Breaking News
June 21, 2018 - People with severe obesity constantly try to reduce or control their weight
June 21, 2018 - Recovery and Treatment | NIH MedlinePlus the Magazine
June 21, 2018 - ‘Hidden’ driver discovered that helps prime the anti-tumor immune response
June 21, 2018 - Groundbreaking discovery could be key to preventing cancer metastasis
June 21, 2018 - Impulse control disorders found to be more common in people taking Parkinson’s drugs
June 21, 2018 - Study finds possible link between Type 2 diabetes and common white pigment
June 21, 2018 - Most emergency department patients wish to be involved in medical decision-making
June 21, 2018 - Study highlights growing problem of ‘iPad neck’ among young adults and women
June 21, 2018 - UT Southwestern scientists identify gene mutation linked with perplexing brain condition
June 21, 2018 - New study sheds light on role of vitamin D in healthy pregnancy
June 21, 2018 - Teva Provides Update on Clinical Trial of Fremanezumab for Use in Chronic Cluster Headache
June 21, 2018 - Unlocking the secrets of HIV’s persistence
June 21, 2018 - New guidelines recommend newborns with Down’s syndrome to receive leukemia test
June 21, 2018 - BetterYou’s new Magnesium Bone Lotion helps maximize bone health
June 21, 2018 - UH scientist receives grant to examine understudied part of glaucoma
June 21, 2018 - Lifestyle intervention could normalize unhealthy behaviors that lead to cancer, chronic disease
June 21, 2018 - Combining two anti-malarial vaccines could greatly reduce number of infections
June 21, 2018 - By 2030, prostate and lung cancers expected to be most common cancers among HIV population
June 21, 2018 - Researchers evaluate patient satisfaction and well-being after breast reconstruction
June 21, 2018 - Combining stem cell technology and artificial intelligence to diagnose genetic cardiac diseases
June 21, 2018 - Monash study reveals why older people have reduced immune responses to cancer therapy
June 21, 2018 - Researchers develop new microscope system that can image living tissue in real time
June 21, 2018 - Long-term estrogen therapy alters microbial composition and activity in the gut
June 21, 2018 - Study points to dangers of feeding non-dairy drink to infants
June 21, 2018 - Cannabis Use Linked to Psychosis Symptoms in Adolescents
June 21, 2018 - Inadequate sleep could cost countries billions
June 21, 2018 - Inhibiting epigenetic proteins with drugs could prevent development of breast cancer
June 21, 2018 - Study identifies factors that contribute to vaginal dryness
June 21, 2018 - Researchers employ nucleotide-based gene silencing to mitigate common ataxia
June 21, 2018 - New tool determines best treatment plan for adults with severe asthma
June 21, 2018 - Identifying gene variants that contribute to ovarian reserve may improve female fertility
June 21, 2018 - Religious involvement has no significant effect on misuse of prescription opioids, study finds
June 21, 2018 - Researchers characterize key signaling network that drives growth of triple negative breast cancers
June 21, 2018 - AHA: Big Weight Gain in 1st Pregnancy Could Boost Preeclampsia Risk
June 21, 2018 - How vaping helps even hardened smokers quit
June 21, 2018 - Gaming disorder an official disease condition says WHO
June 21, 2018 - Oxygen consumption in human BAT increases after a meal, shows research
June 21, 2018 - Research finds addictions to be diseases of the brain, not criminal behavior or personality disorders
June 21, 2018 - New study is testing safety and efficacy of glycoside in breaking up kidney stones
June 21, 2018 - Biosimilar competition may offer hope for cheaper, better psoriasis treatments in the future
June 21, 2018 - Cells form cage-like structures that trap viruses
June 21, 2018 - Wound protector use linked to significant reduction in surgical site infection
June 21, 2018 - African Americans and Latinos are more likely to be at risk for depression than Whites
June 21, 2018 - Genome study presents new way to track historical demographics of US populations
June 20, 2018 - Study sheds light on the early stages of tumorigenesis
June 20, 2018 - Quick adoption of new diagnostic tests could help NHS to save nearly £7 billion
June 20, 2018 - Mayo Clinic researchers find genetic mutations that increase person’s risk for pancreatic cancer
June 20, 2018 - Chemists invent new method for remote chiral induction
June 20, 2018 - Methadone or buprenorphine associated with reductions in opioid related mortality
June 20, 2018 - New simulation approach predicts efficacy of HIV-prophylaxis medications
June 20, 2018 - Rhythm Pharmaceuticals Completes Pivotal Enrollment in Two Ongoing Phase 3 Clinical Trials Evaluating Setmelanotide in Rare Genetic Disorders of Obesity
June 20, 2018 - Threat of malaria left its mark on the immune system in people with African ancestry
June 20, 2018 - Recent-onset type 2 diabetes may be early expression of pancreatic cancer
June 20, 2018 - Why are vaccines less effective in the developing world?
June 20, 2018 - Study opens new window into cellular events that occur in the brain during absence seizures
June 20, 2018 - Humana and Walgreens to provide easier access to primary care and other services for seniors
June 20, 2018 - ANU research could help find life in Mars and other planets
June 20, 2018 - Multidisciplinary Human-Focused Research
June 20, 2018 - ‘Mind-minded’ parents contribute greatly to development of infants’ emotion regulation capacity
June 20, 2018 - New study finds increase in use of alternative medicines among children
June 20, 2018 - Forgetting plays a positive role in learning, research suggests
June 20, 2018 - Elevated NT-proBNP Found to Up Cardiovascular Risk in T2DM
June 20, 2018 - Genetics Home Reference: White-Sutton syndrome
June 20, 2018 - Canadian team reports success in transplanting hepatitis C organs
June 20, 2018 - Separating migrant children from parents at US border tantamount to child abuse
June 20, 2018 - Study finds more information about how gene linked to ASD affects the brain
June 20, 2018 - Researchers develop portable monitor to detect dangerous drop in white blood cells
June 20, 2018 - Floppy eyelids linked to sleep apnea
June 20, 2018 - Can-Fite provides update on Phase II clinical trial with drug candidate Namodenoson
June 20, 2018 - KIYATEC enrolls first patients with solid tumors in clinical study of its EV3D drug response assay
June 20, 2018 - Study finds growing support to allow pharmacists to write prescriptions
June 20, 2018 - Malnutrition could have major health implications on patients’ surgical outcomes, shows research
June 20, 2018 - LabConnect collaborates with Symphony to support clinical research industry
June 20, 2018 - Italian innovative SME receives 2.5 million Euro from RedSeed Ventures
June 20, 2018 - AHA: Kids Can Drown Quickly and Silently, So Prevention Is Key
June 20, 2018 - Continuous glucose monitors proven cost-effective, add to quality of life for diabetics
June 20, 2018 - Researchers use droplet-sized ‘miniecosystems’ to test therapeutic potential of molecules
June 20, 2018 - New approach could provide objective and easy-to-obtain measure of dietary adherence
June 20, 2018 - Dual-therapy approach can help boost motor recovery in stroke victims
June 20, 2018 - ‘Miracle treatment’ long-term success for babies with diabetes
Scientists develop algorithm to predict hypotension during surgery

