Breaking News
February 18, 2019 - New dental adhesive prevents tooth decay around orthodontic brackets
February 18, 2019 - New eHealth tool shows potential to improve quality of asthma care
February 18, 2019 - New Australian initiative helps emergency clinicians to improve patient care
February 17, 2019 - Apellis Pharmaceuticals’ APL-2 Receives Fast Track Designation from the FDA for the Treatment of Patients with Paroxysmal Nocturnal Hemoglobinuria
February 17, 2019 - Researchers identify faulty ‘brake’ that interferes with heart muscle’s ability to contract and relax
February 17, 2019 - Support from trusted adults can reduce risk of dying in suicidal teens, finds study
February 17, 2019 - Heart attack awareness improved since 2008
February 17, 2019 - Exercise gives a better brain boost to older men than women
February 17, 2019 - New research disproves previous assumptions of how looks influence personality
February 17, 2019 - Cannabis use as a teenager linked to depression later in life
February 17, 2019 - Sinks by Toilets in ICU Patient Rooms Harbor Harmful Bacteria
February 17, 2019 - Cancer cells’ plasticity makes them harder to stop
February 17, 2019 - Young cannabis users have increased risk of depression and suicidal behavior
February 17, 2019 - Tasmanian Devils Likely to Survive Cancer Scourge
February 17, 2019 - Neoadjuvant PD-1 blockade seems effective in glioblastoma
February 17, 2019 - Personal, social factors play role in enabling sustainable return to work after ill health
February 17, 2019 - Mouse studies show ‘inhibition’ theory of autism wrong
February 17, 2019 - Study shows how neuroactive steroids inhibit activity of pro-inflammatory proteins
February 17, 2019 - Use of liver grafts from older donors decreased despite better outcomes in recipients
February 17, 2019 - MUSC researchers discover new mechanism for a class of anti-cancer drugs
February 17, 2019 - HPV misconceptions are causing women to miss smear tests
February 17, 2019 - Sanofi and Regeneron Offer Praluent (alirocumab) at a New Reduced U.S. List Price
February 17, 2019 - Researchers say auditory testing can identify children for autism screening
February 17, 2019 - New method analyzes how single biological cells react to stressful situations
February 17, 2019 - WVU gynecologic oncologist investigates novel treatment for cervical and vaginal cancers
February 17, 2019 - ADHD diagnoses poorly documented
February 17, 2019 - Majority of gender minority youth do not identify with traditional sexual identity labels
February 17, 2019 - AbbVie, Teneobio enter into strategic transaction to develop potential treatment for multiple myeloma
February 17, 2019 - Lower Birth Weight May Up Risk for Psychiatric Disorders
February 17, 2019 - Scientists identify reversible molecular defect underlying rheumatoid arthritis
February 17, 2019 - Moffitt researchers shed light on how CAR T cells function mechanistically
February 16, 2019 - Female Anatomy May Play Big Role in Sperm’s Success
February 16, 2019 - BMI may mediate inverse link between fiber intake, knee OA
February 16, 2019 - Movement impairments in autism can be reversed through behavioral training
February 16, 2019 - Studies address racial disparities in postpartum period and cardiovascular health
February 16, 2019 - Scientists implicate hidden genes in the severity of autism symptoms
February 16, 2019 - Decreased deep sleep linked to early signs of Alzheimer’s disease
February 16, 2019 - Neuroscientists show how the brain responds to texture
February 16, 2019 - Gilead Announces Topline Data From Phase 3 STELLAR-4 Study of Selonsertib in Compensated Cirrhosis (F4) Due to Nonalcoholic Steatohepatitis (NASH)
February 16, 2019 - What Can I Do About Sweating? (for Teens)
February 16, 2019 - Companies navigate dementia conversations with older workers
February 16, 2019 - Newly developed stem cell technologies show promise for treating PD patients
February 16, 2019 - Collaborative material research could advance self-assembling nanomaterials
February 16, 2019 - Researchers take major step in creating technology that mimics the human brain
February 16, 2019 - Erasing memories associated with cocaine use reduces drug seeking behavior
February 16, 2019 - Artificial intelligence can accurately predict prognosis of ovarian cancer patients
February 16, 2019 - Racial disparities in cancer deaths on the decline for America
February 16, 2019 - FDA authorizes new interoperable insulin pump for children, adults with diabetes
February 16, 2019 - Coexisting Medical Conditions, Smoking Explain PTSD-CVD Link
February 16, 2019 - Skin Cancer Screening: MedlinePlus Lab Test Information
February 16, 2019 - ‘Happiness’ exercises can boost mood in those recovering from substance use disorder
February 16, 2019 - Cell manipulation could soon halt or reverse aging
February 16, 2019 - Pumped Breast Milk Falls Short of Breastfed Version
February 16, 2019 - Men’s porn habits could fuel partners’ eating disorders, study suggests
February 16, 2019 - Rapid progression of age-related diseases may result from formation of vicious cycles
February 16, 2019 - Immune checkpoint molecule protects against future development of cancer
February 16, 2019 - New method produces hydrogels that have properties similar to cells’ environment
February 16, 2019 - $4.1 million funding for heart research on Valentine’s Day
February 16, 2019 - General anesthesia in early infancy unlikely to have lasting effects on developing brains
February 16, 2019 - New breakthroughs for muscular dystrophy research
February 16, 2019 - First Opinion: Embryo editing for higher IQ is a fantasy. Embryo profiling for it is almost here
February 16, 2019 - Vapers develop cancer-related gene deregulation as cigarette smokers
February 16, 2019 - Bringing Antimicrobial Susceptibility Testing (AST) to the Community
February 16, 2019 - Decolonization protocol after hospital discharge can prevent dangerous infections
February 16, 2019 - Children with ASD more likely to face maltreatment, study finds
February 16, 2019 - Study finds genetic vulnerability to use of menthol cigarettes
February 16, 2019 - Promising drug developed to rejuvenate muscle cells
February 16, 2019 - H-RT should be the standard of care for men with low risk prostate cancer, study shows
February 16, 2019 - New technique using patients’ own modified cells could help treat Crohn’s disease
February 16, 2019 - Therapeutic endoscopy has an expanding role in the treatment of IBD
February 16, 2019 - Blood clot discovery could lead to development of better treatments for blood diseases
February 16, 2019 - Intervention can increase exclusive breastfeeding rates
February 16, 2019 - New project explores how gaming technologies can help cancer patients communicate better
February 16, 2019 - Catalyst Biosciences Presents Updated Data from Its Phase 2/3 Trial of Subcutaneous Marzeptacog Alfa (Activated) in Individuals with Hemophilia A or B with Inhibitors at the 12th Annual EAHAD Congress
February 16, 2019 - Rerouting nerves during amputation reduces phantom limb pain before it starts
February 16, 2019 - A Hormone Produced When We Exercise Might Help Fight Alzheimer’s
February 16, 2019 - Millions of British people breathe toxic air travelling to GPs
February 16, 2019 - Conformance of genetic characteristics found to be crucial for longer preservation of kidney graft
February 16, 2019 - Researchers use optogenetic tool to control, visualize receptor signals in neural cells
February 16, 2019 - New reversible antiplatelet therapy could reduce risk of blood clots, prevent cancer metastasis
Research finds little difference among diet plans’ long-term effectiveness

