Breaking News
January 15, 2019 - AHA: New Cholesterol Guidelines Put Ethnicity in the Spotlight
January 15, 2019 - Different brain areas linked to smoking and drinking
January 15, 2019 - Henry Marsh shares insights into neurosurgery and more at Dean’s Lecture Series
January 15, 2019 - Want to Live Longer? For Just 30 Minutes a Day, Do Anything Else But Sit
January 15, 2019 - The Current issue of “The view from here” is concerned with Targets
January 15, 2019 - Plain packaging sparked tobacco price rises, new study finds
January 15, 2019 - Sedentary lifestyles can be unhealthy, physical activity can lower risk
January 15, 2019 - Gut microbiome may help prevent development of cow’s milk allergy
January 15, 2019 - Lesbian, gay and bisexual individuals more likely to suffer severe substance use disorders
January 15, 2019 - New England Journal of Medicine Publishes Positive Results of the Pivotal Trial of Cablivi (caplacizumab) for Rare Blood Clotting Disorder
January 15, 2019 - Levels of inflammatory marker (CRP) linked to housing type and tenure
January 15, 2019 - Three gifts I’m glad I gave myself in 2018
January 15, 2019 - Columbia’s Pediatrics Department Names New Vice Chairs, Expands Leadership
January 15, 2019 - US FDA Accepts Regulatory Submissions for Review of Tafamidis to Treat Transthyretin Amyloid Cardiomyopathy
January 15, 2019 - Staying fit can cut your risk of heart attack by half
January 15, 2019 - Vitamin D supplements are of no gain to those over 70, study shows
January 15, 2019 - Scientists create comprehensive new method to predict breast cancer risk
January 15, 2019 - Research shows connection between social media use and impaired risky decision-making
January 15, 2019 - FDA Approves Expanded Use of Adacel (Tdap) Vaccine for Repeat Vaccination
January 15, 2019 - Treating spinal pain with replacement discs made of ‘engineered living tissue’ moves closer to reality
January 15, 2019 - Providers Walk ‘Fine Line’ Between Informing And Scaring Immigrant Patients
January 15, 2019 - Outcomes Poorer for Medicaid Beneficiaries With STEMI
January 15, 2019 - Decorative Products on Foods Can Be Unsafe
January 15, 2019 - A dream of sustainable surgery in Uganda
January 15, 2019 - Study shows how herpes viruses and tumors have learned to manipulate the same ancient RNA
January 15, 2019 - Common Heart, Diabetes Meds May Help Ease Mental Illness
January 15, 2019 - Stress and trauma in earliest years linked to reduced hippocampal volume in adolescence
January 15, 2019 - Scientists identify endogenous activator of sigma-1 receptors in human cells
January 15, 2019 - MAR treatments unlikely to be cause of premature or low birth weight babies
January 15, 2019 - Parental CPTSD increases transmission of trauma to offspring of Tutsi genocide survivors
January 15, 2019 - High-fat diets shown to increase blood pressure
January 15, 2019 - New institute for food safety to be established in Netherlands
January 15, 2019 - Keele University researchers receive £2.4 million grant to help reduce overprescribing of opioids
January 15, 2019 - Synthetic compound reverses mutant p53 aggregate accumulation, study shows
January 15, 2019 - First elder care robot tested in a WSU smart home apartment
January 15, 2019 - Oxford researchers explore relationship between technology use and adolescent mental health
January 15, 2019 - From microbiome research to healthier and sustainable foods
January 15, 2019 - How coaching moms and dads improves infants’ language skills
January 15, 2019 - Precision health approach tapped to identify causes of poverty
January 14, 2019 - DNA origami can accurately measure how antibodies interact with several antigens
January 14, 2019 - Researchers identify multiple new subtypes of most common childhood cancer
January 14, 2019 - Total Fertility Rates Vary by State
January 14, 2019 - Elevated blood lead level in early childhood associated with increased risk of academic problems in school-aged children
January 14, 2019 - Superior technique identified that can block CRISPR gene editing
January 14, 2019 - Turning breast cancer cells into fat cells prevents the formation of metastases
January 14, 2019 - Review examines what influences HIV-positive patients to stay on antiretroviral drugs in Africa
January 14, 2019 - Identifying genetic factors that lead to squamous cell carcinoma
January 14, 2019 - Virtual video visits can replace office visits without compromising quality of care
January 14, 2019 - Health Highlights: Jan. 10, 2019
January 14, 2019 - Scientists uncover how protein clumps damage cells in Parkinson’s
January 14, 2019 - Physician-scientist’s “indomitable spirit” prevails over personal adversity
January 14, 2019 - King’s researchers receive £1.25 million to investigate fatal eating disorder
January 14, 2019 - UCR researchers uncover how plants sense temperature
January 14, 2019 - Scientists find link between colitis and colon cancer
January 14, 2019 - New skin patch provides long-acting contraceptive protection
January 14, 2019 - Asparagine synthetase deficiency – Genetics Home Reference
January 14, 2019 - Improved stem cell approach could aid fight against Parkinson’s
January 14, 2019 - New class of sleeping pill preserves ability to wake in response to danger signals
January 14, 2019 - Cancer patients are four times more likely to commit suicide
January 14, 2019 - The human brain works in reverse order to retrieve memories
January 14, 2019 - Simple tips can lead to better food choices
January 14, 2019 - Meth’s Resurgence Spotlights Lack Of Meds To Combat The Addiction
January 14, 2019 - TARA Biosystems and Insilico Medicine collaborate to discover novel therapies for cardiac disease
January 14, 2019 - Early life stress in mice affects their offspring behavior
January 14, 2019 - Depression Tied to Worse Asthma Outcomes in Urban Teens
January 14, 2019 - Santa calorie counting
January 14, 2019 - Opiod prescriptions for pet dogs misused by their masters
January 14, 2019 - People with ASD could be better at recognizing regret and relief in others finds study
January 14, 2019 - Conducting ChIP-Seq with Low Cell Numbers
January 14, 2019 - Study explores support and social networks of family carers of people with dementia
January 14, 2019 - At Risk for an Opioid OD? There’s an App for That
January 14, 2019 - Single national electronic health record will help improve care in Canadian hospitals
January 14, 2019 - Study unearths Britain’s first speech therapists
January 14, 2019 - Study reveals nuances of racial inequalities in breast cancer prevention
January 14, 2019 - Air pollution can raise the risk of miscarriage among women finds study
January 14, 2019 - An extra meal a day cuts deaths by half in elderly with hip fractures
January 14, 2019 - Researchers report vision-based neurotransmitter events for the first time
January 14, 2019 - Pharmacists could significantly reduce ED crowdedness
January 14, 2019 - PTSD linked with cardiovascular disease and cancer, study shows
January 14, 2019 - New analytic model can accurately predict patients at risk of developing PTSD
Blood serum induces spontaneous movement and growth of skin cells

