Breaking News
April 26, 2019 - Can Obesity Shrink Your Brain?
April 26, 2019 - This oral appliance could help you (and your partner) sleep better
April 26, 2019 - Myelination deficits cause abnormal hypersocial behavior associated with Williams syndrome
April 26, 2019 - New sepsis detector uses photonics to make accurate diagnosis in less than thirty minutes
April 26, 2019 - New study describes process to diagnose rare genetic diseases in record time
April 26, 2019 - Scientists and patients gather in Vancouver to discuss about Stevens-Johnson syndrome
April 26, 2019 - Advance in breakthrough cancer treatment eliminates serious side effects
April 26, 2019 - Discovery about cold sensing could pave way for new pain relief drugs
April 26, 2019 - Children often turn to sugary drinks instead of water
April 26, 2019 - Genome analysis shows the combined effect of many genes on cognitive traits
April 26, 2019 - Patients Caught In Middle Of Fight Between Health Care Behemoths
April 26, 2019 - Drug overdoses among adolescents and young adults on the rise
April 26, 2019 - Implementing a Paperless QC Micro Laboratory”
April 25, 2019 - Obesity linked to a reduction in gray matter
April 25, 2019 - Smart assistants could help combat opioid crisis
April 25, 2019 - Diagnostic stewardship strategy reduces inappropriate testing
April 25, 2019 - Three-antibiotic cocktail eradicates ‘persister’ Lyme bacteria in mouse model
April 25, 2019 - Study investigates how early blindness shapes sound processing
April 25, 2019 - Outcomes Worse for Cancer Patients Seen at Noncancer EDs
April 25, 2019 - Link found between temperament of high-risk infants and obesity
April 25, 2019 - Al Letson explores ties between journalists and doctors at Medicine and the Muse symposium
April 25, 2019 - New mobile phone game can detect people at risk of Alzheimer’s
April 25, 2019 - Scientists discover trigger region for absence epileptic seizures
April 25, 2019 - Stretchy wearable patch can do a health check while you work out
April 25, 2019 - Exercise activates brain circuits associated with memory in older adults
April 25, 2019 - Veggies, Fruits and Grains Keep Your Heart Pumping
April 25, 2019 - Healthy meal kits can boost children’s long-term health
April 25, 2019 - Designing an inexpensive surgical headlight: A Q&A with a Stanford surgeon
April 25, 2019 - States Weigh Banning A Widely Used Pesticide Even Though EPA Won’t
April 25, 2019 - Integrator complex proteins are crucial for healthy brain development in fruit flies, study finds
April 25, 2019 - Device converts brain signals into speech, offering hope for patients
April 25, 2019 - Measles vaccination rates are a ‘public health time bomb’
April 25, 2019 - Maths made easier for scientists students who shun the subject wins award
April 25, 2019 - Researchers decode how cancer drug works in brains of Parkinson’s disease patients
April 25, 2019 - Smarter Brain Cancer Trial Comes to Columbia
April 25, 2019 - Researchers Seek Sage Advice Of Elders On Aging Issues
April 25, 2019 - New chemical synthesis strategy leads to identification of novel, simpler derivatives
April 25, 2019 - Vanderbilt investigators discover link between vascular biology and eye disease
April 25, 2019 - Feces transplantation is effective and provides economic benefits
April 25, 2019 - Eisenhower Health first in Southern California to offer new lung valve treatment for COPD/emphysema
April 25, 2019 - Johns Hopkins researchers uncover role of neurotransmitter in the spread of aggressive cancers
April 25, 2019 - Porvair Sciences offers highly effective P3 microplate for biological sample clean-up
April 25, 2019 - Air pollution increases risk for respiratory hospitalization among childhood cancer survivors
April 25, 2019 - We are sitting more! How bad is that?
April 25, 2019 - Majority of stroke survivors not screened for osteoporosis, despite increased risk
April 25, 2019 - ADHD Screening: MedlinePlus Lab Test Information
April 25, 2019 - Cellular alterations increase vulnerability of obese and diabetic individuals to infection
April 25, 2019 - Association Insurance Pushes On Despite Court Ruling
April 25, 2019 - Traditional and e-cigarette users may be more receptive to smoking cessation interventions
April 25, 2019 - Delving into tumor’s cellular lineage may offer clues for customized therapies
April 25, 2019 - Two studies uncover brain mechanisms underlying decision making process
April 25, 2019 - Cardiometabolic Risk Better ID’d in Children Reclassified to Higher BP
April 25, 2019 - How the obesity epidemic is taking a toll on our bones and joints
April 25, 2019 - E-cigarettes contaminated with dangerous microbial toxins
April 25, 2019 - Researchers document specific characteristics of storefront tobacco advertisements
April 25, 2019 - Oncotype DX-guided treatment could reduce cost for breast cancer care, study suggests
April 25, 2019 - Predicting whether a patient will benefit from chemotherapy
April 25, 2019 - New review highlights how lifestyle affects our genes
April 25, 2019 - Study provides evidence that blood tests can detect Alzheimer’s risk
April 25, 2019 - Computer program mimics natural speech using brain signals from epilepsy patients
April 25, 2019 - Physicians turning to antibiotic alternatives for long-term acne treatment
April 25, 2019 - Preschool Is Prime Time to Teach Healthy Lifestyle Habits
April 25, 2019 - Study finds insidious and persistent discrimination among physician mothers
April 25, 2019 - Newly identified skin-gut communication helps illuminate link between food allergy and eczema
April 25, 2019 - Thiazide use linked with reduced risk of low energy fractures in people with Alzheimer’s
April 25, 2019 - Some women are biologically more resilient than others to PTSD
April 25, 2019 - The Current issue of “The view from here” is concerned with Partnerships and Alliances
April 25, 2019 - Imaging method reveals long-lived patterns in cells of the eye
April 25, 2019 - Podcast: KHN’s ‘What The Health?’ The Abortion Wars Rage On
April 25, 2019 - Prolonged exposure therapy is more effective in treating veterans with PTSD, alcohol use disorder
April 24, 2019 - Our artificial cornea breakthrough could lead to self-assembling organs
April 24, 2019 - A Stanford black, female, gay surgery resident speaks out
April 24, 2019 - Donna Lynne on Extreme Sports, Lessons From the '60s, and Taking CUIMC to the Next Level
April 24, 2019 - Pain Clinics’ Doctors Needlessly Tested Hundreds Of Urine Samples, Court Records Show
April 24, 2019 - Researchers uncover potential clue to halt destruction of nerve cells in people with ALS
April 24, 2019 - Study uncovers reasons for poor mental health in bisexual people
April 24, 2019 - Screenings, interventions, and referrals can help adolescents overcome substance abuse
April 24, 2019 - Febrile seizures following vaccination are self-resolving and not dangerous
April 24, 2019 - Flow-UV inline UV-Visible spectrometer monitors dispersion in real time
April 24, 2019 - Rates of Marijuana Use in Cancer Patients on the Rise in U.S.
Thermo Fisher Scientific and Diamond collaborate to launch new cryo-EM capability for use in life sciences industry

