Breaking News
February 22, 2019 - Biologist uses new grant to find ways to eliminate schistosomiasis
February 22, 2019 - Bag-mask ventilation to help patients breathe during intubation prevents complications
February 22, 2019 - AbbVie Announces New Drug Application Accepted for Priority Review by FDA for Upadacitinib for Treatment of Moderate to Severe Rheumatoid Arthritis
February 22, 2019 - Nature versus nurture and addiction
February 22, 2019 - New website connects researchers with data experts, resources | News Center
February 22, 2019 - Today’s Concerns About Drug Prices Echo The Past
February 22, 2019 - CT and Doppler equipment have low accuracy in detecting cerebral vasospasm and ischemia
February 22, 2019 - Study finds out similarity in function between healthy retina cell and tumor cell
February 22, 2019 - CWRU awarded NIH grant to identify effective treatments for intimate partner violence
February 22, 2019 - Oncotype DX Not Cost-Effective for Low-Risk Breast Cancer
February 22, 2019 - Scientists discover new type of immune cells that are essential for forming heart valves
February 22, 2019 - Talk About Déjà Vu: Senators Set To Re-Enact Drug Price Hearing Of 60 Years Ago
February 22, 2019 - Genetic defect linked to pediatric liver disease identified
February 22, 2019 - New cellular atlas could provide a deeper insight into blinding diseases
February 22, 2019 - Growing number of cancer survivors, fewer providers point to challenge in meeting care needs
February 22, 2019 - Innovative compound offers a new therapeutic approach to treat multiple sclerosis
February 22, 2019 - $1.5 million grant to develop opioid treatment program for jail detainees
February 22, 2019 - FDA’s new proposed rule would update regulatory requirements for sunscreen products in the U.S
February 22, 2019 - Most Hip, Knee Replacements Last Decades, Study Finds
February 22, 2019 - Wellness problems prevalent among ob-gyn residents
February 22, 2019 - In the Spotlight: “The world is your oyster in geriatrics”
February 22, 2019 - Successful testing of multi-organ “human-on-a-chip” could replace animals as test subjects
February 22, 2019 - Analysis of cervical precancer shows decline in two strains of HPV
February 22, 2019 - Sugary stent eases suturing of blood vessels
February 22, 2019 - From surgery to psychiatry: A medical student reevaluates his motivations
February 22, 2019 - Is New App From Feds Your Answer To Navigating Medicare Coverage? Yes And No
February 22, 2019 - New pacemakers powered by heartbeats could reduce need for surgery
February 22, 2019 - The United States records highest drug overdose death rates
February 22, 2019 - Phase 1 data reinforce safety profile of new drug for treating Duchenne muscular dystrophy
February 22, 2019 - Vitamin D supplementation less effective in the presence of obesity, shows study
February 22, 2019 - CPRIT awards nearly $20 million to The University of Texas MD Anderson Cancer Center
February 22, 2019 - Sarepta Announces FDA Acceptance of Golodirsen (SRP-4053) New Drug Application for Patients with Duchenne Muscular Dystrophy Amenable to Skipping Exon 53
February 22, 2019 - An institutional effort to reduce the amount of opioids prescribed following lumbar surgery
February 22, 2019 - Family-history-based models perform better than non-family-history based models
February 22, 2019 - Failure to take statins leads to higher mortality rates | News Center
February 22, 2019 - New study explains why some patients report phantom sensations after limb amputation
February 22, 2019 - First motor-controlled heart valves implanted by Mainz University Medical Center
February 22, 2019 - Novel preclinical model mimics persistent interneuron loss seen in preterm infants
February 22, 2019 - Global health burden of glaucoma has increased, study reveals
