Breaking News
January 22, 2019 - Blood marker could aid in early prediction of Alzheimer’s progression
January 22, 2019 - Orthodontic treatment does not guarantee future dental health
January 22, 2019 - Rutgers researchers discover cause of bone loss in people with joint replacements
January 22, 2019 - Diversity among rural Africans extends to their gut microbiomes
January 22, 2019 - Newly developed biological system lets cells to create self-curving cornea
January 22, 2019 - VTv Therapeutics Announces Publication of Comprehensive Data in Science Translational Medicine Detailing the Discovery and Clinical Development of TTP399, including Results of Phase 2 AGATA Study
January 22, 2019 - about one in three adults with prediabetes has arthritis
January 22, 2019 - A look at how data is democratizing health care
January 22, 2019 - Alcohol-Linked Disease Overtakes Hep C As Top Reason For Liver Transplant
January 22, 2019 - Researchers identify new genes linked with age-related macular degeneration
January 22, 2019 - MPFI researchers identify synaptic logic for connections between two brain hemispheres
January 22, 2019 - New study extends our knowledge of the link between miRNAs and cancer
January 22, 2019 - Genetic changes may predict likelihood of relapse in breast cancer patients
January 22, 2019 - Antiepileptic drug use by people with Alzheimer’s disease linked to accumulation of hospital days
January 22, 2019 - IUPUI researcher receives $2.85 million grant to find ways to improve bone strength
January 22, 2019 - Precision medicine can help keep astronauts healthy during deep space missions
January 22, 2019 - Detecting signs of neurodegeneration earlier and more accurately
January 22, 2019 - Mouse studies challenge ‘inhibition’ theory of autism
January 22, 2019 - SSB launches BIOSTAT RM TX single-use bioreactor for producing consistent quality cellular products
January 22, 2019 - Experimental drug can positively modify key characteristic behavior in FXS patients
January 22, 2019 - Low-Income Women Lack Menstrual Hygiene Supplies
January 22, 2019 - Better mouse model built to enable precision-medicine research for Alzheimer’s
January 22, 2019 - Molecular profiling of precancerous lung lesions could lead to early detection and new treatments
January 22, 2019 - Genetic factors influence where fat is stored in our bodies
January 22, 2019 - The Psychology Behind Sticking to Your New Year’s Resolutions
January 22, 2019 - Scientists aim to find genetic causes of developmental abnormalities in the vagina and uterus
January 22, 2019 - New survey reveals scale of preventative healthcare challenge in the UK
January 22, 2019 - Looming Global Crisis Means People’s Diets Must Change: Experts
January 22, 2019 - Excessive social media use is comparable to drug addiction
January 22, 2019 - Researchers show how mechanical stress affects bone development
January 22, 2019 - Study takes a step closer to understanding the body’s response to opioid painkillers
January 22, 2019 - Unexpected connection found between feeding and memory centers of the brain
January 22, 2019 - A revolutionary approach transforms bone trauma treatment
January 22, 2019 - Early studies and recent clinical trials on nerve growth factor
January 22, 2019 - Dry Mouth and Older Adults: Information for Caregivers
January 22, 2019 - Are your grandparents getting tipsy at the holiday party?
January 22, 2019 - New machine learning algorithms identify early symptoms of urinary tract infections
January 22, 2019 - Young women skipping the Pap smear test due to embarrassment
January 22, 2019 - A global influenza pandemic high on the WHO’s agenda
January 22, 2019 - Amgen Makes All Repatha (evolocumab) Device Options Available In The US At A 60 Percent Reduced List Price
January 22, 2019 - Elastronics—hydrogel-based microelectronics for localized low-voltage neuromodulation
January 22, 2019 - Branched-chain amino acids in tumors can be targeted to prevent and treat cancer
January 22, 2019 - Fueling macrophages with energy to attack and eat cancer cells
January 22, 2019 - Amgen And UCB Receive Positive Vote From FDA Advisory Committee In Favor Of Approval For Evenity (romosozumab)
January 22, 2019 - Does being bilingual make children more focused? Study says no
January 22, 2019 - Study reveals new genes and biological pathways linked to osteoarthritis
January 22, 2019 - FSU study provides better understanding of spinal cord injuries
January 22, 2019 - Delaying bath for newborn babies increases breastfeeding rates, finds study
January 21, 2019 - WHO identifies non-communicable diseases as major threat to human health
January 21, 2019 - Many parents still try non-evidence-based cold prevention methods for children
January 21, 2019 - High Levels of Activity, Motor Ability Linked to Better Cognition
January 21, 2019 - Killer blows? Knockout study of pair of mouse MicroRNA provides cancer insight
January 21, 2019 - Buffalo researchers receive grant to quicken development of generic equivalents of contraceptives
January 21, 2019 - One-third of pregnant women do not believe cannabis is harmful to their fetus
January 21, 2019 - Fiderstat could be used as chemopreventative drug for intestinal cancers caused by APC gene mutations
January 21, 2019 - Modifying healthcare delivery practices may improve discussions between youth and healthcare providers
January 21, 2019 - UNIST researcher named as recipient of Merck’s 2018 Life Science Awards
January 21, 2019 - How Getting a Flu Shot Could Save Your Life
January 21, 2019 - Surgical adhesions can be treated, prevented in mice
January 21, 2019 - Increased physician-targeted marketing associated with higher opioid overdose deaths
January 21, 2019 - Researchers uncover specific microbial signatures of intestinal disease
January 21, 2019 - Researchers discover new blood vessel system in bones
January 21, 2019 - Simple blood test reliably detects signs of Alzheimer’s damage before symptoms
January 21, 2019 - Study to investigate new targeted oral treatments for severe asthma
January 21, 2019 - Plan Your Plate | NIH News in Health
January 21, 2019 - Fecal occult blood test may improve CRC outcomes in some
January 21, 2019 - Blood test detects Alzheimer’s disease years before symptoms develop
January 21, 2019 - Mount Sinai joins with Paradigm and ReqMed to repurpose drug for treatment of MPS
January 21, 2019 - FDA Advisory Committee Votes on Zynquista (sotagliflozin) as Treatment for Adults with Type 1 Diabetes
January 21, 2019 - The causes and complications of snoring
January 21, 2019 - Placenta adapts and compensates when pregnant mothers have poor diets or low oxygen
January 21, 2019 - New implant could restore the transmission of electrical signals in injured central nervous system
January 21, 2019 - Rapid-acting fentanyl test strips found to be effective at reducing overdose risk
January 21, 2019 - Coronary Artery Calcium May Help Predict CVD in South Asians
January 21, 2019 - The mystery of the super-ager
January 21, 2019 - Scientists develop smart microrobots that can change shape depending on their surroundings
January 21, 2019 - Keep Moving to Keep Brain Sharp in Old Age
January 21, 2019 - Despite progress, gay fathers and their children still structurally stigmatized
January 21, 2019 - New drug for treating liver parasites in vivax malaria
January 21, 2019 - Merck recognized with 2018 Life Science Industry Award for best use of social media
Married people who fight nastily more likely to suffer from leaky guts, study suggests

