Breaking News
January 20, 2019 - Liver Transplant Survival May Improve With Race Matching
January 20, 2019 - Study implicates hyperactive immune system in aging brain disorders
January 20, 2019 - Cancer Diagnosis May Quadruple Suicide Risk
January 20, 2019 - Parkinson’s disease experts devise a roadmap
January 20, 2019 - Research brings new hope to treating degenerative brain diseases
January 20, 2019 - Scientists pinpoint a set of molecules that wire the body weight center of the brain
January 20, 2019 - Researchers get close to developing elusive blood test for Alzheimer’s disease
January 20, 2019 - UCLA researchers demonstrate new technique to develop cancer-fighting T cells
January 20, 2019 - Researchers discover how cancer cells avoid genetic meltdown
January 20, 2019 - Exercise makes even the ‘still overweight’ healthier: study
January 20, 2019 - University of Utah to establish first-of-its-kind dark sky studies minor in the US
January 20, 2019 - School-based nutritional programs reduce student obesity
January 20, 2019 - Improved maternity care practices in the southern U.S. reduce racial inequities in breastfeeding
January 20, 2019 - New enzyme biomarker test indicates diseases and bacterial contamination
January 20, 2019 - Republican and Democratic governors have different visions to transform health care, say researchers
January 20, 2019 - Researchers discover that spin flips happen in only half a picosecond in the course of a chemical reaction
January 20, 2019 - Suicide Risk Up More Than Fourfold for Cancer Patients
January 20, 2019 - Doctors find 122 nails in Ethiopian’s stomach
January 20, 2019 - UV disinfection technology eliminates up to 97.7% of pathogens in operating rooms
January 20, 2019 - Researchers discover mechanism which drives leukemia cell growth
January 20, 2019 - AHA: Infection as a Baby Led to Heart Valve Surgery for Teen
January 20, 2019 - Injection improves vision in a form of childhood blindness
January 20, 2019 - Multiple sclerosis therapies delay progression of disability
January 20, 2019 - New study finds infrequent helmet use among bike share riders
January 20, 2019 - Clearing up information about corneal dystrophies
January 20, 2019 - Researchers describe new behavior in energy metabolism that refutes existing evidence
January 20, 2019 - New study takes first step toward treating endometriosis
January 20, 2019 - Researchers find how GREB1 gene promotes resistance to prostate cancer treatments
January 20, 2019 - Replacing Sitting Time With Activity Lowers Mortality Risk
January 20, 2019 - A simple, inexpensive intervention makes birth safer for moms and babies in parts of Africa
January 19, 2019 - New anti-inflammatory compound acts as ‘surge protector’ to reduce cancer growth
January 19, 2019 - Significant flaws found in recently released forensic software
January 19, 2019 - New Leash on Life? Staying Slim Keeps Pooches Happy, Healthy
January 19, 2019 - Men and women remember pain differently
January 19, 2019 - Rising air pollution linked with increased ER visits for breathing problems
January 19, 2019 - Study uses local data to model food consumption patterns among Seattle residents
January 19, 2019 - The brain’s cerebellum plays role in controlling reward and social behaviors, study shows
January 19, 2019 - Relationship between nurse work environment and patient safety
January 19, 2019 - Pioneering surgery restores movement to children paralyzed by acute flaccid myelitis
January 19, 2019 - Genetic variants linked with risk tolerance and risky behaviors
January 19, 2019 - New research provides better understanding of our early human ancestors
January 19, 2019 - First-ever tailored reporting guidance to improve patient care and outcomes
January 19, 2019 - 4.6 percent of Massachusetts residents have opioid use disorder
January 19, 2019 - New study suggests vital exhaustion as risk factor for dementia
January 19, 2019 - New antibiotic discovery heralds breakthrough in the fight against drug-resistant bacteria
January 19, 2019 - Ural Federal University scientists synthesize a group of multi-purpose fluorophores
January 19, 2019 - Researchers identify new therapeutic target in the fight against chronic liver diseases
January 19, 2019 - Preparation, characterization of Soyasapogenol B loaded onto functionalized MWCNTs
January 19, 2019 - FDA Approves Ontruzant (trastuzumab-dttb), a Biosimilar to Herceptin
January 19, 2019 - Tobacco use linked with higher use of opioids and sedatives
January 19, 2019 - Study delves deeper into developmental dyslexia
January 19, 2019 - Anti-vaccination movement one of the top health threats in 2019 says WHO
January 19, 2019 - Newly developed risk score more effective at identifying type 1 diabetes
January 19, 2019 - Highly effective protocol to prepare cannabis samples for THC/CBD analysis
January 19, 2019 - Prinston Pharmaceutical Inc. Issues Voluntary Nationwide Recall of Irbesartan and Irbesartan HCTZ Tablets Due to Detection of a Trace Amount of Unexpected Impurity, N-Nitrosodiethylamine (NDEA) in the Products
January 19, 2019 - How does solid stress from brain tumors cause neuronal loss, neurologic dysfunction?
January 19, 2019 - $14.7 million partnership to supercharge vaccine development
January 19, 2019 - Ian Fotheringham receives Charles Tennant Memorial Lecture award
January 19, 2019 - Brain vital signs detect neurophysiological impairments in players with concussions
January 19, 2019 - Lack of job and poor housing conditions increased likelihood of people attending A&E
January 19, 2019 - Novel targeted drug delivery system improves conventional cancer treatments
January 19, 2019 - Rutgers study finds gene responsible for spread of prostate cancer
January 19, 2019 - Complications Higher Than Expected for Invasive Lung Tests
January 19, 2019 - 3-D printed implant promotes nerve cell growth to treat spinal cord injury
January 19, 2019 - Automated texts lead to improved outcomes after total knee or hip replacement surgery
January 19, 2019 - Poor cardiorespiratory fitness could increase risk of future heart attack, finds new study
January 19, 2019 - Drinking soft drinks while exercising in hot weather may increase risk of kidney disease
January 19, 2019 - Formlabs 3D prints anatomical models
January 19, 2019 - Heart-Healthy Living Also Wards Off Type 2 Diabetes
January 19, 2019 - Teaching Kids to Be Smart About Social Media (for Parents)
January 19, 2019 - Metabolite produced by gut microbiota from pomegranates reduces inflammatory bowel disease
January 19, 2019 - Researchers examine how spray from showers and toilets expose us to disease causing bacteria
January 19, 2019 - Behavioral experiments confirm that additional neurons improve brain function
January 19, 2019 - New study compares performance of real-time infectious disease forecasting models
January 19, 2019 - Obesity can be risk factor for developing renal cell carcinoma, confirms study
January 19, 2019 - New regulation designs on cigarette packs direct smokers’ attention to health warnings
January 19, 2019 - QIAGEN receives first companion diagnostic approval in Japan
January 19, 2019 - Study explores role of Dunning-Kruger effect in anti-vaccine attitudes
January 19, 2019 - Hepatitis C-infected patients with a history of liver cancer can be treated with antivirals
January 19, 2019 - Study shows how gut bacteria affect the treatment of Parkinson’s disease
Researchers uncover reason why exercise may be beneficial for the heart

