Breaking News
February 18, 2019 - New dental adhesive prevents tooth decay around orthodontic brackets
February 18, 2019 - New eHealth tool shows potential to improve quality of asthma care
February 18, 2019 - New Australian initiative helps emergency clinicians to improve patient care
February 17, 2019 - Apellis Pharmaceuticals’ APL-2 Receives Fast Track Designation from the FDA for the Treatment of Patients with Paroxysmal Nocturnal Hemoglobinuria
February 17, 2019 - Researchers identify faulty ‘brake’ that interferes with heart muscle’s ability to contract and relax
February 17, 2019 - Support from trusted adults can reduce risk of dying in suicidal teens, finds study
February 17, 2019 - Heart attack awareness improved since 2008
February 17, 2019 - Exercise gives a better brain boost to older men than women
February 17, 2019 - New research disproves previous assumptions of how looks influence personality
February 17, 2019 - Cannabis use as a teenager linked to depression later in life
February 17, 2019 - Sinks by Toilets in ICU Patient Rooms Harbor Harmful Bacteria
February 17, 2019 - Cancer cells’ plasticity makes them harder to stop
February 17, 2019 - Young cannabis users have increased risk of depression and suicidal behavior
February 17, 2019 - Tasmanian Devils Likely to Survive Cancer Scourge
February 17, 2019 - Neoadjuvant PD-1 blockade seems effective in glioblastoma
February 17, 2019 - Personal, social factors play role in enabling sustainable return to work after ill health
February 17, 2019 - Mouse studies show ‘inhibition’ theory of autism wrong
February 17, 2019 - Study shows how neuroactive steroids inhibit activity of pro-inflammatory proteins
February 17, 2019 - Use of liver grafts from older donors decreased despite better outcomes in recipients
February 17, 2019 - MUSC researchers discover new mechanism for a class of anti-cancer drugs
February 17, 2019 - HPV misconceptions are causing women to miss smear tests
February 17, 2019 - Sanofi and Regeneron Offer Praluent (alirocumab) at a New Reduced U.S. List Price
February 17, 2019 - Researchers say auditory testing can identify children for autism screening
February 17, 2019 - New method analyzes how single biological cells react to stressful situations
February 17, 2019 - WVU gynecologic oncologist investigates novel treatment for cervical and vaginal cancers
February 17, 2019 - ADHD diagnoses poorly documented
February 17, 2019 - Majority of gender minority youth do not identify with traditional sexual identity labels
February 17, 2019 - AbbVie, Teneobio enter into strategic transaction to develop potential treatment for multiple myeloma
February 17, 2019 - Lower Birth Weight May Up Risk for Psychiatric Disorders
February 17, 2019 - Scientists identify reversible molecular defect underlying rheumatoid arthritis
February 17, 2019 - Moffitt researchers shed light on how CAR T cells function mechanistically
February 16, 2019 - Female Anatomy May Play Big Role in Sperm’s Success
February 16, 2019 - BMI may mediate inverse link between fiber intake, knee OA
February 16, 2019 - Movement impairments in autism can be reversed through behavioral training
February 16, 2019 - Studies address racial disparities in postpartum period and cardiovascular health
February 16, 2019 - Scientists implicate hidden genes in the severity of autism symptoms
February 16, 2019 - Decreased deep sleep linked to early signs of Alzheimer’s disease
February 16, 2019 - Neuroscientists show how the brain responds to texture
February 16, 2019 - Gilead Announces Topline Data From Phase 3 STELLAR-4 Study of Selonsertib in Compensated Cirrhosis (F4) Due to Nonalcoholic Steatohepatitis (NASH)
February 16, 2019 - What Can I Do About Sweating? (for Teens)
February 16, 2019 - Companies navigate dementia conversations with older workers
February 16, 2019 - Newly developed stem cell technologies show promise for treating PD patients
February 16, 2019 - Collaborative material research could advance self-assembling nanomaterials
February 16, 2019 - Researchers take major step in creating technology that mimics the human brain
February 16, 2019 - Erasing memories associated with cocaine use reduces drug seeking behavior
February 16, 2019 - Artificial intelligence can accurately predict prognosis of ovarian cancer patients
February 16, 2019 - Racial disparities in cancer deaths on the decline for America
February 16, 2019 - FDA authorizes new interoperable insulin pump for children, adults with diabetes
February 16, 2019 - Coexisting Medical Conditions, Smoking Explain PTSD-CVD Link
February 16, 2019 - Skin Cancer Screening: MedlinePlus Lab Test Information
February 16, 2019 - ‘Happiness’ exercises can boost mood in those recovering from substance use disorder
February 16, 2019 - Cell manipulation could soon halt or reverse aging
February 16, 2019 - Pumped Breast Milk Falls Short of Breastfed Version
February 16, 2019 - Men’s porn habits could fuel partners’ eating disorders, study suggests
February 16, 2019 - Rapid progression of age-related diseases may result from formation of vicious cycles
February 16, 2019 - Immune checkpoint molecule protects against future development of cancer
February 16, 2019 - New method produces hydrogels that have properties similar to cells’ environment
February 16, 2019 - $4.1 million funding for heart research on Valentine’s Day
February 16, 2019 - General anesthesia in early infancy unlikely to have lasting effects on developing brains
February 16, 2019 - New breakthroughs for muscular dystrophy research
February 16, 2019 - First Opinion: Embryo editing for higher IQ is a fantasy. Embryo profiling for it is almost here
February 16, 2019 - Vapers develop cancer-related gene deregulation as cigarette smokers
February 16, 2019 - Bringing Antimicrobial Susceptibility Testing (AST) to the Community
February 16, 2019 - Decolonization protocol after hospital discharge can prevent dangerous infections
February 16, 2019 - Children with ASD more likely to face maltreatment, study finds
February 16, 2019 - Study finds genetic vulnerability to use of menthol cigarettes
February 16, 2019 - Promising drug developed to rejuvenate muscle cells
February 16, 2019 - H-RT should be the standard of care for men with low risk prostate cancer, study shows
February 16, 2019 - New technique using patients’ own modified cells could help treat Crohn’s disease
February 16, 2019 - Therapeutic endoscopy has an expanding role in the treatment of IBD
February 16, 2019 - Blood clot discovery could lead to development of better treatments for blood diseases
February 16, 2019 - Intervention can increase exclusive breastfeeding rates
February 16, 2019 - New project explores how gaming technologies can help cancer patients communicate better
February 16, 2019 - Catalyst Biosciences Presents Updated Data from Its Phase 2/3 Trial of Subcutaneous Marzeptacog Alfa (Activated) in Individuals with Hemophilia A or B with Inhibitors at the 12th Annual EAHAD Congress
February 16, 2019 - Rerouting nerves during amputation reduces phantom limb pain before it starts
February 16, 2019 - A Hormone Produced When We Exercise Might Help Fight Alzheimer’s
February 16, 2019 - Millions of British people breathe toxic air travelling to GPs
February 16, 2019 - Conformance of genetic characteristics found to be crucial for longer preservation of kidney graft
February 16, 2019 - Researchers use optogenetic tool to control, visualize receptor signals in neural cells
February 16, 2019 - New reversible antiplatelet therapy could reduce risk of blood clots, prevent cancer metastasis
Oxygen ‘nanobubbles’ could help enhance cancer therapies and hasten wound healing

