Breaking News
May 21, 2018 - Cell phones at summer camp: Research explores the effects
May 21, 2018 - Birth rate decline driven by waiting longer to have children, cost of infertility treatment
May 21, 2018 - In-hospital opioid prescribing may increase post-discharge opioid use, shows study
May 21, 2018 - ABPI expert urges to find new ‘blockbuster treatments’ for brain tumors
May 21, 2018 - Disruption of Circadian Rhythm Negatively Impacts Mental Health
May 21, 2018 - World first use of cognitive training reduces gait freezing in Parkinson’s patients
May 21, 2018 - NIH stops alcohol study that was looking at purported health benefits of drinking
May 21, 2018 - Higher belly fat levels linked to greater risk of vitamin D deficiency
May 21, 2018 - Scientists collate evidence for mismatch between past evolutionary adaptation and modern lives
May 21, 2018 - New case report reveals negative clinical impact of using biotin supplement
May 21, 2018 - Researchers discover new disease mechanism in chronic tobacco smokers
May 21, 2018 - Breast Cancer Patients May Shorten Herceptin Regimen: Study
May 21, 2018 - Bias keeps women with higher body weights away from the doctor: study
May 21, 2018 - Researchers identify protein essential for eye lens development and clear vision
May 21, 2018 - Frontal cortical lesions moderate response to prism adaptation treatment after stroke
May 21, 2018 - Ultrasound guidelines can reliably differentiate between pediatric thyroid nodules that require biopsy
May 21, 2018 - Weight loss is an important predictor of cancer
May 21, 2018 - Ozone exposure at birth linked to increased risk of developing asthma in childhood
May 21, 2018 - CT scan still effective to determine thrombectomy treatment in stroke, study shows
May 21, 2018 - Clot busting drug combo reduces risk of major strokes in high risk patients
May 21, 2018 - New airway transplantation technique shows promising results in lung cancer patients
May 21, 2018 - Biomarker blood test does not appear to curb antibiotic overuse, shows new study
May 21, 2018 - Lilly’s Galcanezumab Meets Primary Endpoint in Phase 3 Study Evaluating Galcanezumab for the Prevention of Episodic Cluster Headache
May 21, 2018 - Grief symptoms similar in donor vs non-donor decision families
May 21, 2018 - Congo to start vaccinating populations against Ebola today to combat outbreak
May 21, 2018 - Researchers use MR spectroscopy to investigate mechanisms behind targeted treatment for gliomas
May 21, 2018 - Study reveals why older workers have higher stress levels than younger colleagues
May 21, 2018 - Health Tip: Taming a Pollen Allergy
May 21, 2018 - Inducing labor at 39 weeks reduces risks of C-section and other complications
May 20, 2018 - Developmental psychotherapy aims at helping antisocial adolescents become responsible adults
May 20, 2018 - People with OCD process emotions differently than their unaffected siblings
May 20, 2018 - Interfering with enzyme’s movement may be new approach for developing of anti-cancer drugs
May 20, 2018 - Prestroke and poststroke oral anticoagulation therapy in AF patients
May 20, 2018 - Why drug users prefer heroin at home, but cocaine while out
May 20, 2018 - Gene therapy that reverses blindness in dogs could also help treat humans
May 20, 2018 - Opioid-Related Payments Linked to Increase in Opioid Rx
May 20, 2018 - Phone apps push people to take their pills
May 20, 2018 - Backbreaking Work May Shorten Men’s Lives
May 20, 2018 - Harsher drug laws won’t stop violence, argues former police chief
May 20, 2018 - Cognitive decline in dementia is not reduced by exercise
May 20, 2018 - Detecting breast cancer with non-invasive ‘disease screening pill’
May 20, 2018 - Simple treatment may minimize hearing loss triggered by loud noises
May 20, 2018 - Alignment of mother and offspring body clock could prevent diseases such as heart disease and obesity
May 20, 2018 - New commercial data warehouse for life sciences
May 20, 2018 - Practice Intervention Targeting IV Opioids May Cut Exposure
May 20, 2018 - New study provides insight into blood signatures of inflammation
May 20, 2018 - Scientists make breakthrough discovery about vitamin B12
May 20, 2018 - What Causes Cancer? Misconceptions Abound
May 20, 2018 - Proper burial of dead cells limits inflammation
May 20, 2018 - Study offers novel solution to suppress metastatic spread of deadly breast cancer
May 20, 2018 - Perspectives of patients and caregivers on care transitions
May 20, 2018 - Guidelines for weight gain in pregnancy should be changed for underweight and very obese women
May 20, 2018 - Researchers transplant retinal sheets derived from human embryonic stem cells in retinal degeneration mouse models
May 20, 2018 - U.S. military personnel at greater risk for skin cancer than general population
May 20, 2018 - Your immune system holds the line against repeat invaders, thanks to this molecule
May 20, 2018 - Between death and deportation
May 20, 2018 - Developing a High Throughput Mass Spectrometry Platform for Drug Discovery
May 19, 2018 - New project aims to increase awareness among hospital clinicians of non-beneficial treatment at end-of-life
May 19, 2018 - Automated bone scan index offers accurate, speedy prognostic information about prostate cancer
May 19, 2018 - Rutgers Cancer Institute nurses research various topics to enhance patient experience
May 19, 2018 - Computer models provide valuable insight to structure and function of Ebola, Zika viruses
May 19, 2018 - Study exposes key tactic used by deadly fungus
May 19, 2018 - Bacterial signals are crucial to development of pre-leukemic myeloproliferation, study shows
May 19, 2018 - Global experts identify key issues in supporting children with brain injuries transition back to school
May 19, 2018 - Social connections may protect black men who have sex with men from acquiring HIV
May 19, 2018 - Study IDs Factors Linked to Quality of Life With Dementia
May 19, 2018 - Potassium — Consumer
May 19, 2018 - HIV-1 viruses transmitted at birth are resistant to antibodies in mother’s blood
May 19, 2018 - Some water pitchers are much better at removing toxins, shows research
May 19, 2018 - Scientists discover how unusually long strands of RNA help colon cancer cells avoid death
May 19, 2018 - International study finds viable treatment option for people with mild asthma
May 19, 2018 - Mayo discovery could enable development of personalized ovarian, brain cancer treatments
May 19, 2018 - ‘Superbug’ Surfaces at Poultry Farm in China
May 19, 2018 - UCLA-designed program helps former HIV-positive inmates maintain health after release from jail
May 19, 2018 - New blood test could help avoid more than 40% of prostate biopsies, study finds
May 19, 2018 - Macrophages play key role in maintaining stem cell niche of mammary gland
May 19, 2018 - Ferritin Blood Test: MedlinePlus Lab Test Information
May 19, 2018 - Prolonged exposure to air pollution leads to genetic changes in rat brains, study finds
May 19, 2018 - Scientists identify new potential target to combat acute myeloid leukemia
May 19, 2018 - Ovarian cancer therapy may help treat patients with aggressive pancreatic cancer
MU researchers use new techniques to fight against diabetic retinopathy