February 22, 2019 - A holistic approach key to minimize treatment complexity in patients with interstitial lung disease
February 22, 2019 - 1 in 10 middle-aged Chinese adults are at high risk for heart disease, finds study
February 22, 2019 - More than half a million breast cancer patient’s lives saved by improvements in treatment
February 22, 2019 - Study finds no evidence that tougher policies prevent teenage cannabis use
February 22, 2019 - New blood test detects genetic disorders in fetuses
February 22, 2019 - Lower Self-Perception Observed in Children With Amblyopia
February 22, 2019 - Up to 15 percent of children have sleep apnea, yet 90 percent go undiagnosed
February 22, 2019 - Rare pulmonary defect prompts parents’ nationwide search for answers | News Center
February 22, 2019 - Lesbian and bisexual women at greater risk of being overweight, study finds
February 22, 2019 - UQ research may explain why vitamin D is essential for brain health
February 22, 2019 - Heart Attacks Rising Among Younger Women
February 22, 2019 - How your smartphone is affecting your relationship
February 22, 2019 - Orthopaedic surgeon receives prestigious award, $10 million grant | News Center
February 22, 2019 - New sepsis test could save thousands of lives
February 22, 2019 - Cervical cancer could be eradicated by 2100
February 21, 2019 - Sustained smoking cessation can lower risk of seropositive RA
February 21, 2019 - Thousands with chronic UTIs are not receiving the treatment they need
February 21, 2019 - Are teens getting high on social media? The surprising study seeking the pot-Instagram link
February 21, 2019 - Stanford expands biobank services | News Center
February 21, 2019 - Scientists identify link between drinking contexts and early onset intoxication among adolescents
February 21, 2019 - Strong social support may reduce cardiovascular disease risk in postmenopausal women
February 21, 2019 - Rapid expansion of interventions could prevent up to 13 million cases of cervical cancer within 50 years
February 21, 2019 - Motif Bio Receives Complete Response Letter From The FDA
February 21, 2019 - Researchers map previously unknown disease in children
February 21, 2019 - A skeptical look at popular diets: Going gluten-free
February 21, 2019 - Podcast: KHN’s ‘What The Health?’ How Safe Are Your Supplements?
February 21, 2019 - Factors associated with increased risk of developing surgical site infections
February 21, 2019 - Anticipatory signals in eye movements can help measure attentive capacity, learning with greater precision
February 21, 2019 - Study explores daily exposure to indoor air pollutants
February 21, 2019 - Evening exercise does not negatively affect sleep, may also reduce hunger
February 21, 2019 - Artificial intelligence technique can be used to identify alcohol misuse in trauma setting
February 21, 2019 - Overweight, obesity in adolescence associated with increased risk of renal cancer later in life
February 21, 2019 - BGU develops new AI platform for monitoring and predicting ALS progression
February 21, 2019 - Researchers discover a new promising target to improve HIV vaccines
February 21, 2019 - Brief Anesthesia in Infancy Does Not Mar Neurodevelopment
February 21, 2019 - Gaming system helps with autism diagnosis
February 21, 2019 - Heart Disease: Six Things Women Should Know
February 21, 2019 - More States Say Doctors Must Offer Overdose Reversal Drug Along With Opioids
February 21, 2019 - Researchers explore case studies focused on industries that kill more people than employed
February 21, 2019 - Only half of GP practice buildings are fit for purpose
February 21, 2019 - Intense exercise, fasting and hormones can enhance waste-protein removal, study shows
High bitter-taste sensitivity linked to increased risk of cancer

