Breaking News
August 16, 2018 - Ablating the mutant p53 gene in mice with colorectal cancer inhibits tumor growth
August 16, 2018 - Higher BMI in people with prediabetes related to evening preference and lack of sufficient sleep
August 16, 2018 - Using peripheral nerve blocks to treat facial pain may produce long-term pain relief
August 16, 2018 - Neural stem cells are the key to tail regeneration
August 16, 2018 - Study compares genetic and neural contributions to ADHD in children with or without TBI
August 16, 2018 - Adding energy drinks to alcohol may exacerbate negative effects of binge drinking
August 16, 2018 - Eye Examination Can Help Detect Abuse in Children
August 16, 2018 - Know the Difference: Rheumatoid Arthritis or Osteoarthritis?
August 16, 2018 - From ‘sea of mutations,’ two possible cancer links rise to the surface
August 16, 2018 - Does medical school take too long?
August 16, 2018 - Brown University researchers reveal key physical properties of ‘giant’ cancer cells
August 16, 2018 - Regular resistance training improves exercise motivation
August 16, 2018 - Feds urge states to encourage cheaper plans off the exchanges
August 16, 2018 - Seven activities that prevent you from getting quality sleep during summer
August 16, 2018 - Five ways to tell if your baby is getting enough milk from breastfeeding
August 16, 2018 - From Pigs to Peacocks, What’s Up With Those ‘Emotional-Support Animals’?
August 16, 2018 - Breast cancers enlist the help of normal cells to help them spread and survive
August 16, 2018 - Engaging with “high-need” patients outside the clinic
August 16, 2018 - Research illuminates how online forum may offer suicide prevention support for males
August 16, 2018 - Researchers identify way to grow immune cells at large scale for preventing cancer reoccurrence
August 15, 2018 - Keck Medicine of USC’s hospitals ranked among nation’s best for the 10th consecutive year
August 15, 2018 - Researchers compare existing approaches for automating diagnostic procedures of skin lesions
August 15, 2018 - Autism risk determined by health of mom’s gut, research reveals
August 15, 2018 - WELL for Life challenges you to explore the great outdoors
August 15, 2018 - ‘Zombie’ gene protects elephants from cancer, study finds
August 15, 2018 - Ebola outbreak in Congo spreads to active combat zone
August 15, 2018 - Study highlights pollution exposure of babies in prams
August 15, 2018 - Study provides insight into link between sleep apnea and lipid metabolism
August 15, 2018 - New study focuses on promise of gene therapy for Amish nemaline myopathy
August 15, 2018 - Researchers discover new approach to alleviate chronic itch
August 15, 2018 - Uncovering the Mysteries of MS: Medical Imaging Helps NIH Researchers Understand the Tricky Disease
August 15, 2018 - Autistic people at greater risk of becoming homeless – new research
August 15, 2018 - New imaging technique can spot tuberculosis infection in an hour
August 15, 2018 - Scientists study effects of eating breakfast versus fasting overnight before exercise
August 15, 2018 - Talking with children about suicide could save lives
August 15, 2018 - Grip strength of children predicts future cardiometabolic health
August 15, 2018 - Innovative oncofertility program launched by RMA of New York and Mount Sinai Health System
August 15, 2018 - Study shows efficacy, safety of AAV5-based gene therapy to treat sheep model of achromatopsia
August 15, 2018 - Simple score helps predict which hospitalized heart attack patients are at high risk of readmissions
August 15, 2018 - New discoveries show how protein droplets do more than keep cells’ interiors tidy
August 15, 2018 - Study shows impact of optimizing airport flight patterns on human health
August 15, 2018 - Life experiences of feeling unwanted or unplanned associated with attachment insecurity
August 15, 2018 - ACS Briefing Discusses Use of Lessons From Combat Care
August 15, 2018 - Study identifies distinct origin of ADHD in children with history of brain injury
August 15, 2018 - IgG3 antibody stops B cells from fighting pathogens in HIV patients
August 15, 2018 - Scientists discover key vulnerability of mixed lineage leukemia
August 15, 2018 - College students may experience pressures from secondary exposure to opioid abuse
August 15, 2018 - Powerful new microscope reveals inner workings of human cells with unprecedented clarity
August 15, 2018 - Married people who fight nastily more likely to suffer from leaky guts, study suggests
August 15, 2018 - Working Out After Baby – Drugs.com MedNews
August 15, 2018 - Rheumatoid Factor (RF) Test: MedlinePlus Lab Test Information
August 15, 2018 - ADHD linked to an increased risk of injury in children, study finds
August 15, 2018 - UIC researchers receive NIH funding to develop a better way to regenerate bone or tissues
August 15, 2018 - Study reveals how immune cells in the brain influence sexual behavior
August 15, 2018 - Researchers move closer to finding potential soft spot in drug-resistant tuberculosis
August 15, 2018 - Real-time dynamic monitoring of cell’s nucleus for effective cancer screening
August 15, 2018 - Lower rates of Medicare preventive care visits found in racial, ethnic minority older adults
August 15, 2018 - Scientists identify stress hormone as key factor in failure of immune system to inhibit leukemia
August 15, 2018 - Cytoplan introduces three new nutritional supplements
August 15, 2018 - Effective hemorrhage control critical for survival after motorsport accidents
August 15, 2018 - Sygnature Discovery announces ambitious expansion plan with addition of Alderley Park facility
August 15, 2018 - Dietary carbohydrates could lead to osteoarthritis, new study finds
August 15, 2018 - Male tobacco smokers have decreased number of cannabinoid CB1 receptors, study reveals
August 15, 2018 - Scientists explore ways for drug therapies to reach deadly brain tumors
August 15, 2018 - Rethinking fundamental rule of stroke care: ‘Time is brain!’
August 15, 2018 - Scientists reveal role of ‘junk DNA’ in cancer dissemination
August 15, 2018 - Google’s DeepMind AI could soon be diagnosing eye conditions
August 15, 2018 - Scientists trick the brain to embody the prosthetic limb
August 15, 2018 - Researchers focus on uncoupling obesity from diabetes
August 15, 2018 - Clinical study shows how EarlySense system effectively detects opioid-induced respiratory depression
August 15, 2018 - A class of proteins shown to be effective in reducing drug-seeking behaviors
August 15, 2018 - FundamentalVR launches first-of-its-kind SaaS software platform for surgical simulation
August 15, 2018 - Gemphire Announces Termination of Phase 2a Clinical Trial of Gemcabene in Pediatric NAFLD
August 15, 2018 - Rheumatoid arthritis in pregnancy associated with low birth weight and premature birth
August 15, 2018 - Study may help increase effectiveness of antibiotics against drug-resistant bacteria
August 15, 2018 - Analyzing resident-to-resident incidents in dementia may hold the key to reducing future fatalities
August 15, 2018 - Robotic walking frame aims to help maintain mobility of older adults
August 15, 2018 - Simple intervention during routine care reduces alcohol consumption in men with HIV
August 15, 2018 - Genetics Home Reference: gout
August 15, 2018 - Scientists ID genesis of disease, focus efforts on shape-shifting tau
Preantral zinc deficiency may affect fertility months