MU researchers use new techniques to fight against diabetic retinopathy

image_pdfDownload PDFimage_print

Diabetic retinopathy is a retinal microvascular disease that often causes blindness in adults who have had diabetes mellitus for 10 years or more. Estimates are that 600 million people will have some sort of diabetic retinopathy by 2040. Previously, no good animal models existed that scientists could use to study the disease, its diagnosis or potential treatments. Now, a team of researchers led by the University of Missouri has employed a mouse model exhibiting diabetic retinopathy symptoms that could lead to future translational research studies.

“Diabetic retinopathy is a common retinal complication of diabetes mellitus that can be categorized in different stages in humans,” said Shyam Chaurasia, an assistant professor of ophthalmology and vision sciences research in the MU College of Veterinary Medicine. “Multiple interlinked pathways–including malfunctions in the immune system–lead to cellular damage. These vascular and neuronal abnormalities in the retina lead to ‘blind spots’ and complete blindness. With the prevalence of diabetes reaching record levels, it is important to develop the tools needed to combat this disease.”

The team focused on a specific inflammasome, a protein responsible for the activation of inflammatory responses, called the NLRP3 inflammasome. Long-term hyperglycemia results in the activation of the NLRP3 inflammasome causing vascular leakages in the retina and eventually leading to neovascularization, which is the formation of new blood vessels or networks in the retina.

Using advanced retinal imaging techniques, the scientists tested these diabetic mice that processed NLRP3. Using a new technique called laser speckle flowgraphy, the group was able to create the “heat map” of blood flow volume and found significantly decreased levels in the NLRP3 mice. These mice also showed an increased prevalence of a buildup of macrophages in the retina that could be caused by immune responses involved in chronic inflammation that leads to diabetic retinopathy.

“Several new techniques and potential diagnostics are demonstrated in this study for the first time, including the laser speckle flowgraphy technique, which may prove useful in the diagnosis of human DR,” Chaurasia said. “This is the first study to show that the activation of the NLRP3 inflammasome is involved in the proliferative changes observed during DR progression, proving that this mouse model could be useful in screening potential drugs to fight the disease.”

The study, “The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy,” was published in Scientific Reports. Major funding was provided by Department of Veterinary Medicine and Surgery Start-up grant to Dr. Chaurasia. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.

Source:

https://munews.missouri.edu/news-releases/2018/0425-fighting-diabetic-blindness-mu-researchers-develop-new-target-to-study-potential-treatments/

Posted in: Medical Science News | Medical Research News | Medical Condition News

Tags: Blindness, Blood, Blood Vessels, Diabetes, Diabetes Mellitus, Diabetic Retinopathy, Diagnostics, Drugs, heat, Hyperglycemia, Imaging Techniques, Immune System, Inflammation, Macrophages, Ophthalmology, Protein, Research, Retinopathy, Surgery, Vascular, Veterinary

Tagged with:

About author

Related Articles