Breaking News
November 13, 2018 - FDA Approves Keytruda (pembrolizumab) in Combination with Carboplatin and Either Paclitaxel or Nab-Paclitaxel for the First-Line Treatment of Patients with Metastatic Squamous Non-Small Cell Lung Cancer (NSCLC)
November 13, 2018 - Scientists take big step toward finding non-addictive painkiller
November 13, 2018 - Diabetes medication reduces risk of heart failure hospitalization
November 13, 2018 - Achieving high follow-up rates for violently injured patient population is feasible
November 13, 2018 - Shortage of specific gene ‘silencing’ molecules linked with pediatric low-grade gliomas
November 13, 2018 - Abx-Resistant Enterobacteriaceae Tied to Clinical Failure in UTI
November 13, 2018 - US approves first new type of flu drug in 2 decades
November 13, 2018 - Is zinc the link to how we think? Some evidence, and a word of warning
November 13, 2018 - Dispelling taboos, Michelle Obama talks IVF and miscarriage
November 13, 2018 - Medical experts discuss future challenges of healthcare at HSMA’s inaugural conference
November 13, 2018 - Growth and spread of deadly eye tumor suppressed in cells, animals
November 12, 2018 - Study finds huge shortfall in use of home-based medical care by frail seniors
November 12, 2018 - Cocaine Cut With Anti-Worming Drug, Levamisole, May Cause Brain Damage
November 12, 2018 - Obese mice lose a third of their fat using a natural protein
November 12, 2018 - Behind many a Parkinson’s case lurks a mutation in a gene called LRRK2 — why?
November 12, 2018 - Drug with fish oil cuts risk of heart attack, stroke, study finds
November 12, 2018 - Mild exposure to single blast can induce meaningful pathogenic effects, study shows
November 12, 2018 - Miniature pacemakers aim to make heart procedures for infants less invasive, more efficient
November 12, 2018 - Treating pre-cancerous stem cells at early stage could be key to preventing bowel cancer
November 12, 2018 - Kawasaki disease triggered by a combination of factors
November 12, 2018 - Optibrium and University of Nottingham Collaborate on Innovative Teaching Programme
November 12, 2018 - RNA defects linked to multiple myeloma progression in high risk patients
November 12, 2018 - Science is on trial – and we need doctors to provide the defense
November 12, 2018 - Salk researchers receive $19.2 million to unravel mysteries of age-related cognitive decline
November 12, 2018 - KE Eye Centers offer new solution for patients with myopia and astigmatism
November 12, 2018 - Trumpeted new Medicare Advantage benefits will be hard for seniors to find
November 12, 2018 - Biogen and Eisai Announce Presentation of Detailed Analyses from the Phase 1b Long-Term Extension Study of Aducanumab at Clinical Trials on Alzheimer’s Disease (CTAD)
November 12, 2018 - Scientists reveal new cystic fibrosis treatments work best in inflamed airways
November 12, 2018 - Hands-Only CPR training kiosks can teach life-saving skills in just minutes
November 12, 2018 - Inexpensive and effective drug does not reduce major adverse cardiovascular event rates
November 12, 2018 - Testing coronary calcium levels can better predict patient’s risk for coronary heart disease
November 12, 2018 - FDA conducts mass seizure of food and medical products held under insanitary conditions
November 12, 2018 - FDA Approves Invokana (canagliflozin) to Reduce the Risk of Heart Attack, Stroke or Cardiovascular Death in Adults with Type 2 Diabetes and Established Cardiovascular Disease
November 12, 2018 - Hormone helps reverse brain damage caused by obesity
November 12, 2018 - Grants aim to provide better cancer clinical trial access for military veterans
November 12, 2018 - Mitochondrial DNA may have strong influence on cellular metabolism and disease susceptibility
November 12, 2018 - High stakes, entrenched interests and the Trump rollback of environmental regs
November 12, 2018 - Stem cells transplanted for treatment of Parkinson’s disease
November 12, 2018 - Sandoz Inc. Issues Voluntary Nationwide Recall of One Lot of Losartan Potassium and Hydrochlorothiazide Due to the Detection of Trace Amounts of NDEA (N-Nitrosodiethylamine) Impurity Found in the Active Pharmaceutical Ingredient (API)
