size is key factor determining accuracy of study results
September 21, 2018 - Study shows how the drive to eat overpowers the brain’s signal to stop
September 21, 2018 - 30 Million Americans Now Have Diabetes
September 21, 2018 - Thousands of breast cancer gene variants engineered and analyzed
September 21, 2018 - The current fellowship interview process is cumbersome — Stanford researchers have a better idea
September 21, 2018 - Progenitor cells for human bone and cartilage have been identified
September 21, 2018 - Study reveals new therapeutic target for pediatric tumor-associated intractable epilepsy
September 21, 2018 - SLU’s College professor receives NIH grant to develop I-TEST project
September 21, 2018 - DermTech completes enrollment in clinical study to assess DNA damage and reversal
September 21, 2018 - Grieving patients treated with talk therapy have lower risk of suicide and psychiatric illness
September 21, 2018 - NIH and FDA call for eliminating involvement of RAC in human gene therapy experiments
September 21, 2018 - New system uses algorithm to convert 2D videos into 3D printed ‘motion sculptures’
September 21, 2018 - Sea squirt model reveals key molecules in dopaminergic neuron differentiation
September 21, 2018 - Effective management of neonatal abstinence syndrome requires coordinated ‘cascade of care’
September 21, 2018 - Refugees seek care for wounds of war
September 21, 2018 - Under the sea, in an octopus’ garden on ecstacy
September 21, 2018 - Eating foods with low nutritional quality ratings linked to cancer risk in large European cohort
September 21, 2018 - Giving kids honest information about water consumption may help them make healthy choices
September 21, 2018 - Horwitz Prize Awarded for Work on Hormones
September 21, 2018 - CHMP issues positive opinion supporting use of Trelegy Ellipta in broader group of COPD patients
September 21, 2018 - Scientists discover new molecules that work together to remove unwanted DNA
September 21, 2018 - Dr. Fenella France to deliver 2019 Plenary Lecture
September 21, 2018 - New research finds that MHC-II molecules have more influence on tumors than MHC-I
September 21, 2018 - Researchers study effects of cardiac cycle in simple learning task
September 21, 2018 - FDA takes new steps to address opioid crisis by approving Opioid Analgesic Risk Evaluation and Mitigation Strategy
September 21, 2018 - Positive Barhemsys Phase 3 Treatment Data Published in Anesthesia & Analgesia
September 21, 2018 - Celiac Disease Screening: MedlinePlus Lab Test Information
September 21, 2018 - Autism linked to egg cells’ difficulty creating large proteins
September 21, 2018 - Tweaking nuclear pores could provide new avenue to battle against cancer
September 21, 2018 - Experts warn health care providers to slow down in allowing smart pill in patient care settings
September 21, 2018 - MoreGrasp reports breakthrough development of grasp neuroprosthetics activated by thought control
September 21, 2018 - Study reveals new way to target HER2-negative metastatic breast cancer
September 21, 2018 - CHMP grants positive opinion for VENCLYXTO plus rituximab for treating relapsed/refractory CLL
September 21, 2018 - Study offers solid link between visceral organs and brain’s reward, motivation system
September 21, 2018 - First U.S. patient treated with innovative gene therapy at Bascom Palmer Eye Institute
September 21, 2018 - New study shows how Ethiopia has managed to achieve extraordinary progress
September 21, 2018 - Choroidal Detachment – The American Society of Retina Specialists
September 21, 2018 - New clinical trial evaluates aesthetic results of conservative surgery in breast cancer
September 21, 2018 - Discovery of a key protein involved in the development of autism
September 21, 2018 - Air pollution appears to be linked to increased risk of developing dementia
September 21, 2018 - Henry Ford Health System receives $600k grant to study genetic makeup of gliomas
September 21, 2018 - Arthritis common in individuals with varying degrees of depression, finds study
September 21, 2018 - Scientist intends to fight pathogenic bacteria with viruses
September 21, 2018 - New research suggests link between PFAS chemicals and hyperthyroidism in pet cats
September 21, 2018 - Multi-year study data shows impact of new soft contact lens to slow myopia progression in children
September 21, 2018 - Neuroscientists identify circuit for brain’s statistical inference about motion
September 21, 2018 - MILabs’ VECTor6 system wins Commercial Innovation Award at WMIC 2018
September 21, 2018 - Scientists find wild African monkeys infected with bacterium that causes syphilis, yaws in humans
September 21, 2018 - 2006 to 2015 Saw Increase in Severe Maternal Morbidity
September 21, 2018 - Similar changes in the brains of patients with ADHD and emotional instability
September 21, 2018 - Cobalt mining in DR Congo takes a high toll on both creuseurs and environment
September 21, 2018 - Eating fatty fish during pregnancy may boost unborn child’s brain development
September 21, 2018 - Study reveals promising new drug candidate to treat acute renal failure
September 21, 2018 - Neural signal that urges to eat overpowers the one that says to stop
September 21, 2018 - Scientists achieve breakthrough in accelerated diagnosis of multi-resistant hospital pathogens
September 21, 2018 - Researchers simulate how different breast tissues respond to heat from MRIs
September 21, 2018 - Despite red flags at surgery centers, overseers award gold seals
September 21, 2018 - Zapping Airway Nerves May Help COPD Patients Breathe
September 21, 2018 - Researchers find answers as to why some people are at risk of gout
September 21, 2018 - Stars of Stanford Medicine: Genetic counseling and compassion
September 21, 2018 - Researchers use reinforcement learning to train gliders to soar like birds
September 21, 2018 - New federally-funded research project could lead to treatments that extend human lifespan
September 21, 2018 - Health insurance ads have shifted over time due to health plans offered via ACA
September 21, 2018 - Use of transcranial electrical stimulation to bolster creativity has far-reaching implications
September 21, 2018 - Scientists find way to boost efficacy of powerful antimalarial drug with anti-cancer medicines
September 21, 2018 - Weighing the risks and benefits of drug tapering—two patients, two perspectives
September 21, 2018 - The “exposome” revealed: a barrage of bacteria, chemicals, microscopic animals and more
September 21, 2018 - Top three immune boosting recommendations to ward off freshers’ flu
September 21, 2018 - Young children’s oral microbiota could serve as early indicator for obesity
September 21, 2018 - Older individuals with multiple sclerosis report higher quality of life than younger counterparts
September 21, 2018 - LineaRx signs agreement with Takis/Evvivax to develop linear-DNA based anti-cancer vaccines
September 21, 2018 - AbbVie Presents Upadacitinib Longer-Term (32-Week) and Patient-Reported Outcomes Data from Phase 2b Atopic Dermatitis Study at 27th European Academy of Dermatology and Venereology (EADV) Congress
SCHILLER provides support for COmPLETE project