Preantral zinc deficiency may affect fertility months

image_pdfDownload PDFimage_print

An estimated 10 percent of couples in the U.S. struggle with infertility. While a variety of factors can make it difficult for some people to get pregnant, ovulation disorders are a leading cause of female infertility. Now, researchers at Pennsylvania State University have found that zinc deficiency can negatively affect the early stages of egg development, reducing the ability of the egg cells to divide and be fertilized. This may affect fertility months in the future. The researchers will present their results at the American Physiological Society annual meeting at Experimental Biology 2018 in San Diego.

The availability of micronutrients in the ovarian environment and their influence on the development, viability and quality of egg cells (oocytes) is the focus of a growing area of research. In mammals, the ovary is made up of thousands of structures called follicles-;women are born with approximately two million-;which consist of one oocyte surrounded by layers of support cells (somatic cells). After puberty, a complex cascade of events occurs to prepare groups of oocytes for maturation, ovulation and fertilization. Though a group of oocytes begins to mature each month, only one will be ovulated and have the chance of being fertilized. Multiple factors can influence whether a given oocyte will mature correctly and one day be ovulated, including the presence of sufficient levels of certain micronutrients.

“More and more evidence is accumulating that zinc is a key player in oocyte development,” lead author James Hester said. In the current study, Hester and his adviser, Francisco Diaz, assessed the effects of zinc on egg development extremely early on in the oocyte maturation process.

“Fertility research and treatment has primarily focused on the largest class of follicles (antral follicles), which are capable of ovulating in response to hormonal signals from the pituitary gland,” Hester wrote. “In contrast, our study examines smaller preantral follicles, which are still growing and don’t respond to the ovulatory signal yet. In humans, preantral follicles have to keep growing for about 90 days before they are ready to ovulate. Previous studies showed that zinc levels are critical in the antral follicle, but no one had tested the effect of zinc deficiency on preantral follicle growth.”

The researchers collected preantral follicles from mice and matured them in a cell culture dish. They compared eggs matured in a zinc deficient environment to those grown with normal levels of zinc. They also exposed the zinc-deficient and control eggs to epidermal growth factor to mimic the hormonal environment necessary for ovulation after the maturation process.

Hester and Diaz found that preantral zinc deficiency:

  • disrupted growth of cells in culture,
  • led to smaller egg cells early in development,
  • caused problems with development of somatic cells and elevated certain cell markers, and
  • impaired the egg cell’s ability to properly divide (meiosis), a necessary step before successful fertilization can occur. This defect persisted even after more zinc was introduced to the environment.

“Animal studies have consistently shown a zinc requirement for oocytes during meiotic division, fertilization and embryo development. Our new research shows that zinc plays a role in oocyte growth at an earlier stage than previously investigated, during development and before division. Otherwise, it doesn’t matter what the conditions are during ovulation,” Hester explained. “Interestingly, the oocytes commonly used for [in vitro fertilization] are collected from antral follicles, so any effects from preantral development have already occurred.”

While the World Health Organization estimates that 17 percent of the global population is vulnerable to zinc deficiency in their diet, the estimate may not include cases of marginal zinc deficiency (people with some zinc in their diet, but less than recommended). Other at-risk populations include people with dietary and disease factors that also affect zinc status such as irritable bowel syndrome, Crohn’s disease, gastrointestinal disorders and liver disease; women facing food insecurity; or women with certain dietary restrictions, such as vegetarians or vegans who don’t take supplemental zinc.

Source:

http://www.the-aps.org/mm/hp/Audiences/Public-Press/2018/21.html

Tagged with:

About author

Related Articles