Married people who fight nastily more likely to suffer from leaky guts, study suggests

image_pdfDownload PDFimage_print

Married people who fight nastily are more likely to suffer from leaky guts – a problem that unleashes bacteria into the blood and can drive up disease-causing inflammation, new research suggests.

It’s the first study to illuminate this particular pathway between bad marriages and poor health, said lead author Janice Kiecolt-Glaser, director of the Institute for Behavioral Medicine Research at The Ohio State University Wexner Medical Center. The study appears in the journal Psychoneuroendocrinology.

“We think that this everyday marital distress – at least for some people – is causing changes in the gut that lead to inflammation and, potentially, illness,” she said.

Researchers at Ohio State recruited 43 healthy married couples, surveyed them about their relationships and then encouraged them to discuss and try to resolve a conflict likely to provoke strong disagreement. Touchy topics included money and in-laws.

The researchers left the couples alone for these discussions, videotaped the 20-minute interactions and later watched how the couples fought. They categorized their verbal and non-verbal fighting behaviors, with special interest in hostility – things such as dramatic eye rolls or criticism of one’s partner.

“Hostility is a hallmark of bad marriages – the kind that lead to adverse physiological changes,” said Kiecolt-Glaser, a professor of psychiatry.

Then the researchers compared blood drawn pre-fight to blood drawn post-fight.

Men and women who demonstrated more hostile behaviors during the observed discussions had higher levels of one biomarker for leaky gut – LPS-binding protein – than their mellower peers. Evidence of leaky gut was even greater in study participants who had particularly hostile interactions with their spouse and a history of depression or another mood disorder.

Previous studies have drawn strong correlations between poor marriages and health woes.

“Marital stress is a particularly potent stress, because your partner is typically your primary support and in a troubled marriage your partner becomes your major source of stress,” Kiecolt-Glaser said.

Research, including some previously conducted at Ohio State, has shown that marital discord can slow wound healing and drive up risk for inflammation-related diseases, including depression, heart disease and diabetes.

The new Ohio State study aimed to search for a novel biological pathway for why that might be.

By looking for the presence of a biomarker associated with bacteria in the bloodstream, the team was able to find evidence of leaky gut, a little-understood condition in which the lining of the intestines becomes more permeable, allowing for the release of partially digested food and bacteria into the bloodstream.

Participants, who ranged in age from 24 to 61 and had been married at least three years. The couples were also part of another Ohio State study looking at how the interactions between marital hostility and depression can lead to obesity.

In the leaky-gut study, the researchers found a strong, significant link between hostility and the biomarker LBP, which indicates the presence of bacteria in the blood. And there was a strong link between that biomarker and evidence of inflammation. Compared to participants with the lowest LBP, those with the highest LBP had 79 percent higher levels of C-reactive protein, the primary biomarker of inflammation.

The researchers also looked at another biomarker of bacteria, called soluble CD14, and at a handful of established inflammatory markers. They found evidence that the biomarkers of leaky gut corresponded to increases in inflammation.

Furthermore, hostile behaviors’ effect on potentially problematic biomarker activity in the bloodstream was more significant for those participants who had a history of depression.

“Depression and a poor marriage – that really made things worse,” Kiecolt-Glaser said. “This may reflect persistent psychological and physiological vulnerabilities among people who have suffered from depression and other mood disorders.”

Michael Bailey, co-author of the study and part of Ohio State’s Institute for Behavioral Medicine Research and The Research Institute at Nationwide Children’s Hospital, said there is an established link between stress, the sympathetic nervous system and changes in the microbes in the gut.

“With leaky gut, the structures that are usually really good at keeping the gunk in our gut – the partially digested food, bacteria and other products – degrade and that barrier becomes less effective,” he said.

And bacteria in the blood driving up inflammation could potentially contribute to poor mental health – creating a troubling loop, Bailey said.

The researchers pointed out that inflammation increases with age and that the average age in this study was 38, which might mean that the results would be more profound in older people.

Lifestyle changes that could contribute to decreased risk of gut-related inflammation include diets high in lean proteins, healthful fats, fruits, vegetables and whole grains, Kiecolt-Glaser said. Probiotics might also be useful, she said.

Tagged with:

About author

Related Articles