SCHILLER provides support for COmPLETE project

image_pdfDownload PDFimage_print

The COmPLETE project (CardiO-PuLmonary Exercise Testing) focuses on cardiopulmonary exercise testing (CPET). The project is carried out at the Medical Faculty of the University of Basel within the Department of Sport, Exercise and Health and the Division of Sports and Exercise Medicine, and it is led by Prof. Dr. med. Arno Schmidt-Trucksäss.

Image: COmPLETE-Projekt

The project consists of three studies: COmPLETE-Health, COmPLETE-Heart and COmPLETE-Lung. It is conducted over a period of three years, with a follow-up after 5 years. Apart from the director, a PhD student, a post-doc researcher, two assistant physicians, a senior physician and six Bachelor and three Master students are participating in the project. SCHILLER supports the study by funding the PhD student and post-doc researcher, and by providing three CARDIOVIT CS-200 Excellence ErgoSpiro.

An overview on the three sub-studies:

COmPLETE-Health

This study examines almost 500 healthy subjects between 20 and 100 years of age. Gender distribution in all age groups is 50/50. Apart from ergo-spirometry, variables such as strength, physical activity or walking pace are collected from these subjects in order to obtain for the first time standard values for the healthy Swiss population regarding various ergo-spiro parameters as well as vascular health and further health markers. Subject recruiting will commence in November 2017.

COmPLETE-Heart and COmPLETE-Lung

The COmPLETE Heart study examines patients suffering from cardiac insufficiency and coronary heart disorders (80 patients each). The study is conducted in close collaboration with the Kantonsspital Liestal, PD Dr. med. Thomas Dieterle, both with regards to the examination as well as the recruitment of patients. For COmPLETE-Lung, the recruitment of 45 patients suffering from chronic-obstructive pulmonary disease (COPD) is planned. Recruitment starts end of 2018, once the recruitment of cardiac patients has been finished.

COmPLETE-Heart and COmPLETE-Lung patients are compared to the healthy subjects with regard to age and gender. This will be possible thanks to the large number of healthy subjects taking part in the study. The broad age range provides the possibility to distinguish between healthy aging and beginning illness.

Aim of the project

Prof. Dr.med. Schmidt-Trucksäss and his team aim at characterizing the transition between health and illness in a significantly improved way, and they want to facilitate the differentiation between being healthy and ill. To do so, they use both the latest and well established ergo-spirometry parameters.

Comparing the COmPLETE-Health, COmPLETE-Heart and COmPLETE-Lung data records aims at detecting variables which filter the differences between a person’s healthy aging and an early stage of cardiac insufficiency or coronary artery disease. The focus lies on submaximal CPET variables and variables of the post-exercise stage. Employing modern computer methods for the analysis of data, so-called Deep Learning or Cluster analysis, is supposed to further increase CPET’s informative value.

Another goal is the improvement and simplification of ergo-spirometry procedures. Thanks to increased user guidance and automatic interpretation, ease of use, result interpretation and diagnosis are significantly improved and facilitated. It is therefore hoped that the group of users is extended considerably. Ergo-spirometry could be pushed as diagnosis and prognosis tool and increasingly be used.

The COmPLETE project is unique, even far beyond the Swiss border. Various ergo-spirometry studies have already been conducted; however, only few have been performed with the desired number of subjects and on a bike ergometer, and even fewer have examined influences such as strength and co-ordination.

Source:

https://www.schiller.ch/us/us/schiller-partner-complete-project

Tagged with:

About author

Related Articles