High bitter-taste sensitivity linked to increased risk of cancer

image_pdfDownload PDFimage_print

High bitter-taste sensitivity is associated with a significantly increased risk of cancer in older British women, according to researchers who conducted a unique study of 5,500 women whose diet, lifestyle and health has been tracked for about 20 years.

The research examined the relationship between the ability to taste the bitter-tasting chemical phenylthiocarbamide, known as PTC, or the presence of specific genetic differences in the bitter taste receptor, TAS2R38, which binds to PTC, and risk of cancer in a subset of the UK Women’s Cohort Study.

The UK Women’s Cohort Study was established in 1995 by nutritional epidemiologists at Leeds University to explore links between diet and chronic disease, cancer in particular. The study had an initial middle-aged female population of 35,000. The researchers obtained cancer incidence data from Great Britain’s National Health Service Central Register.

Researchers analyzed the food intake of women in the study, using a 217-item food-frequency questionnaire administered when the women joined the cohort in the late 1990s. Researchers hypothesized that women with higher bitter-taste sensitivity would consume fewer vegetables and have higher incidence of cancer.

Although there was no correlation between bitter-taste sensitivity and vegetable intake, researchers did find that, among older women, bitter-taste sensitivity was associated with greater cancer risk, according to lead researcher Joshua Lambert, associate professor of food science in the College of Agricultural Sciences, Penn State.

Lambert, who collaborated with scientists in Leeds University’s nutritional epidemiology group while he was on sabbatical in England conducting the research, noted that depending on the level of sensitivity to bitter tastes, study participants were classified as super-tasters, tasters and non-tasters. The findings were published online this month in the European Journal of Nutrition.

“The difference in cancer incidence between the women with the highest bitter-taste sensitivity and those with the lowest was striking,” he said. “Super-tasters had about a 58 percent higher risk of cancer incidence, and the tasters had about a 40 percent higher risk of developing cancer, compared to women who were classified as non-tasters.”

However, in this analysis, high bitter-taste sensitivity didn’t yield the expected link to dietary choices that could explain the higher cancer incidence, Lambert pointed out.

“Our hypothesis was that women who had higher bitter-taste sensitivity — either they were PTC tasters or super-tasters, or they had the TAS2R38 diplotype to suggest that they were tasters or super-tasters — would be at higher risk of developing cancer than women who were non-tasters. We thought that would happen because over their lifetime they would have consumed fewer bitter-tasting vegetables, which have been reported to have cancer preventive activities,” he said.

“When we looked at the data, we saw that for women over 60, our hypothesis was partially correct. Cancer risk was higher among women classified as tasters or super-tasters, but we didn’t see any differences in bitter-tasting vegetable consumption.”

Super-tasters and tasters didn’t eat fewer vegetables than the non-tasters, Lambert noted. They reported consuming as many Brussels sprouts and as much broccoli, for instance, as the non-tasters.

So where does that leave researchers? Anxious to do more studies to unravel the factors that drive the relationship between bitter-taste sensitivity and cancer, Lambert said. He and colleagues in Penn State’s Department of Food Science and Department of Public Health Sciences submitted a grant application in May to the American Institute for Cancer Research to fund a study on the relationship between bitter-taste sensitivity and colon cancer risk in American men and women.

But it also has them thinking that the relationship between bitter-taste sensitivity and cancer likely relates more to overall diet quality than just vegetable consumption, according to Lambert. He said that more and more, cancer experts suspect that dietary connections to the disease will only be revealed if researchers study the bigger picture.

“Our hypothesis that women with greater bitter-taste sensitivity would eat fewer vegetables, putting them at heightened risk for cancer, was perhaps too narrow a concept,” he said. “If you have an aversion to bitter taste, you are also less likely to drink alcohol, and alcohol is a risk factor for cancer. So, do the risks of eating too few vegetables outweigh the benefits of not drinking alcohol in terms of your overall cancer risk, or vice versa? We just don’t know, yet.”

Although researchers didn’t see the relationship between bitter-taste sensitivity and vegetable consumption that they expected, that doesn’t mean it doesn’t exist in the wider context of the total diet, Lambert suggested.

“Maybe, if we pull back and look at the whole-diet level, we will see that women who are super-tasters have a poorer quality overall diet compared to women who are non-tasters,” he said.

Source:

https://news.psu.edu/story/528597/2018/07/18/research/link-found-between-bitter-taste-sensitivity-and-cancer-risk

Tagged with:

About author

Related Articles