Breaking News
April 26, 2019 - Porvair Sciences’ ultra-flat Krystal glass bottom microplates for imaging applications
April 26, 2019 - Medicines Discovery Catapult’s Virtual R&D Discovery Services platform announce twenty-two partnerships
April 26, 2019 - How optimism can bias prognosis in serious illness
April 26, 2019 - Hospitals Chafe Under Medicare’s New Payment Rule For Off-Campus Clinics
April 26, 2019 - New drug minimizes damage after a heart attack by 60 percent
April 26, 2019 - Synthesizing Modified and Pharmaceutically Relevant Peptides
April 26, 2019 - Using blood thinners in heart failure patients associated with reduced risk of thromboembolic events
April 26, 2019 - Study finds different amounts of physical therapy for stroke patients
April 26, 2019 - Psychologists study how application of cortisol affects exposure therapy for anxiety disorders
April 26, 2019 - SibFU scientists create multilayer gilded nanodisks for medical applications
April 26, 2019 - Marking the start of Pediatric Sepsis Week
April 26, 2019 - The Inflamed Brain | NIH News in Health
April 26, 2019 - Stress-free training may enhance surgical skill
April 26, 2019 - Newsom: California Leads On Prescription Drugs
April 26, 2019 - Exploring novel strategies to heal damage after a heart attack
April 26, 2019 - Small army of tiny robots can remove dental plaque
April 26, 2019 - Cellular communication in emotion-processing brain region motivates us to keep eating tasty food
April 26, 2019 - Greater spousal life satisfaction associated with lower mortality risk
April 26, 2019 - Genetic mutations in brain development lead to discovery of rare genetic diseases
April 26, 2019 - Speech-Based Algorithm Helps ID Posttraumatic Stress Disorder
April 26, 2019 - First birth via robot-assisted uterus transplant
April 26, 2019 - Studies verify novel method of HIV transmission among injection drug users and effective prevention
April 26, 2019 - CircRNAs bind to dsRNA-activated protein kinase which is linked to innate immunity
April 26, 2019 - MR Solutions wins third Queen’s Award
April 26, 2019 - Study details how optimism can bias prognosis in serious illness
April 26, 2019 - Vascular surgery after firearm injury linked with higher morbidity and mortality
April 26, 2019 - New findings about aggressive blood cancer may help develop drugs with less harmful side effects
April 26, 2019 - People with intense feelings of responsibility susceptible to developing OCD, anxiety
April 26, 2019 - Despite expansion of insurance coverage for depression, treatment rates are lower than expected
April 26, 2019 - Huge Malaria vaccine trial in Malawi
April 26, 2019 - Can Obesity Shrink Your Brain?
April 26, 2019 - This oral appliance could help you (and your partner) sleep better
April 26, 2019 - Myelination deficits cause abnormal hypersocial behavior associated with Williams syndrome
April 26, 2019 - New sepsis detector uses photonics to make accurate diagnosis in less than thirty minutes
April 26, 2019 - New study describes process to diagnose rare genetic diseases in record time
April 26, 2019 - Scientists and patients gather in Vancouver to discuss about Stevens-Johnson syndrome
April 26, 2019 - Advance in breakthrough cancer treatment eliminates serious side effects
April 26, 2019 - Discovery about cold sensing could pave way for new pain relief drugs
April 26, 2019 - Children often turn to sugary drinks instead of water
April 26, 2019 - Genome analysis shows the combined effect of many genes on cognitive traits
April 26, 2019 - Patients Caught In Middle Of Fight Between Health Care Behemoths
April 26, 2019 - Drug overdoses among adolescents and young adults on the rise
April 26, 2019 - Implementing a Paperless QC Micro Laboratory”
April 25, 2019 - Obesity linked to a reduction in gray matter
April 25, 2019 - Smart assistants could help combat opioid crisis
April 25, 2019 - Diagnostic stewardship strategy reduces inappropriate testing
April 25, 2019 - Three-antibiotic cocktail eradicates ‘persister’ Lyme bacteria in mouse model
April 25, 2019 - Study investigates how early blindness shapes sound processing
April 25, 2019 - Outcomes Worse for Cancer Patients Seen at Noncancer EDs
April 25, 2019 - Link found between temperament of high-risk infants and obesity
April 25, 2019 - Al Letson explores ties between journalists and doctors at Medicine and the Muse symposium
April 25, 2019 - New mobile phone game can detect people at risk of Alzheimer’s
April 25, 2019 - Scientists discover trigger region for absence epileptic seizures
April 25, 2019 - Stretchy wearable patch can do a health check while you work out
April 25, 2019 - Exercise activates brain circuits associated with memory in older adults
April 25, 2019 - Veggies, Fruits and Grains Keep Your Heart Pumping
April 25, 2019 - Healthy meal kits can boost children’s long-term health
April 25, 2019 - Designing an inexpensive surgical headlight: A Q&A with a Stanford surgeon
April 25, 2019 - States Weigh Banning A Widely Used Pesticide Even Though EPA Won’t
April 25, 2019 - Integrator complex proteins are crucial for healthy brain development in fruit flies, study finds
April 25, 2019 - Device converts brain signals into speech, offering hope for patients
April 25, 2019 - Measles vaccination rates are a ‘public health time bomb’
April 25, 2019 - Maths made easier for scientists students who shun the subject wins award
April 25, 2019 - Researchers decode how cancer drug works in brains of Parkinson’s disease patients
April 25, 2019 - Smarter Brain Cancer Trial Comes to Columbia
April 25, 2019 - Researchers Seek Sage Advice Of Elders On Aging Issues
April 25, 2019 - New chemical synthesis strategy leads to identification of novel, simpler derivatives
April 25, 2019 - Vanderbilt investigators discover link between vascular biology and eye disease
April 25, 2019 - Feces transplantation is effective and provides economic benefits
April 25, 2019 - Eisenhower Health first in Southern California to offer new lung valve treatment for COPD/emphysema
April 25, 2019 - Johns Hopkins researchers uncover role of neurotransmitter in the spread of aggressive cancers
April 25, 2019 - Porvair Sciences offers highly effective P3 microplate for biological sample clean-up
April 25, 2019 - Air pollution increases risk for respiratory hospitalization among childhood cancer survivors
April 25, 2019 - We are sitting more! How bad is that?
April 25, 2019 - Majority of stroke survivors not screened for osteoporosis, despite increased risk
April 25, 2019 - ADHD Screening: MedlinePlus Lab Test Information
April 25, 2019 - Cellular alterations increase vulnerability of obese and diabetic individuals to infection
April 25, 2019 - Association Insurance Pushes On Despite Court Ruling
April 25, 2019 - Traditional and e-cigarette users may be more receptive to smoking cessation interventions
April 25, 2019 - Delving into tumor’s cellular lineage may offer clues for customized therapies
Married people who fight nastily more likely to suffer from leaky guts, study suggests