November 12, 2018 - Protein found in patients with severe asthma can help identify who would benefit from targeted drugs
November 12, 2018 - Experts develop a list of competencies in antimicrobial prescribing and stewardship
November 12, 2018 - Allied BioScience receives approved label from EPA for new bacteriostatic surface coating
November 12, 2018 - MR Solutions displays elegant bench top CT scanner with clip-on PET and SPECT at EANM congress
November 12, 2018 - FDA announces emergency use authorization of Ebola fingerstick test with portable reader
November 12, 2018 - Grieving spouses with sleep problems have increased risk of chronic immune activation
November 12, 2018 - Exercise routines affect mental health in Japanese expatriates
November 12, 2018 - Fish oil and vitamin D pills no guard against cancer or serious heart trouble
November 12, 2018 - Excess Gestational Weight Gain Not Better for Child Bone Health
November 12, 2018 - Immune receptor provides protective immunity against Group A Streptococcus
November 12, 2018 - Scientists develop new method to produce irradiated nanomaterials for medical applications
November 12, 2018 - Blue light exposure decreases blood pressure
November 12, 2018 - Researchers discover two proteins essential for development of skeletal muscle
November 12, 2018 - Yelp reviews help understand strengths, weaknesses of emergency departments and urgent care centers
November 12, 2018 - Adolescent obesity linked with increased risk of pancreatic cancer later in life
November 12, 2018 - AHA: Poor Teeth-Brushing Habits Tied to Higher Heart Risk
November 12, 2018 - Researchers find how natural killer cells regulate protective HIV antibodies
November 12, 2018 - Rutgers receives $4.2 million federal grant to improve mental health services
November 12, 2018 - Sussex scientists develop a piece of hardware to show how brains function
November 12, 2018 - Study shows pivotal role of parents in efforts to change sexual orientation of LGBT teens
November 12, 2018 - Neck scan detects dementia way before symptoms appear
November 12, 2018 - Risk-profiling can benefit HIV prevention
November 12, 2018 - New thrombolytic based on magnetite nanoparticles successfully tested on animals
November 12, 2018 - Smoking rates go down in the US, lowest since 1965
November 12, 2018 - Phase III Trial of Darolutamide in Patients with Non-metastatic Castration-resistant Prostate Cancer Meets Primary Endpoint
November 12, 2018 - Moderate exercise before conception resulted in lower body weight, increased insulin sensitivity of offspring
November 11, 2018 - Community choirs for older adults reduce loneliness and increase interest in life
November 11, 2018 - Trevena Receives Complete Response Letter for Oliceridine from FDA
November 11, 2018 - More adults and children are using yoga and meditation
November 11, 2018 - Female smokers at greater risk of heart attacks, finds study
November 11, 2018 - Happy Childhood Memories Associated With Better Health
November 11, 2018 - X-linked infantile spinal muscular atrophy – Genetics Home Reference
November 11, 2018 - RNA thought to spread cancer shows ability to suppress breast cancer metastasis
November 11, 2018 - Study finds that thymus plays key role during normal pregnancy
November 11, 2018 - Exploring why some athletes ice their muscles after exercise
November 11, 2018 - Female Genital Mutilation Decreasing in African Nations
November 11, 2018 - Are humans immune to the CRISPR-Cas9 gene editing scissors?
November 11, 2018 - Breastmilk and saliva mixtures regulate oral microbiome of newborn babies
November 11, 2018 - Learning familiar faces through social interactions reduces variability in face recognition
November 11, 2018 - New open source decision support tool could help clinicians chose chemotherapy drugs
November 11, 2018 - New weapons drawn in global TB fight
NTU Singapore and SERI team invents new ‘pen camera’ to detect patients with glaucoma