Blood serum induces spontaneous movement and growth of skin cells

image_pdfDownload PDFimage_print

What happens to skin cells when they are confronted with blood? A team of researchers from Oslo University Hospital, led by Emma Lång and Stig Ove Bøe, performed experiments on blood-deprived cells that were subsequently exposed to blood serum. Remarkably, all the cells started to move and grow in the same direction as soon as the blood serum was added. Assistant Professor Liesbeth Janssen and master student Marijke Valk from Eindhoven University of Technology (TU/e) developed a matching simulation model, revealing new insights into the mechanisms of wound healing. The results were published in the journal Nature Communications this week.

A person encounters approximately 10.000 injuries during a normal lifespan, ranging from small cuts to traumatic injuries and surgery. In most cases, wounds are miraculously repaired, but in some cases the healing process is defective and leads to chronic wounds. This is commonly associated with aging and certain pathologies such as diabetes and obesity.

It is well established that blood plays an important role in wound healing, and various molecular components in the blood are known to trigger tissue repair processes after injury. In the Nature Communications paper, the authors investigate what happens when dormant skin cells are brought into contact with blood, when no wound is present. They find that the blood serum induces spontaneous movement (migration) and growth (proliferation) of cells–two processes that are important in wound healing. Furthermore, they demonstrate that the cell divisions are polarized and aligned with the direction of cell migration, a new insight that may potentially be relevant in tissue repair. The study shows that the presence of blood serum is sufficient to activate dormant skin cells into a migratory and proliferative state, and that a wound edge–previously believed to trigger cell migration and growth–is not necessarily required.

The team from Oslo subsequently studied how the movement and growth of cells is affected by the connectivity between cells. Interestingly, they saw that disconnected cells undergo only random individual motion, but that strong cell-cell connectivities lead to much more pronounced collective and coordinated cell migration, spanning distances of micro- and even millimeter length scales.

To understand this phenomenon, Valk and Janssen of TU/e developed a numerical simulation model that mimics the shape and movement of the cells both in the presence and absence of blood. In their model, blood-deprived cells remain in a quiescent state, while the addition of blood activates cells to undergo spontaneous motion. The simulations indicate that enhanced cell-cell connectivity causes cells to align more strongly with their neighbors, ultimately giving rise to the large-scale collective motion observed in experiments.

It is known that inflammation and increased blood flow to a wound site can be activated without having an open wound, for example by bruising. The scientists involved think their results may be relevant in this field. “One may speculate, based on our data, that cell migration is also activated in these situations”, says Professor Bøe. “We may also speculate that our skin cells are much more active and dynamic than previously thought and that blood-regulated skin dynamics occurs in many different situations.”

“The next step now is to understand why the presence of blood triggers the active forces inside the cells, and why the cells divide asymmetrically in the direction of cell migration”, says Janssen.

Source:

https://www.tue.nl/en/university/news-and-press/news/10-09-2018-a-mere-drop-of-blood-makes-skin-cells-line-up/

Tagged with:

About author

Related Articles