Thermo Fisher Scientific and Diamond collaborate to launch new cryo-EM capability for use in life sciences industry

image_pdfDownload PDFimage_print

Thermo Fisher Scientific and Diamond Light Source are creating a step change for life sciences sector, a one-stop shop for structural biology and one of largest cryo-EM sites in the world.

An agreement to launch a new cryo-EM capability for use in the life sciences industry sector by Thermo Fisher Scientific, one of the world leaders in high-end scientific instrumentation, and Diamond Light Source, the UK’s national synchrotron and one of the most advanced scientific facilities in the world, was announced today (12 September, 2018) at the official opening of the new national electron bio-imaging center (eBIC) at Diamond.

L to R Dr Richard Henderson, Laboratory of Molecular Biology, Cambridge and one of the recipients of the 2017 Nobel Prize for Chemistry winner; Dan Shine, Senior Vice President, Thermo Fisher Scientific; – Professor Andrew Harrison, CEO Diamond Light Source; Professor Dave Stuart, Life Sciences Director at Diamond and MRC Professor of Structural Biology at University of Oxford; and Katie Cunnea, the Electron Bio-Imaging Center’s (eBIC’s) Senior center coordinator;  at the official opening of the new national electron bio-imaging center (eBIC) at Diamond Light Source, the UK’s national synchrotron

This announcement confirms Diamond as one of the major global cryo-EM sites embedded with an abundance of complementary synchrotron-based techniques, and thereby, provides the life sciences sector with an offer not available anywhere else in the world.

Professor Dave Stuart, Life Sciences Director at Diamond and MRC Professor of Structural Biology at the University of Oxford, Department of Clinical Medicine, says:

Access to 21st century scientific tools to push the boundaries of scientific research is essential for both academia and industry, and what we have created here at Diamond is truly unique in the world in terms of size and scale. The new center offers the opportunity for almost real-time physiology, capturing proteins in action at cryo-temperatures by flash-freezing them at various stages. What Diamond has created with eBIC is an integrated facility for structural biology, which will accelerate R&D for both industry and academic users. The additional advanced instruments made available by Thermo Fisher will position the UK as a global leader in providing large-scale industrial access to cryo-EM for drug discovery research. Our new collaboration provides a step change in our offer for industry users and helps ensure that R&D remains in the UK.”