Researchers uncover reason why exercise may be beneficial for the heart

image_pdfDownload PDFimage_print

Doctors, health organizations, and the Surgeon General all agree that exercise is good for the heart — but the reasons why are still not well understood.

In a new study performed in mice, researchers from the Harvard Department of Stem Cell and Regenerative Biology (HSCRB), Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), and the Harvard Stem Cell Institute (HSCI) uncovered one reason why exercise might be beneficial: it stimulates the heart to make new muscle cells, both under normal conditions and after a heart attack.

Published in Nature Communications on 25 April, the findings have implications for public health, physical education and the rehabilitation of cardiac patients.

The human heart has a relatively low capacity to regenerate itself. Young adults can renew around 1% of their heart muscle cells every year, and that rate decreases with age. Considering that losing heart cells is linked to heart failure, interventions that increase new heart cell formation have potential to prevent heart failure.

The two first authors on the study were Ana Vujic, Ph.D. of HSCRB, and Carolin Lerchenmüller, M.D. of MGH and HMS.

“We wanted to know whether there is a natural way to enhance the regenerative capacity of heart muscle cells,” said Vujic. “So we decided to test the one intervention we already know to be safe and inexpensive: exercise.”

A 5K race every day

To test the effects of exercise, the researchers gave one group of healthy mice voluntary access to a treadmill. When left to their own devices, the mice ran around five kilometers each day. The other healthy group had no such gym membership, and remained sedentary.

To measure heart regeneration in the mice, the researchers administered a labelled chemical that was incorporated into newly made DNA as cells prepared to divide. By following the labelled DNA in the heart muscle, they could see where new cells were being produced.

The researchers found that the exercising mice made over four and a half times the number of new heart muscle cells than the mice without treadmill access.

The results were certainly significant — but were they relevant? To find out, the researchers brought the experiment a little closer to home.

“We also wanted to test this in the disease setting of a heart attack, because our main interest is healing,” said Vujic.

After experiencing a heart attack, mice with treadmill access still ran five kilometers a day, voluntarily. Compared to their sedentary counterparts, the exercising mice showed an increase in the area of heart tissue where new muscle cells were made.

The conclusion: in mice, exercise means regenerating heart tissue — a lot.

“Make your heart younger”

The two senior authors behind the study were Richard Lee, M.D., Harvard Professor of Stem Cell and Regenerative Biology, and Principal Faculty member of HSCI, and Anthony Rosenzweig, M.D., Paul Dudley White Professor of Medicine at HMS, Chief of the Cardiology Division at MGH, and Principal Faculty member of HSCI.

“Maintaining a healthy heart requires balancing the loss of heart muscle cells due to injury or aging with the regeneration or birth of new heart muscle cells. Our study suggests exercise can help tip the balance in favor of regeneration,” said Rosenzweig.

“Our study shows that you might be able to make your heart younger by exercising more every day,” said Lee.

Diving deeper

It’s all very well to say that exercise is good for the heart — but how does that actually work? To find out, the researchers plan to pinpoint which biological mechanisms link exercise with increased regenerative activity in the heart.

In this study, the researchers identified a specific biological pathway that is required for exercise to turn on cardiac regeneration. “Now we need to find the signals that are sufficient to turn this pathway on,” said Rosenzweig.

“If we can turn on these pathways at just the right time, in the right people, then we can improve recovery after a heart attack,” said Lee.

Tagged with:

About author

Related Articles