Breaking News
May 28, 2018 - New consensus statement outlines evidence-based medical opinion on abusive head trauma
May 28, 2018 - E-Cigarettes Don’t Help Smokers Quit, But Cash Might
May 28, 2018 - New screening tool developed to assess tanning addiction
May 28, 2018 - Unhappy combination of alcohol, anger, and aggressive behavior
May 28, 2018 - Loyola survey identifies significant group of burn patients with elevated PTSD symptoms
May 28, 2018 - Cancer cells co-opt pain-sensing ‘wasabi receptor’ to survive oxidative stress
May 27, 2018 - New way of grouping atoms could herald novel materials, drugs and computers
May 27, 2018 - Less is more? Gene switch for healthy aging found
May 27, 2018 - Breast cancer survivors do not receive recommended level of screening after surgery
May 27, 2018 - Recommendations Developed for Managing Postpartum Pain
May 27, 2018 - Rheumatoid Arthritis (RA) | Arthritis Basics | Arthritis Types | Arthritis
May 27, 2018 - ‘Life support’ for transplant livers better than freezing: study
May 27, 2018 - Tree nut consumption linked to improved type 2 diabetes health
May 27, 2018 - Income and education gap causes racial differences in health behaviors, study shows
May 27, 2018 - Even at ‘Safe’ Levels, Air Pollution Puts Seniors at Risk
May 27, 2018 - Obstructive sleep apnea linked to thinning of calvaria, skull base
May 27, 2018 - Epigem’s Managing Director sets the bar for life sciences industry at VentureFest
May 27, 2018 - CPAP may reduce resting heart rate in prediabetic patients
May 27, 2018 - Study reveals striking disparities in health care access and quality across most nations
May 27, 2018 - The Yogi masters were right—meditation and breathing exercises can sharpen your mind
May 27, 2018 - SLU researcher aims to find solutions for diabetes patients at risk of hypoglycemia
May 27, 2018 - Scientists uncover the cause of insulin resistance in obesity
May 27, 2018 - $2.3 million NIH grant to support new project on oxytocin neurons and social behavior
May 27, 2018 - Less Driving Tied to Lower Cardiovascular Disease Risk
May 27, 2018 - Genetics Home Reference: LMNA-related congenital muscular dystrophy
May 27, 2018 - Long-term psychological study confirms time is the best medicine against homesickness
May 27, 2018 - Study explores if CPAP treatment can improve sexual QOL for sleep apnea patients
May 27, 2018 - Study investigates role played by brain in prosocial behavior
May 27, 2018 - New Guidelines Mean 1 in 3 Adults May Need Blood Pressure Meds
May 27, 2018 - Cerebrospinal Fluid (CSF) Analysis: MedlinePlus Lab Test Information
May 27, 2018 - Kids in tough neighborhoods head to ER more often
May 27, 2018 - Exercise alters brain’s dopamine system to help treat addiction, study finds
May 27, 2018 - Sepsis patients treated and released from ED for outpatient follow-up experience good outcomes
May 27, 2018 - Initiative cuts overuse of tests, treatments for bronchiolitis
May 27, 2018 - Study links ‘sleep spindles’ to memory reactivation
May 27, 2018 - Scientists develop new method to speed up genome evolution of baker’s yeast
May 27, 2018 - Sunscreen pills are fake says FDA
May 27, 2018 - Study finds increasing wealth gap between households of seniors and families with children
May 27, 2018 - Link between tuberculosis and Parkinson’s disease discovered
May 27, 2018 - Doctors call on health authorities for permission to provide stroke patients with life-saving treatment
May 26, 2018 - Couples who eat seafood-rich diet tend to get pregnant faster
May 26, 2018 - NIH summit presents recommendations to accelerate treatment development for Alzheimer’s disease
May 26, 2018 - Medication-related harm found to be common among older adults, but preventable
May 26, 2018 - Lunaphore and Vitro announce partnership to develop ISH protocols for RNA, DNA targets
May 26, 2018 - Cryoablation Efficacious for Cancer Pain, Review Finds
May 26, 2018 - Link between IBD and Parkinson’s might allow doctors to slow down condition
May 26, 2018 - Study finds fewer than 5% of low-income, urban mothers use prenatal vitamins before pregnancy
May 26, 2018 - California hospitals urge moms to favor breast milk over formula
May 26, 2018 - Most concussion patients do not receive follow-up care after hospital discharge, says study
May 26, 2018 - Lifetime risks of developing Alzheimer’s dementia vary by age, gender
May 26, 2018 - Researchers find novel ways to improve participation in clinical research
May 26, 2018 - Researchers develop methods for measuring free-base nicotine levels in e-cigarettes
May 26, 2018 - AHA: Preterm Birth Could Warn of Mom’s Future Heart Risks
May 26, 2018 - Some calories more harmful than others
May 26, 2018 - Study links cell size with commitment to division
May 26, 2018 - Researchers develop new, rapid blood test to detect liver damage
May 26, 2018 - Researchers discover cascade of immune processes linked to poor outcomes in aggressive breast cancer
May 26, 2018 - New research will use mathematics to solve mysteries in cell biology
May 26, 2018 - Proposed National Resilience Strategy to reverse catastrophic increases in ‘deaths of despair’
May 26, 2018 - Mice remain slim on burger diet
May 26, 2018 - BMC receives $13.5 million award to test methods for delivering childhood anxiety treatment
May 26, 2018 - ‘Right to Try Act’ will not benefit terminally-ill patients
May 26, 2018 - Study reveals novel statistical algorithm to identify potential disease genes
May 26, 2018 - Two genes play vital roles in malignant brain cancer
May 26, 2018 - Study explores link between groundwater lithium and diagnoses of bipolar disorder, dementia
May 26, 2018 - Researchers reveal stimulatory effects of myelin on young neural cells
May 26, 2018 - Small part of cellular protein that helps form long-term memories also drives neurodegeneration
May 26, 2018 - Four-legged friends can have heart issues, too
May 26, 2018 - Scientists create small, self-contained spaces inside mammalian cells
May 26, 2018 - Better Social Support Network Protects Black Men Against HIV
May 26, 2018 - National Heart, Lung, and Blood Institute (NHLBI)
May 26, 2018 - Burnout, depression can affect ophthalmology residents, study finds
May 26, 2018 - Latinos and African Americans more likely to experience serious depression than Whites
May 26, 2018 - Data from past epidemic could help improve response to future Ebola outbreaks
May 26, 2018 - Researchers provide insight into how the memory molecule limits brain plasticity
May 26, 2018 - OSU biologist describes ‘restoration ecology’ approach toward patient health
May 26, 2018 - New approach to study brown fat could aid in finding treatments for obesity
May 26, 2018 - UCI Center on Stress & Health receives NIH funding to develop digital health interventions
May 26, 2018 - Could More Fish in the Diet Boost Sex Lives and Fertility?
May 26, 2018 - NTU Singapore and SERI invent new scope to diagnose glaucoma
Study highlights potential of stem cells derived from adults in regenerative medicine

