Breaking News
March 25, 2019 - Trastuzumab Tied to Higher Long-Term Risk for Heart Failure
March 25, 2019 - Personal context directly affects CPAP use
March 25, 2019 - Mosquito tracking key to preventing disease outbreaks
March 25, 2019 - Scientists Detect Hidden Signals from Beneficial Bacteria
March 25, 2019 - Treating women with thyroid antibodies with Levothyroxine do not increase live birth rate
March 25, 2019 - Brain area that only processes spoken, not written words identified
March 25, 2019 - Race and ethnicity influence fracture risk in diabetic patients
March 25, 2019 - Researchers report new regenerative medicine approach for treating osteoarthritis of the knee
March 25, 2019 - Exposure to dim light at night may contribute to spread of breast cancer to bones
March 25, 2019 - Benefits of osteoporosis treatment in postmenopausal women outweigh the perceived risks
March 25, 2019 - Researchers find evidence of Cryptosporidium parasite in Minnesota’s public water systems
March 25, 2019 - Three Clues to Raised Risk of Miscarriage
March 25, 2019 - Structured play helps toddlers self-regulate, altering their life course
March 25, 2019 - Translating horror into justice: Stanford psychiatrist advocates for human rights
March 25, 2019 - HORIBA Medical introduces D-Dimer reagent for Yumizen G hemostasis range
March 25, 2019 - Recurrent pregnancy loss may be caused by sperm DNA damage, finds study
March 25, 2019 - Special Collection tracks development of new diagnostic tests for tuberculosis
March 25, 2019 - Air Force develops genetic test to predict mental performance
March 25, 2019 - To abort or not to abort—making difficult choices alone
March 25, 2019 - Computer vision technology could aid ICU care by spotting movement
March 25, 2019 - IONTAS wins ‘Small Business of the Year’ category at Cambridge News Business Excellence Awards 2019
March 25, 2019 - First postpartum depression drug gets FDA nod
March 25, 2019 - Research Recognition Award will help improve lives of young people with absence epilepsy
March 25, 2019 - Bisphosphonates to treat osteoporosis appears to be beneficial for all women
March 25, 2019 - Dolomite Bio releases new Drop-seq datasets for single-cell RNA sequencing
March 25, 2019 - Hemoglobin A1c blood test may underestimate prevalence of diabetes
March 25, 2019 - Immune system errors linked to development of childhood leukemia
March 25, 2019 - Eating leafy green vegetables may help maintain muscle strength and mobility
March 25, 2019 - BMA secures state-backed clinical negligence indemnity scheme for GP trainees
March 25, 2019 - Biohaven Announces Completion of Pre-NDA Meeting With FDA for Oral CGRP Receptor Antagonist Rimegepant
March 25, 2019 - Adding breakfast to classrooms may have a health downside
March 25, 2019 - She Was Dancing On The Roof And Talking Gibberish. A Special Kind Of ER Helped Her.
March 25, 2019 - KNAUER introduces new Sepapure FPLC columns and media for protein purification tasks
March 25, 2019 - Weight loss in obese migraine sufferers can improve their quality of life
March 25, 2019 - Exposure to particulate air pollution may lead to reduced sperm production
March 25, 2019 - Synthetic peptide appears to disrupt inflammation and protect kidneys from nephritis
March 25, 2019 - New guideline focuses on strategies to improve health of older adults with diabetes
March 25, 2019 - Study evaluates prescribing of preventive drugs at the end of life in older adults with cancer
March 25, 2019 - Radial or femoral approaches for PCI are equal in terms of survival in heart attack patients
March 25, 2019 - Study shows how some autoimmune diseases are more closely related than others
March 25, 2019 - Long term opioid medications impacts production of important hormones
March 25, 2019 - FDA Issues Complete Response Letter for Zynquista (sotagliflozin)
March 25, 2019 - CDC researchers report on trends in hospital breastfeeding policies
March 25, 2019 - States Push For Caregiver Tax Credits
March 25, 2019 - Females on ketogenic diet fail to show metabolic benefits in animal model
March 25, 2019 - Modulating stiffness of blood-forming stem cells could facilitate mobilization procedures
March 25, 2019 - Gene editing regulations to be tightened
March 25, 2019 - CPAP treatment can result in weight loss in people with sleep apnea and obseity
March 25, 2019 - Highly attractive businesswomen are considered less trustworthy ‘femmes fatales’
March 25, 2019 - Breast Density Categorization Varies With Screening Modality
March 25, 2019 - Researchers explore link between metal exposure and Parkinson’s symptoms
March 25, 2019 - Later meal timing may contribute to weight gain
March 25, 2019 - Around one in hundred people has autism spectrum condition in China
March 25, 2019 - Research paves way for new standard of care to improve heart’s pump function
March 25, 2019 - Exposure to HIV virus, antiretroviral therapy before birth linked to obesity and asthma-like symptoms
March 25, 2019 - Transgender men preserve their fertility potential after one year of testosterone therapy
March 25, 2019 - Tighter Blood Pressure Control May Prevent Brain Lesions
March 25, 2019 - A reward now or later? Exploring impulsivity in Parkinson’s disease patients
March 25, 2019 - Financial incentives fail to increase completion rates of colorectal cancer screening tests mailed to patients
March 25, 2019 - New research program launched to highlight sexual harassment in academia
March 25, 2019 - Hemoglobin A1c blood test does not detect diabetes in most patients, shows study
March 25, 2019 - Wyss Technology licensed by Sherlock Biosciences to create affordable molecular diagnostics
March 25, 2019 - DWK Life Sciences launches KIMBLE GLS 80 Media Bottle and Multiport Cap System
March 25, 2019 - New study aims to reduce online sexual exploitation of children
March 25, 2019 - Want healthier eating habits? Start with a workout
March 25, 2019 - New approach to prescribing antibiotics could curb resistance
March 24, 2019 - Theravance Biopharma Announces First Patient Dosed in Phase 2b/3 Study of TD-1473 in Patients with Ulcerative Colitis
March 24, 2019 - Prenatal DHA prevents blood-pressure increase from obesity during childhood
March 24, 2019 - Combined immunosuppression may be effective, safe in treating older patients with Crohn’s disease
March 24, 2019 - GSK sells health drinks arm, buys US cancer treatment firm
March 24, 2019 - Bacteria and innate immune factors in birth canal, cervix may be key to predicting preterm births
March 24, 2019 - IgG antibodies play unexpected role in atherosclerosis
March 24, 2019 - Sounds and vibrations are quite similar for the brain, finds new study
March 24, 2019 - Practices for Reducing COPD Hospital Readmissions Explored
March 24, 2019 - Could an eye doctor diagnose Alzheimer’s before you have symptoms?
March 24, 2019 - Enzyme inhibitor stops inflammation and neurodevelopmental disorders in mouse models
March 24, 2019 - Walk, Dance, Clean: Even a Little Activity Helps You Live Longer
March 24, 2019 - Americans used less eye care in 2014 versus 2008
March 24, 2019 - Study finds link between depression in 20s linked to memory loss in 50s
March 24, 2019 - New tool helps physiotherapy students to master complex fine motor skills
Genome research suggests presence of enteric fever in medieval Europe