Married people who fight nastily more likely to suffer from leaky guts, study suggests

image_pdfDownload PDFimage_print

Married people who fight nastily are more likely to suffer from leaky guts – a problem that unleashes bacteria into the blood and can drive up disease-causing inflammation, new research suggests.

It’s the first study to illuminate this particular pathway between bad marriages and poor health, said lead author Janice Kiecolt-Glaser, director of the Institute for Behavioral Medicine Research at The Ohio State University Wexner Medical Center. The study appears in the journal Psychoneuroendocrinology.

“We think that this everyday marital distress – at least for some people – is causing changes in the gut that lead to inflammation and, potentially, illness,” she said.

Researchers at Ohio State recruited 43 healthy married couples, surveyed them about their relationships and then encouraged them to discuss and try to resolve a conflict likely to provoke strong disagreement. Touchy topics included money and in-laws.

The researchers left the couples alone for these discussions, videotaped the 20-minute interactions and later watched how the couples fought. They categorized their verbal and non-verbal fighting behaviors, with special interest in hostility – things such as dramatic eye rolls or criticism of one’s partner.

“Hostility is a hallmark of bad marriages – the kind that lead to adverse physiological changes,” said Kiecolt-Glaser, a professor of psychiatry.

Then the researchers compared blood drawn pre-fight to blood drawn post-fight.

Men and women who demonstrated more hostile behaviors during the observed discussions had higher levels of one biomarker for leaky gut – LPS-binding protein – than their mellower peers. Evidence of leaky gut was even greater in study participants who had particularly hostile interactions with their spouse and a history of depression or another mood disorder.

Previous studies have drawn strong correlations between poor marriages and health woes.

“Marital stress is a particularly potent stress, because your partner is typically your primary support and in a troubled marriage your partner becomes your major source of stress,” Kiecolt-Glaser said.

Research, including some previously conducted at Ohio State, has shown that marital discord can slow wound healing and drive up risk for inflammation-related diseases, including depression, heart disease and diabetes.

The new Ohio State study aimed to search for a novel biological pathway for why that might be.

By looking for the presence of a biomarker associated with bacteria in the bloodstream, the team was able to find evidence of leaky gut, a little-understood condition in which the lining of the intestines becomes more permeable, allowing for the release of partially digested food and bacteria into the bloodstream.

Participants, who ranged in age from 24 to 61 and had been married at least three years. The couples were also part of another Ohio State study looking at how the interactions between marital hostility and depression can lead to obesity.

In the leaky-gut study, the researchers found a strong, significant link between hostility and the biomarker LBP, which indicates the presence of bacteria in the blood. And there was a strong link between that biomarker and evidence of inflammation. Compared to participants with the lowest LBP, those with the highest LBP had 79 percent higher levels of C-reactive protein, the primary biomarker of inflammation.

The researchers also looked at another biomarker of bacteria, called soluble CD14, and at a handful of established inflammatory markers. They found evidence that the biomarkers of leaky gut corresponded to increases in inflammation.

Furthermore, hostile behaviors’ effect on potentially problematic biomarker activity in the bloodstream was more significant for those participants who had a history of depression.

“Depression and a poor marriage – that really made things worse,” Kiecolt-Glaser said. “This may reflect persistent psychological and physiological vulnerabilities among people who have suffered from depression and other mood disorders.”

Michael Bailey, co-author of the study and part of Ohio State’s Institute for Behavioral Medicine Research and The Research Institute at Nationwide Children’s Hospital, said there is an established link between stress, the sympathetic nervous system and changes in the microbes in the gut.

“With leaky gut, the structures that are usually really good at keeping the gunk in our gut – the partially digested food, bacteria and other products – degrade and that barrier becomes less effective,” he said.

And bacteria in the blood driving up inflammation could potentially contribute to poor mental health – creating a troubling loop, Bailey said.

The researchers pointed out that inflammation increases with age and that the average age in this study was 38, which might mean that the results would be more profound in older people.

Lifestyle changes that could contribute to decreased risk of gut-related inflammation include diets high in lean proteins, healthful fats, fruits, vegetables and whole grains, Kiecolt-Glaser said. Probiotics might also be useful, she said.

Tagged with:

About author

Related Articles