Oxygen ‘nanobubbles’ could help enhance cancer therapies and hasten wound healing

image_pdfDownload PDFimage_print

A Purdue University-patented technology shows promise in using microscopic bubbles filled with oxygen to help with various medical treatments, including improving cancer therapeutics and helping wounds heal faster.

Samara Biotech LLC, a Purdue startup, has developed an easy-to-use method to inject oxygen “nanobubbles” intravenously so they can be targeted precisely at wounds or cancerous tumors. The bubbles do not actually do the therapies, but enhance other therapies, such as improving chemotherapeutics or radiation efficacy, said Pushpak Bhandari, Samara Biotech founder.

“It’s an oxygen delivery system at its core that can be applied toward many diseased states,” Bhandari said “Oxygen is critical in almost every biological process, so this helps in a variety of ways.”

Studies have shown that a lack of oxygen in tumor cells changes how cells function, contributing to cancer growth. Low oxygen, or hypoxia, is a major challenge in treating some cancers because it is common in a majority of malignant tumors. Tumor cells are starved of oxygen, causing them to become resistant to conventional treatments such as radiation and chemotherapy. This can lead to a need to increase radiation doses or chemotherapy concentration, which often adversely affects patients.

The nanobubble shells disintegrate inside the tumor cells, increasing the cellular oxygen levels. The release of oxygen inside the hypoxic cells destabilizes the hypoxia-driven pathways and inhibit tumor growth, Bhandari said.

“Normal cells are two to three times more receptive to cancer therapies compared with hypoxic cells,” he said.

Early testing published in the journals Scientific Reports and ACS Nano shows that the oxygen nanobubbles are effective in significantly delaying tumor progression and improving survival rates in clinical trials. The nanobubbles can be guided precisely to a tumor using an ultrasound beam, which can lead to better efficacy while using a 50 percent lower concentration of a chemotherapeutic drug.

“The ability to precisely steer oxygen nanobubbles offers considerable promise for a wide range of biomedical applications,” Bhandari said.

Bhandari believes the oxygen nanobubbles could be particularly effective against brain cancer, bladder cancer and certain sarcomas that are most common in bones, muscles, tendons, cartilage, nerves, fat and blood vessels.

Bhandari, who earned a doctorate in biological engineering from Purdue in 2017, also believes the oxygen nanobubbles can be more effective at treating wounds than a hyperbaric chamber or topical oxygen therapy because the nanobubbles can be more precisely targeted.

Bhandari is continuing to look at other wound-healing applications, saying the method could be used to treat complications from diabetes and other illnesses.

He plans to begin his cancer studies in dogs initially because nearly half of all dogs die of cancer. He said he will be dealing only with naturally occurring cancer in dogs and hopes those studies will help advance and speed the research into human cancers. He said he has been working with Purdue’s College of Veterinary Medicine.

The oxygen nanobubbles also act as contrast agents for ultrasound imaging, allowing researchers to create highly sensitive, highly reliable detection agents to monitor therapy.

Bhandari started Samara Biotech in 2015, taking the name from a winged seed that allows the wind to carry it further from the parent. He said in Eastern philosophy it also connotes the circle of life.

The Purdue Office of Technology Commercialization filed a patent on the technology. The Purdue Foundry and the Purdue Research Foundation have been working with Bhandari to commercialize his research.

“We’re looking for potential strategic partners,” Bhandari said. “We want to get the word out that there is a new technology that been evaluated quite well for a lot of different applications and we’re looking for more.”

Source:

http://www.purdue.edu/newsroom/releases/2018/Q2/microscopic-oxygen-bubbles-could-help-improve-cancer-therapeutics-and-accelerate-wound-healing.html

Tagged with:

About author

Related Articles