NTU Singapore and SERI team invents new ‘pen camera’ to detect patients with glaucoma

image_pdfDownload PDFimage_print

Scientists at Nanyang Technological University, Singapore (NTU Singapore), with clinicians from the Singapore Eye Research Institute (SERI), have invented a new ‘pen camera’ that makes it easier for doctors to diagnose patients with glaucoma.

The ‘pen camera’, called the GonioPEN, could help tackle the eye disease with its ability to detect the type of glaucoma in a faster and cheaper manner. It causes negligible discomfort, unlike the current gonioscopes, which are glass scopes that must be pressed against the eyeball of the patient for doctors to look at the eye’s drainage canal to diagnose the cause.

Glaucoma is a leading cause of blindness in the world. It has no early symptoms, but a build-up of pressure inside the eye can be an indicator. In Singapore, about three per cent of people over the age of 40 years – or over 65,000 people – have glaucoma. This percentage rises with age.

Built by a team led by NTU Associate Professor Murukeshan Vadakke Matham, Director of NTU’s Centre for Optical and Laser Engineering, in collaboration with Professor Aung Tin, the Executive Director of SERI, the GonioPEN allows doctors or trained technicians to capture more detailed images of the eye drainage canal with minimal contact at the side of the cornea. A software is then used to analyze the images, helping doctors and eye specialists with their diagnosis.

In a recent pilot study by Assistant Professor Baskaran Mani from SERI, all 20 patients found the GonioPEN more comfortable than the conventional hand-held lens used with a microscope – a gold standard used in clinics now.

As the current gonioscopy method takes up to 15 minutes to perform and requires a skilled specialist’s expertise to diagnose the problem on the spot, it is not done in clinics as a routine, said Asst Prof Mani. As a result, half the patients here do not go through the test in clinics, leaving glaucoma largely undiagnosed here, he added.

The GonioPEN circumvents these problems with its ability to quickly capture in just three minutes high-resolution digital images of the eye from the side of the cornea. The images, which could be taken by a technician, are reviewed separately by the eye specialist, shortening the time the patient’s eye needs to be under the microscope as the specialist makes his diagnosis as in the existing method.

Innovative devices such as the GonioPEN, developed on campus, are aligned with NTU’s Smart Campus vision of harnessing the power of digital technology and tech-enabled solutions to support better learning and living experiences, the discovery of new knowledge, and the sustainability of resources.

Assoc Prof Murukeshan, who is from NTU’s School of Mechanical and Aerospace Engineering, said: “With the GonioPEN, a digital camera image of a higher resolution can now be stored for future reference and retrieved easily. A technician could perform the gonioscopy before a specialist reviews the images to give an in-depth diagnosis or a second opinion. Doctors can also better track the changes in their patients’ condition over time.

“The GonioPEN’s ease of use means it can be used by primary, secondary or private eye care physicians, while its compact size makes it portable for all healthcare set-ups. The cost is also kept low because a microscope is no longer required.”

Prof Aung Tin, who is also Deputy Medical Director (Research) at the Singapore National Eye Centre, said that in the digital era of healthcare and future teleophthalmic care possibilities, such a device will enable advancement in the standard of medical care. “The GonioPEN, with its compactness and integration to our electronic medical records, will achieve such goals for the future eye care model in Singapore,” he added.

How it works

In glaucoma, high pressure within the eye is caused by an imbalance between fluid production and its drainage out of the eye, typically caused by clogged drainage channels.

An eye specialist determines the type of glaucoma through a gonioscope, a hand-held lens put in direct contact with the eye. The specialist then peers through a microscope paired with the lens to make a visual diagnosis. Each type of glaucoma will require a different form of treatment.

The drawback of this manual method of peering through a lens is that the doctor cannot review the image of the eye at a later date. While there are other machines on the market that can capture images of the angle with or without any direct contact with the eye, they are expensive, ranging from US$25,000 to US$120,000 (S$33,000 to S$158,000).

In contrast, the GonioPEN combines a high-resolution camera and LEDs for illumination to take a high quality image of the human eye. The prototype pen camera, estimated to cost $5,000, is connected to a computer via a USB cable. The camera captures images of the eye from four different perspectives and saves it to the computer, which can then be magnified several times for a better diagnosis by an eye doctor.

Asst Prof Mani said the prototype device is portable and digital, allowing a trained technician to capture images of the eye quickly with minimal training. He added: “With GonioPEN, the diagnosis can be generated with an automated software, instead of only relying on a doctor’s expertise. This saves time for both doctors and patients involved in eye care, allowing more patients to be examined in clinics. Clinically, patients found the GonioPEN more comfortable than a gonioscope.”

Source:

http://media.ntu.edu.sg/NewsReleases/Pages/newsdetail.aspx?news=b53da729-3945-4bda-a60e-7e10bf08af99

Tagged with:

About author

Related Articles