Genome research suggests presence of enteric fever in medieval Europe

image_pdfDownload PDFimage_print

Genome research conducted by the University of Warwick suggests that enteric fever, a potentially lethal disease more commonly found in hot countries, was present in medieval Europe.

Salmonella Paratyphi C causes enteric fever, a life-threatening infection, and has been detected in a 800 year old human skeleton discovered in Trondheim, Norway.

Now scientists are speculating that the evolution of enteric fever could be linked to the domestication of pigs across northern Europe.

The research was conducted by a team of international collaborators led by Professor Mark Achtman of the University’s Warwick Medical School and their paper Pan-genome Analysis of Ancient and Modern Salmonella enterica Demonstrates Genomic Stability of the Invasive Para C Lineage for Millennia has been published in the journal Current Biology.

He and his team analysed bacterial DNA found in the teeth and bones of the skeleton of a young woman who is believed to have migrated to Trondheim from the northernmost areas of Scandinavia or Northwest Russia by her early teens only to die there around the age of 19-24 years.

They reconstructed a genome of Salmonella Paratyphi C which causes enteric fever in areas of poor sanitation and lack of clean drinking water. Their discovery indicates that the young Norwegian died of this disease and suggests that these bacteria have long caused enteric fever across northern Europe,

Prof Achtman said: “Paratyphi C is very rare today in Europe and North America except for occasional travellers from South and East Asia or Africa, where the disease is more common. This is the first time that any Salmonella have been found in old human remains in Europe, which is surprising because other Salmonella are more common today, including Salmonella causing typhoid fever, called Typhi, and Salmonella causing food poisoning. Earlier this year, Vågene and co-authors described related Paratyphi C from skeletons in Mexico, who died in 1545 CE, and speculated the Paratyphi C entered the Americas together with Europeans.”

The new results included comparative analyses of the Paratyphi C genome found in the skeleton against modern Salmonella genome sequences from EnteroBase, an online database developed at the University of Warwick and used internationally. This revealed that Paratyphi C represents the evolutionary descendants of a common ancestor, or clade, within the Para C lineage. The Para C Lineage includes Choleraesuis, which causes septicaemia in pigs and boar and Typhisuis which causes epidemic swine salmonellosis (chronic paratyphoid) in domestic pigs. These different host specificities likely evolved in Europe over the last 4,000 years and coincide with the timing of pig domestication in Europe.

According to historical records, humans have long been afflicted by bacterial infections, yet genomic analyses of living bacterial pathogens routinely estimate a date for the most recent common ancestor of no more than a few centuries. In general, evolutionary trees contain a stem group, which may include lineages that are now rare or extinct, as well as the crown group of living organisms. Historical reconstructions based only on the crown group ignore the older sub-lineages in the stem group and thereby provide an incomplete picture of the older evolutionary history of the pathogen. In contrast, analyses of ancient DNA such as the Paratyphi C genome can shed light on additional millennia of bacterial pathogen evolution that occurred prior to the origin of the crown group.

Professor Achtman added: “Using EnteroBase we were able to define the Para C lineage from 50,000 modern Salmonella enterica genomes and find that over its 3,000 year history only a few genomic changes occurred within the Para C lineage.

“As well as reshaping our understanding of Salmonella enterica, our research has triggered intriguing speculations about historical host jumps during the Neolithic period between humans and their domesticated animals.”

Source:

https://warwick.ac.uk/newsandevents/pressreleases/evidence_of_salmonella

Tagged with:

About author

Related Articles