Scientists develop algorithm to predict hypotension during surgery

image_pdfDownload PDFimage_print

Scientists have developed an algorithm that predicts potentially dangerous low blood pressure, or hypotension, that can occur during surgery. The algorithm identifies hypotension 15 minutes before it occurs in 84 percent of cases, the researchers report in a new study published in the Online First edition of Anesthesiology, the peer-reviewed medical journal of the American Society of Anesthesiologists (ASA).

A variety of factors can impact blood pressure during surgery. In some people, these factors may cause a significant drop in blood pressure.

“Physicians haven’t had a way to predict hypotension during surgery, so they have to be reactive, and treat it immediately without any prior warning. Being able to predict hypotension would allow physicians to be proactive instead of reactive,” said lead researcher Maxime Cannesson, M.D., Ph.D., professor of anesthesiology and vice chair for perioperative medicine at UCLA Medical Center in Los Angeles. “By finding a way to predict hypotension, we can avoid its complications, which can include postoperative heart attack and acute kidney injury, that can lead to death in some cases.”

Serious complications can develop quickly, and the risk of serious complications increases the longer a patient remains hypotensive. Advance warning that hypotension is imminent, even if the warning comes only 10 to 15 minutes ahead, could reduce the risk of harm to patients, the authors note.

In the study, researchers used a technique called machine learning, a discipline within computer sciences that focuses on the application of algorithms to provide computers with the ability to learn and detect patterns associated with a specific outcome in large datasets. The algorithm was developed to observe subtle signs in routinely collected physiological data that could predict the onset of hypotension in surgical patients.

The researchers used two sets of data to build and validate the predictive algorithm. One data set, used for training, consisted of 1,334 patient records with 545,959 minutes of arterial pressure waveform recordings-;recordings of the increase and decrease of blood pressure in the arteries during a heartbeat. That data set included 25,461 episodes of hypotension. A second data set, used for external validation of the model, consisted of 204 patient records with 33,236 minutes of arterial pressure waveform recordings and 1,923 episodes of hypotension.

For each heartbeat, the scientists were able to extract 3,022 individual features from the arterial pressure waveforms. When combined, these features yielded more than 2.6 million bits of information used to build the algorithm. The authors found the algorithm was able to accurately predict an intraoperative hypotensive event 15 minutes before it occurred in 84 percent of cases, 10 minutes before in 84 percent of cases, and 5 minutes before in 87 percent of cases.

“We are using machine learning to identify which of these individual features, when they happen together and at the same time, predict hypotension,” Dr. Cannesson said. “The statistical association between these features and the occurrence of hypotension is fascinating because we can potentially reverse engineer this statistical association and augment our understanding of this complex physiological phenomenon.”

Software that uses the new algorithm, made by Edwards Lifesciences, was granted a De Novo request in March 2018 by the U.S. Food and Drug Administration. It has been commercially available in Europe since 2016, Dr. Cannesson noted.

“It is the first time machine learning and computer science techniques have been applied to complex physiological signals obtained during surgery,” Dr. Cannesson said. “Although future studies are needed to evaluate the real-time value of such algorithms in a broader set of clinical conditions and patients, our research opens the door to the application of these techniques to many other physiological signals, such as EKG for cardiac arrhythmia prediction or EEG for brain function. It could lead to a whole new field of investigation in clinical and physiological sciences and reshape our understanding of human physiology.”​

About author

Related Articles