Research finds little difference among diet plans’ long-term effectiveness

image_pdfDownload PDFimage_print

Whether you pick low-carb, low fat or another diet plan, scientific research indicates each can help some people achieve modest long-term weight loss with potential improvement in health risks, according to the Scientific Statement the Endocrine Society issued today on managing obesity.

The authors found the Mediterranean Diet and DASH diet provide demonstrated benefits for improving cardiovascular disease, and in lower calorie versions may be beneficial for weight loss.

Given the number of diets, medications and surgical procedures available to treat obesity, the best approach for each individual depends on genetics, health and how well they can adhere to a particular regimen, the statement’s authors concluded. Still, maintaining long-term weight loss remains challenging, and individuals with obesity should expect to regain weight when they stop treatment.

“The stigma around this disease makes it difficult to address obesity as a public health problem,” said George A. Bray, M.D., of Louisiana State University’s Pennington Biomedical Research Center in Baton Rouge, La., who chaired the task force that developed the Scientific Statement. “There often is a mismatch between the patient’s cosmetic goals and what can realistically be achieved with diet and exercise. While a modest 5 percent to 10 percent weight loss can yield significant health benefits, that may not provide the cosmetic changes patients seek.”

Obesity remains a worldwide public health issue. More than 1.9 billion adults worldwide meet the criteria for obesity or overweight, according to the World Health Organization.

Obesity is associated with and contributes to a shortened life span, type 2 diabetes, cardiovascular disease, some cancers, kidney disease, sleep apnea, osteoarthritis and other conditions. Weight loss can lower the risk of developing these conditions and improve health outcomes.

The statement’s authors examined the latest scientific evidence on a variety of diets, commercial diet plans such as Weight Watchers, exercise, obesity medications and types of bariatric surgery. Based on a review of more than 400 studies and peer-reviewed articles on obesity, the experts found all of the weight loss interventions had a high degree of variability when it came to effectiveness.

“Individual weight loss approaches worked well for some people and not for others,” Bray said. “Currently, we have limited genetic and other information to predict which intervention will work for a given individual. This demonstrates just how complex the problem of severe obesity is.”

Surgical approaches tended to lead to greater and longer lasting weight loss than other treatment options, the authors found.

Many consumers turn to dietary supplements, which are not evaluated by the U.S. Food and Drug Administration (FDA). There is little scientific evidence to show these supplements can effectively support weight loss or even that they are safe. Having the FDA oversee dietary supplements and holding these products to higher safety and efficacy standards would benefit public health, according to the statement authors.

Recent studies have examined whether some individuals with a body-mass index (BMI) that meets the criteria for obesity can maintain healthy blood pressure, cholesterol levels, blood sugar and levels of fats in the blood called triglycerides. The statement authors concluded metabolically healthy obesity is likely a short-term state, and individuals who fit the criteria are likely to develop metabolic and cardiovascular problems over time.

“Effectively treating obesity is crucial if we are going to be able to address the devastating impact diabetes and cardiovascular disease have on public health,” Bray said. “We are seeing promising research into diabetes medications linked to weight loss, the use of peptides to enhance weight loss, and improved techniques for modulating the way food moves through the digestive system and is absorbed into the body. As our scientific understanding of obesity continues to improve, we hope this will lead to the discovery of new treatment approaches.”


Explore further:
USPSTF urges multicomponent behavioral interventions for obesity

More information:
George A Bray et al, The Science of Obesity Management: An Endocrine Society Scientific Statement, Endocrine Reviews (2018). DOI: 10.1210/er.2017-00253

Provided by:
The Endocrine Society

Tagged with:

About author

Related Articles