Study highlights potential of stem cells derived from adults in regenerative medicine

image_pdfDownload PDFimage_print

Donor age does not appear to influence the functionality of stem cells derived from adult body tissues, concludes a new review. The analysis of research on induced pluripotent stem cells (iPSCs) finds that not only are typical signs of aging reversed in iPSCs, but cells derived from both older and younger donors show the same ability to differentiate into mature body cells. This validates iPSCs as a viable alternative to embryonic stem cells in regenerative medicine. Published in Frontiers in Cardiovascular Medicine, the study highlights the enormous potential of iPSCs derived from elderly patients to treat their age-related diseases — and indicates future areas of research for this relatively new field.

“As average life expectancy continues to rise, so does the rate of age-related chronic and degenerative diseases,” explains Dr. Nicolle Kränkel from Charité, a medical university in Germany. “Organ replacement and other cell-based treatments could increase longevity and improve the quality of life for elderly people with heart disease, kidney failure and even Alzheimer’s disease. Our analysis of current knowledge on iPSCs indicates that stem cells derived from older patients are suitable for personalized regenerative therapies as well as for modeling genetic disease.”

Unlike most cells in the body, stem cells have the potential to develop into different cell types. Their discovery opened the possibility of growing specific cells to treat damaged tissues and organs, as well as genetic diseases.

Stem cells can be derived from two sources: embryos and adult tissues. It was commonly believed that embryonic stem cells (ESCs) are the only reliable source, as these “young” cells have not accumulated the same level of cell damage as older cells. However, embryonic stem cells also have limitations. These include ethical concerns, immunological rejection of transplanted tissue derived from ESCs, and limited availability of donated material.

The 2006 discovery of induced pluripotent stem cells — which can be derived directly from a patient — offers an attractive alternative. Their use has already been proved in a young patient: a boy suffering from a rare genetic disease, in which the skin blisters and tears off, recovered completely after receiving a skin transplant grown from his own gene-corrected stem cells.

However, questions remained about the impact of donor age on iPSC functionality — an especially relevant point given that the elderly stand to benefit the most from these stem cells. Kränkel and colleagues therefore critically analyzed the available research to date, to summarize what is known and identify future research needs.

The analysis revealed that the age of the donor may reduce the efficiency at which their body cells can be reprogrammed into iPSCs. However, once generated, the stem cells appear to be rejuvenated – with typical signs of aging reversed.

“iPSCs show improved functionality compared to the donor’s regular body cells, and can be differentiated into mature body cells with a similar efficiency to younger stem cell donors,” says Kränkel. “This means that stem cells from an elderly patient can be developed into other cells and returned to the patient for treatment.”

Despite this promising conclusion, it is still a matter of debate as to whether cells from older donors have accumulated more damaging mutations than those of younger donors. “This seems logical,” says Elisabeth Strässler, co-author of the study. “There is also the issue of whether such mutations persist during the transformation to stem cells, or whether they are repaired.”

Other important questions also remain unanswered.

“The field of iPSC research is still rather ‘young’ and more research is necessary. This includes whether iPSC-derived cells might form tumors once transplanted back into a patient; consensus on which tests should be mandatory for assessing genetic stability and stem cell function; and defined protocols to better compare results from different labs,” concludes Kränkel.

Source:

http://www.frontiersin.org

Tagged with:

About author

Related Articles