The collaboration with Thermo Fisher will further expand Diamond’s cryo-EM offerings by providing two new dedicated microscopes and professional cryo-EM services designed exclusively for the pharmaceutical industry. New instruments being installed include a Thermo Scientific Glacios Cryo Transmission Electron Microscope (TEM) and a Thermo Scientific Krios Cryo-TEM at eBIC. The two organisations will provide cryo-EM guidance and expertise in sample preparation, cryo-EM sample screening, and high-end data collection to industrial researchers.

“Researchers at leading pharmaceutical companies are already using instruments from Thermo Fisher Scientific to drive impactful research that can help speed the path to understanding and treating viruses and diseases,” says Mike Shafer, President, Materials and Structural Analysis, Thermo Fisher. “The combination of the expert staff members at eBIC and Diamond, alongside these new Thermo Scientific cryo-EM instruments, ensures these researchers are on the cutting edge of discovery.”

The new microscopes will add to Diamond’s four existing high-end microscopes, which are starting operation within eBIC and will continue to support the academic demand.

Recent technology developments in cryo-EM are proving to be powerful for both basic and applied science at Diamond. This is why Diamond, with the wider community led by Birkbeck College and Oxford University, established a center embedded within the synchrotron’s infrastructure through a strategic grant from the Wellcome Trust, Biotechnology and Biological Research Council and Medical Research Council. The center officially opens today by Dr Richard Henderson from the Laboratory of Molecular Biology, Cambridge. Dr Henderson is one of the recipients of the 2017 Nobel Prize for Chemistry for developing the cryo-EM technique.

Dr Henderson says:

Using single particle cryo-EM, researchers can now visualize biomolecules at near atomic resolution. This technology has taken biochemistry into a new era, allowing atomic structure determinations of many protein and other macromolecular building blocks that were previously very difficult or impossible to obtain. The technique also opens up high resolution studies of macromolecules in their cellular context through the use of electron cryotomography. Coupling these techniques with the capabilities at Diamond creates a unique environment that will help keep the UK at the forefront of world-leading science.”

Structural insight into proteins, viruses and other macromolecular complexes helps pharmaceutical companies better understand disease mechanisms, more quickly assess possible drug targets, and accelerates the optimization of these drug targets. Mike Shafer adds:

It’s important for Thermo Fisher to support this effort with both equipment and staffing, allowing researchers to maximize their time spent with the instruments. We are excited Diamond will provide joint staff, expertise in swift and effective data collection and analysis, and support with sample preparation.”

Pharmaceutical company researchers will have easy access to expert knowledge and industry leading cryo-EM equipment, covering the complete workflow for single particle analysis in the first instance. Access to both a Glacios Cryo-TEM and a Krios Cryo-TEM at one location will optimize productivity and time-to-result because of the designed-in connectivity between the two instruments. Scientists will be able to first pre-screen samples on the Glacios Cryo-TEM to find the best quality samples before advancing to the higher resolution imaging on the Krios Cryo-TEM.

The infrastructure on offer at eBIC taps into the expertise of Diamond as a 24-hours per day, six days a week operational model. Typically, eBIC industry users are granted one to three day sessions depending on their requirements. The two new microscopes will have four staff providing support for year-round operation.

Early users of the facility comments include:

Dr John Barker, Senior Vice President and Global Head of Protein Sciences at Evotec says:

The area of single particle cryo-EM is a rapidly developing technology that is delivering a new approach to looking at previously intractable structural questions. It is an area of huge interest to the pharmaceutical industry because we are able to visualize novel atomic structures of new drug targets and, at the same time improve our understanding of challenging current targets.  The decision to expand eBIC, with a focus on industrial users, is an exciting opportunity for UK-based industry to continue to be at the forefront of structural biology in drug discovery.”

Dr Gillian Burgess, Site Head & VP, Research at Vertex Pharmaceuticals Oxford says:

We have collaborated with Diamond Light Source since its inception 10 years ago. The announced investment in cryo-electron microscopy at the Harwell Campus will transform access to this innovative technology for the Life Sciences Industry. We will be able to image large and complex proteins in a way that has previously not been possible with more traditional techniques. At Vertex we are committed to the development of new precision medicines that can treat serious diseases and we believe that cryo-electron microscopy can accelerate the discovery of such medicines.”

Source:

https://www.diamond.ac.uk/

Tagged with:

About author

Related Articles